Top 5 — Ranked by Evidence
Very Strong
Longvida® Optimized Curcumin (Verdure Sciences)
Healthy Cognitive Aging
400 mg/day Longvida (cognitive applications); 800 mg/day (joint health, exercise reco
Strong
Nicotinamide Riboside
Possible cognitive aging support
Standard dose: 250-1,000 mg/day NR. Most clinical trials use 300-600 mg/day. Take wit
Strong
R-Lipoic Acid (Natural / Stabilized R-ALA)
Diabetic Peripheral Neuropathy
100-300 mg/day R-ALA (equivalent to ~200-600 mg racemic ALA); diabetic neuropathy 600
Strong
Ubiquinol (Reduced CoQ10)
Heart Failure Adjunct (Q-SYMBIO Trial)
100-300 mg/day for general use; 200-400 mg/day for heart failure adjunct; 100-200 mg/
Strong
Urolithin A
Skin health and aging applications
Standard dose: 500-1,000 mg/day urolithin A direct supplementation. Most clinical tri
📈 Fastest Growing Longevity Ingredients
NAD+ precursors and senolytic candidates with the strongest current human data.
Trending
Strong
Urolithin A
Mitophagy induction (distinguishing mechanism)
Standard dose: 500-1,000 mg/day urolithin A direct supplementation. Most clinical trials use…
Trending
Strong
Nicotinamide Riboside
Documented blood NAD+ elevation
Standard dose: 250-1,000 mg/day NR. Most clinical trials use 300-600 mg/day. Take with or…
Trending
Very Strong
Longvida® Optimized Curcumin (Verdure Sciences)
Cognitive Function (400 mg/day)
400 mg/day Longvida (cognitive applications); 800 mg/day (joint health, exercise recovery);…
🔬 Future Longevity Ingredients to Watch
Emerging mechanisms (mitophagy, autophagy, NAD+ pathways) with promising preliminary human data.
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Moderate
Ergothioneine (ErgoActive®)
Exceptional cellular antioxidant protection
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms typically 1–5…
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Moderate
Yüth® (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine (Yüth® formulation specifications); typical supplement use: 1.2 mg/day…
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Moderate
Senactiv®
VO2 max and endurance improvement
50–100 mg/day; 50 mg is the established clinical dose
All Longevity Ingredients (37)
Very Strong
Longvida® Optimized Curcumin (Verdure Sciences)
Healthy Cognitive Aging
400 mg/day Longvida (cognitive applications); 800 mg/day (joint health, exercise reco
Strong
Nicotinamide Riboside
Possible cognitive aging support
Standard dose: 250-1,000 mg/day NR. Most clinical trials use 300-600 mg/day. Take wit
Strong
R-Lipoic Acid (Natural / Stabilized R-ALA)
Diabetic Peripheral Neuropathy
100-300 mg/day R-ALA (equivalent to ~200-600 mg racemic ALA); diabetic neuropathy 600
Strong
Ubiquinol (Reduced CoQ10)
Heart Failure Adjunct (Q-SYMBIO Trial)
100-300 mg/day for general use; 200-400 mg/day for heart failure adjunct; 100-200 mg/
Strong
Urolithin A
Skin health and aging applications
Standard dose: 500-1,000 mg/day urolithin A direct supplementation. Most clinical tri
Moderate
Ergothioneine (ErgoActive®)
Cognitive aging and neurodegeneration prevention
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms typica
Moderate
GlyNAC (Glycine + N-Acetylcysteine)
Aging hallmarks improvement (multiple)
PIVOTAL: glycine 1.33 mmol/kg/day (~7 g/70 kg) + NAC 0.83 mmol/kg/day (~9.5 g/70 kg)
Moderate
MitoQ (Mitoquinone)
Improved endothelial function in older adults (pivotal)
ROSSMAN 2018 VASCULAR: 20 mg/day × 6 wk endothelial function. PD PHASE II: 40-80 mg/d
Moderate
Molecular Hydrogen (H2)
Metabolic syndrome improvement (pivotal)
HRW: 1.5-7 ppm H2 in water, 0.5-2 L/day. LeBaron 2020 high-conc: ~7 ppm × 24 wk metab
Moderate
Multivitamin / Multimineral
Reduced total cancer incidence in older men (PHS II)
STANDARD: 1 tablet/day MVMM ~100% DV most vitamins, 25-100% DV minerals. PHS II + COS
Moderate
Tremella fuciformis (Snow Mushroom / Silver Ear Fungus)
Skin hydration vs hyaluronic acid (Applechem 4-week study)
TOPICAL: snow mushroom extract 1-2× daily. ORAL: 1-3 g dried fruiting body or 500-1,0
Moderate
Veri-te™ Resveratrol (Evolva)
Cognitive performance in postmenopausal women
RESHAW PIVOTAL: 75 mg trans-resveratrol BID = 150 mg/day × 12-24 months in postmenopa
Moderate
Yüth® (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine (Yüth® formulation specifications); typical supplement use: 1.
Moderate
ActivAMP® (Gynostemma for Healthy Aging)
Healthy Aging / Longevity Mechanism
200-450 mg/day per Saanroo specification
Moderate
Amla / Indian Gooseberry (Capros®)
Telomere preservation and cellular aging
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day; vita
Moderate
Astragalus (Astragalus membranaceus)
Telomerase activation and telomere preservation
ROOT: 2-6 g/day dried OR 250-500 mg/day standardized extract. IMMUNE: 500 mg BID. TA-
Moderate
EGCG (Epigallocatechin Gallate)
Antioxidant Activity
200-400 mg/day general use; 400-800 mg/day weight management trials; CRITICAL — EFSA
Moderate
NMN (Nicotinamide Mononucleotide)
NAD+ restoration
250–500 mg/day (commonly studied); up to 1,200 mg/day in clinical trials
Moderate
Puremidine™ (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine; observational longevity data at dietary intake of ~10–15 mg/d
Moderate
RiaGev® (NR + D-Ribose NAD+ Complex)
Cellular aging and longevity support
250–500 mg/day RiaGev®; formulated to optimize both NR and ribose at doses below thei
Moderate
Robuvit® (French Oak Wood Extract)
Chronic fatigue reduction
300 mg/day Robuvit®; fatigue studies use 300 mg/day; athletic performance: 300 mg/day
Moderate
Senactiv®
Senescent cell clearance
50–100 mg/day; 50 mg is the established clinical dose
Moderate
GG-Gold® (Geranylgeraniol — American River Nutrition)
Healthy Aging Applications
Per ARN GG-Gold product specification
Limited
Anserine (β-alanyl-3-methyl-L-histidine)
Verbal memory preservation in older adults
HISATSUNE 2016 COGNITIVE: 1.0 g anserine/carnosine 3:1 daily × 3 mo. MASUOKA 2019 MCI
Limited
Oxaloacetate (Anhydrous Enol)
AMPK activation for longevity
Standard dose: 100-300 mg/day anhydrous enol oxaloacetate (benaGene™). Cognitive appl
Limited
Alpha-Ketoglutarate (AKG / Calcium AKG)
Animal lifespan extension across multiple species
REJUVANT/CA-AKG: 1000 mg sustained-release × 4-10 mo. ABLE: 1-2 g/day × 6 mo. POST-SU
Limited
Centrophenoxine (Meclofenoxate)
Reduction of lipofuscin (age-related cellular waste pigment)
DEMENTIA: 1560-2000 mg/day (Pek 1989: 2 g/day × 8 wk). HEALTHY ELDERLY: ~1200 mg/day.
Limited
CyanthOx™ (Sea Buckthorn Proanthocyanidin Extract)
Acute stem cell mobilization — preliminary
Drapeau 2019 acute trial: 500 mg CyanthOx™30 (~150 mg sea buckthorn proanthocyanidins
Limited
Japanese Knotweed (Polygonum cuspidatum)
Anti-aging and longevity (resveratrol-mediated)
STANDARDIZED EXTRACTS (8% trans-resveratrol): 250-500 mg 1-2×/day → 20-40 mg resverat
Limited
Apigenin
CD38 Inhibition / NAD+ Preservation (Theoretical)
50-100 mg/day common in longevity stacks (Bryan Johnson protocol uses 50 mg/day); cha
Limited
Chaga Mushroom (Inonotus obliquus)
Antioxidant Activity
500-2,000 mg/day extract; standardized to beta-glucan content (typically 30%+); tradi
Limited
Fisetin
Senolytic Activity (Eliminates Senescent Cells)
100-1,500 mg/day (continuous) for general antioxidant; HIT PROTOCOL: 20 mg/kg body we
Limited
Luteolin
Mast Cell Stabilization
100-300 mg/day general use; mast cell protocols often use luteolin 100-200 mg with qu
Limited
Phaeodactylum tricornutum (PT Microalga)
Healthy Aging Support (Pilot Data)
STIEFVATTER 2021 BIOAVAILABILITY: 5.3 g/day whole PT biomass × 2 wk (~150-200 mg EPA
Limited
Pterostilbene
SIRT1 Activation (Theoretical Longevity)
50-250 mg/day; trial used 125 mg twice daily (250 mg/day total)
Preliminary
Polygonum multiflorum / Reynoutria multiflora (He Shou Wu / Fo-Ti)
Traditional anti-aging and hair-blackening claims (TCM)
TCM RAW (RPM): ~5 g/day raw root per Chinese Pharmacopoeia. PROCESSED (PMP): ~5-15 g/
Preliminary
Rējen™ (Cellular Rejuvenation Complex)
Cellular rejuvenation and anti-aging
Per Compound Solutions product specifications; newly launched ingredient — clinical d