Home Ingredients Factor21® (Bitter Melon Extract — Verdure Sciences)
Metabolic HealthWeight Management

Factor21® (Bitter Melon Extract — Verdure Sciences)

Momordica charantia
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Factor21® is a bitter melon (Momordica charantia) extract from Verdure Sciences, standardized to momordicosides and positioned to support energy metabolism through the FGF21 pathway and AMPK. Bitter melon is traditionally used to support healthy blood sugar, the basis for Factor21's metabolic positioning.

Studied Dose Per the product specification.
Active Compound Bitter melon (Momordica charantia) extract standardized to momordicosides.

Benefits

Healthy blood sugar

Bitter melon is studied for supporting healthy blood sugar and insulin sensitivity, the core of Factor21's metabolic positioning.

Supported by Trial 1

Energy metabolism

Factor21 is positioned to support the FGF21 pathway and AMPK, key regulators of how the body uses energy and fat.

Supported by Trial 1

Metabolic and weight support

By supporting glucose handling and energy metabolism, the extract is positioned to aid overall metabolic health and weight management.

Supported by Trial 1

Mechanism of action

1

AMPK and FGF21 activation

Bitter melon momordicosides are studied for activating AMPK and the FGF21 pathway, which promote glucose uptake and fat metabolism.

2

Insulin-like glucose support

Bitter melon contains compounds studied for supporting cellular glucose uptake, helping maintain healthy blood sugar.

Clinical trials

1
Bitter Melon and Glycemic Control — Meta-Analysis
PubMed

Systematic review and meta-analysis of Momordica charantia on glycemic control and lipid profile. (Zhang et al. 2024, Heliyon)

Adults across multiple trials.

Bitter melon supplementation supported glycemic control and lipid measures; Factor21 is a standardized bitter melon extract.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED.
Mild digestive upset is occasionally reported.
May lower blood sugar; monitor if you are prone to low blood sugar.

Important Drug interactions

Diabetes medication — may add to blood-sugar lowering; monitor closely.
Tell your doctor if you take insulin or other glucose-lowering drugs.
Use caution if pregnant or breastfeeding.

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Frequently asked questions about Factor21® (Bitter Melon Extract — Verdure Sciences)

What is Factor21® (Bitter Melon Extract — Verdure Sciences)?

Factor21® is a bitter melon (Momordica charantia) extract from Verdure Sciences, standardized to momordicosides and positioned to support energy metabolism through the FGF21 pathway and AMPK. Bitter melon is traditionally used to support healthy blood sugar, the basis for Factor21's metabolic positioning.

What is the recommended dosage of Factor21® (Bitter Melon Extract — Verdure Sciences)?

The clinically studied dose for Factor21® (Bitter Melon Extract — Verdure Sciences) is Per the product specification.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Factor21® (Bitter Melon Extract — Verdure Sciences) used for?

Factor21® (Bitter Melon Extract — Verdure Sciences) is studied for healthy blood sugar, energy metabolism, metabolic and weight support. Bitter melon is studied for supporting healthy blood sugar and insulin sensitivity, the core of Factor21's metabolic positioning.

Are there side effects from taking Factor21® (Bitter Melon Extract — Verdure Sciences)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Factor21® (Bitter Melon Extract — Verdure Sciences) safe to take?

Whether Factor21® (Bitter Melon Extract — Verdure Sciences) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED. It may also interact with certain medications. Factor21® (Bitter Melon Extract — Verdure Sciences) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Zhang X, Zhao Y, Song Y, Miao M. Effects of Momordica charantia L. supplementation on glycemic control and lipid profile: a systematic review and meta-analysis. Heliyon. 2024;10(10):e31126..PubMedUsed to support: Meta-analysis supporting bitter melon for glycemic control (Factor21 is a standardized bitter melon extract).