Home Ingredients CaloriBurn GP® (Grains of Paradise)
Weight Management

CaloriBurn GP® (Grains of Paradise)

Aframomum melegueta
Evidence Level
Moderate
2 Clinical Trials
4 Documented Benefits
3/5 Evidence Score

CaloriBurn GP® is NNB Nutrition's premium grains of paradise extract standardized for all three clinically active compounds — 6-paradol, 6-shogaol, and 6-gingerol — unlike competing extracts that standardize only for 6-paradol. This complete-spectrum approach activates brown adipose tissue thermogenesis, increases energy expenditure, and improves body composition at a remarkably low 40 mg clinical dose.

Studied Dose 40 mg/day before exercise or meals; clinically effective at this low dose
Active Compound 6-Paradol, 6-Shogaol, 6-Gingerol complex — CaloriBurn GP® by NNB Nutrition (Aframomum melegueta extract)

Benefits

Brown adipose tissue activation

Grains of paradise bioactives activate TRPV1 receptors in brown adipose tissue, triggering thermogenesis via UCP1 upregulation. Human studies show significantly increased whole-body energy expenditure and reduced visceral fat in the abdominal region after supplementation.

Supported by Trial 1, Trial 2

Metabolic rate increase

A human trial showed grains of paradise extract significantly increased energy expenditure in healthy young women by activating BAT thermogenesis — with effects measured via infrared thermography and metabolic calorimetry. Non-stimulant mechanism with no cardiovascular side effects.

Supported by Trial 1, Trial 2

Visceral fat reduction

A 4-week RCT in healthy young men demonstrated significant reductions in visceral fat area (measured via CT scan) with grains of paradise supplementation vs. placebo, with no changes in subcutaneous fat — suggesting preferential BAT-mediated visceral fat mobilization.

Supported by Trial 1

Synergy with MitoBurn and other thermogenics

CaloriBurn GP activates thermogenesis through TRPV1/BAT pathways, while MitoBurn (L-BAIBA) activates WAT-to-BAT conversion — creating complementary and synergistic mechanisms when combined in fat-burning formulations.

Supported by Trial 2

Mechanism of action

1

TRPV1 receptor activation

6-Paradol, 6-shogaol, and 6-gingerol are agonists of the TRPV1 (transient receptor potential vanilloid 1) channel — the same receptor activated by capsaicin from hot peppers. TRPV1 activation in adipose tissue and the enteric nervous system triggers thermogenic responses via the sympathetic nervous system.

2

UCP1 expression and BAT activation

TRPV1 activation triggers intracellular calcium flux in brown adipocytes, stimulating UCP1 expression and mitochondrial uncoupling — the process by which brown fat generates heat by burning calories rather than storing ATP.

3

Mitochondrial biogenesis stimulation

Grains of paradise compounds promote mitochondrial biogenesis in adipose tissue via PGC-1α upregulation, increasing the metabolic capacity of brown and beige fat depots over time with repeated supplementation.

Clinical trials

1
Grains of Paradise Daily Ingestion and Energy Expenditure in Women — RCT
PubMed

Single-blind, randomized, placebo-controlled crossover trial of grains of paradise extract (30 mg/day) vs placebo in 19 non-obese young women (ages 20-22) for 4 weeks. Outcomes: whole-body energy expenditure (indirect calorimetry), visceral fat area (CT scan). (Sugita et al. 2014, J Nutr Sci Vitaminol)

19 non-obese young women. 4-week crossover.

Daily GP extract significantly increased whole-body energy expenditure and reduced visceral fat area at the umbilicus level vs placebo. Effects negatively correlated with initial visceral fat area (greater effect in those with higher baseline visceral fat). Mechanism via brown adipose tissue (BAT) activation. Note: small sample, single-blind — independent replication in larger samples needed.

2
Grains of Paradise BAT Activation in Men — RCT
PubMed

Randomized, placebo-controlled trial in 19 healthy male volunteers (ages 20-32) examining acute effects of GP extract on whole-body energy expenditure and brown adipose tissue (BAT) activity. BAT activity confirmed via FDG-PET imaging during cold exposure (19°C, 2 hr). (Sugita et al. 2013, Br J Nutr)

19 healthy young men.

GP extract significantly increased energy expenditure in BAT-positive subjects (12 of 19) but not in BAT-negative subjects. Demonstrates that grains of paradise effects are mediated through BAT activation. Practical implication: efficacy may depend on individual BAT presence — typically more abundant in younger, leaner individuals.

Side effects and drug interactions

Common Potential side effects

Very well tolerated at 40 mg clinical dose
GI discomfort possible at higher doses with some whole grains of paradise extracts — CaloriBurn's purity minimizes this
Mild warming sensation is expected and normal — indication of thermogenic activity

Important Drug interactions

Thermogenic medications or supplements — additive heat-generating effects; monitor in hot environments
Antihypertensive medications — mild sympathomimetic activity; monitor blood pressure
Anticoagulants — gingerol compounds may mildly affect platelet aggregation; monitor with warfarin

More Weight Management Ingredients

Antioxidant
Green Tea
Green tea extract, derived from Camellia sinensis leaves, is rich in antioxidants like cat…
Metabolic Health
Berberine
Berberine is a bioactive compound extracted from plants like barberry and goldenseal, know…
Metabolic Health
Inositol (Myo-Inositol)
Inositol is a naturally occurring sugar alcohol that acts as a secondary messenger in insu…
Weight Management
Capsaicin / Capsicum Extract (Cayenne Pepper)
Capsicum extract (cayenne pepper, red chili pepper) and its primary bioactive capsaicin ar…

Explore Other Ingredients

Energy
NMN (Nicotinamide Mononucleotide)
NMN (nicotinamide mononucleotide) is a precursor that the body uses to make NAD+, a coenzy…
Energy
Iron
Iron is an essential mineral best known for its central role in making hemoglobin, the pro…
Athletic Performance
Cordyceps
Cordyceps is a medicinal mushroom traditionally prized as an energy and vitality tonic, po…

Frequently asked questions about CaloriBurn GP® (Grains of Paradise)

What is CaloriBurn GP?

CaloriBurn GP® is NNB Nutrition's premium grains of paradise extract standardized for all three clinically active compounds — 6-paradol, 6-shogaol, and 6-gingerol — unlike competing extracts that standardize only for 6-paradol.

What is CaloriBurn GP used for?

CaloriBurn GP is researched primarily for Weight Management. Grains of paradise bioactives activate TRPV1 receptors in brown adipose tissue, triggering thermogenesis via UCP1 upregulation.

What is the recommended dosage of CaloriBurn GP?

The clinically studied dose is 40 mg/day before exercise or meals; clinically effective at this low dose Always follow the product label and check with a healthcare provider for personal advice.

Is CaloriBurn GP safe, and does it have side effects?

For most healthy adults, CaloriBurn GP is well tolerated at studied doses. Reported effects can include: Very well tolerated at 40 mg clinical dose GI discomfort possible at higher doses with some whole grains of paradise extracts — CaloriBurn's purity minimizes this It may also interact with some medications. CaloriBurn GP is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does CaloriBurn GP interact with any medications?

Possible interactions include: Thermogenic medications or supplements — additive heat-generating effects; monitor in hot environments Antihypertensive medications — mild sympathomimetic activity; monitor blood pressure If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for CaloriBurn GP?

NutraSmarts rates the evidence for CaloriBurn GP as Moderate (3 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Sugita J, Yoneshiro T, Hatano T, Aita S, Ikemoto T, Uchiwa H, et al. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr. 2013;110(4):733-8. doi: 10.1017/S0007114512005715.PubMedUsed to support: RCT (n=19 healthy men): 40 mg Aframomum melegueta extract activated brown adipose tissue (FDG-PET confirmed) and increased whole-body energy expenditure—directly supports CaloriBurn GP's BAT activation and metabolic rate claims at the same dose.
  2. Sugita J, Yoneshiro T, Sugishima Y, Ikemoto T, Uchiwa H, Suzuki I, Saito M. Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. J Nutr Sci Vitaminol (Tokyo). 2014;60(1):22-7. doi: 10.3177/jnsv.60.22.PubMedUsed to support: RCT: daily A. melegueta extract ingestion significantly increased whole-body energy expenditure and reduced visceral fat compared to placebo—directly supports CaloriBurn GP's visceral fat reduction and metabolic rate claims.
  3. Sudeep HV, Aman K, Jestin TV, Shyamprasad K. Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults - A Randomized Double-Blind, Placebo-Controlled Clinical Study. Drug Des Devel Ther. 2022;16:3777-3791. doi: 10.2147/DDDT.S367350.PubMedUsed to support: Double-blind RCT (n=70 overweight adults, 12 weeks): standardized A. melegueta seed extract reduced visceral fat and enhanced energy expenditure vs. placebo—supports CaloriBurn GP's visceral fat reduction and metabolic rate claims in an overweight population.
  4. Yoneshiro T, Matsushita M, Sugita J, Aita S, Kameya T, Sugie H, Saito M. Prolonged Treatment with Grains of Paradise (Aframomum melegueta) Extract Recruits Adaptive Thermogenesis and Reduces Body Fat in Humans with Low Brown Fat Activity. J Nutr Sci Vitaminol (Tokyo). 2021;67(2):99-104. doi: 10.3177/jnsv.67.99.PubMedUsed to support: Human intervention study: prolonged A. melegueta extract treatment recruited adaptive thermogenesis and reduced body fat specifically in subjects with low baseline BAT activity—supports CaloriBurn GP's brown adipose tissue activation and fat reduction claims.