Top 5 — Ranked by Evidence
Limited
Broccoli Extract (Glucoraphanin)
Detoxication of Airborne Pollutants: Benzene and Acrolein Excretion
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Limited
Chlorophyll / Chlorophyllin
Lower aflatoxin-DNA adduct marker in high-exposure adults
AFLATOXIN PROTECTION: 100 mg sodium copper chlorophyllin 3×/day (300 mg/day total). D
Limited
Setria® Glutathione
Raises glutathione levels in blood and body cells
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Limited
Sulforaphane / Glucoraphanin
Detox support: higher excretion of some air pollutants
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Limited
Zeolite (Clinoptilolite)
Helps limit uptake of lead, a heavy metal, eaten at the same time
1-9 g/day in human studies; most often 2 g once to three times daily (up to 6 g/day);
📈 Fastest Growing Detox & Cleanse Ingredients
Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.
Trending
Limited
Sulforaphane / Glucoraphanin
Detox support: higher excretion of some air pollutants
50 to 150 micromoles sulforaphane a day (autism trial); a drink with 600 micromoles…
Trending
Limited
Setria® Glutathione
Raises glutathione levels in blood and body cells
250 mg/day or 1,000 mg/day for 6 months in the main blood-level trial (250 mg raised blood and…
Trending
Limited
Broccoli Extract (Glucoraphanin)
Detoxication of Airborne Pollutants: Benzene and Acrolein Excretion
Broccoli sprout drink yielding about 25 micromol/day of urinary sulforaphane metabolites…
🔬 Future Detox & Cleanse Ingredients to Watch
Lower current evidence but active research underway — these may become top picks within 2–3 years.
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Preliminary
Hepure™ (Clove & Immortelle Extract — Nexira)
Antioxidant activity of the clove and immortelle pair
No human dose of Hepure has been tested. Related human studies used 250 mg a day of a…
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Preliminary
Calcium D-Glucarate
Toxin / Xenobiotic Clearance
1,000-3,000 mg/day is the range used in practice; no human dosing study is cited, so this…
Watch
Moderate
NAC (N-Acetylcysteine)
Antioxidant Support
600 to 1,200 mg per day (600 mg once or twice daily) in lung and fertility trials; 2,000 to…
Recommended Detox & Cleanse Products
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Real products featuring the best-evidenced detox & cleanse ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.
Best for glutathione & antioxidant support
Amazon →
NOW Foods NAC 600 mg with Selenium & Molybdenum
600 mg veg capsules, 250 ct
NAC is a precursor to glutathione, paired with selenium and molybdenum; non-GMO, vegan, large 250-count.
Best for liver & antioxidant support
Amazon →
Jarrow Formulas Milk Thistle
150 mg 30:1 extract (80% silymarin), 200 ct
Standardized 30:1 extract delivering 80% silymarin flavonoids; non-GMO, vegan, up to a 200-day supply.
Best for phase-1 detox & cellular support
Amazon →
Jarrow Formulas BroccoMax
35 mg SGS delayed-release veg caps, 120 ct
Broccoli seed extract with active myrosinase to convert glucoraphanin into sulforaphane; delayed-release, non-GMO, vegan.
Best for antioxidant recycling & metabolic support
Amazon →
Doctor's Best Alpha-Lipoic Acid 600 mg
600 mg veg capsules, 60 ct
ALA is a versatile antioxidant that helps regenerate other antioxidants and supports glucose metabolism; non-GMO, vegan.
All Detox & Cleanse Ingredients (12)
Limited
Broccoli Extract (Glucoraphanin)
Detoxication of Airborne Pollutants: Benzene and Acrolein Excretion
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Limited
Chlorophyll / Chlorophyllin
Lower aflatoxin-DNA adduct marker in high-exposure adults
AFLATOXIN PROTECTION: 100 mg sodium copper chlorophyllin 3×/day (300 mg/day total). D
Limited
Setria® Glutathione
Raises glutathione levels in blood and body cells
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Limited
Sulforaphane / Glucoraphanin
Detox support: higher excretion of some air pollutants
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Limited
Zeolite (Clinoptilolite)
Helps limit uptake of lead, a heavy metal, eaten at the same time
1-9 g/day in human studies; most often 2 g once to three times daily (up to 6 g/day);
Limited
Polyporus umbellatus (Zhu Ling / Chu Ling)
Traditional diuretic used for fluid balance and urinary support
TCM DECOCTION: 10-15 g/day raw herb. SEVERE EDEMA: 20-30 g short-term under TCM pract
Preliminary
Cilantro (Coriander Leaf)
Heavy metal detox seen in rodents, untested in people
No controlled human dose. One case report used 100 mg tablets 4 times daily; a popular
Limited
4Liver™ (Liver Health Botanical Blend)
Raised blood glutathione and lowered lipid peroxidation markers
Per Saanroo product specification
Limited
Modified Citrus Pectin
Increases urinary excretion of some heavy metals
5 g three times daily in most trials; 15-20 g/day in the metal-excretion pilot
Moderate
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
NRF2 activation and detoxification enzyme upregulation
30-150 mg/day (providing 4-20 mg glucoraphanin) is the usual supplement range; the cited studies used other broccoli sprout preparations, so their doses do not map onto these numbers.
Preliminary
Calcium D-Glucarate
Toxin / Xenobiotic Clearance
1,000-3,000 mg/day is the range used in practice; no human dosing study is cited, so this reflects practice convention rather than a studied dose.
Preliminary
L-Methionine
SAMe synthesis and methylation support
About 500 to 1,000 mg per day on supplement labels; no cited study tested a dose for general health in healthy people, and excess methionine may be harmful.