Home Ingredients GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)
Gut Health

GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)

Glycyrrhiza glabra
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

GutGard® is a flavonoid-rich licorice (Glycyrrhiza glabra) root extract from Natural Remedies, processed to remove most glycyrrhizin (the compound that can raise blood pressure). This makes it a gentler licorice for digestive use, and it is studied for easing reflux, indigestion, and supporting the stomach lining.

Studied Dose Around 150 mg per day.
Active Compound Glycyrrhiza glabra root extract standardized to licorice flavonoids and largely free of glycyrrhizin.

Benefits

Reflux and indigestion

In a clinical study, GutGard supported relief of gastroesophageal reflux and indigestion symptoms, easing heartburn and upper-digestive discomfort.

Supported by Trial 1

Stomach lining support

Licorice flavonoids support the protective mucus lining of the stomach, helping defend it against irritation.

H. pylori balance

Licorice extracts are studied for discouraging the H. pylori bacteria linked to gastritis and ulcers, supporting a healthier stomach environment.

Mechanism of action

1

Mucosal protection

Licorice flavonoids stimulate protective mucus and support the integrity of the stomach and esophageal lining.

2

Glycyrrhizin removed

Removing glycyrrhizin keeps the digestive benefits while avoiding the blood-pressure and potassium effects of whole licorice.

Clinical trials

1
GutGard and Reflux Symptoms — Clinical Study
PubMed

Clinical study of GutGard in managing gastroesophageal reflux symptoms. (Raj et al. 2025, Complementary Medicine Research)

Adults with reflux symptoms.

GutGard supported relief of reflux and indigestion symptoms with a good safety profile, consistent with its mucosal-protective actions.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — deglycyrrhizinated licorice avoids the blood-pressure effects of whole licorice.
Mild digestive upset is occasionally reported.
Much safer than whole licorice for regular use.

Important Drug interactions

Blood pressure medication — DGL minimizes the usual licorice effect, but monitor if sensitive.
Diuretics — whole licorice affects potassium; DGL much less so.
Tell your doctor if you take medication for reflux or ulcers.

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Frequently asked questions about GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)

What is GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)?

GutGard® is a flavonoid-rich licorice (Glycyrrhiza glabra) root extract from Natural Remedies, processed to remove most glycyrrhizin (the compound that can raise blood pressure). This makes it a gentler licorice for digestive use, and it is studied for easing reflux, indigestion, and supporting the stomach lining.

What is the recommended dosage of GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)?

The clinically studied dose for GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) is Around 150 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) used for?

GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) is studied for reflux and indigestion, stomach lining support, h. pylori balance. In a clinical study, GutGard supported relief of gastroesophageal reflux and indigestion symptoms, easing heartburn and upper-digestive discomfort.

Are there side effects from taking GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — deglycyrrhizinated licorice avoids the blood-pressure effects of whole licorice. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) safe to take?

Whether GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — deglycyrrhizinated licorice avoids the blood-pressure effects of whole licorice. It may also interact with certain medications. GutGard® (Deglycyrrhizinated Licorice — Natural Remedies) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Raj JP, Saxena U, Belhekar MN, et al. Efficacy and Safety of GutGard in Managing Gastroesophageal Reflux Disease. Complement Med Res. 2025;32(1):26-36..PubMedUsed to support: Clinical study supporting reflux symptom relief.