Home Ingredients Genopause® (Four-Herb Ayurvedic Menopause Support — Saanroo)
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Genopause® (Four-Herb Ayurvedic Menopause Support — Saanroo)

Evidence Level
Moderate
2 Clinical Trials
7 Documented Benefits
3/5 Evidence Score

Genopause® is Saanroo's (formerly Gencor) patented four-herb Ayurvedic blend for menopausal symptom support — a non-estrogenic formula combining four traditional Indian herbs: Tinospora cordifolia (Guduchi), Asparagus racemosus (Shatavari), Withania somnifera (Ashwagandha), and Commiphora mukul (Guggul). Distinguished from phytoestrogen-based menopause supplements (soy isoflavones, red clover) by its adaptogenic-modulator approach rather than direct estrogen receptor agonism. The 1990s-2000s saw little new research in menopause supplements outside phytoestrogens — Genopause was positioned to fill that gap. Clinical dose: 750 mg/day in the pivotal Australian trial.

Studied Dose 750 mg/day.
Active Compound Four-herb blend: Tinospora cordifolia (Guduchi), Asparagus racemosus (Shatavari), Withania somnifera (Ashwagandha), Commiphora mukul (Guggul).

Benefits

Hot flash and night sweat reduction

In peri- and post-menopausal women, Genopause at 750 mg/day produced significant reductions in hot flash frequency and night sweat severity vs placebo, with improvements in the menopausal-specific quality of life questionnaire (MENQOL) and the Greene Climacteric Scale — standard instruments used across menopause research.

Supported by Trial 1

Non-estrogenic mechanism — different from phytoestrogens

Unlike soy isoflavones, red clover, or hop-derived 8-prenylnaringenin (which work via direct estrogen receptor binding), Genopause uses adaptogenic and hormone-modulating herbs that don't activate estrogen receptors directly. Practical advantage: suitable for women with estrogen-sensitive conditions (history of ER+ breast cancer, endometriosis, fibroids) where phytoestrogen-based supplements are contraindicated.

Supported by Trial 1, Trial 2

Mood and stress support

Two of the four herbs — Ashwagandha and Shatavari — have well-documented adaptogenic effects on stress, mood, and HPA axis regulation. Menopausal symptoms include significant mood, anxiety, and sleep components alongside vasomotor symptoms. Genopause's broader adaptogenic profile addresses these alongside hot flashes — reflected in the MENQOL psychological domain scores.

Supported by Trial 2, Trial 1

Sleep disturbance improvement

Menopausal sleep disturbance has multiple drivers: night sweats, mood fluctuation, and circadian shifts. Genopause showed improvements in sleep-related quality of life measures. Ashwagandha specifically has independent evidence for sleep support, contributing to this domain alongside the night sweat reduction.

Supported by Trial 2, Trial 1

Lipid profile maintenance

Menopause is associated with adverse lipid changes (total cholesterol and LDL increases, HDL decreases) tied to estrogen decline. The Guggul component has independent evidence for cholesterol modulation, and the Ashwagandha component supports metabolic health. Combined effect potentially mitigates some of the cardiometabolic impact of menopause without estrogenic stimulation.

Supported by Trial 2

Liver and antioxidant support

Tinospora cordifolia (Guduchi) has documented hepatoprotective and antioxidant properties. Estrogen metabolism occurs primarily in the liver — supporting hepatic function is mechanistically relevant during menopausal hormonal shifts. The antioxidant effects also support the broader oxidative stress increase that accompanies aging and menopause.

Supported by Trial 2, Trial 1

Suitable alternative to phytoestrogen products

For women avoiding phytoestrogens (estrogen-sensitive cancer history, tamoxifen or aromatase inhibitor users, those with concerns about long-term phytoestrogen exposure), Genopause offers a fundamentally different mechanism. Patient should still consult oncologist for supplement use in active cancer treatment contexts, but the absence of ER agonism is a meaningful differentiation.

Supported by Trial 1, Trial 2

Mechanism of action

1

Non-estrogenic adaptogenic modulation

Unlike phytoestrogens, Genopause's bioactives do not bind estrogen receptors. Instead, the four-herb blend appears to work through HPA axis modulation, cortisol regulation, and hepatic estrogen metabolism support. This 'adaptogenic-modulator' approach addresses menopausal symptoms via stress resilience rather than estrogen replacement.

2

Ashwagandha — cortisol and HPA modulation

Withania somnifera (Ashwagandha) modulates the hypothalamic-pituitary-adrenal (HPA) axis, reducing baseline cortisol and dampening cortisol response to stressors. Documented in independent trials to reduce serum cortisol 15-30% over 8-12 weeks. Stress modulation is mechanistically tied to vasomotor symptom severity in menopause.

3

Shatavari — traditional women's health adaptogen

Asparagus racemosus (Shatavari) is the most-studied Ayurvedic herb for female reproductive health, with traditional use for menopause spanning centuries. Preclinical research shows estrogen-modulating effects without direct ER agonism, including support for serotonergic neurotransmission relevant to mood and vasomotor stability.

4

Guggul — cholesterol and steroidogenesis support

Commiphora mukul (Guggul) contains guggulsterones with documented cholesterol-lowering and hormone-modulating effects. Mechanism involves farnesoid X receptor (FXR) antagonism affecting cholesterol metabolism, and broader steroidogenesis support relevant to the hormonal changes of menopause.

5

Guduchi — hepatoprotection and immune modulation

Tinospora cordifolia (Guduchi) provides hepatoprotective antioxidant effects and immune modulation. Hepatic function is central to estrogen metabolism and bile acid recycling; supporting liver function may help with menopausal estrogen processing. Immune modulation contributes to general well-being during menopausal transitions.

Clinical trials

1
Genopause for Menopausal Symptoms — Australian Pivotal Clinical Trial

Double-blind randomized placebo-controlled trial evaluating Genopause in Australian peri- and post-menopausal women. Authors: Steels E, Steele M, Harold M, Adams L, Coulson S. Outcomes measured via the menopausal-specific quality of life questionnaire (MENQOL), the Greene Climacteric Scale, and hot flash frequency tracking — the standard instrument battery in menopause research.

Australian peri-menopausal and post-menopausal women experiencing menopausal symptoms. Multi-week intervention.

Genopause significantly reduced multiple menopausal symptoms vs placebo across MENQOL and Greene Climacteric Scale instruments. Reductions captured across vasomotor (hot flashes, night sweats), psychological, and physical symptom domains. No safety concerns documented across the intervention period — supports the broader safety profile of the traditional Ayurvedic herb combination.

2
Component Herb Class Evidence — Independent Trials

Beyond the Genopause-specific clinical trial, each of the four component herbs has independent clinical trial evidence in related contexts. Notable: Ashwagandha for menopausal symptoms (Journal of Obstetrics and Gynecology Research) and broader ashwagandha trials for stress, cortisol, and sleep across multiple Ayurvedic herbal research programs.

Various — clinical trials of individual component herbs (Ashwagandha, Shatavari, Guggul, Guduchi) across different supplementation contexts.

Ashwagandha at 300 mg twice daily over 8 weeks reduced menopausal symptom scores by more than double the placebo response — supporting the rationale for its inclusion in Genopause. Guggul has independent evidence for cholesterol modulation. Shatavari has traditional and preclinical support for women's health. The four-herb combination may produce additive effects beyond any single ingredient.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated in the Australian pivotal trial — no significant adverse events vs placebo.
Mild GI effects rare.
Ashwagandha component may produce mild sedation in some users (relevant in the menopausal sleep-disturbance context — usually beneficial, but worth noting).
Ashwagandha may modestly increase thyroid hormone (T3/T4) — relevant for hyperthyroid patients to monitor; menopausal women with thyroid conditions should consult clinician.
Guggul may cause occasional rash, headache, or mild GI symptoms in sensitive individuals.
Pregnancy and lactation: avoid. Ashwagandha is traditionally contraindicated in pregnancy due to potential abortifacient effects in animal studies. Genopause is positioned for menopausal women, not pregnancy.

Important Drug interactions

Thyroid medications — Ashwagandha component may increase T3/T4; monitor and adjust thyroid medication dose if needed.
Immunosuppressants — Ashwagandha and Guduchi components have immune-stimulating effects; theoretical interaction with transplant immunosuppression; consult prescriber.
Sedatives and anxiolytics — additive sedation possible via Ashwagandha; use caution.
Statins / lipid medications — Guggul component may affect lipid metabolism; theoretical additive or competing effects with statins; monitor lipids.
Anticoagulants — Guggul may have mild anticoagulant effects; monitor INR with warfarin.
Hormone-sensitive cancers — although Genopause is non-estrogenic, consult oncologist before use during active cancer treatment.
Pregnancy and lactation — avoid.

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Frequently asked questions about Genopause® (Four-Herb Ayurvedic Menopause Support — Saanroo)

What is Genopause?

Genopause® is Saanroo's (formerly Gencor) patented four-herb Ayurvedic blend for menopausal symptom support — a non-estrogenic formula combining four traditional Indian herbs: Tinospora cordifolia (Guduchi), Asparagus racemosus (Shatavari), Withania somnifera (Ashwagandha), and Commiphora mukul (Guggul).

What is Genopause used for?

Genopause is researched primarily for Women's Health and Menopause Support. In peri- and post-menopausal women, Genopause at 750 mg/day produced significant reductions in hot flash frequency and night sweat severity vs placebo, with improvements in the menopausal-specific quality of life questionnaire (Menqol) and…

What is the recommended dosage of Genopause?

The clinically studied dose is 750 mg/day. Always follow the product label and check with a healthcare provider for personal advice.

Is Genopause safe, and does it have side effects?

For most healthy adults, Genopause is well tolerated at studied doses. Reported effects can include: Generally well-tolerated in the Australian pivotal trial — no significant adverse events vs placebo. Mild GI effects rare. It may also interact with some medications. Genopause is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Genopause interact with any medications?

Possible interactions include: Thyroid medications — Ashwagandha component may increase T3/T4; monitor and adjust thyroid medication dose if needed. Immunosuppressants — Ashwagandha and Guduchi components have immune-stimulating effects; theoretical interaction with transplant immunosuppression; consult prescr… If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Genopause?

NutraSmarts rates the evidence for Genopause as Moderate (3 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021;47(12):4414-4425. doi: 10.1111/jog.15030.PubMedUsed to support: Randomized double-blind placebo-controlled trial of Withania somnifera (one of Genopause's four herbs) in perimenopausal women showing significant reductions in total menopause rating scale (p<0.0001), somato-vegetative symptoms (p=0.0152), and psychological scores (p=0.0003), plus increased estradiol and decreased FSH/LH. Supports 'hot flash and night sweat reduction,' 'mood and stress support,' and 'non-estrogenic mechanism' claims for the ashwagandha component.
  2. Gudise VS, Dasari MP, Kuricheti SSK Efficacy and Safety of Shatavari Root Extract for the Management of Menopausal Symptoms: A Double-Blind, Multicenter, Randomized Controlled Trial. Cureus. 2024;16(4):e57879. doi: 10.7759/cureus.57879.PubMedUsed to support: Multicenter double-blind RCT of Asparagus racemosus (shatavari — one of Genopause's four herbs) in 70 menopausal women showing significant reductions in hot flashes, night sweats, insomnia, anxiety, nervousness, and vaginal dryness, with improved Utian quality-of-life scores. Supports 'hot flash and night sweat reduction,' 'mood and stress support,' and 'sleep disturbance improvement' claims for the shatavari component.
  3. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. doi: 10.1371/journal.pone.0257843.PubMedUsed to support: Systematic review and meta-analysis of 5 RCTs (n=400) showing ashwagandha extract produces a small but significant improvement in overall sleep quality, particularly in adults with insomnia, at ≥600 mg/day for ≥8 weeks. Supports the 'sleep disturbance improvement' claim for the ashwagandha component of Genopause.
  4. Nohr LA, Rasmussen LB, Straand J Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther Med. 2009;17(1):16-22. doi: 10.1016/j.ctim.2008.07.001.PubMedUsed to support: RCT of Commiphora mukul (guggul — one of Genopause's four herbs) showing significant reductions in total cholesterol and HDL-C over 12 weeks in hypercholesterolemic adults. Supports the 'lipid profile maintenance' claim for the guggul component. Caveat: the study found no significant LDL-C or triglyceride reduction, and the clinical magnitude was described as unclear; note this when communicating to consumers.