Top Picks — Metabolic Health

🔥 Best Metabolic Health Supplements

Metabolic health supplements ranked by clinical evidence — for blood sugar, insulin sensitivity, lipid balance, and metabolic flexibility.

230 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

Citrus Bergamot (Citrus bergamia)

Blood glucose and insulin resistance improvement

500–1,500 mg/day standardized BPF; lipid-lowering studies typically use 500 mg twice

May Improve Blood Sugar Control

14–16 mg/day (RDA); lipid-lowering: 1,500–3,000 mg/day (extended-release niacin, under

Flaxseed / Flaxseed Oil (Linum usitatissimum)

Blood sugar: limited and indirect evidence

1–2 tablespoons (10–20g) ground flaxseed/day; flaxseed oil: 1–2 tablespoons/day

Psyllium Husk (Plantago ovata)

Blood sugar and postprandial glucose blunting

5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day;

Salacia (Salacinol)

Reduced postprandial glucose spikes

T2D (Kajimoto): 240 mg/day S. reticulata × 6 wk. NR-Salacia: 250-500 mg with carb

📈 Fastest Growing Metabolic Health Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

Blood Sugar Regulation

500 to 1,500 mg per day, usually split into 2 or 3 doses with meals to reduce digestive upset.…

DeltaGold® (Annatto Tocotrienols — American River Nutrition)

Triglycerides: What the Cited Evidence Shows

430 or 860 mg/day of the annatto extract, delivering roughly 300 or 600 mg/day tocotrienol, in…

Psyllium Husk (Plantago ovata)

Blood sugar and postprandial glucose blunting

5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day; take with 8…

🔬 Future Metabolic Health Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Banaba Leaf (Lagerstroemia speciosa)

Fasting Blood Glucose Reduction

32-48 mg/day extract at 1% corosolic acid (0.32-0.48 mg corosolic acid/day); higher: up to 10…

Salacia (Salacinol)

Reduced postprandial glucose spikes

240 mg/day S. reticulata; 500–1,000 mg S. oblonga; standard 200–1,000 mg with largest carb…

Blood sugar regulation

150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or liposomal…

NūGensia™ (Akkermansia muciniphila Postbiotic)

Improved glucose and metabolic markers

Manufacturer trial: ~10 billion CFU/day for 60 days. The landmark Akkermansia RCT used ~10…

Recommended Metabolic Health Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced metabolic health ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best for blood-sugar & metabolic support Amazon →

Thorne Berberine-500

500 mg berberine HCl/capsule, 60 ct

Clean single-ingredient berberine at the studied 500 mg dose from a clinician-trusted, four-times-tested brand.

Best for true Ceylon cinnamon value Amazon →

Nutricost Organic Ceylon Cinnamon

1,200 mg per 2-cap serving, 150 ct

Organic true Ceylon (not cassia) cinnamon, third-party tested and non-GMO, at an affordable per-serving cost.

Best for carbohydrate-metabolism support Amazon →

Thorne Chromium Picolinate

500 mcg chromium (picolinate)/capsule, 60 ct

Well-absorbed picolinate form from a third-party-certified brand; simple, additive-light metabolic-support pick.

Best for antioxidant metabolic support Amazon →

Doctor's Best Alpha-Lipoic Acid 600 mg

600 mg veggie capsules, 60 ct

Full 600 mg ALA per capsule, vegan and non-GMO; a budget-friendly pick that helps regenerate other antioxidants.

All Metabolic Health Ingredients (231)

Citrus Bergamot (Citrus bergamia)

Blood glucose and insulin resistance improvement

500–1,500 mg/day standardized BPF; lipid-lowering studies typically use 500 mg twice

May Improve Blood Sugar Control

14–16 mg/day (RDA); lipid-lowering: 1,500–3,000 mg/day (extended-release niacin, under

Flaxseed / Flaxseed Oil (Linum usitatissimum)

Blood sugar: limited and indirect evidence

1–2 tablespoons (10–20g) ground flaxseed/day; flaxseed oil: 1–2 tablespoons/day

Psyllium Husk (Plantago ovata)

Blood sugar and postprandial glucose blunting

5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day;

Salacia (Salacinol)

Reduced postprandial glucose spikes

T2D (Kajimoto): 240 mg/day S. reticulata × 6 wk. NR-Salacia: 250-500 mg with carb

Resistant Starch

Reduced fasting insulin and HOMA-IR

GUT/MICROBIOME: 15-30 g/day (1-2 tbsp Hi-Maize® or raw potato starch). T2D METABOLIC:

Cinnamon FenuMat® (Cinnamon + Fenugreek Soft Hydrogel — Akay Bioactives)

Fasting blood glucose reduction (class evidence)

Typical cinnamon clinical doses: 120-500 mg/day standardized extract or 1-3 g/day

Cinnulin PF® (Water-Soluble Cinnamon Extract — Verdure Sciences)

8.4% fasting blood glucose reduction (12-week clinical trial)

500 mg/day Cinnulin PF — the dose used in the 12-week pivotal RCT. Recommended

Palatinose™ (Isomaltulose)

Low-glycemic carbohydrate energy

25–75 g per dose in acute glycemic and exercise trials, typically replacing sucrose or

Blood Sugar Regulation

25–35 mcg/day (AI); blood sugar: 200–1,000 mcg/day chromium picolinate; insulin

White Mulberry (Morus alba)

Postprandial Glucose Spike Reduction

LOWN 2017: Reducose® 5% DNJ 250 mg/dose (12.5 mg DNJ) + 50 g maltodextrin. HWANG 2016

Blood sugar and HbA1c improvement

Standard cardiometabolic dose: 500-2,000 mg/day cold-pressed black seed oil.

Glucomannan (Konjac Root Fiber)

Blood sugar and diabetes management

3–4 g/day before meals (1 g three times daily, 30 minutes before meals with 250 mL

Allulose (D-Psicose)

Supports healthy blood glucose

Typical study doses range from 5–15 g per meal; larger amounts above 0.4 g/kg body

Amla / Indian Gooseberry (Capros®)

Lower fasting blood sugar in randomized trials

250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day;

BioBerb® (Bioavailable Berberine — Saanroo)

Blood sugar: studied in people with type 2 diabetes, using ordinary berberine

Standard berberine clinical dose: 500 mg three times daily with meals (1,500 mg/day

Alpha Lipoic Acid

Insulin sensitivity

DIABETIC NEUROPATHY: 600 mg/day racemic ALA (SYDNEY 2 + NATHAN 1). T2DM IR: 300

BarliV™ (Barley Beta-Glucan — Cargill)

Glycemic Control

3 g/day barley beta-glucan (FDA health claim threshold)

Ginger (Zingiber officinale)

Anti-inflammatory and lipid effects

250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/day;

Inositol (Myo-Inositol)

Insulin sensitivity and metabolic markers

2-4 g/day myo-inositol for metabolic and general use. PCOS: 4 g myo-inositol + 100 mg

Olive Leaf Extract

Blood sugar regulation (modest evidence)

Standard dose: 500-1,000 mg/day standardized olive leaf extract (containing 20-40%

Sulforaphane / Glucoraphanin

Cardiovascular and metabolic biomarkers

Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides

Modest calorie and glycemic reduction

Dental caries prevention: 5-10 g/day in chewing gum or candies. Acute otitis media

Chromax® (Chromium Picolinate)

Insulin sensitivity: studied mainly in people with type 2 diabetes

200–1,000 mcg/day chromium as Chromax® chromium picolinate; insulin sensitivity:

Blood sugar regulation

500–600 mg/day standardized extract; 5–30 g/day whole seed for glucose effects

FenuLife® (Fenugreek Galactomannan — BioActor)

Healthy blood sugar

Commonly a few grams of fenugreek fiber per day with meals.

BarleyTrim® (Barley Beta-Glucan)

Steadier blood sugar

About 3 grams of barley beta-glucan per day for cholesterol benefit.

Beta-Glucans (Oat & Yeast-Derived)

Glycemic control — supportive trial evidence

Cholesterol (FDA claim): 3 g/day oat β-glucan. Immune (Wellmune®): 250-500 mg/day

Cofactor role in glucose-metabolism enzymes (biochemical)

1.8–2.3 mg/day (AI for adults); upper limit 11 mg/day; most multivitamins contain 2–5

Oat Bran (Beta-Glucan)

Reduces post-meal blood sugar spikes

FDA HEALTH CLAIM: ≥3 g beta-glucan/day (~75 g raw oat bran, ~140 g cooked oatmeal).

Soy Isoflavones (Glycine max)

Blood sugar and metabolic regulation

40–80 mg/day total isoflavones; menopausal symptoms: 50–80 mg/day; bone health: 54–100

Metabolic Disorders

1.1–1.2 mg/day (RDA); Benfotiamine (fat-soluble form): 150–300 mg/day;

Blood Sugar Regulation

500–1,500 mg per day, often divided into 2–3 doses taken with meals to improve

Better Blood Sugar Control

2–10 g/day for prebiotic/gut microbiome effects; gradual dose increase recommended to

Banaba Leaf (Lagerstroemia speciosa)

Fasting Blood Glucose Reduction

MOST TRIALS: 32-48 mg/day extract 1% corosolic acid (= 0.32-0.48 mg corosolic

D-Chiro-Inositol

Supports Insulin Sensitivity

DCI alone: 600-1,200 mg/day (older trials). Modern 40:1 MI:DCI: 4 g myo-inositol + 100

Metabolic syndrome — multiple markers improve together

METABOLIC SYNDROME (Hidalgo-Lozada 2022): 500 mg BID = 1000 mg/day pomegranate 90% EA

Gencinia® (Coccinia indica / Ivy Gourd Blood Sugar Support — Saanroo)

Fasting blood glucose reduction (~16%)

1 gram (1,000 mg) daily of Gencinia. Effects on fasting and post-prandial blood

Saberry® (Standardized Amla Extract — Sabinsa)

Fasting blood sugar lowered in an open-label diabetes trial

1 g/day or 2 g/day Saberry — both clinically studied. 1 g comparable to metformin 500

Salacia reticulata (Kothala Himbutu)

Helps blunt post-meal blood sugar spikes

Acute postprandial trials have used 240–1,000 mg of Salacia extract before

Silbinol® (Indian Kino Pterostilbene Extract — Sabinsa)

Blood sugar support — ICMR Phase 2 evidence

200 mg/day Silbinol 90% pterostilbene (100 mg twice daily) — dose established in the

Dill Seed and Leaf

Insulin Markers Improved, Fasting Glucose Largely Unchanged

Dill tablet 1-1.5 g/day or dill extract 650 mg/day for 8-12 weeks in lipid and

Arabinoxylan (Arrabina®)

Blood sugar and postprandial glucose blunting

4–15 g/day; blood sugar management: 8–15 g/day with meals; immune studies: 4–10 g/day;

Chromium Dinicocysteinate

Insulin Sensitivity Support

The key trial used 400 mcg/day elemental chromium as chromium dinicocysteinate for 3

Cinnamon (Ceylon vs Cassia)

Modest Blood Glucose Reduction (T2DM)

1-6 g/day cinnamon powder; 250-500 mg/day water-soluble extract (Cinnulin PF®

Gymnema Sylvestre (Gurmar — 'Sugar Destroyer')

Glycemic Improvement in T2DM

200-400 mg/day standardized extract (typically 25% gymnemic acids); traditional form

Neem (Azadirachta indica)

Blood Sugar Support — Studied as a Metformin Adjunct (RCT)

PINGALI 2020 T2DM: 125/250/500 mg standardized neem BID = 250-1000 mg/day × 12 wk +

Improved glucose and metabolic markers

~10 billion CFU/day

Lipid profile improvement (primary application)

Standard lipid management dose: 600-900 mg/day pantethine in divided doses (typically

DeltaGold® (Annatto Tocotrienols — American River Nutrition)

Triglycerides: What the Cited Evidence Shows

125-300 mg/day DeltaGold (250 mg in T2DM trial)

GlucoVantage® (Dihydroberberine)

Blood sugar and insulin regulation

100–200 mg/day (equivalent to 500–1,000 mg standard berberine); taken before meals

Glucose Metabolism Support

Yeast-chromium diabetes trials commonly used about 400 mcg/day elemental Cr. General

Molecular Hydrogen (H2)

Cholesterol and blood sugar markers (small effects)

HRW: 1.5-7 ppm H2 in water, 0.5-2 L/day. LeBaron 2020 high-conc: ~7 ppm × 24 wk

Acacia Fiber (inavea™ Pure Acacia)

Blood sugar response after a meal

RANGE: 5-30 g/day. PREBIOTIC (bifidogenic): ~10 g/day onset. SATIETY/METABOLIC: 15-30

Adipromin® (Herbal Weight-Management Complex)

Around 900 mg per day in the clinical study.

Bergacyn® (Bergamot and Cardoon Extract — Bionap)

Lipids and metabolic support

Around 600 mg per day of the combined extract.

Carb10® (Pea Starch Carbohydrate)

82% less insulin response than maltodextrin

15–25g per serving for workout fueling; can be used pre, intra, or post-workout;

Cardiometabolic / lipid support

250 mg twice daily, 50% chlorogenic acids

Eriocitrin / Eriomin® (Lemon Flavonoid)

Postprandial blood sugar and insulin reduction

200–400 mg/day Eriomin® standardized extract; blood sugar: 200 mg/day; uric acid:

Gynostemma pentaphyllum (Jiaogulan / Southern Ginseng)

Blood sugar: studied in people with type 2 diabetes

Standardized extract: 200-450 mg twice daily (containing standardized gypenosides).

InnoSlim® (Stimulant-Free Fat Burning)

Adiponectin elevation and insulin sensitivity

250 mg/day InnoSlim®; human study confirmed significant fat loss, glucose reduction,

iXOS® (Xylooligosaccharides Prebiotic)

Metabolic and immune health benefits

1–2g/day iXOS® for prebiotic bifidogenic effects (much lower than other prebiotics at

Lovia® (Monk Fruit + Stevia Combination — Layn USA)

No Glycemic Impact

Sweetener use per product specification

Magnesium Chloride

Metabolic health support

Oral trials commonly use solutions delivering roughly 250-400 mg elemental magnesium

Maitake Mushroom (Grifola frondosa)

Blood Sugar / Insulin Sensitivity

1-3 mg D-fraction/kg body weight (50-300 mg D-fraction/day for typical adults); whole

Maqui Berry (MaquiBright®)

Glucose Findings Come From a Different Branded Extract

60 mg/day MaquiBright® standardized extract for dry eye; 162 mg/day delphinidin-rich

Factor21® (Bitter Melon Extract — Verdure Sciences)

Healthy blood sugar

Per the product specification.

FenuFibers® (Fenugreek Fiber)

Healthy blood sugar

Commonly a few grams of fenugreek fiber per day with meals.

Fenumannan® (Fenugreek Galactomannan Fiber)

Healthy blood sugar

Commonly a few grams of fenugreek fiber per day with meals.

OnoSweet® (Monk Fruit + Allulose Sweetener)

Zero-glycemic natural sweetening

Formulation ingredient — use per product recipe to achieve target sweetness; no

Sukré® (Ultra-Pure Allulose)

Lower postprandial blood glucose in healthy adults

As sweetener: 5–15g/serving; metabolic health benefits: 7–15g/day allulose with meals;

Vitosa® (Next Generation Stevia — BGG)

No Glycemic Impact

Sweetener use per product specification (typically mg amounts)

Advantra Z® (Bitter Orange p-Synephrine — Nutratech)

Modest metabolic boost

Commonly 50 mg of p-synephrine per day, often taken before activity.

Beanblock® (White Kidney Bean Extract — Indena)

Gentler post-meal glucose

Around 500 mg taken shortly before a starch-containing meal.

BenfoPure® (Benfotiamine — Vitamin B1 Derivative)

Healthy glucose metabolism

Commonly 300 to 600 mg per day.

Chlorogenic Acid

Reduces post-meal blood sugar spikes

BP: 140 mg/day green coffee bean × 4 wk. WEIGHT: 500 mg/day GBCE ≥30% CGA → -1.30 kg

Clarinol® (Conjugated Linoleic Acid — Stepan Lipid Nutrition)

Body fat and composition

3 to 4 grams per day of CLA isomers.

EcoGuar® (Partially Hydrolyzed Guar Gum)

Blood sugar and fullness

Commonly 5 to 7 grams per day.

Pycnogenol® (French Maritime Pine Bark)

Blood sugar control in type 2 diabetes

50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic

Metabolic syndrome marker support

400 μg or 800 μg chromium daily as the Crominex blend (with proportional amla and

Improved glucose tolerance in metabolic syndrome

GLUCOSE TOLERANCE: 3.3-10 g/day (Mizote 2017: 10 g; Yoshizane 2020: 3.3 g). PAD pilot:

Trigogen® (Fenugreek/Trigonelline Glucose Support — Saanroo)

Fasting blood glucose support

Per the published Pharmaceutics 2022 trial — Trigogen is sold to formulators with

ActivAMP® (Gynostemma pentaphyllum AMPK Activator — Saanroo)

Glucose uptake and fat oxidation support

450 mg/day ActivAMP is the clinical dose used in both pivotal RCTs (body composition

Lipid profile support

150 mg/day of Altilix® standardized extract for 6 months in metabolic syndrome and

Healthy lipid profile

250–500 mg twice daily of standardized amla extract for 12 weeks in cardiometabolic

Blood Sugar and Blood Fats: Limited Evidence

30 mcg/day (AI); hair/nail: 2,500–10,000 mcg/day (evidence weak);

Healthy lipid profile support

Capros® amla extract is the anchor component; human cardiovascular trials of the amla

Lipid and glucose modulation in metabolic syndrome

General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome: 5

ChromeMate® (Niacin-Bound Chromium — Lonza)

Blood sugar: the controlled trial of this form was negative

200 mcg elemental chromium as ChromeMate per day. Clinical studies up to 1,000 mcg/day

Chromium Chloride

Glucose Metabolism Role

Adequate intake 20-35 mcg/day elemental Cr. Parenteral-nutrition formulas supply

Chromium Picolinate

Glucose Metabolism Support

Adequate intake 20-35 mcg/day elemental Cr. Diabetes trials commonly used 200-1,000

InSea2® (Brown Seaweed Polyphenols — InnoVactiv)

Gentler post-meal glucose

About 500 mg taken before a carbohydrate-containing meal.

Jamun (Java Plum)

Supports Healthy Blood Sugar

Traditional and trial doses typically range from 5-15 g/day of jamun seed powder or

Supports Healthy Postprandial Glucose

Typically co-administered at approximately 3-4% of the sucrose load (e.g., ~1-2 g

Portusana® (Purslane Extract for Blood Sugar — Frutarom/IFF)

Blood sugar support (responder subgroup in one trial)

180 mg/day Portusana — taken as three oral capsules. Notably small clinical dose vs

Rooibos (Red Bush Tea)

Helps support a healthy lipid profile

Clinical lipid and oxidative-stress trials have used about six cups (about 750 mL

Svetol® (Decaffeinated Green Coffee Extract — Givaudan/Naturex)

Post-meal glucose: one small coffee study

400 mg/day Svetol, taken before meals (often 1-3 doses daily). Dellalibera 2006 used

Insulin Resistance Improvement

PIVOTAL: 0.14 g FOS/kg/day × 120 d (~10 g FOS = 20-25 g syrup for 70-kg adult).

Clovinol® (Clove Bud Polyphenol for Metabolic Health — Akay Bioactives)

Insulin resistance modulation (HOMA-IR, HbA1c, FBS, PPG)

250 mg/day Clovinol — the dose validated across multiple clinical trials. Effects on

Aloe Vera (Aloe barbadensis miller)

Supports healthy blood sugar

INNER LEAF GEL: 50-300 mL/day juice OR 100-300 mg/day freeze-dried powder (blood sugar

Bitter Melon (Momordica charantia)

T2DM Glycemic Modest Improvement

1-3 g/day fruit/seed powder; 200-500 mg/day standardized extract; juice 50-100 mL/day

Chromium Polynicotinate (Niacin-Bound Chromium)

Glucose Metabolism (Limited)

200-400 µg elemental chromium/day; some trials use up to 1,000 µg combined with other

Fiit-ns® (Fruit Polyphenol Extract — Fytexia)

Metabolic support

A standardized daily polyphenol dose.

Liver fat reduction and metabolic health

2.4-12 mg/day fucoxanthin in human trials: 2.4 mg/day with 300 mg pomegranate seed oil

Go-Luo® (Monk Fruit Extract — Layn USA)

No Glycemic Impact

Sweetener use per product specification (typical mg amounts)

Holy Basil (Tulsi)

Blood sugar regulation

300–600 mg/day dried leaf extract; 1–2 g/day whole leaf powder

Lacprodan® (Branded Family of Hydrolyzed Whey and Milk Proteins)

Higher short-term insulin response with hydrolyzed whey

Class-level whey protein dosing in muscle protein synthesis trials is typically 20–40

LuraLean® (Propolmannan Konjac Fiber — AHD International)

Blood glucose lowering effects

1-3 g LuraLean per day, taken BEFORE meals with water for satiety. 8-week trials at

Melostacio® (Mango Leaf Extract)

Carbohydrate and glucose handling: laboratory and animal evidence only

100–300 mg/day mangiferin (as Melostacio® standardized extract); metabolic effects

Meratrim® (Sphaeranthus indicus + Garcinia mangostana)

Supports healthy lipid markers in overweight adults

Sponsor-funded RCTs used 400 mg twice daily (800 mg/day total) of Meratrim®, taken 30

Millet Sprout Powder

Supports Healthy Glycemic Response

Typical food-based intake of millet flour ~50-100 g/day in dietary trials; no

Oligonol® (Lychee + Green Tea Polyphenol — Amino Up)

Post-meal blood glucose and lipid support

Visceral fat protocol: 200 mg/day Oligonol® (50 mg twice daily) for 10 weeks.

StarchLite® (White Kidney Bean Extract)

Post-meal glucose support

Commonly 500 mg to 1 g before starchy meals.

Terminalia Chebula (Rejuna®)

Blood sugar: limited and mixed human data

500–1,000 mg/day standardized extract; Rejuna® clinical dose: 500 mg/day; traditional

ThinOgen® (Fucoxanthin from Brown Seaweed — BGG)

Metabolic Health Support

2.4 mg/day fucoxanthin (research-validated; some products use higher amounts of total

Vanadium (Vanadyl Sulfate)

Insulin sensitivity and blood sugar reduction

10–100 mg/day vanadyl sulfate in human studies; organic vanadium (BMOV): 10–30 mg/day;

Xanthigen® (Fucoxanthin + Pomegranate Seed Oil)

Triglycerides in the same trial

PIVOTAL: 600 mg Xanthigen®/day × 16 weeks (300 mg PSO + 300 mg brown seaweed extract

Blood Sugar Control

KSM-66® root extract: 300-600 mg/day (most stress/sleep trials). Shoden®: 120-240

Caffeine-free metabolic support

500 mg/day, 6-paradol

Calanus® Oil (Arctic Zooplankton Omega-3 Wax Esters)

Metabolic health in prediabetic populations

2g/day Calanus® Oil capsules; clinical study: 2–4g/day; wax ester form may have

EnergySMART® (Low-Glycemic Carbohydrate Complex — Anderson)

Lower-glycemic sweetness

Per the product or recipe.

Bulk sugar replacement with zero glycemic impact

Typical food and beverage use: 5-30 g per serving. GI tolerance: roughly 50 g single

FiberSMART® (Soluble Tapioca Fiber — Anderson)

Low glycemic impact

Commonly several grams of fiber per serving.

FucoVital® (Microalgae Fucoxanthin — Algatech)

Metabolic support

Commonly a few milligrams of fucoxanthin per day.

GCBest® (Green Coffee Bean Extract)

Metabolic support

Commonly 200 to 400 mg of green coffee extract per day.

Mythocondro® (Non-Animal Chondroitin Sulfate — Gnosis by Lesaffre)

Secondary metabolic markers within the single OA trial (not a metabolic indication)

PIVOTAL: 600 mg/day × 12 weeks (n=60 overweight knee OA). Notably lower than typical

Phytofare® (Bioavailable Green Tea Catechin Complex — Plandaí)

Metabolic support

A standardized daily dose of bioavailable catechins.

Polyphenol/quercetin metabolic support

400 mg/day (200 mg twice daily)

SantEnergy™ Nu

Flavonoid antioxidant and metabolic activity

400 mg twice daily

Metabolic Health

500–3,000 mg/day; energy drinks typically contain 1,000 mg; athletic performance: 1–3

Akkermansia muciniphila

Insulin sensitivity and glucose regulation

Depommier 2019: 10¹⁰ CFU/day pasteurized × 3 months. Most products: 10⁸-10⁹ CFU/day.

CyaniMax® (Cyanidin-3-O-Glucoside Anthocyanin — BGG World)

Metabolic health support (preclinical)

300 mg/day BSHE/C3G (black soybean hull extract) — the dose used in the pivotal

GlyNAC (Glycine + N-Acetylcysteine)

Support for healthy glucose metabolism (HOMA-IR fell 68% in one small trial)

PIVOTAL: glycine 1.33 mmol/kg/day (~7 g/70 kg) + NAC 0.83 mmol/kg/day (~9.5 g/70 kg) ×

Supports Healthy Postprandial Glucose

Okra powder 1-2 g/day in T2D trials; whole okra pods 100 g/day in dietary interventions.

4-Hydroxy-L-Isoleucine

Glucose-dependent insulin secretion support

Standalone 4-OH-Ile human data is limited; preclinical doses range 18–50 mg/kg in

Reduced insulin sensitivity and dysbiosis findings (concerning)

Acceptable Daily Intake (ADI): 5 mg/kg/day per FDA; 15 mg/kg/day per EU EFSA. Typical

Blood sugar regulation

150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or liposomal

inavea™ CINNAMON ACACIA

Glucose and Insulin Markers (Animal Model + Cinnamon Component Data)

5 g/day (research-validated dose)

Antioxidant support, with mixed human results

2–7 g/day leaf powder; clinical studies typically use 6–8 g/day

Chromium Histidinate

Chromium's Role in Glucose Metabolism

The human absorption study used a single 200 mcg elemental Cr dose. Chromium adequate

Csat+® (Pharmactive Carob Extract)

Blood lipids: dose-dependent and, in humans, mixed

Per Pharmactive product specification — Csat+ is sold to formulators for incorporation

pTeroWhite® (99% trans-Pterostilbene)

Metabolic and Cardiovascular Support

50–250 mg/day; the foundational human trials used 125 mg twice daily (250 mg/day).

R-Lipoic Acid (Natural / Stabilized R-ALA)

Insulin Sensitivity / Blood Sugar

100-300 mg/day R-ALA (equivalent to ~200-600 mg racemic ALA); diabetic neuropathy 600

Aged Black Garlic ABG10+® (Pharmactive)

Glycemic control support

Standard dose: 250-500 mg/day ABG10+® standardized aged black garlic extract.

Hibiscus (Roselle)

Supports Metabolic Wellness

Typical clinical trials use 1.25-10 g dried calyces brewed as tea, or 250-500 mg of

Phase 2® (White Kidney Bean Extract — Ashland)

Unproven blood sugar effect

Commonly 500 mg to 1 g before starchy meals.

Capsinoids (Non-Pungent Capsaicin Analogs)

Glucose metabolism (mainly animal data)

WEIGHT MANAGEMENT (Snitker 2009 + Galgani 2010): 6 mg capsinoids daily × 4-12 wk.

CarbLite® (White Kidney Bean Carb Blocker)

Carbohydrate blocking

Commonly 500 mg to 1 g before starchy meals.

Ecklonia Cava (Brown Seaweed Polyphenol)

Metabolic health — fat oxidation and glucose management

400–800 mg/day Ecklonia cava extract standardized for phlorotannins; clinical studies

Glabridin (Licorice Isoflavone)

Glucose and body-fat effects (preclinical)

LDL oxidation: 250 mg/day for 6 months. Type 2 diabetes and metabolic syndrome: 300

Dietary intake associated with metabolic health in epidemiological studies

DIETARY: 1-4 mg/day (walnuts, cranberries, blueberries, red wine, tea). SUPPLEMENT:

Cardiovascular / Lipid Effects

150-500 mg/day; emerging supplement category; standardized doses not yet

Helps support a healthy lipid profile

Small clinical trials have used about 5–10 mL of sacha inchi oil per day for 16 weeks,

SelectSIEVE® Bergamot (Citrus bergamia Extract — Bionap)

Healthy cholesterol and lipids

Commonly 500 to 1000 mg of bergamot extract per day.

Slendesta® (Potato Protein Extract)

Blood sugar and insulin response modulation

600 mg/day Slendesta® (providing ~30 mg PI2); taken 30 minutes before main meals;

Stevia (Stevia rebaudiana)

Glycemic neutrality

Acceptable Daily Intake (steviol equivalents): 4 mg/kg/day (FDA, EFSA). Common

Theoretical metabolic benefits (animal studies)

MUSCLE/STRENGTH: 400-450 mg/day divided (Bang 2014: 450 mg POSITIVE; Pereira 2020: 400

AcaiVida® (Açaí Berry Extract)

Metabolic support

Commonly around 1 to 2 g of açaí preparation per day.

MangoSelect® (African Mango Seed Extract)

Metabolic markers

Commonly around 150 mg twice daily before meals.

Buckwheat Sprout

Contains D-chiro-inositol, but blood sugar effects are untested

Buckwheat sprout extracts standardized to rutin are commonly used at 100–500 mg/day;

GyngerLean® (Ginger Weight Management Extract)

Thermogenesis and metabolic rate

400–800 mg/day GyngerLean® standardized ginger extract; clinical studies at 400 mg

Naturally Lower-Glycemic Sweetener

No established clinical dose; commonly used as 5-15 g/day of lucuma powder added to

NMN (Nicotinamide Mononucleotide)

Metabolic health

250–500 mg/day (commonly studied); up to 1,200 mg/day in clinical trials

p-Synephrine (Bitter Orange)

Metabolic Rate: Small and Not Significant for Synephrine Alone

Most human studies used p-synephrine 25-50 mg per day, alone or combined with caffeine

Post-Meal Blood Sugar: Benefit Belonged to Other Pea Components

5-15 g/day in divided doses with adequate water; satiety trials used 7-15 g acute

Pleurotus ostreatus (Oyster Mushroom)

What the trials actually found on cholesterol and blood sugar

OYSTER MUSHROOM SOUP: 30 g dried daily × 21 days (lipid trial). β-GLUCAN SUPPLEMENT:

Capsaicin / Capsicum Extract (Cayenne Pepper)

Cardiovascular and lipid effects

2-10 mg total capsaicinoids per day, typically from 25-100 mg of capsicum extract. 2

Astragalus (Astragalus membranaceus)

Blood sugar regulation

ROOT: 2-6 g/day dried OR 250-500 mg/day standardized extract. IMMUNE: 500 mg BID.

Manganese Sulfate

Supports normal metabolic function

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Used in fortification and

MitoBurn® (L-BAIBA)

Insulin sensitivity and glycogen storage

250–500 mg/day; 500 mg is the full clinical dose

Prenulin® (L-Arabinose and Chromium — Pharmachem)

Post-meal blood sugar

Taken before sugar-containing meals; dose per product.

Tinospora Cordifolia (Tinofend®)

Blood sugar regulation

300 mg/day Tinofend® (standardized extract); traditional Ayurvedic dose: 1–3 g/day

Black Pepper Extract

Metabolic effects: not measured in the studies cited here

Standard supplemental dose: 5-20 mg piperine per dose (typically standardized to ≥95%

Long Pepper (Pippali)

Promotes Metabolic Wellness

Traditional Ayurvedic use of 1-3 g/day of dried fruit; standardized extracts typically

Manganese Picolinate

Supports normal metabolic enzymes

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Picolinate products

Blood pressure reduction

RDA 310–420 mg/day; therapeutic 200–400 mg elemental Mg/day. Glycinate/malate for

Fetal brain development and pregnancy

425 mg/day (women AI); 550 mg/day (men AI); 930 mg/day (pregnant); up to 3,500 mg/day

Potassium Chloride

Efficient Potassium Repletion

Repletion regimens commonly use 20 mEq/day to prevent and 40-100 mEq/day to treat low

Antioxidant defense

55 mcg/day (RDA); therapeutic studies: 100–200 mcg/day; upper limit 400 mcg/day

ThymoQuin® (Black Seed Oil — TriNutra)

Cardiometabolic biomarker improvements

Standard formulation use: 500-1,000 mg ThymoQuin® daily. Cardiometabolic protocols

Vitamin B6 (Pyridoxine)

Brain Health and Mood Regulation

1.3–1.7 mg/day (RDA); therapeutic: 25–100 mg/day; upper limit 100 mg/day long-term

Aronia / Chokeberry (Aronia melanocarpa)

Modest Blood Pressure Reduction

STANDARDIZED EXTRACT: 100-300 mg/day (25-50 mg anthocyanins) OR juice 200-300 mL/day ×

Capsifen® (Bioavailable Capsaicinoids via FenuMat® — Akay Bioactives)

Dose-dependent weight reduction

100-200 mg/day Capsifen (Roopashree 2024 trial protocol). The 200 mg/day dose produced

Capsimax® (Beadlet-Encapsulated Capsicum Extract — OmniActive)

Increased resting energy expenditure

100 mg/day (providing ~2 mg capsaicinoids) is the standard clinical dose. Some trials

Evening Primrose Oil (Oenothera biennis)

Eczema and atopic dermatitis improvement

3–6 g/day EPO (providing 240–480 mg GLA); eczema: 4–8 g/day; PMS: 3–4 g/day; diabetic

GarSlim® (Garlic Extract)

Cardiovascular support

Commonly providing several milligrams of allicin potential per day.

Cardiovascular support (studied in heart patients)

General supplementation: 1-3 g/day L-carnitine. Athletic recovery: 2 g/day L-carnitine

Metabolaid® (Hibiscus + Lemon Verbena)

AMPK activation and fat oxidation

500 mg/day Metabolaid® (325 mg lemon verbena + 175 mg hibiscus); taken before exercise

NEOBEE® (Medium-Chain Triglycerides — Stepan)

Body composition

Commonly 10 to 20 grams per day with meals.

Nicotinamide Riboside

Documented blood NAD+ elevation

Standard dose: 250-1,000 mg/day NR. Most clinical trials use 300-600 mg/day. Take with

Pantothenic Acid

Supports Energy Metabolism

AI (Adequate Intake): 5 mg/day adults (no RDA). PREGNANCY: 6 mg/day. LACTATION: 7

Trpti™ (Bioavailable Oleoylethanolamide / OEA — Saanroo)

Akkermansia muciniphila enrichment

300 mg/day Trpti (delivering 250 mg OEA), taken as two 150 mg capsules — one morning,

Witholytin® (Olive Leaf Extract — Verdure Sciences)

Reduced fatigue and low energy

Clinical trial protocol: 500 mg twice daily (1,000 mg/day total) for 8 weeks.

Amlaac® (Amla / Indian Gooseberry Extract)

Healthy cholesterol

Commonly around 500 mg to 1 g per day.

Ammonium Molybdate

Sulfite Metabolism Support

RDA 45 mcg/day elemental Mo. Liquid molybdenum products typically provide 25-500

Beef Pancreas (Desiccated)

Natural digestive enzyme content

Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef

Bergavit® (Bergamot Flavonoid Extract — Bionap)

Healthy cholesterol levels

About 150 mg of bergamot flavonoids per day.

BioPerine® (Black Pepper Extract — Sabinsa)

The curcumin figure: widely quoted, not cited here

Standard formulation use: 5-10 mg BioPerine® per dose alongside compounds requiring

Bladderwrack Extract

Traditional support for thyroid nutrition

Whole bladderwrack powder traditionally used at 500–2,000 mg/day; fucoidan-rich F.

Caffinity® (natural coffee-fruit caffeine complex — FutureCeuticals)

Supports exercise performance and endurance output

286 mg Caffinity (~200 mg natural caffeine + ~15 mg coffee-fruit polyphenols), single pre-exercise dose

Citrin® / Citrin K® (Garcinia cambogia Hydroxycitric Acid)

Standardized, Soluble HCA Source

Garcinia/HCA trials commonly used ~1,000–1,500 mg HCA/day in divided doses before

Glavonoid® / Kaneka Glavonoid™ (Licorice Flavonoid Oil)

Body fat and visceral fat 8-week dose-finding RCT

TOMINAGA 2009 DOSE-FINDING: 300, 600, or 900 mg LFO/day × 8 weeks in overweight adults

Greenselect® Phytosome (Decaffeinated Green Tea Catechin Phytosome — Indena)

Weight loss alongside a hypocaloric diet (Di Pierro 2009, blinding not stated)

300 mg/day Greenselect Phytosome, split as 150 mg twice daily (one dose before lunch,

KiOtransine® (Chitin-Glucan Prebiotic Fiber — KitoZyme)

Gut microbiome support

Commonly a few grams per day.

Lactobacillus gasseri

Abdominal fat: one trial, one strain, in fermented milk

10 billion CFU/day (BNR17 weight loss); 200 mL fermented milk with 5 × 10^10 CFU/100

LeanGard® (Weight-Management Blend)

Body-Composition Support (Adjunct)

No independently established consumer dose for the finished blend; used per

Manganese Bisglycinate

Gentle chelated trace-mineral source

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Premium multivitamins

Manganese Gluconate

Supports antioxidant enzyme defense

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Multivitamins typically

Molybdenum Glycinate

Sulfite Metabolism Support

RDA 45 mcg/day elemental Mo. Chelated molybdenum supplements commonly supply 50-500

Morosil® (Moro Red Orange Extract)

Modest body weight and fat mass reduction

PIVOTAL DOSE: 400 mg/day Morosil® dry extract. CARDILE 2015: × 12 wk. BRISKEY 2022: ×

Adds Undigested Bulk to Stool

5-15 g/day of insoluble oat fiber for stool bulking; total fiber intake target 25-38

Pantesin® (Pantethine — Daiichi Fine Chemical)

What the cholesterol trials actually found

Standard clinical protocol: 600-900 mg/day Pantesin® in divided doses (300 mg three

Pentadecanoic Acid (C15:0)

Cellular Energy and Mitochondrial Support

100-200 mg/day (single capsule); taken with food. Most published cellular and

Phosphocomplex® (Silybin Phytosome — Indena)

A standardized daily dose providing bioavailable silybin.

Potassium Bicarbonate

Supports Bone Mineral Conservation

Bone-health trials used about 1 to 1.5 mmol/kg per day (roughly 60-90 mEq potassium

Potassium Gluconate

Convenient Potassium Source

OTC tablets are typically capped at 99 mg elemental potassium each; total daily

Satiereal® (Standardized Saffron Extract for Snacking Control)

Helps reduce snacking frequency

The pivotal Gout 2010 RCT used 176.5 mg/day of Satiereal® saffron extract for 8 weeks

Stress-Related Eating Support

Component-level dosing in published trials: Sensoril 125-250 mg twice daily; Capros

Sinetrol® (Citrus Polyphenol Blend)

Reduced abdominal fat in one 12-week trial

Published RCTs used 900–1,400 mg/day Sinetrol® or Sinetrol-XPur, typically as 450 mg

Sodium Molybdate

Sulfite Metabolism Support

RDA 45 mcg/day elemental Mo for adults. Supplements commonly provide 50-500 mcg/day. A

SteviUp® M2 (Next-Gen Stevia Reb M — Layn USA)

Superior Water Solubility

Sweetener use per product specification

Tonalin® CLA (Conjugated Linoleic Acid)

Modest reduction in body fat mass

Typical Tonalin® CLA dose in body composition trials: 3.2–6.4 g/day total CLA isomers,

Tributyrin (CoreBiome® Butyrate Prodrug)

Microbiome and inflammation effects (in vitro)

SHIME® IN VITRO: 300 mg cap + 450 mg softgel. FSU CrossOver: 300 mg/day × 4 wk

Evodia rutaecarpa (Wu Zhu Yu)

Traditional use for digestive complaints (no human studies)

Traditional Chinese Medicine doses of the dried fruit are commonly 1.5–6 g per day in

FB3 Fusion® (Fat-Absorption Botanical Blend — Bio Actives Japan)

What the Coleus forskohlii trial measured

Per the product specification.

Gugulipid® (Standardized Commiphora mukul Extract)

Joint symptoms: no controlled trial has ever been run

Historic Indian trials used guggulipid providing ~25 mg total guggulsterones three

Inositol Hexanicotinate (IHN)

Niacin-Form Marketed as Flush-Free

Trials and marketed products typically deliver 500-2,000 mg/day in divided doses;

Manganese Citrate

Clean-label trace-mineral source

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Clean-label multivitamins

Metabolyte® (BHB Energy + B-Vitamins)

Dual-pathway cellular energy support

Per Compound Solutions product specifications; typical BHB component 3–6g; combined

TraceReplace™ (plant-derived trace mineral complex — FutureCeuticals)

Broad-spectrum trace mineral replenishment

No established human clinical dose; used at low mg-level trace-mineral inclusions in foods/beverages