Home Ingredients BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)
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BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

BioPQQ® is a fermentation-produced pyrroloquinoline quinone (PQQ) from Mitsubishi Gas Chemical, a vitamin-like redox compound studied for brain and mitochondrial support. PQQ is unusual in that it appears to promote the growth of new mitochondria, the cell's energy producers, and human studies have looked at its effects on memory, attention, and fatigue.

Studied Dose About 20 mg per day.
Active Compound Pyrroloquinoline quinone disodium salt (PQQ), a redox cofactor that supports mitochondrial function and acts as an antioxidant.

Benefits

Memory and cognition

PQQ supplementation has been studied for supporting memory and attention, particularly in older adults and people with age-related cognitive complaints.

Supported by Trial 1

Mitochondrial and energy support

PQQ is studied for promoting mitochondrial biogenesis and reducing fatigue, reflecting its role in cellular energy production.

Supported by Trial 1

Antioxidant protection

As a stable redox compound, PQQ cycles through many oxidation-reduction reactions, helping protect cells from oxidative stress.

Supported by Trial 1

Mechanism of action

1

Mitochondrial biogenesis

PQQ activates signaling pathways (such as PGC-1-alpha) that stimulate the creation of new mitochondria, supporting cellular energy capacity.

2

Redox cycling

PQQ can undergo thousands of oxidation-reduction cycles, giving it durable antioxidant activity that protects neurons and other cells.

Clinical trials

1
PQQ and Cognitive/Biological Function — Study
PubMed

Study of pyrroloquinoline quinone and a related imidazole compound on biological and cognitive function. (Yamada et al. 2020, Heliyon)

Adults.

PQQ supplementation was associated with supportive effects on cognitive and biological measures, consistent with its mitochondrial and antioxidant roles.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — side effects are uncommon at studied doses.
Mild headache or sleep changes are occasionally reported.
Take earlier in the day if it feels stimulating.

Important Drug interactions

No significant drug interactions are established.
Use caution combining with other stimulatory nootropics.
Tell your doctor if pregnant, breastfeeding, or managing a condition.

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Frequently asked questions about BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)

What is BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)?

BioPQQ® is a fermentation-produced pyrroloquinoline quinone (PQQ) from Mitsubishi Gas Chemical, a vitamin-like redox compound studied for brain and mitochondrial support.

What is the recommended dosage of BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)?

The clinically studied dose for BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) is About 20 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) used for?

BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) is studied for memory and cognition, mitochondrial and energy support, antioxidant protection. PQQ supplementation has been studied for supporting memory and attention, particularly in older adults and people with age-related cognitive complaints.

Are there side effects from taking BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — side effects are uncommon at studied doses. Mild headache or sleep changes are occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) safe to take?

Whether BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — side effects are uncommon at studied doses. It may also interact with certain medications. BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Yamada Y, Nishii K, Kuwata K, et al. Effects of pyrroloquinoline quinone and imidazole pyrroloquinoline on biological activities and neural functions. Heliyon. 2020;6(1):e03240..PubMedUsed to support: Study supporting PQQ cognitive and biological effects.