Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)

Cissus quadrangularis
Evidence Level
Moderate
2 Clinical Trials
6 Documented Benefits
3/5 Evidence Score

Cissus Extract from Verdure Sciences is a STANDARDIZED CISSUS QUADRANGULARIS extract — distinguished by proprietary standardization for bone health and joint support applications. Cissus has long traditional Ayurvedic use as 'Asthi Sandhani' (bone-uniter). Used for: bone health, joint health, exercise recovery, cortisol modulation in athletes.

Studied Dose Per Verdure product specification
Active Compound Cissus quadrangularis standardized extract (ketosterones, vitamin C, calcium)

Benefits

Bone Health Support

Cissus has documented effects on bone metabolism — supports bone formation markers; relevant to bone density support.

Fracture Healing Adjunct

Long traditional use for fracture healing ('Asthi Sandhani' = bone-uniter); modern animal and limited human research supports.

Joint Health

Reduces inflammatory markers in joint tissue; supports comprehensive joint health.

Exercise Recovery

Some athletes report improved recovery from training; cortisol modulation may contribute.

Cortisol Modulation in Athletes

Some evidence for cortisol-lowering effects relevant to overtraining syndrome.

Glucocorticoid Receptor Effects

Some research suggests anti-glucocorticoid activity — relevant to bone health (glucocorticoids cause bone loss).

Mechanism of action

1

Anti-Glucocorticoid Activity

Some research suggests Cissus has anti-glucocorticoid effects; relevant to bone health (chronic glucocorticoid exposure causes osteoporosis) and possibly cortisol-related concerns.

2

Bone Formation Support

Effects on osteoblast function and bone formation markers.

3

Anti-Inflammatory

Reduces inflammatory markers relevant to joint health.

4

Antioxidant Activity

Vitamin C and polyphenol content provide antioxidant support.

Clinical trials

1
Cissus quadrangularis for Fracture Healing — Animal Studies
PubMed

Multiple animal studies of Cissus on fracture healing and bone formation.

Animal models.

Documented effects on bone formation and fracture healing rates.

2
Cissus for Joint Health — Limited Human Evidence
PubMed

Limited human clinical studies of Cissus for joint and bone applications.

Adults with joint concerns.

Modest improvements in joint comfort markers.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Headache rare.
Allergic reactions rare.

Important Drug interactions

Diabetes medications — modest hypoglycemic effects.
Anticoagulants — modest effects.
Glucocorticoids — theoretical opposing effects.
Pregnancy — limited safety data; AVOID.
Lactation — limited data.

Frequently asked questions about Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)

What is Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)?

Cissus Extract from Verdure Sciences is a STANDARDIZED CISSUS QUADRANGULARIS extract — distinguished by proprietary standardization for bone health and joint support applications.

What does Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) do?

Some research suggests Cissus has anti-glucocorticoid effects; relevant to bone health (chronic glucocorticoid exposure causes osteoporosis) and possibly cortisol-related concerns. In clinical research, Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) has been studied for bone health support, fracture healing adjunct, joint health.

Who should take Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)?

Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) may be most relevant for people interested in bone health, joint health, athletic performance. It has been clinically studied for bone health support, fracture healing adjunct, joint health. As with any supplement, consult your healthcare provider before starting, especially if you have medical conditions or take prescription medications.

How long does Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) take to work?

Most clinical trial effects appear over weeks of consistent use; individual response varies. Acute or same-day effects (where applicable) typically appear within hours, but most cumulative benefits — particularly those affecting biomarkers, mood, sleep quality, or chronic symptoms — require 4-12 weeks of regular use to fully assess. If you don't notice benefit after 12 weeks at the appropriate dose, it may not be your responder.

When is the best time to take Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)?

Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) can typically be taken with breakfast or dinner — taking with food reduces GI sensitivity for most supplements. Specific timing matters less than daily consistency for cumulative effects. Always check product labeling and follow personalized guidance from your healthcare provider.

Is Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) worth taking?

Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) has moderate clinical evidence (Evidence Level 3/5 on NutraSmarts) — meaningful trial support exists, though results are less consistent than top-tier ingredients. Whether it's worth taking depends on your specific goals, what you've already tried, your budget, and your overall supplement strategy. The honest framing: no supplement is essential for most people, and lifestyle factors (sleep, exercise, diet, stress management) typically produce larger effects than any single supplement. Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) is most worth trying if its evidence-supported uses align with your specific goals.

What is the recommended dosage of Cissus Extract (Cissus quadrangularis for Bone Health — Verdure)?

The clinically studied dose for Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) is Per Verdure product specification. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) used for?

Cissus Extract (Cissus quadrangularis for Bone Health — Verdure) is studied for bone health support, fracture healing adjunct, joint health. Cissus has documented effects on bone metabolism — supports bone formation markers; relevant to bone density support.