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Energy

Best energy
supplements.

Support ATP production, mitochondrial function, and cellular bioenergetics — from NAD+ precursors and adaptogenic herbs to direct mitochondrial cofactors.

80
Ingredients
216
Clinical trials
3
Trending now
🏆 Evidence Ranked
Top Energy Supplements
Ranked by evidence level, then number of clinical trials.
#1 Pick
Energy
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or methylcobalamin, essential for r…
Very Strong
10 trials
#2 Pick
Energy
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like caffeine anhydrous (typically 1…
Very Strong
8 trials
#3 Pick
Energy
Glucose / Dextrose
Glucose (also called dextrose in its pure crystalline form) is the body's primary fuel sugar and a foundational component of evidence-based…
Very Strong
3 trials
#4 Pick
Energy
Iron
Iron is an essential trace mineral and a central component of hemoglobin, enabling red blood cells to carry oxygen throughout the body. It i…
Very Strong
2 trials
#5 Pick
Energy
Riboflavin
Riboflavin, or vitamin B2, is a water-soluble vitamin essential for energy production and maintaining healthy skin, eyes, and nervous system…
Strong
8 trials
📈 Trending Now
Fastest Growing Energy Ingredients
Ingredients seeing rapid growth in research interest and formulator adoption in 2024–2025.
Trending
Energy
Carnipure® (L-Carnitine — Lonza)
Carnipure® is the branded L-carnitine from Lonza (Switzerland) — the most clinically researched L-carnitine product with consistent manufact…
Strong
3 trials
Trending
Energy
LJ100® (Tongkat Ali — HP Ingredients)
LJ100® is the branded standardized tongkat ali extract from HP Ingredients (Florida, USA) — one of the two most clinically researched tongka…
Strong
3 trials
Trending
Energy
Mitopure® (Urolithin A — Amazentis)
Mitopure® is the branded urolithin A from Amazentis (Switzerland) — essentially the only commercial source of direct urolithin A with reliab…
Strong
3 trials
🔬 Emerging Research
Future Energy Ingredients to Watch
Lower evidence now but active research underway — these may become top picks within 2–3 years.
Watch
Energy
PrimaVie® (Shilajit Extract — Natreon)
PrimaVie® is the patented purified shilajit extract from Natreon Inc. — the most clinically-researched standardized shilajit product, with d…
Moderate
4 trials
Watch
Energy
Alpinia Galanga (enXtra®)
enXtra® (OmniActive Health Technologies) is a patented, caffeine-free standardized extract of Alpinia galanga — a ginger-family rhizome nati…
Moderate
3 trials
Watch
Energy
Ergothioneine (ErgoActive®)
Ergothioneine (EGT) is a naturally occurring amino acid and potent antioxidant synthesized exclusively by certain fungi, bacteria, and actin…
Moderate
3 trials
Watch
Energy
TeaCrine® (Theacrine)
TeaCrine® is Compound Solutions' patented theacrine — a purine alkaloid (1,3,7,9-tetramethyluric acid) structurally related to caffeine but…
Moderate
3 trials
All Ingredients
All 80 Energy Supplements
Complete list, sorted by evidence strength.
Energy
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or methylcobalamin, essential for r…
Very Strong
10 trials
Energy
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like caffeine anhydrous (typically 1…
Very Strong
8 trials
Energy
Glucose / Dextrose
Glucose (also called dextrose in its pure crystalline form) is the body's primary fuel sugar and a foundational component of evidence-based…
Very Strong
3 trials
Energy
Iron
Iron is an essential trace mineral and a central component of hemoglobin, enabling red blood cells to carry oxygen throughout the body. It i…
Very Strong
2 trials
Energy
Riboflavin
Riboflavin, or vitamin B2, is a water-soluble vitamin essential for energy production and maintaining healthy skin, eyes, and nervous system…
Strong
8 trials
Energy
CoEnzyme Q10
Coenzyme Q10 (CoQ10) is a lipid-soluble compound essential to mitochondrial ATP production via the electron transport chain. Found in two fo…
Strong
5 trials
Energy
Acetyl-L-Carnitine (ALCAR)
Acetyl-L-carnitine (ALCAR) is the acetylated form of L-carnitine — a naturally occurring amino acid derivative that, unlike standard L-carni…
Strong
4 trials
Energy
Nicotinamide Riboside
Nicotinamide Riboside (NR) is a vitamin B3 derivative that serves as a precursor to NAD+ (nicotinamide adenine dinucleotide), the central co…
Strong
4 trials
Energy
Pantothenic Acid
Pantothenic acid, or vitamin B5, is a water-soluble vitamin essential for synthesizing coenzyme A, which supports energy metabolism by break…
Strong
4 trials
Energy
Carnipure® (L-Carnitine — Lonza)
Carnipure® is the branded L-carnitine from Lonza (Switzerland) — the most clinically researched L-carnitine product with consistent manufact…
Strong
3 trials
Energy
LJ100® (Tongkat Ali — HP Ingredients)
LJ100® is the branded standardized tongkat ali extract from HP Ingredients (Florida, USA) — one of the two most clinically researched tongka…
Strong
3 trials
Energy
Mitopure® (Urolithin A — Amazentis)
Mitopure® is the branded urolithin A from Amazentis (Switzerland) — essentially the only commercial source of direct urolithin A with reliab…
Strong
3 trials
Energy
Niagen® (Nicotinamide Riboside — ChromaDex)
Niagen® is the branded nicotinamide riboside (NR) from ChromaDex — essentially the only commercially viable NR product with reliable manufac…
Strong
3 trials
Energy
Methylcobalamin (Active B12)
Methylcobalamin is the bioactive coenzyme form of vitamin B12 — directly usable by methionine synthase in the methionine/folate cycle. Disti…
Strong
2 trials
Energy
PEAK ATP® (Disodium Adenosine Triphosphate)
PEAK ATP® (TSI Group) is a patented, clinically validated form of adenosine 5'-triphosphate disodium — the only nutritional ingredient struc…
Strong
2 trials
Energy
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and Asia, used for centuries in Russian and Scandinavian…
Strong
2 trials
Energy
TestFACTOR® (Testosterone + Sexual Wellness)
TestFACTOR® (PLT Health Solutions) is a multi-patented testosterone and sexual wellness ingredient — the same Sphaeranthus indicus and Mangi…
Strong
2 trials
Energy
Ubiqsome® (Coenzyme Q10 Phytosome — Indena)
Ubiqsome® is a COENZYME Q10 PHYTOSOME® formulation developed by Indena (Italy) — applying Phytosome® technology to CoQ10 (ubiquinone) to add…
Strong
2 trials
Energy
Ubiquinol (Reduced CoQ10)
Ubiquinol is the REDUCED, electron-rich form of CoQ10 — distinct from ubiquinone (oxidized form, most common supplement). Body interconverts…
Strong
2 trials
Energy
Urolithin A
Urolithin A is a postbiotic compound — a metabolite produced when gut bacteria convert ellagitannins (found in pomegranates, walnuts, raspbe…
Strong
2 trials
Energy
Zynamite® S (Non-Stim Mental Energy — Water Soluble)
Zynamite® S (PLT Health Solutions / Nektium Pharma) is the water-soluble beverage-compatible form of Zynamite® — mango leaf extract (Mangife…
Strong
2 trials
Energy
enXtra® (Standardized Alpinia galanga Extract — OmniActive)
enXtra® is OmniActive's branded extract of DNA-authenticated Alpinia galanga (Thai ginger, related to the ginger and turmeric family), posit…
Strong
2 trials
Energy
Cereboost™ (American Ginseng for Cognition — Givaudan)
Cereboost™ is an AMERICAN GINSENG (Panax quinquefolius) EXTRACT from Givaudan — distinguished from Asian ginseng by ginsenoside profile and…
Strong
1 trial
Energy
PeakO2® (Adaptogenic Mushroom Blend)
PeakO2® (Compound Solutions) is a patented, USDA Certified Organic blend of six adaptogenic mushrooms grown on organic oats in the USA — hea…
Strong
1 trial
Energy
Ginseng
Ginseng, derived from the roots of plants like Panax ginseng, contains ginsenosides, active compounds known for their adaptogenic and energy…
Moderate
6 trials
Energy
PrimaVie® (Shilajit Extract — Natreon)
PrimaVie® is the patented purified shilajit extract from Natreon Inc. — the most clinically-researched standardized shilajit product, with d…
Moderate
4 trials
Energy
Shilajit
Shilajit is a mineral-rich resinous exudate formed over millennia from the decomposition of plant matter compressed between Himalayan, Altai…
Moderate
4 trials
Energy
Adenosine 5'-Triphosphate (ATP)
Adenosine 5'-Triphosphate (ATP) is the FUNDAMENTAL ENERGY-CARRYING MOLECULE in all living cells — composed of adenine, ribose, and three pho…
Moderate
3 trials
Energy
Alpinia Galanga (enXtra®)
enXtra® (OmniActive Health Technologies) is a patented, caffeine-free standardized extract of Alpinia galanga — a ginger-family rhizome nati…
Moderate
3 trials
Energy
Black Ginger (Kaempferia parviflora / Krachaidum / Thai Ginseng)
Kaempferia parviflora (also called Black Ginger, Krachaidum, or Thai Ginseng) is a traditional Thai medicinal plant with growing clinical ev…
Moderate
3 trials
Energy
Capsinoids (Non-Pungent Capsaicin Analogs)
Non-pungent capsaicin analogs from CH-19 Sweet pepper variety — capsiate, dihydrocapsiate, nordihydrocapsiate. Provide thermogenic and metab…
Moderate
3 trials
Energy
Codonopsis pilosula (Dang Shen / Poor Man's Ginseng)
Traditional Chinese 'Dang Shen' or 'poor man's ginseng' — Codonaceae family (formerly Campanulaceae). Used >2,000 years in TCM as a gentler…
Moderate
3 trials
Energy
Ergothioneine (ErgoActive®)
Ergothioneine (EGT) is a naturally occurring amino acid and potent antioxidant synthesized exclusively by certain fungi, bacteria, and actin…
Moderate
3 trials
Energy
TeaCrine® (Theacrine)
TeaCrine® is Compound Solutions' patented theacrine — a purine alkaloid (1,3,7,9-tetramethyluric acid) structurally related to caffeine but…
Moderate
3 trials
Energy
zümXR® (Targeted-Release Caffeine — PLT Health Solutions)
zümXR® is a targeted-release caffeine technology from PLT Health Solutions in three forms: Extended Release (ER), Delayed Release (DR), and…
Moderate
3 trials
Energy
B-Complex (Combined B Vitamins)
B-Complex supplements contain all eight essential B vitamins — B1 (thiamine), B2 (riboflavin), B3 (niacin/niacinamide), B5 (pantothenic acid…
Moderate
2 trials
Energy
Coffee Fruit Extract (CoffeeFruit Pure™)
Coffee fruit extract (CFE) is derived from the pulp of the coffee cherry — the red fruit surrounding the coffee bean that is normally discar…
Moderate
2 trials
Energy
Cordyceps
Cordyceps is a medicinal fungus traditionally used in Tibetan and Chinese medicine for energy, stamina, and longevity. Modern research focus…
Moderate
2 trials
Energy
D-Ribose (Bioenergy Ribose®)
D-ribose is a naturally occurring pentose sugar that serves as the structural backbone of ATP, ADP, AMP, RNA, coenzyme A, NADH, and FADH2 —…
Moderate
2 trials
Energy
Dynamine® (Methylliberine)
Dynamine® (Compound Solutions) is a patented methylliberine — a purine alkaloid found naturally in kucha tea leaves that is structurally rel…
Moderate
2 trials
Energy
Eleuthero / Siberian Ginseng (Eleutherococcus senticosus)
Eleuthero (also called Siberian ginseng — though botanically distinct from true Panax ginsengs) is an adaptogen used in Russian and East Asi…
Moderate
2 trials
Energy
FastBliss® (Paraxanthine)
FastBliss® (NNB Nutrition) is a purified paraxanthine (1,7-dimethylxanthine) supplement — the primary metabolite of caffeine that accounts f…
Moderate
2 trials
Energy
Guarana (Paullinia cupana)
Guarana is the seed of an Amazonian climbing plant — distinguished by EXTRAORDINARILY HIGH CAFFEINE CONTENT (4-9% by weight, 4× more than co…
Moderate
2 trials
Energy
MCT Oil (Medium-Chain Triglycerides)
Medium-chain triglycerides (MCTs) are saturated fatty acids with 6–12 carbon chains (caprylic C8, capric C10, lauric C12) derived primarily…
Moderate
2 trials
Energy
NMN (Nicotinamide Mononucleotide)
NMN is a direct precursor to NAD+, a coenzyme essential for cellular energy production, DNA repair, and sirtuin activation. NAD+ levels natu…
Moderate
2 trials
Energy
PQQ (Pyrroloquinoline Quinone)
Pyrroloquinoline quinone (PQQ) is a redox-active coenzyme and potent antioxidant naturally present in human breast milk, soil bacteria, and…
Moderate
2 trials
Energy
RiaGev® (NR + D-Ribose NAD+ Complex)
RiaGev® (Bioenergy Life Science) is a patented combination of nicotinamide riboside (NR) and D-ribose — two compounds that work synergistica…
Moderate
2 trials
Energy
Robuvit® (French Oak Wood Extract)
Robuvit® (Horphag Research) is a standardized extract from the heartwood of French oak (Quercus robur) trees grown in specific French forest…
Moderate
2 trials
Energy
SalidroPure™ (Pure Salidroside)
SalidroPure™ is NNB Nutrition's precision-fermented pure salidroside — the primary bioactive compound in Rhodiola responsible for its adapto…
Moderate
2 trials
Energy
Yerba Mate (Ilex paraguariensis)
Yerba mate is the dried leaves of a South American holly tree — traditionally consumed as a beverage in Argentina, Paraguay, Uruguay, and Br…
Moderate
2 trials
Energy
goBHB® (Beta-Hydroxybutyrate Ketone Salts)
goBHB® (NNB Nutrition / Compound Solutions) is a patented form of beta-hydroxybutyrate (BHB) ketone salts providing exogenous ketones as cal…
Moderate
2 trials
Energy
AB-Fortis® (Microencapsulated Iron — Frutarom)
AB-Fortis® is a MICROENCAPSULATED FORM OF IRON developed by Frutarom Health (now IFF) — designed to fortify foods with iron without changing…
Moderate
1 trial
Energy
Carb10® (Pea Starch Carbohydrate)
Carb10® (Compound Solutions) is a patented, non-GMO pea starch (Pisum sativum) carbohydrate ingredient uniquely characterized by a very low…
Moderate
1 trial
Energy
CardaMind® (Black Cardamom for Mental Energy — Akay Bioactives)
CardaMind® is a PROPRIETARY BLACK CARDAMOM FRUIT EXTRACT (Amomum subulatum) developed by Akay Bioactives — designed to support mental energy…
Moderate
1 trial
Energy
cellflo6® (Gallate-Enhanced Green Tea Oligomers)
cellflo6® (PLT Health Solutions) is a novel, patented, clinically studied gallate-enhanced oligomer extract from green tea (Camellia sinensi…
Moderate
1 trial
Energy
Coconut Oil
Coconut oil is a dietary supplement derived from the meat of mature coconuts, rich in medium-chain triglycerides (MCTs), particularly lauric…
Limited
4 trials
Energy
Oxaloacetate (Anhydrous Enol)
Oxaloacetate is a Krebs cycle intermediate available as a supplement (typically the anhydrous enol form, marketed as benaGene™). Clinical in…
Limited
4 trials
Energy
Pyruvate (Calcium Pyruvate / Sodium Pyruvate)
Endogenous metabolic intermediate at the junction of glycolysis and the citric acid cycle. Studied as a weight loss aid and ergogenic supple…
Limited
4 trials
Energy
Beef Heart (Desiccated)
Beef heart is a working muscle organ — nutritionally distinct from both standard muscle meat and other organs (liver, kidney). It's the rich…
Limited
3 trials
Energy
Beef Liver (Desiccated)
Beef liver is among the most nutrient-dense foods in human nutrition — sometimes called 'nature's multivitamin' for genuine reason. A 3-ounc…
Limited
3 trials
Energy
Beef Spleen (Desiccated)
Beef spleen is the most concentrated natural source of heme iron in the food supply — making it of particular interest for those addressing…
Limited
3 trials
Energy
Bemethyl (Bemitil / Metaprot)
Synthetic benzimidazole 'actoprotector' developed in the 1970s by Vladimir Vinogradov at the S.M. Kirov Military Medical Academy (Leningrad…
Limited
3 trials
Energy
Bromantane (Ladasten)
Atypical CNS stimulant + anxiolytic developed in USSR. Adamantane family (related to amantadine, memantine). Approved Russia for neurastheni…
Limited
3 trials
Energy
Catuaba (Trichilia catigua)
Bark extract of Trichilia catigua (Meliaceae family) — a Brazilian Amazon medicinal tree. Critical species note: 'catuaba' is a common name…
Limited
3 trials
Energy
Mildronate (Meldonium)
Cardioprotective synthetic drug developed in the 1970s by Ivars Kalvins at the Latvian Institute of Organic Synthesis. A competitive inhibit…
Limited
3 trials
Energy
Pfaffia paniculata / Hebanthe eriantha (Brazilian Ginseng / Suma)
Pfaffia paniculata (recently renamed Hebanthe eriantha or Hebanthe paniculata) is a Brazilian medicinal plant, often marketed as Brazilian G…
Limited
3 trials
Energy
Phenylpiracetam (Phenotropil / Carphedon)
Phenylated piracetam derivative developed in Russia (1983) by Russian Academy of Sciences for COSMONAUTS. Stimulant + cognitive effects; pre…
Limited
3 trials
Energy
Sulbutiamine (Arcalion)
Synthetic lipophilic dimer of thiamine (vitamin B1) developed in Japan in 1960s. Trade name Arcalion (used in France/Russia/Asia for astheni…
Limited
3 trials
Energy
Guayusa (AMATEA® Organic Guayusa)
Guayusa (Ilex guayusa) is a caffeinated holly tree native to the upper Amazon basin, traditionally consumed as a morning ritual tea by indig…
Limited
2 trials
Energy
Magnesium Malate
Magnesium malate combines magnesium with malic acid — a TCA cycle intermediate involved in cellular energy production. Marketed for fibromya…
Limited
2 trials
Energy
PureATP (Pure Adenosine 5'-Triphosphate Disodium)
PureATP is a NON-PROPRIETARY GENERIC FORM of adenosine 5'-triphosphate disodium used as a sports performance ingredient — distinguished from…
Limited
2 trials
Energy
Tesnor® (Cordyceps & Cistanche for Vitality)
Tesnor® is a PROPRIETARY BLEND developed by Saanroo (formerly Gencor Pacific) for male vitality and reproductive health — combining standard…
Limited
2 trials
Energy
Axivite® (Energy and Cognitive Performance Ingredient)
Axivite® (SEE Nutrition) is a specialty energy and cognitive performance ingredient featured on NXT Ingredients' platform. Positioned in the…
Limited
1 trial
Energy
Metabolyte® (BHB Energy + B-Vitamins)
Metabolyte® (Compound Solutions) is a patented combination of beta-hydroxybutyrate (BHB) ketone salts and B-vitamins specifically formulated…
Limited
1 trial
Energy
MitoGreens® (Mitochondrial Greens Complex)
MitoGreens® (NNB Nutrition) is a proprietary greens blend specifically formulated to support mitochondrial function and cellular energy prod…
Limited
1 trial
Energy
MitoReds™ (Mitochondrial Reds Complex)
MitoReds™ (NNB Nutrition) is a proprietary reds and berry blend formulated to support mitochondrial function, cardiovascular health, and nit…
Limited
1 trial
Energy
Testncrease® (Testosterone Support Blend)
Testncrease® (Cepham Inc.) is a standardized botanical testosterone support blend combining traditional herbal ingredients with clinical evi…
Limited
1 trial
Energy
goFAT® (Structured Lipid Blend)
goFAT® (Compound Solutions) is a proprietary structured lipid blend combining medium-chain triglycerides (MCTs) with other functional fat so…
Limited
1 trial
Energy
Glucuronolactone (D-Glucurono-γ-Lactone)
Naturally-occurring metabolite of glucose, found endogenously and in connective tissues. Famous as Red Bull energy drink ingredient. Human e…
Preliminary
3 trials
Energy
Hordenine
Phenethylamine alkaloid (N,N-dimethyltyramine) found in sprouted barley, bitter orange, and cacti. Marketed as fat burner and stimulant in p…
Preliminary
3 trials