Home Ingredients GABACare® (Gamma-Aminobutyric Acid)
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GABACare® (Gamma-Aminobutyric Acid)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

GABACare® supplies GABA (gamma-aminobutyric acid), the brain's main calming neurotransmitter, produced naturally by fermentation. Taken as a supplement, GABA is studied for promoting relaxation and supporting easier, more restful sleep, with effects measurable on brain-wave activity.

Studied Dose Commonly around 100 to 200 mg per day.
Active Compound Gamma-aminobutyric acid (GABA), produced by natural lactic-acid fermentation.

Benefits

Relaxation

In human studies, oral GABA increased calming alpha brain-wave activity and reduced stress-related beta waves, supporting a relaxed state.

Supported by Trial 1

Easier sleep

GABA has been shown to shorten the time it takes to fall asleep and support deeper non-REM sleep in clinical research.

Supported by Trial 1

Stress support

By promoting relaxation, GABA is used to help take the edge off everyday stress.

Supported by Trial 1

Mechanism of action

1

Inhibitory neurotransmission

GABA is the body's primary inhibitory neurotransmitter, calming over-excited nerve signaling to promote relaxation.

2

Gut-brain and autonomic effects

Because oral GABA crosses into the brain poorly, its calming effects are thought to act partly through the enteric nervous system and a shift toward parasympathetic activity.

Clinical trials

1
Oral GABA and Sleep — Human Study
PubMed

Study of the effect of oral GABA administration on sleep and its absorption in humans. (Yamatsu et al. 2016, Food Science and Biotechnology)

Healthy adults.

Oral GABA shortened sleep latency and supported sleep measures versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Sedatives or sleep medication — possible additive calming effect; use caution.
Blood pressure medication — GABA may modestly lower blood pressure; monitor.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about GABACare® (Gamma-Aminobutyric Acid)

What is GABACare® (Gamma-Aminobutyric Acid)?

GABACare® supplies GABA (gamma-aminobutyric acid), the brain's main calming neurotransmitter, produced naturally by fermentation. Taken as a supplement, GABA is studied for promoting relaxation and supporting easier, more restful sleep, with effects measurable on brain-wave activity.

What is the recommended dosage of GABACare® (Gamma-Aminobutyric Acid)?

The clinically studied dose for GABACare® (Gamma-Aminobutyric Acid) is Commonly around 100 to 200 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is GABACare® (Gamma-Aminobutyric Acid) used for?

GABACare® (Gamma-Aminobutyric Acid) is studied for relaxation, easier sleep, stress support. In human studies, oral GABA increased calming alpha brain-wave activity and reduced stress-related beta waves, supporting a relaxed state.

Are there side effects from taking GABACare® (Gamma-Aminobutyric Acid)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is GABACare® (Gamma-Aminobutyric Acid) safe to take?

Whether GABACare® (Gamma-Aminobutyric Acid) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. GABACare® (Gamma-Aminobutyric Acid) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Yamatsu A, Yamashita Y, Pandharipande T, et al. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food Sci Biotechnol. 2016;25(2):547-551..PubMedUsed to support: Human study supporting sleep and relaxation benefit of oral GABA.