Top 5 — Ranked by Evidence
Strong
Nicotinamide Riboside (Niagen®)
NAD+ elevation
250–500 mg/day; most clinical trials use 300–500 mg/day; doses up to 2,000 mg/da
Strong
Urolithin A (Mitopure® — Mitophagy Activator)
Muscle strength improvement — 12% gain in ATLAS RCT
500–1,000 mg/day Urolithin A (as Mitopure®); ATLAS trial: 500 mg (significant) a
Moderate
Amla / Indian Gooseberry (Capros®)
Exceptional antioxidant capacity and vitamin C delivery
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day;
Moderate
Astragalus (Astragalus membranaceus)
Immune system modulation and enhancement
9–30 g/day dried root (traditional TCM dose); standardized extract: 400–1,200 mg
Moderate
Ergothioneine (ErgoActive®)
Exceptional cellular antioxidant protection
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms t
All Longevity Ingredients (15)
Strong
Nicotinamide Riboside (Niagen®)
NAD+ elevation
250–500 mg/day; most clinical trials use 300–500 mg/day; doses up to 2,000 mg/da
Strong
Urolithin A (Mitopure® — Mitophagy Activator)
Muscle strength improvement — 12% gain in ATLAS RCT
500–1,000 mg/day Urolithin A (as Mitopure®); ATLAS trial: 500 mg (significant) a
Moderate
Amla / Indian Gooseberry (Capros®)
Exceptional antioxidant capacity and vitamin C delivery
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day;
Moderate
Astragalus (Astragalus membranaceus)
Immune system modulation and enhancement
9–30 g/day dried root (traditional TCM dose); standardized extract: 400–1,200 mg
Moderate
Ergothioneine (ErgoActive®)
Exceptional cellular antioxidant protection
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms t
Moderate
NMN (Nicotinamide Mononucleotide)
NAD+ restoration
250–500 mg/day (commonly studied); up to 1,200 mg/day in clinical trials
Moderate
PQQ (Pyrroloquinoline Quinone)
Mitochondrial biogenesis stimulation
10–20 mg/day; 20 mg most studied for cognitive effects; often combined with 200–
Moderate
Pomegranate Extract (Pomella®)
Cardiovascular protection and blood pressure
200–1,000 mg/day standardized extract; pomegranate juice studies use 240–500 mL/
Moderate
Puremidine™ (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine; observational longevity data at dietary intake of ~10–15
Moderate
Resveratrol
Cardiovascular protection
150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or lipo
Moderate
RiaGev® (NR + D-Ribose NAD+ Complex)
Synergistic NAD+ elevation beyond NR alone
250–500 mg/day RiaGev®; formulated to optimize both NR and ribose at doses below
Moderate
Robuvit® (French Oak Wood Extract)
Chronic fatigue reduction
300 mg/day Robuvit®; fatigue studies use 300 mg/day; athletic performance: 300 m
Moderate
Senactiv®
VO2 max and endurance improvement
50–100 mg/day; 50 mg is the established clinical dose
Moderate
Yüth® (Longevity Polyphenol Blend)
Cellular senescence clearance (senolytics)
Per Yüth® product specifications; individual component doses vary: fisetin 100–5
Preliminary
Rējen™ (Cellular Rejuvenation Complex)
Cellular rejuvenation and anti-aging
Per Compound Solutions product specifications; newly launched ingredient — clini