Top 5 — Ranked by Evidence
Strong
NAC (N-Acetylcysteine)
Liver Health and Detoxification
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver support: 60
Strong
Broccoli Extract (Glucoraphanin)
Type 2 diabetes — modest improvements in glucose markers
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Strong
Alpha Lipoic Acid
Glutathione recycling
DIABETIC NEUROPATHY: 600 mg/day racemic ALA (SYDNEY 2 + NATHAN 1). T2DM IR: 300 mg/da
Strong
Sulforaphane / Glucoraphanin
Detoxification enzyme support
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Strong
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
Standardized glucoraphanin delivery
Standard formulation use: 30-150 mg Truebroc® daily (providing 4-20 mg glucoraphanin)
📈 Fastest Growing Detox & Cleanse Ingredients
Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.
Trending
Strong
Sulforaphane / Glucoraphanin
NRF2 activation (master antioxidant response)
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10-40 mg…
Trending
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Trending
Strong
Broccoli Extract (Glucoraphanin)
Type 2 diabetes — modest improvements in glucose markers
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials: 50-150…
🔬 Future Detox & Cleanse Ingredients to Watch
Lower current evidence but active research underway — these may become top picks within 2–3 years.
Watch
Limited
Hepure™ (Clove + Immortelle Liver Detox)
In vitro hepatoprotective antioxidant activity
No published human clinical dose for Hepure™ specifically. Per Nexira product literature,…
Watch
Limited
MitoGreens® (Mitochondrial Greens Complex)
Mitochondrial energy production support
Per product label serving size; typical greens blend 3–8g/day; specific MitoGreens® dosing per…
Watch
Moderate
Betaine / TMG (Trimethylglycine)
Athletic performance — power and strength
2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine reduction: 1.5–6…
All Detox & Cleanse Ingredients (20)
Strong
NAC (N-Acetylcysteine)
Liver Health and Detoxification
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver support: 60
Strong
Broccoli Extract (Glucoraphanin)
Type 2 diabetes — modest improvements in glucose markers
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Strong
Alpha Lipoic Acid
Glutathione recycling
DIABETIC NEUROPATHY: 600 mg/day racemic ALA (SYDNEY 2 + NATHAN 1). T2DM IR: 300 mg/da
Strong
Sulforaphane / Glucoraphanin
Detoxification enzyme support
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Strong
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
Standardized glucoraphanin delivery
Standard formulation use: 30-150 mg Truebroc® daily (providing 4-20 mg glucoraphanin)
Moderate
Milk Thistle
Liver Health Support
The efficacy of these mechanisms depends on silymarin content (standardized extracts
Moderate
SAMe (S-Adenosyl-L-Methionine)
Liver Function
400–800 mg/day for depression; 600–1,200 mg/day for osteoarthritis; taken on empty st
Moderate
Activated Charcoal
Acute toxin decontamination (poisoning emergency)
ACUTE POISONING (medical, supervised): 50-100 g (1-2 g/kg) within 1 hr. MDAC: 25-50 g
Moderate
Chlorophyll / Chlorophyllin
Reduction of aflatoxin-DNA adducts (high-risk populations)
AFLATOXIN PROTECTION: 100 mg sodium copper chlorophyllin 3×/day (300 mg/day total). D
Moderate
Polyporus umbellatus (Zhu Ling / Chu Ling)
Diuretic for kidney/urinary conditions
TCM DECOCTION: 10-15 g/day raw herb. SEVERE EDEMA: 20-30 g short-term under TCM pract
Moderate
Betaine / TMG (Trimethylglycine)
Liver protection and methylation support
2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine reductio
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Moderate
L-Methionine
Glutathione and antioxidant production
500–3,000 mg/day; general supplementation: 500–1,000 mg/day; therapeutic: up to 3 g/d
Limited
Chlorella
Heavy metal 'detox' — popular claim, weak human evidence
General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome:
Limited
Beef Kidney (Desiccated)
Exceptional selenium concentration
Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef ki
Limited
Burdock Root (Arctium lappa)
Traditional 'Detoxification' / Skin Conditions
MAGHSOUMI-NOROUZABAD 2016 OA: 3 cups burdock tea daily (each 2 g root in 150 mL boile
Limited
Hepure™ (Clove + Immortelle Liver Detox)
Nutrigenomic activation of liver antioxidant genes
No published human clinical dose for Hepure™ specifically. Per Nexira product literat
Limited
4Liver™ (Liver Health Botanical Blend)
Liver Health Support
Per Saanroo product specification
Limited
Fucoxanthin
Liver fat reduction and metabolic health
2.4–8 mg/day fucoxanthin; human trials use 2.4–8 mg/day combined with pomegranate oil
Limited
MitoGreens® (Mitochondrial Greens Complex)
Antioxidant and detoxification support
Per product label serving size; typical greens blend 3–8g/day; specific MitoGreens® d