Top Picks — Metabolic Health

🔥 Best Metabolic Health Supplements

Metabolic health supplements ranked by clinical evidence — for blood sugar, insulin sensitivity, lipid balance, and metabolic flexibility.

189 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

Beta-Glucans (Oat & Yeast-Derived)

Smaller blood sugar rise after carbohydrate meals

Cholesterol: 3 g/day oat beta-glucan (the FDA and EFSA claim amount). Immune: 250 to 500 mg/day yeast beta-glucan in the Wellmune trials.

Oat Bran (Beta-Glucan)

Smaller blood sugar rise after carbohydrate meals

FDA HEALTH CLAIM: ≥3 g beta-glucan/day (~75 g raw oat bran, ~140 g cooked oatmeal).

Fasting glucose and insulin sensitivity

RDA 310-420 mg/day; trial doses ran from 248 mg/day to magnesium L-threonate 1 to 2 g/day; the tolerable upper limit for supplemental magnesium is 350 mg/day for adults.

Psyllium Husk (Plantago ovata)

Supports healthy blood sugar levels

5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day;

Ginger (Zingiber officinale)

Blood sugar and HbA1c

250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/day;

📈 Fastest Growing Metabolic Health Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

Blood Sugar Regulation

500 to 1,500 mg per day, split into 2 or 3 doses with meals. Long-term safety at these doses…

Cinnamon FenuMat® (Cinnamon + Fenugreek Soft Hydrogel — Akay Bioactives)

Fasting blood glucose (generic cinnamon, inconsistent, mostly in diabetics)

120-500 mg/day standardized extract, or 1-3 g/day powder.

Psyllium Husk (Plantago ovata)

Supports healthy blood sugar levels

About 10.2 g/day of psyllium husk in the cholesterol trials, often split before meals; 5.1 g…

🔬 Future Metabolic Health Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Banaba Leaf (Lagerstroemia speciosa)

Fasting Blood Glucose Reduction

32-48 mg/day extract at 1% corosolic acid (0.32-0.48 mg corosolic acid/day); higher: up to 10…

Salacia (Salacinol)

Smaller blood sugar rise after carbohydrate meals

Single doses of 150 to 1,000 mg of extract taken with a carbohydrate meal or sugar drink in…

Cholesterol and insulin resistance markers

Trials have used about 150 mg/day (75 mg twice daily in the two-year postmenopausal trial) up…

NūGensia™ (Akkermansia muciniphila Postbiotic)

Improved glucose and metabolic markers

Manufacturer trial: ~10 billion CFU/day for 60 days. The landmark Akkermansia RCT used ~10…

Recommended Metabolic Health Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced metabolic health ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best for blood-sugar & metabolic support Amazon →

Thorne Berberine-500

500 mg berberine HCl/capsule, 60 ct

Clean single-ingredient berberine at the studied 500 mg dose from a clinician-trusted, four-times-tested brand.

Best for true Ceylon cinnamon value Amazon →

Nutricost Organic Ceylon Cinnamon

1,200 mg per 2-cap serving, 150 ct

Organic true Ceylon (not cassia) cinnamon, third-party tested and non-GMO, at an affordable per-serving cost.

Best for carbohydrate-metabolism support Amazon →

Thorne Chromium Picolinate

500 mcg chromium (picolinate)/capsule, 60 ct

Well-absorbed picolinate form from a third-party-certified brand; simple, additive-light metabolic-support pick.

Best for antioxidant metabolic support Amazon →

Doctor's Best Alpha-Lipoic Acid 600 mg

600 mg veggie capsules, 60 ct

Full 600 mg ALA per capsule, vegan and non-GMO; a budget-friendly pick that helps regenerate other antioxidants.

All Metabolic Health Ingredients (189)

Beta-Glucans (Oat & Yeast-Derived)

Smaller blood sugar rise after carbohydrate meals

Cholesterol: 3 g/day oat beta-glucan (the FDA and EFSA claim amount). Immune: 250 to 500 mg/day yeast beta-glucan in the Wellmune trials.

Oat Bran (Beta-Glucan)

Smaller blood sugar rise after carbohydrate meals

FDA HEALTH CLAIM: ≥3 g beta-glucan/day (~75 g raw oat bran, ~140 g cooked oatmeal).

Fasting glucose and insulin sensitivity

RDA 310-420 mg/day; trial doses ran from 248 mg/day to magnesium L-threonate 1 to 2 g/day; the tolerable upper limit for supplemental magnesium is 350 mg/day for adults.

Psyllium Husk (Plantago ovata)

Supports healthy blood sugar levels

5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day;

Ginger (Zingiber officinale)

Blood sugar and HbA1c

250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/day;

Amla (Indian Gooseberry)

Lower fasting blood sugar in randomized trials

The hyperlipidemia trial used 500 mg/day for 42 days; the diabetes trial used 250 mg or 500 mg of Capros twice a day for 12 weeks. There is no established dose for healthy consumers.

Resistant Dextrin (Resistant Maltodextrin)

Smaller blood sugar rise after carbohydrate meals

Post-meal glucose and fat tests: 5 to 10 g with a meal. Bowel trials: about 4 to 15

BarliV™ (Barley Beta-Glucan — Cargill)

Glycemic Control

3 g/day barley beta-glucan (FDA health claim threshold)

Flaxseed / Flaxseed Oil (Linum usitatissimum)

Blood sugar and insulin sensitivity

30 g/day of milled flaxseed for 6 months (blood pressure), 40 g/day for hot flashes; everyday use of 10 to 20 g/day is less than the amounts actually tested.

Glucomannan (Konjac Root Fiber)

Fasting and post-meal blood sugar

About 3 g/day (1 g three times daily before meals) in the cholesterol meta-analysis; always take with a large glass of water.

Chromax® (Chromium Picolinate — Nutrition 21)

Insulin sensitivity and glycemic control

200–1,000 mcg/day chromium as Chromax® chromium picolinate; insulin sensitivity:

BarleyTrim® (Barley Beta-Glucan)

Steadier blood sugar

About 3 grams of barley beta-glucan per day for cholesterol benefit.

Metabolic Disorders

1.1 to 1.2 mg/day is the adult RDA; products commonly supply 25 to 100 mg/day. High doses for Wernicke encephalopathy are injected in hospital, not taken as a supplement.

Salacia (Salacinol)

Smaller blood sugar rise after carbohydrate meals

240-480 mg S. oblonga per meal in type 2 diabetes; 500-1,000 mg in healthy adults; 150-600 mg S. chinensis; taken with the largest carbohydrate meal.

Allulose (D-Psicose)

Supports healthy post-meal blood glucose

5 g with a meal, or 4 g or 7 g twice daily in the body fat trial; single amounts above roughly 0.4 g per kg of body weight commonly cause gas, bloating or loose stools.

Blood Sugar Regulation

500 to 1,500 mg per day, split into 2 or 3 doses with meals. Long-term safety at these doses has not been established.

Resistant Starch

Supports healthy fasting insulin levels

GUT/MICROBIOME: 15-30 g/day (1-2 tbsp Hi-Maize® or raw potato starch). T2D METABOLIC:

Blackcurrant Extract (Ribes nigrum Fruit)

Blood sugar and insulin response after meals

Sports trials: 300 to 600 mg/day of New Zealand blackcurrant extract (about 105 to 210

Propolis (Bee Propolis)

Blood sugar and insulin markers

About 1,000 mg/day (500 mg twice daily) in a 90-day trial of 94 adults with type 2

White Kidney Bean Extract (Phaseolus vulgaris)

Smaller blood sugar and insulin rise after a starchy meal

Weight trials mostly used 2,000 to 3,000 mg/day split before starchy meals (for

Blood Sugar Regulation

25–35 mcg/day (AI); blood sugar studies used 200–1,000 mcg/day chromium picolinate in people with diagnosed type 2 diabetes rather than healthy adults.

D-Chiro-Inositol

Supports Insulin Sensitivity

DCI alone: 600-1,200 mg/day (older trials). Modern 40:1 MI:DCI: 4 g myo-inositol + 100

Metabolic syndrome — multiple markers improve together

METABOLIC SYNDROME (Hidalgo-Lozada 2022): 500 mg BID = 1000 mg/day pomegranate 90% EA

Blood Sugar: Little Effect in Most People

2–10 g/day for prebiotic/gut microbiome effects; gradual dose increase recommended to

Palatinose™ (Isomaltulose)

Low-glycemic carbohydrate energy

25–75 g per dose in acute glycemic and exercise trials, typically replacing sucrose or

Pectin (Apple and Citrus Pectin)

Smaller rise in blood glucose after a meal at 10 g per meal

6 g/day (EU cholesterol claim) up to 15 g/day in cholesterol trials; 10 g with a meal

Cholesterol and insulin resistance markers

150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or liposomal

Salacia reticulata (Kothala Himbutu)

Helps blunt post-meal blood sugar spikes

Acute postprandial trials have used 240–1,000 mg of Salacia extract before

White Mulberry (Morus alba)

Postprandial Glucose Spike Reduction

LOWN 2017: Reducose® 5% DNJ 250 mg/dose (12.5 mg DNJ) + 50 g maltodextrin. HWANG 2016

Dill Seed and Leaf

Insulin Markers Improved, Fasting Glucose Largely Unchanged

3 g/day dried dill leaf powder for 8 weeks (type 2 diabetes trial); a separate hyperlipidemia trial using 650 mg twice daily for 6 weeks found no lipid effect.

Blood sugar and HbA1c improvement

Standard cardiometabolic dose: 500-2,000 mg/day cold-pressed black seed oil.

Blueberry (Vaccinium corymbosum and V. angustifolium)

Insulin sensitivity and blood sugar markers

About 22 to 26 g/day of freeze-dried whole-berry powder (roughly 1 cup, or 150 to 180

Cinnamon (Ceylon vs Cassia)

Modest Blood Glucose Reduction (T2DM)

1-6 g/day cinnamon powder; 250-500 mg/day water-soluble extract (Cinnulin PF®

Citrus Bergamot (Citrus bergamia)

Triglyceride and VLDL reduction

500–1,500 mg/day standardized BPF; lipid-lowering studies typically use 500 mg twice

Neem (Azadirachta indica)

Blood sugar and inflammation markers, studied as a metformin adjunct (RCT)

PINGALI 2020 T2DM: 125/250/500 mg standardized neem BID = 250-1000 mg/day × 12 wk +

Improved glucose and metabolic markers

~10 billion CFU/day

Lipid profile improvement (primary application)

Standard lipid management dose: 600-900 mg/day pantethine in divided doses (typically

Insulin and Blood Sugar Markers

1.5 to 3 g/day in the two primary trials (500 mg three times daily; 3,000 mg/day); endurance studies used 1 to 6 g/day, with no sign larger doses worked better.

GlucoVantage® (Dihydroberberine)

Blood sugar and insulin regulation

100–200 mg/day before meals; the only human study gave single 100 mg or 200 mg doses, so no trial has established an effective daily dose.

Glucose Metabolism Support

Yeast-chromium diabetes trials commonly used about 400 mcg/day elemental Cr. General

Alpha Lipoic Acid

Insulin sensitivity

DIABETIC NEUROPATHY: 600 mg/day racemic ALA (SYDNEY 2 + NATHAN 1). T2DM IR: 300

Bergacyn® (Bergamot and Cardoon Extract — Bionap)

Lipids and metabolic support

Around 600 mg per day of the combined extract.

Fasting glucose and insulin in pooled green coffee trials

250 mg twice daily, 50% chlorogenic acids

Chlorogenic Acid

Post-meal blood sugar response

BP: 140 mg/day green coffee bean × 4 wk. WEIGHT: 500 mg/day GBCE ≥30% CGA → -1.30 kg

Eriocitrin / Eriomin® (Lemon Flavonoid)

Postprandial blood sugar and insulin reduction

200–400 mg/day Eriomin® standardized extract; blood sugar: 200 mg/day; uric acid:

Blood sugar levels

600 mg/day of a standardized seed extract for 12 weeks in the main testosterone trial; roughly 5 to 30 g/day of whole seed in the blood sugar research in people with diagnosed diabetes.

Gynostemma pentaphyllum (Jiaogulan / Southern Ginseng)

Blood sugar: studied in people with type 2 diabetes

200 to 450 mg standardized extract daily, or 3 to 9 g a day of dried herb as tea; the diabetes trial used 6 g a day. Products and doses studied differ, so results may not transfer.

Inositol (Myo-Inositol)

Insulin sensitivity and metabolic markers

2-4 g/day myo-inositol for metabolic and general use. PCOS: 4 g myo-inositol + 100 mg

Lovia® (Monk Fruit + Stevia Combination — Layn USA)

No Glycemic Impact

Sweetener use per product specification

Magnesium Chloride

Metabolic health support

Oral trials commonly use solutions delivering roughly 250-400 mg elemental magnesium

Amlaac® (Amla / Indian Gooseberry Extract)

Blood glucose and CRP improved in pooled trials of generic amla

Commonly around 500 mg to 1 g per day of amla extract. The pooled meta-analysis used various doses and preparations, and no Amlaac®-specific dose has been established in a trial.

Factor21® (Bitter Melon Extract — Verdure Sciences)

Healthy blood sugar

Per the product specification.

FenuFibers® (Fenugreek Fiber)

Healthy blood sugar

Commonly a few grams of fenugreek fiber per day with meals.

Fenumannan® (Fenugreek Galactomannan Fiber)

Healthy blood sugar

An acute satiety trial used 4 g and 8 g of isolated fenugreek fiber, with 8 g working better; fenugreek gum glucose trials used about 6 to 16 g.

GarSlim® (Garlic Extract)

Lower triglycerides and LDL cholesterol in pooled garlic trials

Commonly providing several milligrams of allicin potential per day.

OnoSweet® (Monk Fruit + Allulose Sweetener)

Zero-glycemic natural sweetening

Used as a sweetener, not a supplement dose; no trial has tested the OnoSweet blend, so there is no studied dose for it.

Sukré® (Ultra-Pure Allulose)

Lower postprandial blood glucose in healthy adults

As sweetener 5-15 g/serving; 5 g and 10 g single doses in the glucose meta-analysis; 7 g twice daily in the body composition trial. The 54 g/day ceiling is not supported by any reference cited here.

BenfoPure® (Benfotiamine — Vitamin B1 Derivative)

Healthy glucose metabolism

Commonly 300 to 600 mg per day.

Small reductions in fasting glucose and HbA1c

General supplementation: 1-3 g/day L-carnitine. Athletic recovery: 2 g/day L-carnitine

Pycnogenol® (French Maritime Pine Bark)

Blood sugar and HbA1c

50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic

(R)-1,3-Butanediol (Ketone Precursor)

Lower blood glucose after a dose

Single servings of 10 to 11.5 g, up to 34.5 g split into three servings 30 minutes

Apple Polyphenols (Malus domestica Extract)

Glucose tolerance in adults with high-normal fasting glucose

600 mg/day of apple polyphenols for 12 weeks in the Japanese trials; 300 mg/day for 8

Carob (Ceratonia siliqua Pod Fiber and Extract)

Insulin and blood sugar markers with inositol-rich carob extracts

Carob pod fiber: 15 g/day in foods (6 to 8 weeks) or 4 g twice daily of a

Chia Seed (Salvia hispanica)

Smaller rise in blood sugar after a meal

25 to 50 g/day of whole or milled seed for 10 to 12 weeks; 35 to 40 g/day in the blood

Oleoylethanolamide (OEA)

Blood sugar and insulin markers

250 mg a day (two 125 mg capsules) for 8 to 12 weeks in the obesity and fatty liver

7-Keto DHEA (3-Acetyl-7-Oxo-DHEA)

Helps maintain resting metabolic rate during calorie restriction

102 to 200 mg/day in two divided doses for 1 to 8 weeks; safety tested up to 200

Barley Grass (Young Barley Leaf)

Helps moderate post-meal blood sugar in small tests

Leaf powder 1.5-3 g per serving; concentrated leaf powder 8 g/day plus tablets; leaf

L-Carnosine (Beta-Alanyl-L-Histidine)

Blood sugar response during a glucose tolerance test

2 g a day for 12 to 14 weeks in most trials; 1 g a day (500 mg twice daily) in one

Prickly Pear Cactus (Opuntia ficus-indica)

Smaller blood sugar rise after carbohydrate meals (nopal pads)

Depends on the plant part: about 300 g cooked nopal pads with a meal; pad fiber 3 g a

Rice Bran Extract (Stabilized Rice Bran and Gamma-Oryzanol)

Blood sugar response after meals

Stabilized rice bran 20 g/day; gamma-oryzanol 300 to 600 mg/day; rice bran oil about

Aronia / Chokeberry (Aronia melanocarpa)

Blood Lipid Support: Total and LDL Cholesterol

STANDARDIZED EXTRACT: 100-300 mg/day (25-50 mg anthocyanins) OR juice 200-300 mL/day ×

Banaba Leaf (Lagerstroemia speciosa)

Fasting Blood Glucose Reduction

MOST TRIALS: 32-48 mg/day extract 1% corosolic acid (= 0.32-0.48 mg corosolic

Cinnamon FenuMat® (Cinnamon + Fenugreek Soft Hydrogel — Akay Bioactives)

Fasting blood glucose (generic cinnamon, inconsistent, mostly in diabetics)

Typical cinnamon clinical doses: 120-500 mg/day standardized extract or 1-3 g/day

Cinnulin PF® (Water-Soluble Cinnamon Extract — Verdure Sciences)

Supports fasting blood glucose already within the normal range (small 12-week trial)

500 mg/day Cinnulin PF — the dose used in the 12-week pivotal RCT. Recommended

Metabolic syndrome marker support

In the one trial, 400 micrograms chromium with 6 mg amla extract and 6 mg shilajit, or 800 micrograms chromium with 12 mg of each, daily for 12 weeks; for a finished product, follow the label.

Liver fat reduction and metabolic health

2.4-12 mg/day fucoxanthin in human trials, up to 12 mg/day alone for 12 weeks; trials at 1-2 mg/day found no change in body fat.

Gencinia® (Coccinia indica / Ivy Gourd Blood Sugar Support — Saanroo)

Fasting blood glucose reduction (~16%)

1 gram (1,000 mg) daily of Gencinia. Effects on fasting and post-prandial blood

Pantesin® (Pantethine — Daiichi Fine Chemical)

LDL cholesterol and blood lipids: small changes in two pantethine trials

600 to 900 mg a day in divided doses (300 mg three times daily); trial participants also followed a therapeutic diet.

Silbinol® (Indian Kino Pterostilbene Extract — Sabinsa)

Blood sugar support (open-label decoction trial)

200 mg/day Silbinol 90% pterostilbene (100 mg twice daily) — dose established in the

ThinOgen® (Fucoxanthin from Brown Seaweed — BGG)

Triglycerides, insulin and metabolic markers

2.4 mg/day fucoxanthin (research-validated; some products use higher amounts of total

Improved glucose tolerance in metabolic syndrome

GLUCOSE TOLERANCE: 3.3-10 g/day (Mizote 2017: 10 g; Yoshizane 2020: 3.3 g). PAD pilot:

Trigogen® (Fenugreek/Trigonelline Glucose Support — Saanroo)

Fasting blood glucose support

Per the published Pharmaceutics 2022 trial — Trigogen is sold to formulators with

ActivAMP® (Gynostemma pentaphyllum AMPK Activator — Saanroo)

Glucose uptake and fat oxidation support

450 mg/day ActivAMP is the clinical dose used in both pivotal RCTs (body composition

Lipid profile support

150 mg/day of Altilix® standardized extract for 6 months in metabolic syndrome and

Healthy lipid profile

250–500 mg twice daily of standardized amla extract for 12 weeks in cardiometabolic

Arabinoxylan (Arrabina®)

Blood sugar and postprandial glucose blunting

15 g/day for 6 weeks in the impaired-glucose-tolerance trial; 6 to 12 g with a meal in the acute glucose study; 10 g/day AXOS for 3 weeks in the prebiotic study.

Blood Sugar and Blood Fats: Limited Evidence

30 mcg/day (AI); hair/nail: 2,500–10,000 mcg/day (evidence weak);

Healthy lipid profile support

Capros® amla extract is the anchor component; human cardiovascular trials of the amla

Cholesterol and glucose markers

General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome: 5

ChromeMate® (Niacin-Bound Chromium — Lonza)

Blood sugar: the controlled trial of this form was negative

200 mcg elemental chromium/day is the typical supplement dose; the 1,000 mcg/day figure comes from a rat safety study, not a human efficacy trial.

Chromium Chloride

Glucose Metabolism Role

Adequate intake 20-35 mcg/day elemental Cr. Parenteral-nutrition formulas supply

Chromium Dinicocysteinate

Insulin Sensitivity Support

The key trial used 400 mcg/day elemental chromium as chromium dinicocysteinate for 3

Chromium Picolinate

Glucose Metabolism Support

Adequate intake 20-35 mcg/day elemental Cr. Diabetes trials commonly used 200-1,000

DeltaGold® (Annatto Tocotrienols — American River Nutrition)

Fasting glucose, HbA1c and insulin resistance studied in prediabetes

430 or 860 mg/day annatto extract (roughly 300 or 600 mg/day tocotrienol) in the

FenuLife® (Fenugreek Galactomannan Fiber — IFF)

Healthy blood sugar

Products typically supply a few grams of fenugreek galactomannan fiber per day with meals. No FenuLife-specific dose-finding trial; the pooled doses were whole-seed preparations.

Fucoidan (Brown Seaweed Polysaccharide)

Blood sugar and insulin markers

300 mg/day (vaccine trial); 500 mg to 1 g/day (blood sugar, urinary symptom and

Gymnema Sylvestre (Gurmar — 'Sugar Destroyer')

Blood Sugar Support

200-400 mg/day standardized extract (typically 25% gymnemic acids); traditional form

Hemp Protein (Hemp Seed, Cannabis sativa)

Post-meal blood sugar and insulin response

50 g/day hemp seed protein powder for 6 weeks (blood pressure trial); 60 g/day hemp

InnoSlim® (Stimulant-Free Fat Burning)

Fasting blood glucose

250 mg/day InnoSlim®; human study confirmed significant fat loss, glucose reduction,

InSea2® (Brown Seaweed Polyphenols — InnoVactiv)

Gentler post-meal glucose

About 500 mg taken before a carbohydrate-containing meal.

Jamun (Java Plum)

Supports Healthy Blood Sugar

Traditional and trial doses typically range from 5-15 g/day of jamun seed powder or

Supports Healthy Postprandial Glucose

Typically co-administered at approximately 3-4% of the sucrose load (e.g., ~1-2 g

Molecular Hydrogen (H2)

Cholesterol and blood sugar markers (small effects)

Oral hydrogen-rich water, about 11 mg H2/day (one tablet in 250 mL, three times daily) in the 24-week metabolic syndrome trial; other cited trials used 3.5 mg/day and 7.5 mg/day.

Portusana® (Purslane Extract for Blood Sugar — Frutarom/IFF)

Blood sugar support (responder subgroup in one trial)

180 mg/day Portusana — taken as three oral capsules. Notably small clinical dose vs

Rooibos (Red Bush Tea)

Helps support a healthy lipid profile

Clinical lipid and oxidative-stress trials have used about six cups (about 750 mL

Saberry® (Standardized Amla Extract — Sabinsa)

Fasting and After-Meal Blood Sugar

1 g/day or 2 g/day Saberry — both clinically studied. 1 g comparable to metformin 500

Sulforaphane / Glucoraphanin

Blood glucose and metabolic biomarkers

Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides

Svetol® (Decaffeinated Green Coffee Extract — Givaudan/Naturex)

Post-meal glucose: one small coffee study

400 mg/day before meals, or up to 400 mg three times daily. None of the cited studies tested this branded extract by name, and two used coffee drinks rather than capsules.

Acacia Fiber (inavea™ Pure Acacia)

Blood sugar response after a meal

Nearly all the human evidence used 30 g/day of gum arabic powder for 6 weeks to 3 months. Mild gas, bloating and rumbling are reported around 40 g/day.

Aloe Vera (Aloe barbadensis miller)

Supports healthy blood sugar

INNER LEAF GEL: 50-300 mL/day juice OR 100-300 mg/day freeze-dried powder (blood sugar

Bergavit® (Bergamot Flavonoid Extract — Bionap)

Studied for healthy cholesterol and blood lipid levels

About 150 mg of bergamot flavonoids per day.

BioBerb® (Bioavailable Berberine — Saanroo)

Healthy blood sugar support (ordinary berberine research)

The cited trials used ordinary berberine, typically 500 mg three times daily (1,500 mg/day). No dose of BioBerb specifically has been tested, so lower enhanced-absorption doses are unproven for this brand.

Bitter Melon (Momordica charantia)

T2DM Glycemic Modest Improvement

1–3 g/day fruit/seed powder; 200–500 mg/day standardized extract; juice 50–100 mL/day, in prediabetes or diabetes studies. No dose is established for people without a blood sugar problem.

Carb10® (Pea Starch Carbohydrate)

Lower insulin response than maltodextrin (manufacturer testing)

15–25g per serving for workout fueling; can be used pre, intra, or post-workout;

Chromium Polynicotinate (Niacin-Bound Chromium)

Glucose Metabolism (Limited)

200-400 µg elemental chromium/day; some trials use up to 1,000 µg combined with other

Fiit-ns® (Fruit Polyphenol Extract — Fytexia)

Metabolic support

A standardized daily polyphenol dose.

Go-Luo® (Monk Fruit Extract — Layn USA)

No Glycemic Impact

No therapeutic dose has been established; the extract is added to taste as a sweetener. Human trials gave monk fruit as a sweetness-matched serving; none used this branded extract.

Greenselect® Phytosome (Decaffeinated Green Tea Catechin Phytosome — Indena)

Metabolic markers in borderline metabolic syndrome (24 week registry study)

300 mg/day Greenselect Phytosome, split as 150 mg twice daily (one dose before lunch,

Holy Basil (Tulsi)

Blood sugar regulation

300–600 mg/day dried leaf extract; 1–2 g/day whole leaf powder

LuraLean® (Propolmannan Konjac Fiber — AHD International)

Blood glucose lowering effects

1-3 g LuraLean per day, taken BEFORE meals with water for satiety. 8-week trials at

Maitake Mushroom (Grifola frondosa)

Blood Sugar / Insulin Sensitivity

1-3 mg D-fraction/kg body weight (50-300 mg D-fraction/day for typical adults); whole

Mangosteen Pericarp (Garcinia mangostana)

Insulin sensitivity alongside a weight-loss diet

Extracts: 400 mg/day standardized to 40% mangostins for 26 weeks, 1,000 mg/day (2 x

Melostacio® (Mango Leaf Extract)

Carbohydrate and glucose handling: laboratory and animal evidence only

150 mg/day of mangiferin for 12 weeks in the only human trial, generic and not Melostacio; no published trial has tested Melostacio itself.

Meratrim® (Sphaeranthus indicus + Garcinia mangostana)

Supports healthy lipid markers in overweight adults

Sponsor-funded RCTs used 400 mg twice daily (800 mg/day total) of Meratrim®, taken 30

Oligonol® (Lychee + Green Tea Polyphenol — Amino Up)

Post-meal blood glucose and lipid support

Visceral fat protocol: 200 mg/day Oligonol® (50 mg twice daily) for 10 weeks.

Terminalia Chebula (Rejuna®)

Blood sugar: limited and mixed human data

500–1,000 mg/day of standardized aqueous fruit extract, given as 250–500 mg twice daily, the range used in the human trials. Traditional whole-fruit powder use is higher, around 3–5 g/day.

Vanadium (Vanadyl Sulfate)

Blood sugar support and insulin sensitivity

Human trials used vanadyl sulfate 75 to 300 mg/day; these doses approach the level that causes GI upset and toxicity.

Vitosa® (Next Generation Stevia — BGG)

No Glycemic Impact

No published trial has tested Vitosa; everyday use is a few to tens of milligrams of steviol glycosides per serving, unlike the 1,500 mg/day of purified stevioside in the cited blood pressure study.

Xanthigen® (Fucoxanthin + Pomegranate Seed Oil)

Triglycerides in the same trial

PIVOTAL: 600 mg Xanthigen®/day × 16 weeks (300 mg PSO + 300 mg brown seaweed extract

Advantra Z® (Bitter Orange p-Synephrine — Nutratech)

Modest metabolic boost

Commonly 50 mg of p-synephrine per day, often taken before activity.

Caffeine-free metabolic support

Published AfperFIT trial: 250 mg twice daily (500 mg/day, standardized to at least 2 percent 6-paradol) for 12 weeks.

Calanus® Oil (Arctic Zooplankton Omega-3 Wax Esters)

Metabolic health in prediabetic populations

2g/day Calanus® Oil capsules; clinical study: 2–4g/day; wax ester form may have

Bulk sugar replacement with zero glycemic impact

5-30 g per serving as a sugar substitute; most adults tolerate roughly 50 g at one time, though 30 g produced a large rise in blood erythritol lasting more than 2 days in an 8-person pilot.

FiberSMART® (Soluble Tapioca Fiber — Anderson)

Low glycemic impact

The one supporting human study used 6 g a day of maize soluble fiber; finished products list servings as several grams of fiber, which may be more or less than the amount studied.

FucoVital® (Microalgae Fucoxanthin — Algatech)

Metabolic support

No established dose for FucoVital itself, as no trial of it is cited; in the Xanthigen trial, energy expenditure rose at fucoxanthin above 2.4 mg per day, a product also containing pomegranate seed oil.

Phosphocomplex® (Silybin Phytosome — Indena)

Lower insulin resistance score in a 12-month fatty liver trial

A standardized daily dose providing bioavailable silybin.

Polyphenol/quercetin metabolic support

400 mg/day (200 mg twice daily)

Olive Leaf Extract

Insulin sensitivity: one positive trial, glucose not improved in pooled data

Standard dose: 500-1,000 mg/day standardized olive leaf extract (containing 20-40%

Blood pressure and fasting glucose: one 12-week extract trial

No trial of isolated oleocanthal. Oils: 30-40 mL with 172-621 mg/kg oleocanthal;

Black Tea Extract (Camellia sinensis)

Blood sugar after a sugary drink

Beverage trials: about 2 to 5 cups of black tea a day (pooled blood-pressure trials

Akkermansia muciniphila

Insulin sensitivity and glucose regulation

Depommier 2019: 10¹⁰ CFU/day pasteurized × 3 months. Most products: 10⁸-10⁹ CFU/day.

CyaniMax® (Cyanidin-3-O-Glucoside Anthocyanin — BGG World)

Metabolic health support (preclinical)

300 mg/day BSHE/C3G (black soybean hull extract) — the dose used in the pivotal

Supports Healthy Postprandial Glucose

Okra powder 1-2 g/day in T2D trials; whole okra pods 100 g/day in dietary interventions.

4-Hydroxy-L-Isoleucine

Glucose-dependent insulin secretion support

Standalone 4-OH-Ile human data is limited; preclinical doses range 18–50 mg/kg in

Csat+® (Pharmactive Carob Extract)

Blood lipids: carob fiber trials, not Csat+

No dose of Csat+ has been tested in people. No finished-product serving size is published; the two mouse studies fed the extract at 4.8% of total diet by weight, which gives no capsule dose.

Reduced insulin sensitivity and dysbiosis findings (concerning)

ADI 5 mg/kg/day (FDA), 15 mg/kg/day (EU EFSA); typical product use 0-50 mg per serving.

NEOBEE® (Medium-Chain Triglycerides — Stepan)

Lower insulin resistance score in MCT trials; lipid effects vary

Commonly 10 to 20 grams per day with meals.

inavea™ CINNAMON ACACIA

Glucose and Insulin Markers (Animal Model + Cinnamon Component Data)

5 g/day (research-validated dose)

Better fasting glucose and HbA1c in one prediabetes trial; others vary

2–7 g/day leaf powder; clinical studies typically use 6–8 g/day

Panax notoginseng (Sanqi)

Blood sugar rise after a glucose drink

1,350 mg/day for 30 days in the endurance trial; 3 g/day for 3 days in the blood sugar

Fasting insulin and HOMA-IR

0.14 g FOS/kg/day (roughly 10 g FOS, or 20 to 25 g of syrup for a 70-kg adult) in the single 120-day trial; the higher 0.29 g FOS/kg/day dose caused digestive side effects.

Chromium Histidinate

Chromium's Role in Glucose Metabolism

The human absorption study used a single 200 mcg elemental Cr dose. Chromium adequate

pTeroWhite® (99% trans-Pterostilbene)

Metabolic and Cardiovascular Support

50-250 mg/day; the blood-pressure reduction appeared only in the 250 mg/day arm, and 50 to 100 mg/day doses have not produced a measured clinical benefit in any published trial.

R-Lipoic Acid (Natural / Stabilized R-ALA)

Insulin Sensitivity / Blood Sugar

Products typically supply 100-300 mg/day of R-ALA. The cited studies gave only single absorption doses (600 mg sodium R-lipoate; 50 to 600 mg racemic thioctic acid), not a daily regimen.

Hibiscus (Roselle)

Fasting Blood Sugar

Typical clinical trials use 1.25-10 g dried calyces brewed as tea, or 250-500 mg of

Capsinoids (Non-Pungent Capsaicin Analogs)

Glucose metabolism (mainly animal data)

WEIGHT MANAGEMENT (Snitker 2009 + Galgani 2010): 6 mg capsinoids daily × 4-12 wk.

Clovinol® (Clove Bud Polyphenol for Metabolic Health — Akay Bioactives)

Insulin resistance modulation (HOMA-IR, HbA1c, FBS, PPG)

250 mg/day Clovinol — the dose validated across multiple clinical trials. Effects on

Coleus forskohlii (Forskolin)

Insulin levels alongside a reduced-calorie diet

250 mg of root extract standardized to 10% forskolin, taken twice daily (500 mg

Ecklonia Cava (Brown Seaweed Polyphenol)

Metabolic health — fat oxidation and glucose management

Trial doses range from 72 to 1,500 mg/day; the European Food Safety Authority set a maximum safe intake of 263 mg/day for adults, below several research doses.

Glabridin (Licorice Isoflavone)

Glucose and body-fat effects (preclinical)

Licorice-root extract with ~60 mg/day glabridin (LDL oxidation); licorice flavonoid oil 300–900 mg/day (body fat). No established pure-glabridin human dose.

GlyNAC (Glycine + N-Acetylcysteine)

Insulin resistance and glucose metabolism

PIVOTAL: glycine 1.33 mmol/kg/day (~7 g/70 kg) + NAC 0.83 mmol/kg/day (~9.5 g/70 kg) ×

iXOS® (Xylooligosaccharides Prebiotic)

Short-chain fatty acids, and what the metabolic trials actually showed

1.4 and 2.8 g/day in the bifidobacteria trial, 2 g/day for prediabetes, 4 g/day for type 2 diabetes, 5 g/day and 8 g/day in immune trials; no trial tested the iXOS brand.

Dietary intake associated with metabolic health in epidemiological studies

DIETARY: 1-4 mg/day (walnuts, cranberries, blueberries, red wine, tea). SUPPLEMENT:

Cardiovascular / Lipid Effects

150-500 mg/day; emerging supplement category; standardized doses not yet

NMN (Nicotinamide Mononucleotide)

Muscle insulin sensitivity in postmenopausal women with overweight

250–500 mg/day (commonly studied); up to 1,200 mg/day in clinical trials

Pentadecanoic Acid (C15:0)

Lower LDL cholesterol, a blood lipid marker, in one diet trial

100-200 mg/day (single capsule); taken with food. Most published cellular and

SelectSIEVE® Bergamot (Citrus bergamia Extract — Bionap)

Healthy cholesterol and lipids

Commonly 500 to 1000 mg of bergamot extract per day.

Slendesta® (Potato Protein Extract)

Blood sugar and insulin response modulation

600 mg/day Slendesta (providing ~30 mg PI2) before main meals; one trial found no appetite or food-intake effect at that 30 mg PI2 dose.

Stevia (Stevia rebaudiana)

Glycemic neutrality

Acceptable Daily Intake (steviol equivalents): 4 mg/kg/day (FDA, EFSA). Common

ThymoQuin® (Black Seed Oil — TriNutra)

Waist size and metabolic markers in a black seed oil trial

Standard formulation use: 500-1,000 mg ThymoQuin® daily. Cardiometabolic protocols

Trpti™ (Bioavailable Oleoylethanolamide / OEA — Saanroo)

Lower triglyceride and glucose markers in generic OEA trials

300 mg/day (delivering 250 mg OEA) as two 150 mg capsules; a 150 mg/day dose is also described, but only in an unpublished, unverified manufacturer study.

AcaiVida® (Açaí Berry Extract)

Metabolic support

Commonly around 1 to 2 g of açaí preparation per day.

MangoSelect® (African Mango Seed Extract)

Metabolic markers

150 mg twice daily before meals in two of the five trials (daily doses across trials ranged 300 mg to 1,050 mg); no dose has worked in a low risk of bias trial.

GyngerLean® (Ginger Weight Management Extract)

Thermogenesis and metabolic rate

400–800 mg/day GyngerLean® standardized ginger extract; clinical studies at 400 mg

Millet Sprout Powder

Supports Healthy Glycemic Response

Typical food-based intake of millet flour ~50-100 g/day in dietary trials; no

Opextan® (Verbascoside-Rich Olive Fruit Extract — Indena)

Fasting blood glucose: one small 12-week trial

Indena's recommended oral dose is 100 to 400 mg a day (its Japanese brochure

p-Synephrine (Bitter Orange)

Metabolic Rate: Small and Not Significant for Synephrine Alone

Most human studies used p-synephrine 25-50 mg per day, alone or combined with caffeine

Post-Meal Blood Sugar: Benefit Belonged to Other Pea Components

There is no established effective dose; the only human study used a single 7 g serving with no effect. Products typically supply about 5 to 15 g a day, taken with water.

BioPerine® (Black Pepper Extract — Sabinsa)

Lower fasting glucose and triglycerides in one small 5 mg piperine trial

5-20 mg alongside another compound; the one positive trial used 5 mg with 120 mg CoQ10 for 21 days, while 20 mg with 250 mg resveratrol showed no change in resveratrol levels.

MitoBurn® (L-BAIBA)

Insulin sensitivity and glycogen storage

250–500 mg/day; 500 mg is the full clinical dose

Prenulin® (L-Arabinose and Chromium — Pharmachem)

Post-meal blood sugar

No dose of Prenulin itself has been tested in a published study. Cited studies used L-arabinose and 600 mcg/day chromium picolinate; amounts in finished products vary and may not match.

Blood lipid support from the amla component (Capros)

No studied dose for the SensorilTrim combination itself. Its ashwagandha trial used 300 mg of root extract twice daily, more than the 125-250 mg of Sensoril twice daily usually listed.

SteviUp® M2 (Next-Gen Stevia Reb M — Layn USA)

Glucose-neutral sugar swap in generic stevia trials (not SteviUp M2)

Sweetener use per product specification

Black Pepper Extract

Metabolic effects: not measured in the studies cited here

5-20 mg piperine per dose (standardized to 95% or more piperine); products commonly use 5 mg, an amount not tested in anything cited here.

FB3 Fusion® (Fat-Absorption Botanical Blend — Bio Actives Japan)

Studied for insulin response in a Salacia-only trial (not the blend)

Per the product specification.

Manganese Picolinate

Supports normal metabolic enzymes

Adult AI 1.8–2.3 mg/day elemental manganese; UL 11 mg/day. Picolinate products

Phytofare® (Bioavailable Green Tea Catechin Complex — Plandaí)

Small fasting glucose and HbA1c drops in generic green tea trials

A standardized daily dose of bioavailable catechins.

Ammonium Molybdate

Metabolic health: sulfite enzyme cofactor; glucose effects unproven

RDA 45 mcg/day elemental Mo. Liquid molybdenum products typically provide 25-500

Sodium Molybdate

Metabolic health: sulfite enzyme cofactor; glucose effects unproven

RDA 45 mcg/day elemental Mo for adults. Supplements commonly provide 50-500 mcg/day. A