Top 5 — Ranked by Evidence
Strong
Alpha Lipoic Acid
Universal antioxidant
300–600 mg/day racemic ALA; 100–300 mg/day R-ALA (more bioavailable)
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
Strong
Black Seed Oil / Thymoquinone (ThymoQuin®)
Immune system modulation and respiratory health
450–2,000 mg/day black seed oil; ThymoQuin® clinical doses: 450–900 mg/day; most
Strong
Curcumin C3 Complex® (Most Studied Curcumin Extract)
Anti-inflammatory activity across 80+ studies
500–1,000 mg/day curcumin C3 Complex® (standardized to 95% curcuminoids); combin
Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyr
All Detox & Cleanse Ingredients (41)
Strong
Alpha Lipoic Acid
Universal antioxidant
300–600 mg/day racemic ALA; 100–300 mg/day R-ALA (more bioavailable)
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
Strong
Black Seed Oil / Thymoquinone (ThymoQuin®)
Immune system modulation and respiratory health
450–2,000 mg/day black seed oil; ThymoQuin® clinical doses: 450–900 mg/day; most
Strong
Curcumin C3 Complex® (Most Studied Curcumin Extract)
Anti-inflammatory activity across 80+ studies
500–1,000 mg/day curcumin C3 Complex® (standardized to 95% curcuminoids); combin
Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyr
Strong
L-Theanine
Promotes Relaxation Without Sedation
100–400 mg/day; relaxation: 200 mg; caffeine synergy: 100–200 mg with caffeine;
Strong
Lutein
Eye Health Benefits
6–20 mg/day; AREDS2: 10 mg/day lutein + 2 mg zeaxanthin; eye health: 10–20 mg/da
Strong
NAC (N-Acetylcysteine)
Antioxidant Support
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver suppor
Strong
Riboflavin
Migraine Prevention
1.1–1.3 mg/day (RDA); migraine prevention: 400 mg/day (clinical studies); metabo
Strong
Saffron Extract (Saffretine®)
Antidepressant effects comparable to SSRIs
28–88.5 mg/day standardized extract; most trials use 30 mg twice daily (60 mg/da
Strong
Selenium
Antioxidant defense
55 mcg/day (RDA); therapeutic studies: 100–200 mcg/day; upper limit 400 mcg/day
Strong
Sulforaphane / Glucoraphanin (Truebroc®)
Nrf2 pathway activation and antioxidant defense
30–60 mg/day glucoraphanin (equivalent to ~10–20 mg sulforaphane); 100g fresh br
Moderate
Amla / Indian Gooseberry (Capros®)
Exceptional antioxidant capacity and vitamin C delivery
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day;
Moderate
Astaxanthin
Eye Health Benefits
4–12 mg/day from Haematococcus pluvialis extract; skin: 4–6 mg/day; exercise rec
Moderate
Betaine / TMG (Trimethylglycine)
Athletic performance — power and strength
2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine red
Moderate
Bilberry (Vaccinium myrtillus)
Night vision and dark adaptation
80–480 mg/day standardized extract (25% anthocyanosides = 20–120 mg anthocyanins
Moderate
Coffee Fruit Extract (CoffeeFruit Pure™)
BDNF elevation — the brain growth factor
100–200 mg/day whole coffee fruit concentrate; NeuroFactor™ clinical dose: 100 m
Moderate
Curcumin/Turmeric
Anti-Inflammatory Effects
General studies suggest a dose of 500–2,000 mg of turmeric powder daily, which t
Moderate
Ecklonia Cava (Brown Seaweed Polyphenol)
Superior antioxidant activity — unique marine polyphenols
400–800 mg/day Ecklonia cava extract standardized for phlorotannins; clinical st
Moderate
Ergothioneine (ErgoActive®)
Exceptional cellular antioxidant protection
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms t
Moderate
Glycine
Improved Sleep Quality
3–5 g/day for sleep quality; metabolic/detox: 5–10 g/day; collagen support: 3–5
Moderate
L-Glutamine
Gut Health Support
5–10 g/day for gut health and recovery; immune support: 20–30 g/day in clinical
Moderate
L-Methionine
SAMe synthesis and methylation support
500–3,000 mg/day; general supplementation: 500–1,000 mg/day; therapeutic: up to
Moderate
Lion's Mane Mushroom
Brain Health and Cognitive Support
500–3,000 mg/day dried mushroom powder; extract: 250–500 mg/day (standardized to
Moderate
Lycopene
Antioxidant Protection
8–21 mg/day from food or supplements; cardiovascular/prostate: 15–45 mg/day; tom
Moderate
MSM (Methylsulfonylmethane)
Joint Health and Arthritis Relief
1,000–3,000 mg/day elemental sulfur form; joint/anti-inflammatory: 1,500–3,000 m
Moderate
Milk Thistle
Liver Health Support
The efficacy of these mechanisms depends on silymarin content (standardized extr
Moderate
Moringa
Antioxidant and anti-inflammatory
2–7 g/day leaf powder; clinical studies typically use 6–8 g/day
Moderate
SAMe (S-Adenosyl-L-Methionine)
Mood and Depression Support
400–800 mg/day for depression; 600–1,200 mg/day for osteoarthritis; taken on emp
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Moderate
Shilajit / Fulvic Acid (PrimaVie®)
Testosterone and male reproductive health
250–500 mg/day purified shilajit or PrimaVie®; testosterone studies use 250 mg t
Moderate
Taurine
Heart Health
500–3,000 mg/day; energy drinks typically contain 1,000 mg; athletic performance
Moderate
Terminalia Chebula (Rejuna®)
Exceptional antioxidant capacity and cellular protection
500–1,000 mg/day standardized extract; Rejuna® clinical dose: 500 mg/day; tradit
Moderate
Yüth® (Longevity Polyphenol Blend)
Cellular senescence clearance (senolytics)
Per Yüth® product specifications; individual component doses vary: fisetin 100–5
Moderate
effera® (Human-Identical Lactoferrin)
Superior immune activation vs. bovine lactoferrin
Per effera® product specifications; Helaina clinical dosing; typical lactoferrin
Limited
Astrion® (NuLiv Science Beauty-From-Within)
Skin hydration and moisture retention
Per Astrion® product specifications; NuLiv Science beauty-from-within dosing dat
Limited
Chlorella
Heavy metal and toxin binding
3–10 g/day dried powder (tablets or powder); cracked cell wall preparation essen
Limited
CompleteGreens™ (Comprehensive Greens Base)
Complete phytonutrient and micronutrient coverage
3–8g/day comprehensive greens blend; specific CompleteGreens™ dosing per NNB pro
Limited
Fucoxanthin
White adipose tissue thermogenesis (UCP1 induction)
2.4–8 mg/day fucoxanthin; human trials use 2.4–8 mg/day combined with pomegranat
Limited
MitoGreens® (Mitochondrial Greens Complex)
Mitochondrial energy production support
Per product label serving size; typical greens blend 3–8g/day; specific MitoGree
Limited
ZinjaBurn® (Dehydrozingerone)
Thermogenic fat oxidation
100–300 mg/day dehydrozingerone; NNB ZinjaBurn® formulation dose per product lab