Top 5 — Ranked by Evidence
Very Strong
Calcium
Bone Health and Osteoporosis Prevention
1,000 mg/day (adults under 50); 1,200 mg/day (women 51+, men 71+); supplement no
Very Strong
Copper
Iron metabolism and anemia prevention
0.9 mg/day (RDA); 1–2 mg/day supplement; upper limit 10 mg/day; use 1 mg copper
Very Strong
Vitamin D
Bone Health and Fracture Prevention
600–800 IU/day (RDA); optimal blood levels (50–80 ng/mL) typically require 2,000
Strong
K2Quest® (Fermentation-Derived Vitamin K2 MK-7)
Bone density and fracture risk reduction
90–180 mcg/day MK-7 for bone and cardiovascular health; PMS: 90 mcg/day; 3-year
Strong
Manganese
Mitochondrial antioxidant defense via MnSOD
1.8–2.3 mg/day (AI for adults); upper limit 11 mg/day; most multivitamins contai
All Bone Health Ingredients (21)
Very Strong
Calcium
Bone Health and Osteoporosis Prevention
1,000 mg/day (adults under 50); 1,200 mg/day (women 51+, men 71+); supplement no
Very Strong
Copper
Iron metabolism and anemia prevention
0.9 mg/day (RDA); 1–2 mg/day supplement; upper limit 10 mg/day; use 1 mg copper
Very Strong
Vitamin D
Bone Health and Fracture Prevention
600–800 IU/day (RDA); optimal blood levels (50–80 ng/mL) typically require 2,000
Strong
K2Quest® (Fermentation-Derived Vitamin K2 MK-7)
Bone density and fracture risk reduction
90–180 mcg/day MK-7 for bone and cardiovascular health; PMS: 90 mcg/day; 3-year
Strong
Manganese
Mitochondrial antioxidant defense via MnSOD
1.8–2.3 mg/day (AI for adults); upper limit 11 mg/day; most multivitamins contai
Strong
PEA — Palmitoylethanolamide (Levagen+®)
Chronic pain relief across multiple conditions
300–600 mg/day Levagen+® (LipiSperse® form); standard PEA: 300–1,200 mg/day in d
Strong
Phosphorus / Phosphate
Bone mineral density and skeletal strength
700 mg/day (RDA for adults); athletic phosphate loading: 3–4 g/day sodium phosph
Strong
Soy Isoflavones (Glycine max)
Menopausal symptom reduction
40–80 mg/day total isoflavones; menopausal symptoms: 50–80 mg/day; bone health:
Strong
Vitamin K
Blood Clotting
90–120 mcg/day K1 (RDA); MK-7 (K2): 90–200 mcg/day for bone/cardiovascular; Mena
Moderate
Aquamin® (Marine Minerals)
Superior bone mineral density support
800–1,200 mg/day Aquamin® (providing ~256–384 mg elemental calcium); bone health
Moderate
Boron
Bone health and density
3–10 mg/day elemental boron
Moderate
Celadrin® (Cetylated Fatty Acids)
Joint pain and stiffness reduction
Oral: 1,000–1,500 mg/day cetylated fatty acid complex; Topical: apply to affecte
Moderate
Chondroitin
Joint Health and Mobility
800–1,200 mg/day chondroitin sulfate; often combined with glucosamine; 8–12 week
Moderate
Collagen
Skin Health Improvement
Take 2.5g to 10g a day of collagen peptides
Moderate
Earthlight® (Whole Food Mushroom Vitamin D2)
Plant-based whole food Vitamin D for clean labels
250–1000 IU Vitamin D2 equivalent per serving as Earthlight®; dosing equivalent
Moderate
FLEXIR® (Joint Health Complex)
Rapid joint comfort and flexibility
500 mg/day NEM component (clinical NEM dose); FLEXIR® full blend per PLT Health
Moderate
Glucosamine
Joint Health Support
1,500 mg/day glucosamine sulfate (most studied form); split into 3×500 mg doses
Moderate
Kinexa® (Joint Longevity Complex)
Joint structural integrity and longevity
Per Kinexa® clinical dosing specifications; launched March 2026
Moderate
L-Lysine
Herpes simplex virus (HSV) suppression
500–3,000 mg/day; herpes suppression: 1,000–3,000 mg/day during outbreaks, 500–1
Moderate
Red Clover (Trifolium pratense)
Hot flash and menopausal symptom relief
40–160 mg/day total isoflavones; Promensil® clinical dose: 40–80 mg/day; hot fla
Limited
Silicon / Orthosilicic Acid
Bone mineral density support
10–40 mg/day bioavailable silicon as ch-OSA®; dietary silicon: 20–50 mg/day from