Top Picks — Cognitive

🧠 Best Cognitive Supplements

Top cognitive supplements ranked by clinical evidence — for memory, focus, mental clarity, and brain health. Bacopa, Lion's Mane, Citicoline, and more.

203 ingredients reviewed Ranked by clinical evidence

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Top 5 — Ranked by Evidence

Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)

Cognitive Function — BDNF and Multi-Domain Improvements

Adults: 10mg lutein+2mg zeaxanthin (low) or 20mg+4mg (high) daily. Children: 10mg+2mg

Creatine Monohydrate

Neuroprotective effects in aging

Standard daily: 3-5 g/day (no loading needed). Optional loading: 20 g/day × 5-7 days,

Enhances Alertness and Focus

100–400 mg/day; performance: 3–6 mg/kg body weight 60 minutes pre-exercise; upper safe

Mental Health and Cognitive Function

2.4 mcg/day (RDA); deficiency treatment: 1,000–2,000 mcg/day oral (sublingual

Longvida® Optimized Curcumin (Verdure Sciences)

Cognitive Function (400 mg/day)

400 mg/day Longvida (cognitive applications); 800 mg/day (joint health, exercise

📈 Fastest Growing Cognitive Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

Omega-3 Fatty Acids

Brain & nervous system support (DHA)

1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction (under…

Creatine Monohydrate

Neuroprotective effects in aging

Standard daily: 3-5 g/day (no loading needed). Optional loading: 20 g/day × 5-7 days, then 3-5…

Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)

Cognitive Function — BDNF and Multi-Domain Improvements

Adults: 10mg lutein+2mg zeaxanthin (low) or 20mg+4mg (high) daily. Children: 10mg+2mg gummy.…

🔬 Future Cognitive Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Lion's Mane Mushroom

Brain Health and Cognitive Support

500–3,000 mg/day dried mushroom powder; extract: 250–500 mg/day (standardized to >30%…

EGb 761® (Standardized Ginkgo biloba Extract)

Symptomatic Support in Mild–Moderate Dementia

120–240 mg/day; dementia and anxiety trials predominantly used 240 mg/day, given once daily or…

Cognitive support (preliminary)

Standard clinical dose: 250 mg twice daily (500 mg/day total) of purified shilajit…

SaraPEPP™ Nu (Timut / Nepalese Pepper)

Improved speed of attention (branded RCT)

Branded trial: studied acutely and at a daily dose over 8 weeks. Taken as a capsule with its…

Recommended Cognitive Products

Heads up: NutraSmarts may earn a commission from purchases made through these links, at no extra cost to you. We curate these picks based on the same evidence we cite throughout the page. Full disclosure.

Real products featuring the best-evidenced cognitive ingredients ranked above - chosen for clinically-studied forms and doses, third-party testing, and value. Match the supplement to your specific need.

Best for brain & overall omega-3 support Amazon →

Nordic Naturals Ultimate Omega

1,280 mg omega-3/serving (EPA/DHA), 120 softgels

High-potency triglyceride-form fish oil with substantial EPA/DHA; lemon-flavored, non-GMO, third-party purity tested.

Best for focus & memory support Amazon →

Jarrow Formulas Citicoline (CDP Choline)

250 mg capsules, 120 ct

Citicoline supports brain energy metabolism and attention; non-GMO, vegan, up to a 120-day supply.

Best for focus & nervous-system support Amazon →

Host Defense Lion's Mane Capsules

Organic mycelium capsules, 120 ct

Certified-organic lion's mane from mycologist-founded Host Defense, U.S.-grown and vegan.

Best for calm, focused alertness Amazon →

NOW Foods L-Theanine Double Strength 200 mg

200 mg + 100 mg inositol veg capsules, 120 ct

L-theanine, the amino acid from green tea, promotes relaxation without drowsiness; vegetarian, non-GMO, pairs with caffeine.

All Cognitive Ingredients (203)

Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)

Cognitive Function — BDNF and Multi-Domain Improvements

Adults: 10mg lutein+2mg zeaxanthin (low) or 20mg+4mg (high) daily. Children: 10mg+2mg

Creatine Monohydrate

Neuroprotective effects in aging

Standard daily: 3-5 g/day (no loading needed). Optional loading: 20 g/day × 5-7 days,

Enhances Alertness and Focus

100–400 mg/day; performance: 3–6 mg/kg body weight 60 minutes pre-exercise; upper safe

Mental Health and Cognitive Function

2.4 mcg/day (RDA); deficiency treatment: 1,000–2,000 mcg/day oral (sublingual

Longvida® Optimized Curcumin (Verdure Sciences)

Cognitive Function (400 mg/day)

400 mg/day Longvida (cognitive applications); 800 mg/day (joint health, exercise

Acetyl-L-Carnitine (ALCAR)

Cognitive aging and mild cognitive impairment

COGNITIVE/AGING: 1500-3000 mg/day divided. DIABETIC NEUROPATHY: 1000 mg × 3/day = 3000

Bacopa Monnieri

Memory consolidation — strongest evidence

300–450 mg/day of 55% bacoside-standardized extract; effects require 8–12 weeks of

Magtein® (Magnesium L-Threonate)

Brain magnesium elevation — only form crossing the blood-brain barrier

2g/day Magtein® (145 mg elemental magnesium); taken as 1g morning + 1g evening; 6-week

Nutricog® (Haritaki + Boswellia Cognitive Performance Complex — PLT Health)

Multi-domain cognitive improvement

Per Nutricog clinical trial protocol — daily dosing for 120 days. Effects on memory

Creapure® (Pharmaceutical-Grade Creatine Monohydrate)

Cognitive support under stress, sleep loss, or aging

Loading: 0.3 g/kg/day for 5–7 days (typically 20 g/day split in 4 doses). Maintenance:

Pycnogenol® (French Maritime Pine Bark)

Attention & focus support

50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic

CurQfen® (Curcumin-Fenugreek FenuMat — Akay Bioactives)

Curcumin with enhanced brain delivery

400-500 mg/day CurQfen (research-validated; some applications use higher)

Fish Oil (EPA + DHA)

Brain & nervous system support (DHA)

General: 1 g/day EPA+DHA. Hypertriglyceridemia: 3-4 g/day. REDUCE-IT regimen: 4 g/day

FloraGLO® Lutein (Kemin)

Cognitive function in older adults

AREDS2 standard: 10 mg lutein + 2 mg zeaxanthin/day. Cognitive: 12 mg/day.

Cognitive Function

8–11 mg/day (RDA); therapeutic: 25–40 mg/day elemental zinc; upper limit 40 mg/day;

Cognitive function in age-related decline

AD/MCI: 400 mg × 3/day = 1200 mg/day. COGNITIVE: 300-600 mg/day. ATHLETIC: 250-600 mg

Hericium erinaceus (Mycelium vs Fruiting Body — Strain Specifics)

Mild Cognitive Impairment 16-week trial

Fruiting body powder: 3 g/day × 16 weeks (the mild cognitive impairment trial

Phosphatidylserine

Age-related memory complaints — modest benefit

Cognitive (elderly): 100-300 mg/day. Athletic (cortisol): 600-800 mg/day × 10-15 days.

Choline Bitartrate

Supports Acetylcholine Synthesis

AI: 425-550 mg/day adults; 450 mg pregnancy, 550 mg lactation. Bitartrate supplements

Memory in age-associated memory impairment

250–500 mg/day (as Cognizin®); cognitive: 500 mg/day; stroke recovery studies use

DailyZz™ (Spearmint + Green Tea Sleep Nootropic — Kemin)

60% working memory improvement

485 mg DailyZz once daily — taken 30 minutes before bedtime per the published clinical

Cerebrolysin (FPF-1070)

Vascular dementia — strongest indication

VASCULAR DEMENTIA: 20 mL IV/day × two 4-wk courses. STROKE (CARS-1/2): 30 mL/day IV ×

Polygala (Yuan Zhi)

Memory enhancement in healthy adults (BT-11 RCT)

BT-11 STANDARDIZED EXTRACT (Korean RCTs): 200-300 mg 3×/day = 600-900 mg/day × 4-12

Bacopin® (Bacopa monnieri Extract — Sabinsa)

Memory and learning (Bacopa class evidence)

100-300 mg/day Bacopin standardized extract, typically split into 1-2 daily doses with

enXtra® (Standardized Alpinia galanga Extract — OmniActive)

Sustained 5-hour alertness

300 mg/day (single serving) is the standard dose used across all published trials. Can

GeniusPure® (High-Purity Alpha-GPC)

Memory, learning, and cognitive enhancement

300–600 mg/day alpha-GPC (as standard 50% — adjust for GeniusPure® 70% or 90%

Improves Focus and Attention

100–400 mg/day; relaxation: 200 mg; caffeine synergy: 100–200 mg with caffeine; sleep:

Neumentix® (Spearmint Extract — Kemin)

Working memory in older adults

Standard cognitive protocol: 900 mg/day Neumentix® (typically 600 mg morning + 300 mg

Neuravena® (Wild Green Oat Extract — Frutarom)

Cognitive Function and Attention

800-1,600 mg/day Neuravena (research-validated)

Pine Bark Extract

Cognitive function support

Standard dose: 100-300 mg/day standardized pine bark extract (≥85% proanthocyanidins).

Zynamite® S (Non-Stim Mental Energy — Water Soluble)

Non-stimulant cognitive performance for beverages

100–150 mg Zynamite® S (single dose, acute cognitive benefits within 30 minutes); 150

Alzheimer's Disease Cognitive Improvement

50-200 mcg twice daily (100-400 mcg/day total); China research uses up to 400 mcg/day

Algal Oil DHA (Vegan Omega-3)

Cognitive support in older adults

General health: 200-500 mg DHA/day. Pregnancy: 200-300 mg DHA/day minimum (matches

AlphaSize® (Alpha-GPC — Chemi Nutra)

Memory and cognition

300 to 600 mg per day for cognition; about 600 mg pre-exercise in sports studies.

Cognitive Function

KSM-66® root extract: 300-600 mg/day (most stress/sleep trials). Shoden®: 120-240

BaCognize® (Standardized Bacopa monnieri — Verdure Sciences)

Cognitive function in healthy adults (Kumar 2016)

300 mg/day BaCognize, typically 150 mg twice daily (Kumar 2016 dosing schedule). Some

BacoMind® (Bacopa monnieri Extract — Natural Remedies)

Memory and learning

About 300 mg per day, typically taken for 8 to 12 weeks for cognitive effects.

Cereboost™ (American Ginseng for Cognition — Givaudan)

Cognitive Performance

200 mg/day Cereboost (research-validated)

Fetal brain development and pregnancy

425 mg/day (women AI); 550 mg/day (men AI); 930 mg/day (pregnant); up to 3,500 mg/day

Cognizin® (Citicoline — Kyowa Hakko)

Attention and focus

250 to 500 mg per day.

EPAX® (Concentrated Omega-3 Fish Oil)

A serving typically providing several hundred milligrams to over a gram of combined E

Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)

Cognitive Function and Working Memory

120-240 mg/day Ginkgoselect Phytosome

goCOCOA® (Cocoa Flavanol Extract)

Cognitive function and memory

200–400 mg/day cocoa flavanols (epicatechin equivalent); cardiovascular/cognitive:

Memory and Focus

300–600 mg/day KSM-66® root extract (5% withanolides); 300 mg twice daily or 600 mg

Methylcobalamin (Active B12)

Neurological Function

500-2,000 µg/day sublingual or oral for general supplementation; 1,000-2,500 µg/day

Nitrosigine® (Arginine Silicate)

Cognitive performance and focus

1,500 mg/day; most studies use 1,500 mg taken 30–60 minutes pre-exercise

nooLVL® (Inositol-Enhanced Arginine for Gaming & Cognition)

Gaming performance — accuracy and reaction time

1,600 mg/day nooLVL® (clinically tested dose); cognitive benefits within 15 minutes;

Cognitive performance

200–600 mg/day standardized extract; taken before meals

Cofactor for brain energy metabolism (B2)

1.1–1.3 mg/day (RDA); migraine prevention: 400 mg/day (clinical studies); metabolic

SerinAid® (Phosphatidylserine — Chemi Nutra)

Memory and cognition

100 to 300 mg per day; 300 mg/day is common in cognition studies.

Alpha brainwave induction

50–200 mg/day; 100–200 mg for relaxation/focus; 50 mg for caffeine stacking

BioPure DHA® (Omega-3 DHA)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

Dry N-3® (Powdered Omega-3)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

DurOmega® (Stabilized Omega-3)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

EFADuo® (Omega-3 and Omega-6 Complex)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

Elantria® Algal DHA (Vegan Omega-3 DHA)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

EssentiOmega® (Omega-3 Concentrate)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

Cognitive Function

250–500 mg/day EGCG standardized extract; whole green tea: 3–5 cups/day (≈240–320 mg

Saffron Extract (Crocus sativus)

Mild cognitive impairment and early Alzheimer's

Depression (most-studied): 30 mg/day standardized stigma extract × 6-8 weeks. PMS:

Sensoril® (Ashwagandha Extract — Verdure/Natreon)

Cognitive Performance

125-500 mg/day Sensoril (research-validated; stress applications often 250 mg/day)

V-Krill Omega® (Krill Omega-3)

Brain and mood support

Commonly 1 to 3 g of combined EPA and DHA per day.

Vitamin B6 (Pyridoxine)

Brain Health and Mood Regulation

1.3–1.7 mg/day (RDA); therapeutic: 25–100 mg/day; upper limit 100 mg/day long-term

EGb 761® (Standardized Ginkgo biloba Extract)

Symptomatic Support in Mild–Moderate Dementia

120–240 mg/day; dementia and anxiety trials predominantly used 240 mg/day, given once

Lion's Mane Mushroom

Brain Health and Cognitive Support

500–3,000 mg/day dried mushroom powder; extract: 250–500 mg/day (standardized to >30%

Omega-3 Fatty Acids

Brain & nervous system support (DHA)

1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction

CocoaVia® (Mars Edge Cocoa Flavanol Extract)

Cognitive function in older adults

Standard dose: 500-750 mg cocoa flavanols daily (1-2 CocoaVia® servings). COSMOS trial

CoffeeBerry® Cascara

Acute Elevation of Plasma BDNF

100 mg single acute dose (BDNF study); 100-300 mg/day in subsequent cognitive trials.

enfinity® Paraxanthine

Supports Cognitive Performance

100-200 mg per serving; 50, 100, and 200 mg evaluated in published dose-response trials.

Acute Cognitive Performance

50-200 mg as a single acute dose; 100-200 mg is the most commonly studied range for

Sage Extract / Cognivia® (Salvia officinalis)

Memory and cognitive performance

COGNIVIA®: 600 mg/day (400 mg S. officinalis aqueous + 50 µL S. lavandulaefolia oil).

Theracurmin® (Colloidal Nanoparticle Curcumin — Theravalues)

Cognitive function in older adults

Theracurmin®: 30-180 mg/day (provides curcumin equivalent of much higher standard

Piracetam (2-Oxo-1-pyrrolidine-acetamide)

Cognitive impairment in elderly — evidence is mixed and conflicted

DEMENTIA: 2.4-9.6 g/day. UCB MCI: 4.8-9.6 g/day × 12 mo. STROKE: 4.8-9.6 g/day. AD: 8

Alpha-Lactalbumin

Morning alertness from evening tryptophan loading

EVENING: 20 g 60-90 min pre-bed. DAYTIME: 20 g stress-vulnerable. EXERCISE: 20-30 g

Alpinia galanga (Greater Galangal)

Caffeine-free alertness and attention

300 mg/day standardized Alpinia galanga rhizome extract — the dose used in published

Bifidobacterium longum 1714 (Zenflore™ / 1714-Serenitas™)

Improved cognition under stress

Standard dose: 1 billion CFU (1×10⁹) once daily as Zenflore™ or 1714-Serenitas™. Trial

CardaMind™ (Black Cardamom Cognitive Performance — Akay Bioactives)

Caffeine-level cognitive performance — without caffeine

250 mg/day CardaMind (MA2-24) — the dose used in the pivotal clinical trial. Effects

Coffee Fruit Extract (CoffeeFruit Pure™)

BDNF elevation — the brain growth factor

100–200 mg/day whole coffee fruit concentrate; NeuroFactor™ clinical dose: 100 mg/day

Cognivia™ (Garden + Spanish Sage Cognitive)

Working memory in healthy adults

PIVOTAL: 600 mg/day Cognivia™ × 29 days (Northumbria University n=94). DOSE

Ergothioneine (ErgoActive®)

Cognitive aging and neurodegeneration prevention

5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms

Cognitive Function

200–400 mg/day standardized extract (ginsenosides ≥4–7%); American ginseng: 100–200

Cognitive performance under stress and sleep deprivation

500–2,000 mg/day; cognitive/stress: 100–150 mg/kg before demanding tasks

Lemon Balm (Melissa officinalis)

Mild Cognitive Performance

300-600 mg/day standardized extract; tea 1.5-4.5 g dried herb per cup; tincture 2-3 mL

PQQ (Pyrroloquinoline Quinone)

Cognitive function and memory

10–20 mg/day; 20 mg most studied for cognitive effects; often combined with 200–300 mg

Cognitive performance under stress

200–400 mg/day of standardized Rhodiola rosea extract in stress, anxiety, and fatigue

Spearmint Extract

Cognitive function in older adults

Cognitive applications: 900 mg/day Neumentix® standardized spearmint extract.

Cerebrovascular Insufficiency / Stroke Recovery (Eastern European Use)

5-10 mg three times daily (15-30 mg/day total); some research uses up to 60 mg/day

Yüth® (Spermidine)

Cognitive function and neuroprotection

1–10 mg/day spermidine (Yüth® formulation specifications); typical supplement use: 1.2

Guayusa (AMATEA® Organic Guayusa)

Clean energy and sustained focus

300–600 mg/day AMATEA® extract (providing 50–100 mg natural caffeine equivalent);

Cognitive function in older adults

4–12 mg/day from Haematococcus pluvialis extract; skin: 4–6 mg/day; exercise recovery:

BioPQQ® (Pyrroloquinoline Quinone — Mitsubishi)

Memory and cognition

About 20 mg per day.

Bluenesse® (Lemon Balm Extract — Vital Solutions)

Calm, focused cognition

Around 300 mg per day.

Dynamine® (Methylliberine)

Fast-onset energy and focus

100–200 mg Dynamine® standalone; 100 mg Dynamine® + 100–200 mg caffeine (synergistic

FastBliss® (Paraxanthine)

Cognitive enhancement without caffeine anxiety

50–200 mg/day paraxanthine; cognitive benefits at doses as low as 50 mg; full effect

Ginkgo 24/6 (Standardized Ginkgo biloba Extract)

Cognition and memory

Commonly 120 to 240 mg of standardized extract per day.

Ginkgolden® (Ginkgo biloba Extract)

Cognition and memory

Commonly 120 to 240 mg of standardized extract per day.

GinPure® (Ginkgo biloba Extract)

Cognition and memory

Commonly 120 to 240 mg of standardized extract per day.

GinSelect® (Ginkgo biloba Extract)

Cognition and memory

Commonly 120 to 240 mg of standardized extract per day.

goBHB® (Beta-Hydroxybutyrate Ketone Salts)

Rapid ketosis and alternative brain fuel

6–12g BHB salts to achieve meaningful blood ketone elevation (0.5–1.0 mmol/L);

Holy Basil (Tulsi)

Cognitive function

300–600 mg/day dried leaf extract; 1–2 g/day whole leaf powder

Human Milk Oligosaccharides (HMOs)

Supports Cognitive Development

Adult clinical trials have used 5-20 g/day of 2'-FL and/or LNnT; infant formulas

i-Sabi® (Wasabi Extract — 6-MSITC)

Memory in older adults

About 0.8 mg of 6-MSITC (around 100 mg of wasabi extract) per day.

Supports Cognitive Performance

Vimang mango bark extract: 300-900 mg/day standardized to mangiferin; Zynamite mango

MCT Oil (Medium-Chain Triglycerides)

Cognitive performance and brain energy

15–30 mL/day (1–2 tablespoons); start with 5–10 mL and increase gradually to avoid GI

Multivitamin / Multimineral

Slowing of cognitive decline (COSMOS-Mind)

STANDARD: 1 tablet/day MVMM ~100% DV most vitamins, 25-100% DV minerals. PHS II +

Puremidine™ (Spermidine)

Cognitive function and neuroprotection

1–10 mg/day spermidine; observational longevity data at dietary intake of ~10–15

Rosmarinic Acid

Slowed cognitive decline in mild Alzheimer's disease

ALLERGIC RHINITIS: 50-200 mg/day Perilla × 21 d. AD COGNITION (Noguchi-Shinohara): 500

Improved speed of attention (branded RCT)

Daily with MCT carrier

Schisandra Chinensis (Five-Flavor Berry)

Cognitive Performance and Mental Stamina

500-2,000 mg/day extract (standardized to schisandrin content); berry powder 1-6

Sharp-PS® (Soy-Free Sunflower Phosphatidylserine)

Memory and cognitive support in older adults with complaints

Most cognition and stress trials use 100–400 mg/day PS (typically 100 mg three times

Synapsa® (Bacopa monnieri Extract — KeyView)

Memory and learning

About 320 mg per day, taken for several weeks for cognitive effects.

Veri-te™ Resveratrol (Evolva)

Cognitive performance in postmenopausal women

RESHAW PIVOTAL: 75 mg trans-resveratrol BID = 150 mg/day × 12-24 months in

VitaCholine® (Choline Bitartrate — Balchem)

Brain and memory support

Commonly 300 to 550 mg of choline per day.

Zembrin® (Sceletium tortuosum)

Cognitive performance under stress

8–25 mg/day Zembrin®; anxiety/mood: 8–25 mg/day; cognitive studies use 25 mg/day;

Zensera™ (Stress-Cognitive Ingredient by Givaudan)

Same-day cognitive benefits under stress

Per Zensera™ clinical dosing from Givaudan; single-dose acute benefits confirmed in

AlphaWave® L-Theanine (NutriScience)

Focus and attention

100 to 200 mg per day, taken as needed for calm focus or before sleep.

BioPS® (Soy Phosphatidylserine — ECA Healthcare)

Memory and cognition

Commonly 100 to 300 mg per day.

Chocamine® (Cocoa Extract — RFI)

Smooth energy and focus

Commonly around 500 mg to 1.5 g of cocoa extract per day.

CocoaGanic® (Organic Cocoa Flavanols)

Cognitive support

Commonly providing a few hundred milligrams of cocoa flavanols per day.

CocoaNol® (Cocoa Flavanol Extract)

Cognitive support

Commonly providing a few hundred milligrams of cocoa flavanols per day.

Ecklonia Cava (Brown Seaweed Polyphenol)

Cognitive function and neuroprotection

400–800 mg/day Ecklonia cava extract standardized for phlorotannins; clinical studies

Eupoly-3® (DHA and EPA Omega-3)

Brain and cognition

A serving providing several hundred milligrams of combined DHA and EPA per day.

Gotu Kola (Centella asiatica)

Anxiety and Cognitive Support

60-120 mg/day standardized extract (containing total triterpenes ~30%); whole herb 1-2

Lactobacillus helveticus R0052 + Bifidobacterium longum R0175 (Probio'Stick® / Cerebiome®)

Brain-imaging mechanism evidence

3 billion CFU per sachet daily for 30 days (Probio'Stick® / Cerebiome®). Longer

Mucuna Pruriens (Velvet Bean / Kapikacchu)

Mood and Cognitive Support

Standardized to L-DOPA content: 250-500 mg L-DOPA per dose for Parkinson-related uses

Shagandha® (Ashwagandha Root Extract)

Cognitive and Wellbeing Support

Ashwagandha root-extract stress/sleep trials commonly used 300–600 mg/day of

Anserine (β-alanyl-3-methyl-L-histidine)

Verbal memory preservation in older adults

HISATSUNE 2016 COGNITIVE: 1.0 g anserine/carnosine 3:1 daily × 3 mo. MASUOKA 2019 MCI

Aniracetam (Ro 13-5057)

Mild Alzheimer's disease (Senin 1991 multicenter RCT)

AD RCT: 1500 mg/day × 6 mo. STANDARD: 750-1500 mg/day in 2-3 doses with meals.

Brainberry® (Aronia melanocarpa Extract)

Long-term cognitive performance in middle-aged adults

: 90 mg or 150 mg AME daily × 24 wk middle-aged adults. CROSSOVER: 160 mg/day older

Centrophenoxine (Meclofenoxate)

DMAE/cholinergic precursor effect

DEMENTIA: 1560-2000 mg/day (Pek 1989: 2 g/day × 8 wk). HEALTHY ELDERLY: ~1200 mg/day.

Cognigrape® (Vitis vinifera Grape Extract)

Cognitive function in older adults

PIVOTAL: 250 mg/day Cognigrape® × 12 wk single daily dose. 2024 FOLLOW-UP: 250 mg/day

Memophenol™ (Grape + Blueberry Polyphenol Extract)

Episodic memory in healthy elderly

Healthy elderly: 600 mg/day Memophenol™ (containing 258 mg flavonoids) × 6 months. MCI

Oxiracetam (4-Hydroxy Piracetam)

Mild-moderate dementia cognitive support

Dementia trials: 800 mg twice daily (1,600 mg/day). Nootropic users: 800-2,400 mg/day

Phenylpiracetam (Phenotropil / Carphedon)

Cognitive impairment from organic causes

RUSSIAN: 100-200 mg/day divided morning + early afternoon. STROKE/TBI: 200-400 mg/day.

Pyritinol (Pyrithioxine / Encephabol)

Senile dementia cognitive support

Dementia (European Rx protocol): 200 mg hydrochloride three times daily (600 mg/day).

Silk Amino Acids / Silk Fibroin Hydrolysate

Cognitive function support — memory, attention, mental focus

COGNITIVE: 200-600 mg silk fibroin enzyme hydrolysate (FEH)/day × 3-16 wk. STAMINA:

Apoaequorin Protein

Marketed for memory support

Manufacturer trials have typically used 10 mg of apoaequorin per day; the commercial

NMDA co-agonist (cognitive research)

SCHIZOPHRENIA: 30 mg/kg/day (~2-2.5 g/day adult) up to 120 mg/kg/day dose-escalation.

Enzogenol® (Pinus radiata Bark Extract)

Working memory in healthy older adults

Cognitive: 480 mg/day × 5 weeks. Mild TBI: 1,000 mg/day × 6-12 weeks. Take with food.

Ligusticum Chuanxiong (Chuan Xiong)

Promotes Cerebrovascular Wellness

Traditional decoctions use 3-9 g/day of dried rhizome; modern standardized extracts

Magnesium Acetyl-Taurate

Cognitive and brain interest

Human dosing is not well established; animal studies used weight-based doses. Products

Mexidol (Ethylmethylhydroxypyridine Succinate)

Stroke rehabilitation cognitive recovery

MIR 2024 STROKE PROTOCOL: 500 mg IV 2×/day × 10 days, then Mexidol FORTE 250 mg PO

Semax (ACTH 4-7 PGP)

Cognitive enhancement / nootropic effects

STROKE (Russian approved): 12-18 mg/day intranasal in 3-6 doses × 10-14 days.

Virtiva® (Ginkgo biloba Phytosome)

Mental Performance Interest

Ginkgo cognition trials commonly used standardized extract ~120–240 mg/day; phytosome

Levagen+® (PEA — Palmitoylethanolamide — Gencor)

Cognitive function support

Standard dose: 300-600 mg/day Levagen+® — substantially lower than typical PEA

Axivite® (Energy and Cognitive Performance Ingredient)

Sustained energy and mental alertness

Per Axivite® product specifications; clinical dosing per SEE Nutrition product

Centellory® (Gotu Kola Extract)

Cognition and memory

Commonly 250 to 750 mg of standardized extract per day.

Cera-Q® (Silk Fibroin Peptides)

About 400 to 600 mg of fibroin hydrolysate per day, in divided doses.

Hōlistiq™ (Adaptogen + Mushroom Wellness Blend)

Cognitive clarity and mental performance

Per product label; typical adaptogen blend 300–800mg/day; mushroom component

Nefiracetam (DM-9384)

Alzheimer's disease (NIH-sponsored Phase 2)

ROBINSON 2009 (poststroke apathy): 600-900 mg/day × 12 wk. NOOTROPIC: 150-450 mg/day

NeuGrape® (Grape Seed Extract for Cognition)

Cognitive support

Commonly 100 to 300 mg per day.

Neurosteroid (cognitive research)

10-100 mg/day (start LOW); some integrative practitioners use 5-30 mg; trials have

Brain Phospholipid Precursor

JENSEN 2008 BIPOLAR: triacetyluridine (TAU) up to 18 g/day × 6 wk. KONDO 2011

Pomegranate Extract

Cognitive aging support (preliminary)

Standard cardiovascular dose: 500-1,500 mg/day pomegranate extract standardized to

Soy Isoflavones (Glycine max)

Cognitive support in menopause

40–80 mg/day total isoflavones; menopausal symptoms: 50–80 mg/day; bone health: 54–100

Bromantane (Ladasten)

Sleep deprivation cognitive performance

RUSSIAN APPROVED (asthenia): 50-100 mg/day morning × 28 days. NOOTROPIC: 25-50 mg/day.

Centevita® (Centella asiatica Extract — Indena)

Cognitive and calm support

Commonly 60 to 120 mg of standardized extract per day.

GS15-4® (Enzyme-Fermented Ginseng — Ilhwa)

Cognitive support

Around 165 mg of fermented ginseng extract per day.

Hoki Roe Powder

Promotes Cognitive Function

Commercial supplements typically provide 500-1,500 mg of hoki roe powder daily,

PANMOL® NADH Micro

Mental Clarity and Focus

5-10 mg/day taken sublingually or on an empty stomach in morning; CFS trial used 10

Phenylethylamine (β-PEA)

Pre-Workout Focus Component

100-500 mg orally as a single acute dose; effects are very brief (<10 minutes) due to

Cognitive Function and Memory

120–240 mg/day standardized leaf extract (24% flavonol glycosides, 6% terpene

Pramiracetam (Pramistar)

Senile cognitive disorders (Italian approval — limited evidence)

STANDARD: 600 mg BID (1200 mg/day) with meals. AD TRIALS: 400-1500 mg/day. POST-TBI /

Lysoveta® (LPC-Bound EPA/DHA from Krill — Aker BioMarine)

>2-fold brain DHA elevation (preclinical)

NDI-approved up to 1.5 g/day for general adult population (US). Preclinical brain

Cognitive support (preliminary)

Standard clinical dose: 250 mg twice daily (500 mg/day total) of purified shilajit

Fasoracetam (NS-105 / NFC-1)

Experimental nootropic (mGluR modulator)

HAKONARSON 2017 (ADHD adolescents): 50-800 mg/day, escalation up to 400 mg BID × 4 wk.

Methylene Blue (Methylthioninium Chloride)

Cognitive Function (Limited Human Evidence)

Pharmaceutical (methemoglobinemia): 1-2 mg/kg IV; 'biohacking' use: 0.5-4 mg/day oral

Oxaloacetate (Anhydrous Enol)

Cognitive function support

Standard dose: 100-300 mg/day anhydrous enol oxaloacetate (benaGene™). Cognitive

DMAE (Dimethylaminoethanol / Deanol)

ADHD/learning disabilities in children (1970s historical RCTs)

ADHD HISTORICAL: 500 mg/day in 1970s pediatric trials. NOOTROPIC: 100-200 mg/day.

Lithium Orotate

Cognitive Function (Theoretical)

5-20 mg elemental lithium/day (lithium orotate 130-520 mg providing ~4.6%-20%

Picamilon (N-Nicotinoyl-GABA)

Cerebrovascular disease and cerebral circulation

RUSSIAN APPROVED: 50 mg 3×/day (150 mg/day). CEREBROVASCULAR: 100-300 mg/day. ANXIETY:

Codonopsis lanceolata (Deodeok / Korean Bonnet Bellflower)

Cognitive enhancement (preclinical)

TCM TYPICAL: 9-15 g/day root decoction. SARCOPENIA RCT (Park 2022 protocol): 750 mg

PhosphatidylCholine

Cognitive function — choline pathway

NAFLD/MASLD: 1.5-2.1 g/day standardized PC × 6 months. General choline/cognitive:

Anemarrhena asphodeloides (Zhi Mu)

Supports cognitive function

Traditional TCM decoctions use 6–12 g dried rhizome daily; standardized extracts in

Catuaba (Trichilia catigua)

Antifatigue and memory effects (preclinical)

TRADITIONAL TINCTURE: 30-60 drops 2-3×/day. CAPSULE: 500-1,000 mg standardized bark

Euphoria longana (Longan Fruit Pulp Extract)

Supports cognitive and memory function

Traditional Chinese Medicine doses of dried longan aril typically range from 6 to 15 g

Potential cognitive-aging support

No established human supplemental dose. Mechanistic studies estimate that

Sulbutiamine (Arcalion)

Cognitive enhancement (limited evidence)

ASTHENIA (Arcalion approved): 200-600 mg/day divided. Shipelowitz 1984 best at 600 mg.

Nicotinamide Riboside

Possible cognitive aging support

Standard dose: 250-1,000 mg/day NR. Most clinical trials use 300-600 mg/day. Take with

Cognitive function in early Alzheimer's (preliminary)

DIABETIC NEUROPATHY (BENDIP): 600 mg/day × 6 wk then 300 mg/day. BOND: 300 mg BID × 12

PrimaVie® (Shilajit Extract — Natreon)

Cognitive support (preliminary)

Clinical trial dose: 250 mg twice daily (500 mg/day total) for 90 days. CoQ10

SAMe (S-Adenosyl-L-Methionine)

Cognitive Health

400–800 mg/day for depression; 600–1,200 mg/day for osteoarthritis; taken on empty

Tocotrienols (Vitamin E Family)

Neuroprotection (Stroke Research)

100-400 mg/day total tocotrienols; for cholesterol/CV: 200-300 mg gamma+delta

Bemethyl (Bemitil / Metaprot)

Cognitive performance under stress

RUSSIAN/CIS APPROVED: 250-500 mg 1-2×/day for asthenia; courses 3-5 days with 2-3 day

Lecithin (Phosphatidylcholine Complex)

Possible Cognitive Support (As Choline Source)

CV: 500 mg to 22.5 g/day soy lecithin (Knuiman 1980: 7.5 g × 3/day). Spilburg 2003

Cognitive Function Support

50-250 mg/day; trial used 125 mg twice daily (250 mg/day total)

Alcolec® (Phosphatidylcholine / Lecithin — American Lecithin)

Choline and brain support

Commonly a few hundred milligrams to grams per day.

Decursinol-50® (Angelica gigas Extract)

Cognitive interest

Commonly around 100 to 200 mg per day.

FerroChel® (Ferrous Bisglycinate Chelate)

Iron — supports cognition when deficient

Typical FerroChel® doses provide 14–28 mg elemental iron once daily for routine

Niagen® (Nicotinamide Riboside — ChromaDex)

NAD+ precursor (cognitive-aging research)

Clinical trial doses: 250-1,000 mg/day Niagen®. Most studies use 300-600 mg/day. Take

Quatrefolic® (L-5-MTHF Methylfolate — Gnosis)

Active folate — brain & homocysteine support

General supplementation: 400-1,000 mcg DFE Quatrefolic® daily. Pregnancy: 400-800 mcg

Zenroot® (Low-Dose Bioavailable Ashwagandha Root Extract — OmniActive)

Low-dose ashwagandha — stress & cognition

125 mg/day Zenroot (used in both 2025 published trials). The bioavailability advantage

Asera™ (Ashwagandha)

Ashwagandha — stress & cognitive support

B-Complex (Combined B Vitamins)

Brain & nervous-system support (B vitamins)

1× RDA (basic) to 5-10× RDA (high-potency) of each B vitamin; varies by product

Mitochondrial support (cognitive-aging research)

LHON (Raxone® EMA-approved): 900 mg/day in 3 divided doses (150 mg × 2 caps × 3/day).

TeaCrine® (Theacrine)

Clean energy & sustained focus

STANDARD: 100-300 mg/day (safety to 300 mg × 8 wk continuous). STACK: 125-150 mg

Mild, sustained alertness

Controlled trials have used 250-1000 mg pure theobromine acutely and 700-979 mg/day

Vanizem® (Grains of Paradise Extract for Stress + Mood + Sleep — PLT Health)

Stress, mood & sleep support

100-150 mg/day Vanizem — the doses producing significant effects in the clinical

L-Phenylalanine / DLPA

Catecholamine precursor (focus & mood)

L-phenylalanine: 500–1,500 mg/day for mood/cognitive support; DLPA: 375–2,250 mg/day

Neuroinflammation support (preliminary)

100-300 mg/day general use; mast cell protocols often use luteolin 100-200 mg with

Anxiolytic nootropic peptide

RUSSIAN APPROVED (intranasal): 2700 μg/day in 2-3 doses. NOOTROPIC: 250-500 μg/dose,

Autophagy induction (neuroprotection research)

GLUCOSE TOLERANCE: 3.3-10 g/day (Mizote 2017: 10 g; Yoshizane 2020: 3.3 g). PAD pilot:

Coluracetam (BCI-540 / MKC-231)

Choline-uptake nootropic (early research)

BrainCells PHASE IIa: 240 mg/day (80 mg × 3). NOOTROPIC: 5-80 mg per dose, 1-3×/day.

L-Glutamic Acid / Glutamate

Excitatory neurotransmitter (glutamate)

Not typically supplemented; dietary intake substantial (10–20 g/day in typical diet,