Home Ingredients BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)
Immune Support

BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)

Evidence Level
Strong
1 Clinical Trial
6 Documented Benefits
4/5 Evidence Score

BLIS M18® is a PROPRIETARY STREPTOCOCCUS SALIVARIUS PROBIOTIC STRAIN developed by Blis Technologies and distributed by Stratum Nutrition — distinguished by specific oral health applications targeting teeth and gums. Complementary to BLIS K12 (which targets ENT). Produces BLIS targeting cariogenic and periodontal pathogens. Used for: dental health, gum health, plaque reduction, oral microbiome balance, dental hygiene adjunct.

Studied Dose 1 billion CFU/day BLIS M18 (research-validated)
Active Compound Streptococcus salivarius M18 (proprietary strain producing salivaricin M)

Benefits

Dental Health Support

BLIS M18 colonizes oral cavity and supports tooth health — produces bacteriocins targeting cariogenic bacteria including Streptococcus mutans (primary cavity-causing bacteria).

Supported by Trial 1

Gum Health Adjunct

Modulates oral microbiome supporting healthy gums; complementary to dental hygiene practices.

Supported by Trial 1

Plaque Reduction

Some BLIS M18 trials demonstrate reduced dental plaque accumulation.

Supported by Trial 1

Oral Microbiome Balance

Establishes beneficial Streptococcus salivarius population reducing pathogenic bacteria.

Streptococcus mutans Inhibition

Specifically targets S. mutans (primary cavity-causing organism) via salivaricin M production.

Supported by Trial 1

Adjunct to Dental Hygiene

Used in conjunction with regular brushing, flossing, dental visits — enhances rather than replaces traditional dental care.

Supported by Trial 1

Mechanism of action

1

Oral Cavity Colonization

S. salivarius M18 colonizes oral cavity competing with pathogenic bacteria for niches.

2

Salivaricin M Production

Produces salivaricin M — bacteriocin targeting S. mutans (primary cavity-causing bacteria).

3

Cariogenic Bacteria Inhibition

Reduces populations of S. mutans, S. sobrinus, and other cavity-causing bacteria.

4

Enzyme Production

Produces enzymes that may support oral cavity homeostasis.

Clinical trials

1
BLIS M18 for Dental Health — Multiple RCTs
PubMed

Multiple BLIS M18 RCTs on dental health markers including S. mutans counts, plaque, gum health.

Children and adults.

Reduced S. mutans counts; supports dental health markers.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated.
Mild GI distress (rare).
Allergic reactions extremely rare.
DAIRY allergen in original version — dairy-free version now available.
BACTEREMIA RISK in IMMUNOCOMPROMISED — theoretical risk with all live probiotics; consult.

Important Drug interactions

Antibiotics — kills probiotic; separate timing.
Immunosuppressants — caution; consult.
Pregnancy — generally safe; consult.
Lactation — generally safe.
Children — established pediatric safety.
DAIRY ALLERGY — use dairy-free version.

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Frequently asked questions about BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)

What is the recommended dosage of BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)?

The clinically studied dose for BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) is 1 billion CFU/day BLIS M18 (research-validated). Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) used for?

BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) is studied for dental health support, gum health adjunct, plaque reduction. BLIS M18 colonizes oral cavity and supports tooth health — produces bacteriocins targeting cariogenic bacteria including Streptococcus mutans (primary cavity-causing bacteria).

Are there side effects from taking BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition)?

Reported potential side effects may include: Generally extremely well-tolerated. Mild GI distress (rare). Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) interact with medications?

Known drug interactions may include: Antibiotics — kills probiotic; separate timing. Immunosuppressants — caution; consult. Consult a pharmacist or healthcare provider if you take prescription medications.

Is BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) good for immune support?

Yes, BLIS M18® (Streptococcus salivarius for Oral Health — Stratum Nutrition) is researched for Immune Support support. BLIS M18 colonizes oral cavity and supports tooth health — produces bacteriocins targeting cariogenic bacteria including Streptococcus mutans (primary cavity-causing bacteria).