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Top Picks — Immune Support

🛡️ Best Immune Support Supplements

Beta-glucans, vitamins, and immunomodulatory ingredients clinically studied for cold/flu prevention, immune resilience, and host defense.

159 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

Common Cold Duration and Severity Reduction

75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip

Bifidobacterium animalis subsp. lactis (BB-12 / HN019)

Immune function and respiratory infection reduction

1–10 billion CFU/day (BB-12); 17.2 billion CFU/day (HN019 in constipation studies)

Respiratory infections

RDA: 600-800 IU/day. Optimal serum 25(OH)D: 30-50 ng/mL (typically 1,000-2,000 IU/day

Beta-Glucans (Oat & Yeast-Derived)

Respiratory immune support (yeast β-glucan)

Cholesterol (FDA claim): 3 g/day oat β-glucan. Immune (Wellmune®): 250-500 mg/day yea

May Shorten the Common Cold (Cold Lozenges)

13–23 mg elemental zinc per lozenge for cold use (75–100 mg/day total); 50 mg three t

📈 Fastest Growing Immune Support Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

EpiCor® (Postbiotic Yeast Fermentate — Cargill)

Gut-immune axis support

BLIS K12® (Streptococcus salivarius for ENT — Stratum Nutrition)

Salivary Immunity Support

1 billion CFU/day for oral maintenance (1 lozenge or slow-release tablet); the pediatric…

🔬 Future Immune Support Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

ResistAid® (Larch Arabinogalactan — Lonza)

Antibody Response Enhancement

PEA — Palmitoylethanolamide

Neuropathic pain relief (substantial evidence)

300-1,200 mg/day; commonly 600 mg twice daily (1,200 mg total); bioavailable forms (Levagen+®)…

Bifidobacterium breve

Atopic dermatitis and food allergy: studied in infants under clinical supervision

Infant/preterm (M-16V) 1×10⁹ CFU/day; adult immune 1×10⁹–1×10¹⁰ CFU/day; pregnancy allergy…

Recommended Immune Support Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced immune support ingredients ranked above — chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best foundation — fix Vitamin D deficiency first Amazon →

Sports Research Vitamin D3 5000 IU + Coconut MCT Oil

Vitamin D3 (cholecalciferol) — 5000 IU + MCT

Vitamin D deficiency directly impairs immune function and affects 40%+ of U.S. adults. The 5000 IU (125 mcg) dose corrects deficiency reliably — typical 1000-2000 IU products often don't move serum levels enough. Coconut MCT oil pairing improves fat-soluble vitamin absorption. Year-round daily prevention. Test serum 25-hydroxyvitamin D after 8-12 weeks; target 40-60 ng/mL. Best foundational immune supplement before anything else.

Best beta-glucan immune modulator (Wellmune®) Amazon →

Immune Health Basics Ultra Strength Immunity (Wellmune®)

Wellmune® beta-1,3/1,6-glucan — 250 mg

Wellmune® is the most-studied branded beta-glucan with 13+ peer-reviewed clinical trials. 250 mg matches the clinical RCT dose — Talbott 2013 showed a 10% URI rate in stressed adults vs. 29% on placebo. Different mechanism than vitamin D: primes innate immune cells (macrophages and neutrophils) via gut Peyer's patches. Best for daily prevention during high-stress periods (work, travel, training).

Best postbiotic for URI prevention (gut-immune axis) Amazon →

Doctor's Best EpiCor Immune Support

EpiCor® dried yeast fermentate — 500 mg

EpiCor® is a dried yeast fermentate (postbiotic) with the strongest evidence among postbiotics for upper respiratory infection prevention. 500 mg matches the clinical dose and activates NK (natural killer) cells within 2 hours. Different mechanism than Wellmune — works via gut-immune axis with postbiotic metabolites rather than direct immune cell priming. Doctor's Best provides genuine EpiCor at a reasonable price.

Best botanical for active illness (take at first symptoms) Amazon →

Double Wood Andrographis with AP-Bio®

Andrographis paniculata — AP-Bio® standardized

Andrographis has the strongest clinical evidence for reducing cold duration and severity when started at first symptoms. AP-Bio® is the patented standardized extract used in the RCTs — different from generic andrographis powder, which is less potent. Take for 3-5 days at first symptoms, not as daily prophylaxis. Distinct use case from the other three products: this one is for active illness, not prevention.

All Immune Support Ingredients (168)

Common Cold Duration and Severity Reduction

75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip

Bifidobacterium animalis subsp. lactis (BB-12 / HN019)

Immune function and respiratory infection reduction

1–10 billion CFU/day (BB-12); 17.2 billion CFU/day (HN019 in constipation studies)

Respiratory infections

RDA: 600-800 IU/day. Optimal serum 25(OH)D: 30-50 ng/mL (typically 1,000-2,000 IU/day

Beta-Glucans (Oat & Yeast-Derived)

Respiratory immune support (yeast β-glucan)

Cholesterol (FDA claim): 3 g/day oat β-glucan. Immune (Wellmune®): 250-500 mg/day yea

May Shorten the Common Cold (Cold Lozenges)

13–23 mg elemental zinc per lozenge for cold use (75–100 mg/day total); 50 mg three t

Lactobacillus rhamnosus GG (LGG)

Upper Respiratory Tract Infection Reduction

10–20 billion CFU/day; 5–10 billion CFU/day commonly used in pediatric protocols

ResistAid® (Larch Arabinogalactan — Lonza)

Antibody Response Enhancement

1.5-4.5 g/day ResistAid (research-validated)

Upper respiratory tract infections

Standard URI dose: 200-1,200 mg/day andrographis extract standardized to ≥10% androgr

BetaVia™ (Euglena gracilis Algae Beta-1,3-Glucan — Kemin)

Fewer URTI sick days (90-day RCT)

Pivotal trial: 367 mg/day BetaVia Complete for 90 days. Kemin recommended dosing: 375

Bioferrin® (Lactoferrin — Glanbia)

100-1000 mg/day lactoferrin (varies by application; immune support typical 100-300 mg

Garlic (Allium sativum)

Antimicrobial and immune activity

600–1,200 mg/day aged garlic extract (AGE); raw garlic equivalent: 2–4 cloves/day; al

Immune function

55 mcg/day (RDA); therapeutic studies: 100–200 mcg/day; upper limit 400 mcg/day

Immune modulation

15 mg/day (RDA); therapeutic studies use 400–1,000 IU/day

Immune System Support

8–11 mg/day (RDA); therapeutic: 25–40 mg/day elemental zinc; upper limit 40 mg/day; a

effera® (Human-Identical Lactoferrin)

Manufacturer study found no antibody response to effera®

Per effera® product specifications; Helaina clinical dosing; typical lactoferrin dose

Probiotics (Multi-strain Blends)

Immune modulation

1–10 billion CFU/day maintenance; up to 50 billion CFU/day therapeutic

Ester-C® (Buffered Calcium Ascorbate Vitamin C — American Health)

500 to 1000 mg of vitamin C per day.

Common Cold Symptom Reduction

15–50 mg elemental zinc/day for general supplementation; for cold treatment 13.3–23 m

FucoMax® (Fucoidan from Brown Seaweed — BGG)

Antiviral and antibacterial activity (laboratory findings only)

Per BGG FucoMax product specification

Immune System Support

200–400 mg/day standardized extract (ginsenosides ≥4–7%); American ginseng: 100–200 m

ParActin® (Andrographis Extract — HP Ingredients)

Immune and respiratory claims come from a two-herb combination

Standard formulation use: 100-300 mg ParActin® once or twice daily. Take with food to

PROMUNEL® (Propolis Immune Extract)

Immune modulation and inflammatory regulation

400–800 mg/day propolis extract; PROMUNEL® clinical dose per PLT specifications; immu

Reduced upper respiratory symptoms

600–900 mg extract/day during illness; 150–300 mg/day for prevention

Reishi Mushroom

Immune modulation

1.5–9 g/day whole mushroom powder; 1–1.5 g/day standardized extract

AHCC (Active Hexose Correlated Compound)

Immune Cell Activation

1-3 g/day; 3 g/day used in HPV clearance trials (Smith 2019 — 6 months); 1-3 g/day fo

Aqua-D3® (Water-Dispersible Vitamin D3)

Commonly 1000 to 4000 IU per day.

Bacillus subtilis

Immune system training and infection resistance

1–10 billion CFU/day; DE111 commonly dosed at 1 billion CFU/day

BLIS K12® (Streptococcus salivarius for ENT — Stratum Nutrition)

Salivary Immunity Support

1 billion CFU/day BLIS K12 (research-validated)

DE111® (Bacillus subtilis Probiotic — ADM Deerland)

Commonly 1 billion CFU per day.

Kyolic® (Aged Garlic Extract — Wakunaga)

Immune system support

Standard cardiovascular protocol: 1,200-2,400 mg/day Kyolic® in divided doses. Differ

L-OptiZinc® (Zinc Mono-L-Methionine — Lonza)

Immune System Support

10-30 mg elemental zinc/day (per L-OptiZinc product specification)

Maitake Mushroom (Grifola frondosa)

Immune Activation (D-Fraction)

1-3 mg D-fraction/kg body weight (50-300 mg D-fraction/day for typical adults); whole

Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)

Commonly 100 to 200 mg per day.

SoWell™ (Postbiotic Heat-Killed Lactobacillus)

Shelf-stable immune modulation

Per SoWell™ product specifications; typical postbiotic dose 10–100 billion CFU equiva

Streptococcus thermophilus (Specific Strains)

ST36 immune + intestinal function support

ST81: 3 billion CFU/day. ST36: similar consumer dose. AAD prevention combination with

Beef Spleen (Desiccated)

Immune-related peptides (mechanistically interesting, clinically uncharacterized)

Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef sp

C-Fence® (Sustained-Release Vitamin C — Nutriventia)

Commonly providing a standard daily vitamin C dose in one sustained-release serving.

Streptococcus salivarius

Looked at in children prone to repeated ear infections (K12)

1 billion CFU/day (K12 lozenge); 1 billion CFU/day (M18 lozenge)

Arabinoxylan (Arrabina®)

Immune system modulation

4–15 g/day; blood sugar management: 8–15 g/day with meals; immune studies: 4–10 g/day

Immune modulation

1,000–3,000 mg/day mycelium powder; 400–800 mg/day standardized extract

iXOS® (Xylooligosaccharides Prebiotic)

Metabolic and immune health benefits

1–2g/day iXOS® for prebiotic bifidogenic effects (much lower than other prebiotics at

Lactobacillus plantarum

Immune function in athletes and stressed populations

10–50 billion CFU/day; 299v strain typically 20 billion CFU/day; weight management st

Polypodium Leucotomos

Immune Modulation

Typically dosed at 240–480 mg/day

Setria® Glutathione

Immune system enhancement

250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels

Immune Function and Mucosal Barrier Integrity

700–900 mcg RAE/day (adults); upper limit 3,000 mcg RAE/day

Zinc Bisglycinate (Zinc Glycinate)

15–30 mg elemental zinc/day for general supplementation; up to 50 mg for short-term t

Earthlight® (Whole Food Mushroom Vitamin D2)

Immune function support

250–1000 IU Vitamin D2 equivalent per serving as Earthlight®; dosing equivalent to 25

Spectramune® (Immune Defense Complex)

No published evidence that it prevents infections

Per Spectramune® clinical dosing; PLT Health Solutions product specifications

Astragalus (Astragalus membranaceus)

Immune modulation and upper-respiratory support

ROOT: 2-6 g/day dried OR 250-500 mg/day standardized extract. IMMUNE: 500 mg BID. TA-

Bovine Colostrum

Upper respiratory illness in athletes

10-20 g/day for 8-12 weeks in most human trials; a smaller set of trials used 0.5-1.0

10-20 g/day for 8-12 weeks in most human trials; a smaller set of trials used 0.5-1.0

Isenolic® (Olive Polyphenols for Cold/Flu)

Neuraminidase inhibition (anti-influenza mechanism)

Per Pharmactive product specification

SelenoForce® (Selenium-Enriched Yeast — Sabinsa)

Immune function support

100-200 mcg/day elemental selenium from SelenoForce. RDA: 55 mcg/day; tolerable upper

AlvioLife® (Respiratory Health & Performance)

Immune biomarker modulation (IFN-γ up, IL-4 down)

Per AlvioLife® clinical dosing; PLT Health Solutions product specifications

CM-Glucan™ Nu

Immune 'training' and resilience

EpiCor® (Postbiotic Yeast Fermentate — Cargill)

Gut-immune axis support

500 mg/day EpiCor (research-validated)

Kutki (Picrorhiza kurroa)

Immunomodulation

TRADITIONAL AYURVEDIC: 250-500 mg dried rhizome 2-3×/day OR 1-3 g/day decoction. STAN

Lactobacillus casei

Colds and respiratory infections: not measured in the study cited here

10^9–10^10 CFU/day (Yakult provides 10^10 CFU/65mL bottle); 10–100 billion CFU/day in

Lactobacillus paracasei (Multi-Strain Specialist)

Upper respiratory symptom duration

L. CASEI 431® RESPIRATORY: ≥1×10⁹ CFU/day × 42 days. KW3110 POLLEN ALLERGY: 4×10¹⁰ CF

Phyto-C® (whole-food vitamin C and polyphenol immune complex — FutureCeuticals)

Everyday immune support

150 mg/day of the finished whole-food blend; acerola supplies the natural vitamin C.

Shiitake Mushroom (Lentinula edodes)

Immune Modulation

1,000-3,000 mg/day mushroom extract; lentinan is typically given INJECTABLY (1-2 mg/w

Tinofend® (Tinospora cordifolia for Immune — Verdure)

Adaptogenic immune balance (not stimulation)

Per Verdure Tinofend product specification

VitAlign® (plant polyphenol cellular-vitality blend — FutureCeuticals)

Supports healthy immune balance

Single 50 mg oral dose; 50 mg/day (90-day metabolic study is manufacturer data)

Zinmax® (Premium Zinc Picolinate - Nutrition 21)

8-15 mg elemental zinc daily (typical zinc supplementation; therapeutic doses higher)

Bifidobacterium bifidum

Immune modulation and balanced inflammation

IBS (live MIMBb75): 1×10⁹ CFU/day for 4+ weeks; IBS (heat-inactivated MIMBb75 / SYN-H

Attenutin® (Scutellaria and Acacia for Respiratory Health — Unigen)

Immune and inflammatory balance

Per the product specification.

Berriqi® (Boysenberry and Apple Polyphenols — Anagenix)

Immune cells in the lung, animal data only

A daily serving of the standardized polyphenol concentrate.

GS15-4® (Enzyme-Fermented Ginseng — Ilhwa)

Around 165 mg of fermented ginseng extract per day.

Nutramunity® Beta-Glucan (Yeast Beta-Glucan)

Commonly around 75 to 250 mg per day.

PeakO2® (Adaptogenic Mushroom Blend)

Immune and stress claims have no cited study behind them

1–4g/day for ongoing use; 4g/day for clinical performance benefits (21-day loading);

Prodiet® Colostrum (Bovine Colostrum — Ingredia)

Commonly a few grams of colostrum per day.

Sparassis crispa (Cauliflower Mushroom / Hanabiratake)

Dectin-1 / GM-CSF immunomodulation pathway

β-GLUCAN content: >40% of dry weight (highest among medicinal mushrooms). MOUSE Sarco

SynBalance® (Probiotic Strains — ROELMI)

Commonly billions of CFU per day, depending on the strain.

Turkey Tail Mushroom

Immune system activation

1–3 g/day PSK extract; 2–9 g/day whole mushroom powder

15–50 mg elemental zinc/day; toothpaste/mouthwash use 0.1–0.3% concentration

Immune System Support

300–500 mg three times daily (900–1,500 mg/day) during illness; prevention: 300 mg/da

Phellinus linteus (Meshimakobu / Sanghuang)

Immune markers in a 30-person pilot trial (trend-level results)

: PL mycelium extract 1,000 mg/day × 8 weeks (n=98, KCTC0399BP strain). IMMUNITY RCT:

500–1,000 mg/day; absorption enhanced significantly with vitamin C or bromelain; quer

Immunell™ (Nucleotides + Prebiotic Acacia)

Immune Response Reinforcement

Nexira specifies recommended dose; clinical research uses varying nucleotide intake l

merLIX™ (marine DNA & nucleotide complex — InnoVactiv)

Supports normal immune function

~200 to 400 mg/day

Olivactive® (Olive Leaf Extract for Immune Support)

Reduced sick days in athletes

Per Pharmactive product specification

Agaricus blazei Murill (AbM / Himematsutake / Royal Sun Mushroom)

Lung cancer surgery pilot: a combination product, and the main immune result was not…

ANDOSAN™ ORAL: 60 mL/day liquid extract × 7 weeks (multiple myeloma protocol). NSCLC

Goldenseal (Hydrastis canadensis)

Antimicrobial and immune support

500–1,000 mg/day dried root powder; standardized extract: 250–500 mg/day; typically u

Immune function — preliminary evidence

General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome:

Eleuthero / Siberian Ginseng (Eleutherococcus senticosus)

Preliminary Antiviral/Immune Signal (Not a Treatment)

300-1,200 mg/day standardized extract; root powder 1-3 g/day

Antiviral activity (preclinical)

Traditional/clinical doses: 100-500 mg/day humic acid extract. No FDA-recognized stan

Hōlistiq™ (Adaptogen + Mushroom Wellness Blend)

Immune modulation and defense

Per product label; typical adaptogen blend 300–800mg/day; mushroom component 500mg–2g

Chaga Mushroom (Inonotus obliquus)

Immune Modulation

500-2,000 mg/day extract; standardized to beta-glucan content (typically 30%+); tradi

StaiMune® (Inactivated Bacillus coagulans GBI-30 — Kerry)

Around 0.5 to 1 billion inactivated cells per day.

Thymocid® (Black Cumin Seed Extract — Natural Remedies)

Immune effects in the plant literature

A standardized daily dose providing a defined amount of thymoquinone.

Uva ursi (Bearberry)

REGATTA trial: fewer antibiotic courses, but worse symptoms and more kidney infections

ATAFUTI 2019: 3600 mg extract = 720 mg arbutin/day × 5 d. REGATTA: 6 caps × 105 mg =

Shatavari (Asparagus racemosus / Xeya®)

Immune support — modest evidence

500-1,000 mg/day standardized root extract. Lactation: 300 mg twice daily. PCOS (CL22

Cat's Claw (Uncaria tomentosa)

Immune system modulation

250–500 mg/day standardized POA extract; rheumatoid arthritis trials: 60 mg freeze-dr

Spirumune® (Spirulina for Immunity)

Commonly 1 to 2 grams of spirulina per day.

Tinospora Cordifolia (Tinofend®)

Immune system modulation

300 mg/day Tinofend® (standardized extract); traditional Ayurvedic dose: 1–3 g/day wh

Biootic® (Probiotic Cultures)

Commonly billions of CFU per day, depending on the strain.

Brewster Probiotics™ (Probiotic Cultures)

Varies by strain and product; commonly billions of CFU per day.

ColostrumOne™ (Bovine Colostrum — PanTheryx)

Immune support during heavy training, with honest limits

500 mg to 1 g per serving

Eyebright (Euphrasia officinalis)

Upper respiratory mucosal support

Oral: 400–800 mg/day dried herb or standardized extract; ophthalmic solution: 1–2 dro

Morinaga BB536 (Bifidobacterium longum BB536)

Immune effects: not tested

Often 1 to 5 billion CFU or more per day.

Noni (Morinda citrifolia)

Immune modulation

30–750 mL/day noni juice; most studies use 29–118 mL (1–4 oz) daily; freeze-dried pow

PhytoServ® (concentrated fruit & vegetable phytonutrient extract — FutureCeuticals)

Supports immune resilience

Not established for the finished ingredient; dosed to a "1 serving" phytonutrient equivalent per label

Ferrous Sulfate

Established Standard for Iron Deficiency

60-200 mg elemental iron/day for adult IDA treatment (often 325 mg ferrous sulfate =

Aged Garlic Extract

Blood pressure reduction in hypertension

Standard cardiovascular dose: 600-2,400 mg/day AGE standardized to S-allyl cysteine c

Bifidobacterium breve

Atopic dermatitis and food allergy: studied in infants under clinical supervision

INFANT AD (M-16V Morinaga): 1×10⁹ CFU/day × 1 mo. PRETERM (M-16V): 1×10⁹ CFU/day NICU

Ferrous Bisglycinate

Superior GI Tolerability

25-60 mg elemental iron/day; pregnancy: 25-30 mg/day often sufficient

Ferrous Fumarate

Higher Elemental Iron Content

60-200 mg elemental iron/day for adult IDA (often 200 mg ferrous fumarate = 65 mg ele

Gingever® (High-Potency Ginger Extract — OmniActive)

Occasional constipation

280 mg/day Gingever (Eraiah 2024 constipation trial, taken nightly after dinner for 8

Limosilactobacillus reuteri DSM 17938 (BioGaia Protectis®)

Infant colic crying time reduction

Infants: 100 million CFU (1×10⁸) once daily as drops (BioGaia Protectis® dosing). Chi

PEA — Palmitoylethanolamide

Neuropathic pain relief (substantial evidence)

Standard dose: 300-1,200 mg/day PEA. Most clinical trials use 600 mg twice daily (1,2

Aged Black Garlic ABG10+® (Pharmactive)

Blood pressure reduction in hypertensive adults

Standard dose: 250-500 mg/day ABG10+® standardized aged black garlic extract. Cardiov

Bacillus clausii (Enterogermina® / Erceflora)

Acute diarrhea — supports faster recovery in children

Standard dose: 2 billion spores (2×10⁹ CFU) 2-3 times daily as oral suspension. AAD p

Bifidobacterium longum

Stress reduction and emotional regulation (psychobiotic effects)

1–10 billion CFU/day; 1714 strain studies use 1 billion CFU/day for psychobiotic effe

Anti-inflammatory and pain relief

200–400 mg/day (500–2,000 GDU) for anti-inflammatory; 400–800 mg/day with meals for d

Codonopsis lanceolata (Deodeok / Korean Bonnet Bellflower)

Sarcopenia 12-week RCT protocol (Kyung Hee)

TCM TYPICAL: 9-15 g/day root decoction. SARCOPENIA RCT (Park 2022 protocol): 750 mg w

Cran-d'Or® (Cranberry Extract)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Cran-Gyn PRO® (Cranberry for Urinary and Feminine Health)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Urinary Tract Health

400–500 mg/day standardized extract (PAC 36 mg); for UTI prevention: daily long-term;

ImmuseLC-Plasma (Lactococcus lactis strain Plasma)

Plasmacytoid dendritic cell activation

100 billion (10¹¹) heat-killed L. lactis strain Plasma/day standard RCT dose. Kirin i

LactoSpore® (Heat-Stable Bacillus coagulans Probiotic)

Studied in people with IBS and in adults with gas and bloating

1–4 billion CFU/day LactoSpore® Bacillus coagulans; IBS and gut health: 2 billion CFU

Multivitamin / Multimineral

Reduced total cancer incidence in older men (PHS II)

STANDARD: 1 tablet/day MVMM ~100% DV most vitamins, 25-100% DV minerals. PHS II + COS

Neem (Azadirachta indica)

Plaque and Gingivitis Reduction (RCT-Confirmed)

PINGALI 2020 T2DM: 125/250/500 mg standardized neem BID = 250-1000 mg/day × 12 wk + m

Selenium Yeast (High-Selenium Yeast)

What the Cancer Trials Actually Found

100-200 µg elemental selenium/day; SELECT used 200 µg/day; NPC trial used 200 µg/day

Zinc Picolinate

Bioavailability

15–50 mg elemental zinc/day; for short-term immune/skin: up to 50 mg/day for 4–8 week

Better vitamin C retention in one small single-dose study (n=6)

UCHIDA 2011 BIOAVAILABILITY: 50 mg vit C from acerola juice. COMMERCIAL: 100-500 mg p

Akkermansia muciniphila

GLP-1 secretion via P9 protein (mechanistic)

Depommier 2019: 10¹⁰ CFU/day pasteurized × 3 months. Most products: 10⁸-10⁹ CFU/day.

Beef Liver (Desiccated)

Highest natural source of preformed vitamin A (retinol)

Typical supplementation: 3-6 g/day (4-8 capsules at 750 mg each) desiccated beef live

BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)

Dental Health Support

1 billion CFU/day BLIS M18 (research-validated)

Butterbur (Petasites hybridus)

Migraine prevention

50–75 mg twice daily PA-free Petadolex® (75–150 mg/day) for migraine prevention; alle

Calendula (Pot Marigold)

Topical use during cancer radiotherapy (supportive care, not a consumer use)

RADIATION DERMATITIS: Boiron Pommade au Calendula 2×/day during radiotherapy. WOUND/S

Superior antioxidant effect vs isolated vitamin C

RCT: 70 mL 100% camu juice daily (~1050 mg vit C) × 7 d. POWDER SUPPLEMENTS: 100-500

CaroCare® (Natural Beta-Carotene — DSM)

Vitamin A support

Commonly providing a few milligrams of beta-carotene per day.

Carotex® (Natural Beta-Carotene and Carotenoids — Zeus Hygia)

Vitamin A and antioxidant support

Commonly providing a few milligrams of carotenoids per day.

Clostridium butyricum MIYAIRI 588 (CBM588 / MIYA-BM® / Butirrisan®)

Butyrate production in the gut

Standard dose: 20-80 mg/day of MIYA-BM® powder providing 1-4×10⁸ CFU. Adult AAD preve

Codonopsis pilosula (Dang Shen / Poor Man's Ginseng)

Traditional use for tiredness, with no human trial of Codonopsis alone

TCM TYPICAL: 9-15 g/day root decoction. oncology adjunct: oral liquid (approved Chine

CompleteGreens™ (Comprehensive Greens Base)

Ready-to-use turnkey superfood base

3–8g/day comprehensive greens blend; specific CompleteGreens™ dosing per NNB product

Cranbey® (Cranberry Extract)

Urinary tract health

Commonly around 500 mg of cranberry concentrate per day.

Faecalibacterium prausnitzii (Next-Generation Probiotic)

Anti-inflammatory effects in IBD

Clinical trial doses: typically 1-10 billion CFU/day in oxygen-protected formulations

Ferrous Gluconate

Often Chosen for Sensitive Stomachs

50-300 mg elemental iron/day; often 325 mg ferrous gluconate = ~38 mg elemental Fe pe

GliSODin® (Vegetal SOD with Gliadin — Isocell)

Antioxidant blood markers in a 19-person athlete trial

Around 250 mg per day.

Heme Iron Polypeptide (HIP)

Absorbed by a Different Route Than Iron Salts

10-22 mg elemental heme iron/day; Proferrin Forte = 11 mg elemental iron per tablet

Iron Polysaccharide Complex (Niferex®)

Better GI Tolerability

150-300 mg elemental iron/day (Niferex® Forte = 150 mg elemental iron per capsule)

IBS-D and post-infectious IBS — strongest gut evidence

Gut barrier: 15 g/day (3x5g). Permeability (2024 meta): >30 g/day, <2 weeks. Sickle c

Lactobacillus fermentum CECT5716 (Lc40 / Hereditum®)

Studied for breast health during breastfeeding

Mastitis prevention/treatment: 3×10⁹ CFU/day for 21 days minimum, ideally throughout

Lactobacillus johnsonii La1 (NCC533 / CNCM I-1225)

Cell-free La1 liquid partly lowered H. pylori in 20 adults

MICHETTI 1999 H. PYLORI: La1 whey-based culture supernatant ~10⁹ CFU/mL adults. FERME

Lactobacillus salivarius (Multi-Strain)

Caries risk reduction (WB21)

ORAL HEALTH (WB21): 2.0×10⁹ CFU/day × 2 weeks (caries). PERIODONTAL (heat-killed CP33

Myrrh (Commiphora molmol)

Anti-inflammatory Activity (Mechanistic / Preclinical)

MIRAZID® antiparasitic: 600 mg (2 × 300 mg) daily empty stomach × 3-6 d. Soliman 2004

Optibiome® BS50 (Bacillus subtilis MB40 — BIO-CAT Microbials)

Decreased gastrointestinal symptoms in healthy adults

Per BIO-CAT Optibiome BS50 product specification

Oregano Oil (Origanum vulgare)

Enteric Parasite Activity (Limited Human Evidence)

FORCE 2000 ENTERIC PARASITES: 600 mg emulsified oregano oil daily × 6 wk. CONSUMER: 1

Rosmarinic Acid

Studied in people with seasonal hay fever

ALLERGIC RHINITIS: 50-200 mg/day Perilla × 21 d. AD COGNITION (Noguchi-Shinohara): 50

Cholesterol effects are unsettled — squalene is a cholesterol precursor that can raise…

CV: 860 mg/day × 20 wk hypercholesterolemia. STRANDBERG 1990: 900 mg/day. PK: 500 mg

Thyme (Thymus vulgaris)

Acute Bronchitis Cough Reduction (Thyme-Ivy Combination)

BRONCHIPRET® THYME-IVY: 5.4 mL × 3/day × 11 d. BRONCHIPRET® TP: 1 tablet × 3/day × 11

Verilla® (Perilla Extract for Seasonal Allergy)

Seasonal allergy comfort

Around 50 to 200 mg of rosmarinic acid per day.

Beef Kidney (Desiccated)

Exceptional selenium concentration

Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef ki

BiAloe® (Aloe Vera Polysaccharides)

Digestive support

Commonly a few hundred milligrams per day.

BioEcolians® (Alpha-Glucan Oligosaccharide — Solabia)

Fermented by bifidobacteria in laboratory cultures

Typically a few grams per day for digestive use; lower amounts in topical application

Cold sores: what the cited research actually found

500–3,000 mg/day; herpes suppression: 1,000–3,000 mg/day during outbreaks, 500–1,500

NaturSYN® Defense (Rye and Oyster Mushroom Blend)

Inflammatory mediators: laboratory testing only

Per the product specification.

TruServ® (whole-food fruit & vegetable servings — FutureCeuticals)

Helps bridge the produce gap

No established finished-product dose; sold to deliver label-defined USDA fruit/vegetable serving equivalents