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Cognitive

Best cognitive
supplements.

Ingredients proven to support memory, focus, mental clarity, and long-term brain health — from clinically-validated nootropics to neuroprotective antioxidants.

144
Ingredients
457
Clinical trials
3
Trending now
🏆 Evidence Ranked
Top Cognitive Supplements
Ranked by evidence level, then number of clinical trials.
#1 Pick
Cognitive
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyun…
Very Strong
11 trials
#2 Pick
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or methylcobalamin, essential for r…
Very Strong
10 trials
#3 Pick
Cognitive
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like caffeine anhydrous (typically 1…
Very Strong
8 trials
#4 Pick
Cognitive
Creatine Monohydrate
Creatine monohydrate is the most-researched and most-validated form of creatine, with 500+ studies confirming its effects on strength, power…
Very Strong
5 trials
#5 Pick
Cognitive
Pycnogenol® (French Maritime Pine Bark)
Pycnogenol® (Horphag Research) is a standardized extract from the bark of French maritime pine trees grown along the Landes coast of southwe…
Very Strong
5 trials
📈 Trending Now
Fastest Growing Cognitive Ingredients
Ingredients seeing rapid growth in research interest and formulator adoption in 2024–2025.
Trending
Cognitive
FloraGLO® Lutein (Kemin)
FloraGLO® Lutein (Kemin Industries) is the most clinically studied lutein extract — derived from marigold flowers (Tagetes erecta), standard…
Very Strong
4 trials
Trending
Cognitive
CurQfen® (Curcumin-Fenugreek FenuMat — Akay Bioactives)
CurQfen® is a PATENTED CURCUMIN COMPLEX from Curcuma longa rhizomes formulated with FENUMAT® (fenugreek soluble fiber) technology developed…
Very Strong
3 trials
Trending
Cognitive
Longvida® Optimized Curcumin (Verdure Sciences)
Longvida® is a PATENTED CURCUMIN EXTRACT developed by Verdure Sciences using SLCP™ (Solid Lipid Curcumin Particle) TECHNOLOGY designed by UC…
Very Strong
3 trials
🔬 Emerging Research
Future Cognitive Ingredients to Watch
Lower evidence now but active research underway — these may become top picks within 2–3 years.
Watch
Cognitive
PrimaVie® (Shilajit Extract — Natreon)
PrimaVie® is the patented purified shilajit extract from Natreon Inc. — the most clinically-researched standardized shilajit product, with d…
Moderate
4 trials
Watch
Cognitive
Alpinia Galanga (enXtra®)
enXtra® (OmniActive Health Technologies) is a patented, caffeine-free standardized extract of Alpinia galanga — a ginger-family rhizome nati…
Moderate
3 trials
Watch
Cognitive
Bifidobacterium longum 1714 (Zenflore™ / 1714-Serenitas™)
Bifidobacterium longum 1714 is a specific 'psychobiotic' strain commercialized as Zenflore™ and 1714-Serenitas™ by Precision Biotics. It's o…
Moderate
3 trials
Watch
Cognitive
CocoaVia® (Mars Edge Cocoa Flavanol Extract)
CocoaVia® is a branded cocoa flavanol extract from Mars Edge, standardized to high cocoa flavanol (CF) content per serving. It's one of the…
Moderate
3 trials
All Ingredients
All 144 Cognitive Supplements
Complete list, sorted by evidence strength.
Cognitive
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyun…
Very Strong
11 trials
Cognitive
Vitamin B12
Vitamin B12, also known as cobalamin, is a water-soluble vitamin commonly supplemented as cyanocobalamin or methylcobalamin, essential for r…
Very Strong
10 trials
Cognitive
Caffeine
Caffeine, a natural stimulant found in coffee, tea, and other plants, is commonly supplemented in forms like caffeine anhydrous (typically 1…
Very Strong
8 trials
Cognitive
Creatine Monohydrate
Creatine monohydrate is the most-researched and most-validated form of creatine, with 500+ studies confirming its effects on strength, power…
Very Strong
5 trials
Cognitive
Pycnogenol® (French Maritime Pine Bark)
Pycnogenol® (Horphag Research) is a standardized extract from the bark of French maritime pine trees grown along the Landes coast of southwe…
Very Strong
5 trials
Cognitive
Fish Oil (EPA + DHA)
Oil from oily fish (anchovy, sardine, mackerel, herring, salmon) — the most studied source of marine long-chain omega-3 fatty acids EPA and…
Very Strong
4 trials
Cognitive
FloraGLO® Lutein (Kemin)
FloraGLO® Lutein (Kemin Industries) is the most clinically studied lutein extract — derived from marigold flowers (Tagetes erecta), standard…
Very Strong
4 trials
Cognitive
Zinc
Zinc, an essential trace mineral, is commonly supplemented in forms like zinc gluconate, acetate, or citrate, playing a critical role in imm…
Very Strong
4 trials
Cognitive
CurQfen® (Curcumin-Fenugreek FenuMat — Akay Bioactives)
CurQfen® is a PATENTED CURCUMIN COMPLEX from Curcuma longa rhizomes formulated with FENUMAT® (fenugreek soluble fiber) technology developed…
Very Strong
3 trials
Cognitive
Longvida® Optimized Curcumin (Verdure Sciences)
Longvida® is a PATENTED CURCUMIN EXTRACT developed by Verdure Sciences using SLCP™ (Solid Lipid Curcumin Particle) TECHNOLOGY designed by UC…
Very Strong
3 trials
Cognitive
Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)
Lutemax® 2020 is a PATENTED LUTEIN INGREDIENT from MARIGOLD FLOWERS (Tagetes erecta) developed by OmniActive — distinguished by inclusion of…
Very Strong
3 trials
Cognitive
Alpha-GPC
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a natural compound and dietary supplement that serves as a precursor to acetylcholine, supp…
Strong
9 trials
Cognitive
L-Theanine
L-Theanine, an amino acid primarily found in green tea (Camellia sinensis), is commonly supplemented in doses of 100–400 mg/day to promote r…
Strong
8 trials
Cognitive
Riboflavin
Riboflavin, or vitamin B2, is a water-soluble vitamin essential for energy production and maintaining healthy skin, eyes, and nervous system…
Strong
8 trials
Cognitive
Ashwagandha
Ashwagandha is an adaptogenic herb that may reduce stress, enhance mood, and support overall vitality by modulating the body's response to p…
Strong
7 trials
Cognitive
KSM-66®
KSM-66 Ashwagandha, a standardized root extract, promotes stress relief and cognitive clarity by balancing cortisol levels and enhancing neu…
Strong
7 trials
Cognitive
Green Tea
Green tea extract, derived from Camellia sinensis leaves, is rich in antioxidants like catechins, particularly epigallocatechin gallate (EGC…
Strong
6 trials
Cognitive
Saffron Extract (Crocus sativus)
Saffron is the dried stigmas of Crocus sativus — the most expensive spice in the world by weight (~150 flowers per gram). Used in Persian, M…
Strong
6 trials
Cognitive
Citicoline
Citicoline (CDP-choline) is a naturally-occurring intermediate in phosphatidylcholine biosynthesis, marketed primarily as the branded form C…
Strong
5 trials
Cognitive
Phosphatidylserine
Phosphatidylserine (PS) is a phospholipid concentrated in neuronal cell membranes (10-20% of brain phospholipid). FDA approved a Qualified H…
Strong
5 trials
Cognitive
Pomegranate Extract
Pomegranate Extract is concentrated from Punica granatum fruit (juice and peel) and rich in punicalagin — a unique large polyphenol found al…
Strong
5 trials
Cognitive
Vitamin B6 (Pyridoxine)
Vitamin B6 (pyridoxine) is a water-soluble vitamin essential for amino acid metabolism, neurotransmitter synthesis, and red blood cell forma…
Strong
5 trials
Cognitive
Acetyl-L-Carnitine (ALCAR)
Acetyl-L-carnitine (ALCAR) is the acetylated form of L-carnitine — a naturally occurring amino acid derivative that, unlike standard L-carni…
Strong
4 trials
Cognitive
Algal Oil DHA (Vegan Omega-3)
Omega-3 oil produced by fermentation of marine microalgae (most commonly Schizochytrium sp., a thraustochytrid; sometimes Crypthecodinium co…
Strong
4 trials
Cognitive
Hericium erinaceus (Mycelium vs Fruiting Body — Strain Specifics)
A strain-specific Lion's Mane mushroom entry focused on the chemistry distinction that determines whether a product actually works: erinacin…
Strong
4 trials
Cognitive
Nicotinamide Riboside
Nicotinamide Riboside (NR) is a vitamin B3 derivative that serves as a precursor to NAD+ (nicotinamide adenine dinucleotide), the central co…
Strong
4 trials
Cognitive
Pine Bark Extract
Pine Bark Extract is concentrated from the bark of various pine species — most commonly French maritime pine (Pinus pinaster, the source of…
Strong
4 trials
Cognitive
Levagen+® (PEA — Palmitoylethanolamide — Gencor)
Levagen+® is the branded bioavailable palmitoylethanolamide (PEA) from Gencor (Austin, TX) — addressing the major issue with standard PEA: p…
Strong
3 trials
Cognitive
Neumentix® (Spearmint Extract — Kemin)
Neumentix® is the branded standardized spearmint extract from Kemin Industries (Iowa, USA) — specifically developed and clinically validated…
Strong
3 trials
Cognitive
Niagen® (Nicotinamide Riboside — ChromaDex)
Niagen® is the branded nicotinamide riboside (NR) from ChromaDex — essentially the only commercially viable NR product with reliable manufac…
Strong
3 trials
Cognitive
Quatrefolic® (L-5-MTHF Methylfolate — Gnosis)
Quatrefolic® is the branded crystal salt form of L-5-methyltetrahydrofolate (methylfolate) from Gnosis SpA (Italy/Lonza) — the most-studied…
Strong
3 trials
Cognitive
BaCognize® (Standardized Bacopa monnieri — Verdure Sciences)
BaCognize® is a branded standardized hydroalcoholic extract of Bacopa monnieri (whole herb) from Verdure Sciences. Standardized to bacosides…
Strong
2 trials
Cognitive
Bacopa Monnieri
Bacopa monnieri (Brahmi) is a cornerstone herb in Ayurvedic medicine with over 3,000 years of use for cognitive enhancement and memory. Its…
Strong
2 trials
Cognitive
Bacopin® (Bacopa monnieri Extract — Sabinsa)
Bacopin® is Sabinsa's branded Bacopa monnieri extract — standardized to ≥20% bacosides by gravimetry. Bacopa monnieri (Brahmi) has been used…
Strong
2 trials
Cognitive
Choline
Choline is an essential nutrient and precursor to acetylcholine (the primary learning and memory neurotransmitter) and phosphatidylcholine (…
Strong
2 trials
Cognitive
GeniusPure® (High-Purity Alpha-GPC)
GeniusPure® (NNB Nutrition) is a patent-pending stabilized alpha-GPC (alpha-glycerylphosphorylcholine) at 70% or 90% concentration — solving…
Strong
2 trials
Cognitive
Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)
Ginkgoselect® Phytosome is a GINKGO BILOBA EXTRACT PHYTOSOME® developed by Indena (Italy) — using Phytosome® technology applied to standardi…
Strong
2 trials
Cognitive
Magtein® (Magnesium L-Threonate)
Magtein® (ThreoTech / AIDP) is a patented form of magnesium L-threonate — the only magnesium compound clinically demonstrated to cross the b…
Strong
2 trials
Cognitive
Methylcobalamin (Active B12)
Methylcobalamin is the bioactive coenzyme form of vitamin B12 — directly usable by methionine synthase in the methionine/folate cycle. Disti…
Strong
2 trials
Cognitive
Neuravena® (Wild Green Oat Extract — Frutarom)
Neuravena® (EFLA® 955) is a PROPRIETARY WILD GREEN OAT EXTRACT (Avena sativa) developed by Frutarom Health (now IFF) — distinguished from ge…
Strong
2 trials
Cognitive
Nitrosigine® (Arginine Silicate)
Nitrosigine® (Nutrition 21) is a patented, inositol-stabilized arginine silicate complex specifically engineered to overcome the poor bioava…
Strong
2 trials
Cognitive
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and Asia, used for centuries in Russian and Scandinavian…
Strong
2 trials
Cognitive
Sensoril® (Ashwagandha Extract — Verdure/Natreon)
Sensoril® is a STANDARDIZED ASHWAGANDHA EXTRACT (Withania somnifera) originally developed by Natreon (now part of Verdure Sciences) — distin…
Strong
2 trials
Cognitive
Soy Isoflavones (Glycine max)
Soy isoflavones — primarily genistein, daidzein, and glycitein — are phytoestrogens found in soybeans that bind estrogen receptors with sele…
Strong
2 trials
Cognitive
Suntheanine®
Suntheanine® is a patented, 100% pure L-isomer theanine produced via an enzymatic process that mimics biosynthesis in green tea leaves — yie…
Strong
2 trials
Cognitive
Zenroot® (Low-Dose Bioavailable Ashwagandha Root Extract — OmniActive)
Zenroot® is OmniActive's root-only ashwagandha (Withania somnifera) extract — standardized to 1.5% withanolides using USP methodology, with…
Strong
2 trials
Cognitive
Zynamite® S (Non-Stim Mental Energy — Water Soluble)
Zynamite® S (PLT Health Solutions / Nektium Pharma) is the water-soluble beverage-compatible form of Zynamite® — mango leaf extract (Mangife…
Strong
2 trials
Cognitive
enXtra® (Standardized Alpinia galanga Extract — OmniActive)
enXtra® is OmniActive's branded extract of DNA-authenticated Alpinia galanga (Thai ginger, related to the ginger and turmeric family), posit…
Strong
2 trials
Cognitive
Cereboost™ (American Ginseng for Cognition — Givaudan)
Cereboost™ is an AMERICAN GINSENG (Panax quinquefolius) EXTRACT from Givaudan — distinguished from Asian ginseng by ginsenoside profile and…
Strong
1 trial
Cognitive
goCOCOA® (Cocoa Flavanol Extract)
goCOCOA® (Compound Solutions) is a standardized cocoa (Theobroma cacao) flavanol extract providing a concentrated, consistent dose of cocoa…
Strong
1 trial
Cognitive
nooLVL® (Inositol-Enhanced Arginine for Gaming & Cognition)
nooLVL® (Nutrition21) is a patented, non-stimulant cognitive performance ingredient specifically designed and clinically tested on gamers —…
Strong
1 trial
Cognitive
Ginseng
Ginseng, derived from the roots of plants like Panax ginseng, contains ginsenosides, active compounds known for their adaptogenic and energy…
Moderate
6 trials
Cognitive
Lion's Mane Mushroom
Lion’s Mane (Hericium erinaceus) is a medicinal and edible mushroom with long, white, cascading spines resembling a lion’s mane. Native to N…
Moderate
6 trials
Cognitive
Astaxanthin
Astaxanthin is a powerful red-orange antioxidant carotenoid best known for its anti-inflammatory and skin-protective properties. It is natur…
Moderate
5 trials
Cognitive
Ginkgo Biloba
Ginkgo biloba is a popular herbal supplement derived from the leaves of the Ginkgo tree, one of the oldest living tree species. It is common…
Moderate
5 trials
Cognitive
PhosphatidylCholine
Phosphatidylcholine (PC) is the most abundant phospholipid in cell membranes and the major form of dietary choline. It serves as the structu…
Moderate
5 trials
Cognitive
Alpha-Lactalbumin
Whey protein fraction with the HIGHEST tryptophan-to-LNAA ratio of any protein source. RCT showed evening intake increased plasma tryptophan…
Moderate
4 trials
Cognitive
PrimaVie® (Shilajit Extract — Natreon)
PrimaVie® is the patented purified shilajit extract from Natreon Inc. — the most clinically-researched standardized shilajit product, with d…
Moderate
4 trials
Cognitive
SAMe (S-Adenosyl-L-Methionine)
S-Adenosyl-L-Methionine (SAMe) is a naturally occurring compound in the body, synthesized from methionine and adenosine triphosphate (ATP)…
Moderate
4 trials
Cognitive
Shilajit
Shilajit is a mineral-rich resinous exudate formed over millennia from the decomposition of plant matter compressed between Himalayan, Altai…
Moderate
4 trials
Cognitive
Alpinia Galanga (enXtra®)
enXtra® (OmniActive Health Technologies) is a patented, caffeine-free standardized extract of Alpinia galanga — a ginger-family rhizome nati…
Moderate
3 trials
Cognitive
Benfotiamine
Lipid-soluble synthetic prodrug of thiamine (vitamin B1) — about 5x more bioavailable than thiamine HCl. Initially developed in Japan in 195…
Moderate
3 trials
Cognitive
Bifidobacterium longum 1714 (Zenflore™ / 1714-Serenitas™)
Bifidobacterium longum 1714 is a specific 'psychobiotic' strain commercialized as Zenflore™ and 1714-Serenitas™ by Precision Biotics. It's o…
Moderate
3 trials
Cognitive
Cerebrolysin (FPF-1070)
Standardized peptide preparation derived from purified porcine brain proteins. Manufactured by EVER Neuro Pharma (Austria). Approved in 50+…
Moderate
3 trials
Cognitive
CocoaVia® (Mars Edge Cocoa Flavanol Extract)
CocoaVia® is a branded cocoa flavanol extract from Mars Edge, standardized to high cocoa flavanol (CF) content per serving. It's one of the…
Moderate
3 trials
Cognitive
Codonopsis lanceolata (Deodeok / Korean Bonnet Bellflower)
Korean Deodeok (더덕) / Sasam (沙蔘, 'sand ginseng') — a Campanulaceae perennial herb. Distinct from Codonopsis pilosula (Chinese Dang Shen) — s…
Moderate
3 trials
Cognitive
Ergothioneine (ErgoActive®)
Ergothioneine (EGT) is a naturally occurring amino acid and potent antioxidant synthesized exclusively by certain fungi, bacteria, and actin…
Moderate
3 trials
Cognitive
Idebenone
Synthetic short-chain CoQ10 analogue with enhanced bioavailability. APPROVED in Europe as Raxone® (Santhera) for Leber's Hereditary Optic Ne…
Moderate
3 trials
Cognitive
Lactobacillus helveticus R0052 + Bifidobacterium longum R0175 (Probio'Stick® / Cerebiome®)
A branded two-strain probiotic combination from Lallemand Health Solutions, marketed as Probio'Stick® and Cerebiome®. The strain pair is L…
Moderate
3 trials
Cognitive
Multivitamin / Multimineral
Combination supplement providing multiple essential vitamins and minerals at or near RDA levels. Three large RCTs (PHS II, COSMOS, COSMOS-Mi…
Moderate
3 trials
Cognitive
Polygala (Yuan Zhi)
Chinese herb root used in TCM for 2,000+ years for sedation, memory enhancement, and amnesia — called 'yuan zhi' meaning 'far-reaching aspir…
Moderate
3 trials
Cognitive
Rosmarinic Acid
Caffeic acid ester polyphenol abundant in Lamiaceae herbs (rosemary, lemon balm, sage, perilla, basil, oregano). Multiple human RCTs show be…
Moderate
3 trials
Cognitive
Sage Extract / Cognivia® (Salvia officinalis)
Sage (Salvia officinalis) has a centuries-long reputation as a memory herb — its Latin name derives from 'salvare' (to save/heal) and it app…
Moderate
3 trials
Cognitive
Spearmint Extract
Spearmint (Mentha spicata) is a traditional culinary and medicinal herb with concentrated extracts providing rosmarinic acid, polyphenols, a…
Moderate
3 trials
Cognitive
TeaCrine® (Theacrine)
TeaCrine® is Compound Solutions' patented theacrine — a purine alkaloid (1,3,7,9-tetramethyluric acid) structurally related to caffeine but…
Moderate
3 trials
Cognitive
Theracurmin® (Colloidal Nanoparticle Curcumin — Theravalues)
Theracurmin® is a colloidal nanoparticle curcumin from Theravalues (Japan) — one of the better-evidenced enhanced-absorption curcumin formul…
Moderate
3 trials
Cognitive
Veri-te™ Resveratrol (Evolva)
Branded yeast-fermented pharmaceutical-grade trans-resveratrol from Evolva (Switzerland). Distinguishing feature: produced via fermentation…
Moderate
3 trials
Cognitive
Yüth® (Spermidine)
Yüth® (Compound Solutions) is a patent-pending high-purity spermidine ingredient designed to support healthy aging through cellular renewal…
Moderate
3 trials
Cognitive
zümXR® (Targeted-Release Caffeine — PLT Health Solutions)
zümXR® is a targeted-release caffeine technology from PLT Health Solutions in three forms: Extended Release (ER), Delayed Release (DR), and…
Moderate
3 trials
Cognitive
B-Complex (Combined B Vitamins)
B-Complex supplements contain all eight essential B vitamins — B1 (thiamine), B2 (riboflavin), B3 (niacin/niacinamide), B5 (pantothenic acid…
Moderate
2 trials
Cognitive
Coffee Fruit Extract (CoffeeFruit Pure™)
Coffee fruit extract (CFE) is derived from the pulp of the coffee cherry — the red fruit surrounding the coffee bean that is normally discar…
Moderate
2 trials
Cognitive
Cognivia™ (Garden + Spanish Sage Cognitive)
Cognivia™ is a sage-based cognitive ingredient from Nexira (France) combining garden sage (Salvia officinalis) leaf extract with encapsulate…
Moderate
2 trials
Cognitive
DailyZz™ (Spearmint + Green Tea Sleep Nootropic)
DailyZz™ is a NATURAL SLEEP NOOTROPIC developed by Kemin Industries — proprietary botanical blend of SPEARMINT (Mentha spicata) and GREEN TE…
Moderate
2 trials
Cognitive
Dynamine® (Methylliberine)
Dynamine® (Compound Solutions) is a patented methylliberine — a purine alkaloid found naturally in kucha tea leaves that is structurally rel…
Moderate
2 trials
Cognitive
FastBliss® (Paraxanthine)
FastBliss® (NNB Nutrition) is a purified paraxanthine (1,7-dimethylxanthine) supplement — the primary metabolite of caffeine that accounts f…
Moderate
2 trials
Cognitive
Gotu Kola (Centella asiatica)
Gotu kola is a small herbaceous plant native to Asia and Africa — used in Ayurvedic, Traditional Chinese Medicine, and Indonesian healing sy…
Moderate
2 trials
Cognitive
Holy Basil (Tulsi)
Holy basil (Tulsi) is a sacred plant in Ayurvedic medicine and one of the most revered adaptogens in Indian traditional healing. Its eugenol…
Moderate
2 trials
Cognitive
Huperzine A
Huperzine A is a sesquiterpene alkaloid isolated from CHINESE CLUB MOSS (Huperzia serrata) — used in Traditional Chinese Medicine for centur…
Moderate
2 trials
Cognitive
L-Tyrosine
L-Tyrosine is a conditionally essential amino acid and the direct precursor to the catecholamine neurotransmitters dopamine, norepinephrine…
Moderate
2 trials
Cognitive
Lemon Balm (Melissa officinalis)
Lemon balm is a member of the mint family with a distinctive lemony aroma — used in European herbal medicine for over 2,000 years for anxiet…
Moderate
2 trials
Cognitive
Lysoveta® (LPC-Bound EPA/DHA from Krill — Aker BioMarine)
Lysoveta® is Aker BioMarine's novel omega-3 ingredient — krill-derived EPA and DHA bound to lysophosphatidylcholine (LPC). The mechanistic r…
Moderate
2 trials
Cognitive
MCT Oil (Medium-Chain Triglycerides)
Medium-chain triglycerides (MCTs) are saturated fatty acids with 6–12 carbon chains (caprylic C8, capric C10, lauric C12) derived primarily…
Moderate
2 trials
Cognitive
Mucuna Pruriens (Velvet Bean / Kapikacchu)
Mucuna pruriens (also called velvet bean, cowitch, kapikacchu) is a tropical legume distinguished by HIGH NATURAL L-DOPA (levodopa) CONTENT…
Moderate
2 trials
Cognitive
PQQ (Pyrroloquinoline Quinone)
Pyrroloquinoline quinone (PQQ) is a redox-active coenzyme and potent antioxidant naturally present in human breast milk, soil bacteria, and…
Moderate
2 trials
Cognitive
Puremidine™ (Spermidine)
Puremidine™ (NNB Nutrition) is a highly purified spermidine supplement derived from wheat germ. Spermidine is a naturally occurring polyamin…
Moderate
2 trials
Cognitive
Schisandra Chinensis (Five-Flavor Berry)
Schisandra is the dried fruit of a vine native to Northeast Asia — called 'wu wei zi' (five-flavor berry) in Chinese medicine because it pos…
Moderate
2 trials
Cognitive
Tocotrienols (Vitamin E Family)
Tocotrienols are the LESS COMMON 4 of 8 vitamin E family members — distinct from the 4 tocopherols. Found primarily in palm oil, annatto, ri…
Moderate
2 trials
Cognitive
Vinpocetine
Vinpocetine is a SEMI-SYNTHETIC DERIVATIVE of vincamine — an alkaloid from periwinkle (Vinca minor). Developed in Hungary in the 1970s as PR…
Moderate
2 trials
Cognitive
Zembrin® (Sceletium tortuosum)
Zembrin® (PLT Health Solutions) is a patented, standardized extract of Sceletium tortuosum — a South African succulent plant used by the San…
Moderate
2 trials
Cognitive
goBHB® (Beta-Hydroxybutyrate Ketone Salts)
goBHB® (NNB Nutrition / Compound Solutions) is a patented form of beta-hydroxybutyrate (BHB) ketone salts providing exogenous ketones as cal…
Moderate
2 trials
Cognitive
CardaMind® (Black Cardamom for Mental Energy — Akay Bioactives)
CardaMind® is a PROPRIETARY BLACK CARDAMOM FRUIT EXTRACT (Amomum subulatum) developed by Akay Bioactives — designed to support mental energy…
Moderate
1 trial
Cognitive
Ecklonia Cava (Brown Seaweed Polyphenol)
Ecklonia cava is a species of brown kelp seaweed native to the Pacific Ocean coasts of Japan and Korea that contains a unique class of polyp…
Moderate
1 trial
Cognitive
Nutricog® (Cognitive Performance + Sleep)
Nutricog® (PLT Health Solutions) is a cognitive performance ingredient supporting advanced cognition, mental performance, and sleep quality…
Moderate
1 trial
Cognitive
Zensera™ (Stress-Cognitive Ingredient by Givaudan)
Zensera™ (Givaudan Active Beauty) is a novel botanical-derived ingredient clinically demonstrated to provide same-day cognitive and emotiona…
Moderate
1 trial
Cognitive
Enzogenol® (Pinus radiata Bark Extract)
Enzogenol® is a branded New Zealand pine bark extract (Pinus radiata) made by ENZO Nutraceuticals via water-only extraction (no chemical sol…
Limited
5 trials
Cognitive
Anserine (β-alanyl-3-methyl-L-histidine)
Anserine is an imidazole dipeptide closely related to carnosine, found mainly in chicken, turkey, and fish. Investigated as an anserine/carn…
Limited
4 trials
Cognitive
Lecithin (Phosphatidylcholine Complex)
Lecithin is a phospholipid mixture (predominantly phosphatidylcholine) sourced from soy, sunflower, or eggs. Used for cholesterol management…
Limited
4 trials
Cognitive
Oxaloacetate (Anhydrous Enol)
Oxaloacetate is a Krebs cycle intermediate available as a supplement (typically the anhydrous enol form, marketed as benaGene™). Clinical in…
Limited
4 trials
Cognitive
Aniracetam (Ro 13-5057)
Fat-soluble racetam developed by Roche (1970s), marketed in some European/Asian countries for cognitive impairment. Senin 1991 multicenter R…
Limited
3 trials
Cognitive
Bemethyl (Bemitil / Metaprot)
Synthetic benzimidazole 'actoprotector' developed in the 1970s by Vladimir Vinogradov at the S.M. Kirov Military Medical Academy (Leningrad…
Limited
3 trials
Cognitive
Brainberry® (Aronia melanocarpa Extract)
Branded Aronia melanocarpa (chokeberry) extract from Solabia Nutrition (BioActor BV, Netherlands), standardized to 15-18% anthocyanins (cyan…
Limited
3 trials
Cognitive
Bromantane (Ladasten)
Atypical CNS stimulant + anxiolytic developed in USSR. Adamantane family (related to amantadine, memantine). Approved Russia for neurastheni…
Limited
3 trials
Cognitive
Catuaba (Trichilia catigua)
Bark extract of Trichilia catigua (Meliaceae family) — a Brazilian Amazon medicinal tree. Critical species note: 'catuaba' is a common name…
Limited
3 trials
Cognitive
Centrophenoxine (Meclofenoxate)
Synthetic ester of DMAE and parachlorphenoxyacetic acid, marketed in Europe as Lucidril® for cognitive decline since the 1950s. Six older RC…
Limited
3 trials
Cognitive
Cognigrape® (Vitis vinifera Grape Extract)
Standardized solid extract from Sicilian grape (Vitis vinifera L.) developed by Italian company BioNAP. High in anthocyanins + proanthocyani…
Limited
3 trials
Cognitive
D-Serine
D-Serine is an endogenous amino acid that acts as a co-agonist at the NMDA glutamate receptor's glycine-binding site. Studied primarily as a…
Limited
3 trials
Cognitive
Fasoracetam (NS-105 / NFC-1)
Pyrrolidone racetam developed by Nippon Shinyaku (1980s). Failed Phase 3 vascular dementia (efficacy lacking) — abandoned. Repurposed for AD…
Limited
3 trials
Cognitive
Memophenol™ (Grape + Blueberry Polyphenol Extract)
Memophenol™ is a branded combination of grape (Vitis vinifera) and blueberry (Vaccinium angustifolium) polyphenol extracts from the French c…
Limited
3 trials
Cognitive
Mexidol (Ethylmethylhydroxypyridine Succinate)
Russian antioxidant/anti-ischemic drug (EMHPS, ethylmethylhydroxypyridine succinate). 25+ years clinical use. EPICA RCT (n=151), MEMO RCT, M…
Limited
3 trials
Cognitive
Nefiracetam (DM-9384)
Pyrrolidone racetam developed by Daiichi Pharmaceutical (Japan, 1980s). RCT in poststroke depression with apathy showed positive effects — S…
Limited
3 trials
Cognitive
Oxiracetam (4-Hydroxy Piracetam)
Oxiracetam is a hydroxylated piracetam analog developed in Italy in the 1980s as a cognitive enhancer. Evidence is mixed: positive trial dat…
Limited
3 trials
Cognitive
Phenylpiracetam (Phenotropil / Carphedon)
Phenylated piracetam derivative developed in Russia (1983) by Russian Academy of Sciences for COSMONAUTS. Stimulant + cognitive effects; pre…
Limited
3 trials
Cognitive
Piracetam (2-Oxo-1-pyrrolidine-acetamide)
Original 'nootropic' compound — coined by Corneliu Giurgea (1972), developed by UCB Pharma. Cyclic GABA derivative with proposed mechanisms…
Limited
3 trials
Cognitive
Pyritinol (Pyrithioxine / Encephabol)
Pyritinol (also called pyrithioxine, marketed as Encephabol®) is a compound consisting of two vitamin B6 (pyridoxine) molecules linked by a…
Limited
3 trials
Cognitive
Selank (TP-7)
Synthetic heptapeptide derived from endogenous tuftsin (immunomodulatory peptide). Developed at Russian Academy of Sciences Institute of Mol…
Limited
3 trials
Cognitive
Semax (ACTH 4-7 PGP)
Synthetic heptapeptide containing ACTH (4-7) fragment + Pro-Gly-Pro stabilizing tripeptide. Developed at Institute of Molecular Genetics, Ru…
Limited
3 trials
Cognitive
Silk Amino Acids / Silk Fibroin Hydrolysate
Hydrolyzed silk protein from silkworm cocoons (Bombyx mori), composed of fibroin (~70%) and sericin (~30%). Modest evidence (200-600 mg/day…
Limited
3 trials
Cognitive
Sulbutiamine (Arcalion)
Synthetic lipophilic dimer of thiamine (vitamin B1) developed in Japan in 1960s. Trade name Arcalion (used in France/Russia/Asia for astheni…
Limited
3 trials
Cognitive
Trehalose
Natural disaccharide (two glucoses joined α-1,1) found in mushrooms, yeast, and certain plants. Studied as autophagy inducer for neurodegene…
Limited
3 trials
Cognitive
Guayusa (AMATEA® Organic Guayusa)
Guayusa (Ilex guayusa) is a caffeinated holly tree native to the upper Amazon basin, traditionally consumed as a morning ritual tea by indig…
Limited
2 trials
Cognitive
L-Phenylalanine / DLPA
L-Phenylalanine is an essential aromatic amino acid and the precursor to tyrosine, dopamine, norepinephrine, epinephrine, and melanin. Found…
Limited
2 trials
Cognitive
Luteolin
Luteolin is a flavone found in parsley, celery, broccoli, artichoke, peppers, and various herbs. Studied for anti-inflammatory effects, mast…
Limited
2 trials
Cognitive
Methylene Blue (Methylthioninium Chloride)
Methylene blue is a SYNTHETIC SYNTHETIC PHENOTHIAZINE DYE first synthesized in 1876 — used as histological stain (1880s) and as PRESCRIPTION…
Limited
2 trials
Cognitive
Pregnenolone
Pregnenolone is a STEROID HORMONE PRECURSOR — synthesized from cholesterol in adrenals, gonads, and brain. Often called the 'mother of all s…
Limited
2 trials
Cognitive
Pterostilbene
Pterostilbene is a methylated analog of resveratrol — found primarily in blueberries, cranberries, and peanuts. Better oral bioavailability…
Limited
2 trials
Cognitive
Uridine
Uridine is a pyrimidine nucleoside present in human breast milk and many foods. Investigated for bipolar depression with promising small-tri…
Limited
2 trials
Cognitive
Axivite® (Energy and Cognitive Performance Ingredient)
Axivite® (SEE Nutrition) is a specialty energy and cognitive performance ingredient featured on NXT Ingredients' platform. Positioned in the…
Limited
1 trial
Cognitive
Hōlistiq™ (Adaptogen + Mushroom Wellness Blend)
Hōlistiq™ (Compound Solutions) is a proprietary adaptogenic mushroom and botanical blend formulated for comprehensive mind-body wellness — c…
Limited
1 trial
Cognitive
Coluracetam (BCI-540 / MKC-231)
Tetrahydrofuro-quinoline racetam developed by Mitsubishi Tanabe Pharma (1990s) for Alzheimer's. Failed AD endpoints; in-licensed by BrainCel…
Preliminary
3 trials
Cognitive
DMAE (Dimethylaminoethanol / Deanol)
Choline analog (2-dimethylaminoethanol). Marketed as Deaner/Deanol for ADHD/learning disabilities 1960s-1970s; WITHDRAWN by FDA 1983 after m…
Preliminary
3 trials
Cognitive
Picamilon (N-Nicotinoyl-GABA)
Synthetic combination of NIACIN (vitamin B3) and GABA developed in USSR (1969). Acts as GABA prodrug — niacin moiety enables BBB penetration…
Preliminary
3 trials
Cognitive
Pramiracetam (Pramistar)
Highly lipophilic racetam developed by Parke-Davis (late 1970s). 30x more potent than piracetam by weight. Mechanism: enhances high-affinity…
Preliminary
3 trials
Cognitive
Lithium Orotate
Lithium orotate is a low-dose form of lithium (the mood-stabilizing element) bound to orotate. CRITICAL DISTINCTION: this is NOT pharmaceuti…
Preliminary
2 trials
Cognitive
L-Glutamic Acid / Glutamate
L-Glutamic acid is a non-essential amino acid and the most abundant excitatory neurotransmitter in the central nervous system. Found in prot…
Preliminary
1 trial