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Top Picks — Gut Health

🦠 Best Gut Health Supplements

Prebiotics, probiotics, and gut barrier ingredients ranked by clinical evidence for microbiome health, IBS relief, and digestive wellness.

174 ingredients reviewed Ranked by clinical evidence
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Top 5 — Ranked by Evidence

Strong
Lactobacillus rhamnosus GG (LGG)
Digestive Support During Antibiotic Use in Children
10–20 billion CFU/day; 5–10 billion CFU/day commonly used in pediatric protocols
Strong
Saccharomyces boulardii
Digestive support during antibiotic use
250–500 mg twice daily (5–10 billion CFU/day); 250 mg three times daily for C. diffic
Very Strong
Psyllium Husk (Plantago ovata)
Supports bowel regularity and softer stools
5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day; ta
Strong
Limosilactobacillus reuteri DSM 17938 (BioGaia Protectis®)
Fewer spit-ups and better gut motility in infants
Infants: 100 million CFU (1×10⁸) once daily as drops (BioGaia Protectis® dosing). Chi
Moderate
Inulin
More Bifidobacteria in the Gut
2–10 g/day for prebiotic/gut microbiome effects; gradual dose increase recommended to

📈 Fastest Growing Gut Health Ingredients

Postbiotic, fiber, and strain-specific ingredients gaining traction with formulators in 2024–2026.

Trending
Moderate
Sunfiber® (Partially Hydrolyzed Guar Gum)
Less bloating and gas
5-6 g/day in the IBS trials; 10 g/day in the type 2 diabetes trial; up to 15 g/day in the…
Trending
Limited
EpiCor® (Postbiotic Yeast Fermentate — Cargill)
Constipation and GI discomfort reduction
500 mg/day.
Trending
Strong
Lactobacillus rhamnosus GG (LGG)
Digestive Support During Antibiotic Use in Children
Children on antibiotics: L. rhamnosus or S. boulardii at 5 to 40 billion CFU/day (Cochrane).…

🔬 Future Gut Health Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Watch
Limited
Akkermansia muciniphila
Gut barrier integrity
10^10 cells/day of the pasteurized form was the amount used in the single human trial. Many…
Watch
Limited
AstraGin® (Astragalus and Notoginseng Saponin Extract)
Intestinal absorption of amino acids from whey protein
50 mg twice daily (100 mg/day) in both supplementation trials; the two acute absorption tests…
Watch
Limited
Arabinoxylan (Arrabina®)
Prebiotic feeding of bifidobacteria
Trials of other arabinoxylans used 15 g/day for 6 weeks (impaired glucose tolerance), 6 or 12…

All Gut Health Ingredients (174)

Strong
Lactobacillus rhamnosus GG (LGG)
Digestive Support During Antibiotic Use in Children
10–20 billion CFU/day; 5–10 billion CFU/day commonly used in pediatric protocols
Strong
Saccharomyces boulardii
Digestive support during antibiotic use
250–500 mg twice daily (5–10 billion CFU/day); 250 mg three times daily for C. diffic
Very Strong
Psyllium Husk (Plantago ovata)
Supports bowel regularity and softer stools
5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day; ta
Strong
Limosilactobacillus reuteri DSM 17938 (BioGaia Protectis®)
Fewer spit-ups and better gut motility in infants
Infants: 100 million CFU (1×10⁸) once daily as drops (BioGaia Protectis® dosing). Chi
Moderate
Inulin
More Bifidobacteria in the Gut
2–10 g/day for prebiotic/gut microbiome effects; gradual dose increase recommended to
Moderate
Probiotics (Multi-strain Blends)
Digestive support during antibiotic courses
1–10 billion CFU/day maintenance; up to 50 billion CFU/day therapeutic
Moderate
Curcumin/Turmeric
Digestive Health Benefits
About 1,000 to 1,500 mg/day of extract in divided doses in knee joint trials; most
Moderate
Lactulose (Synthetic Disaccharide Laxative)
Supports regular bowel movements and softer stool
Prebiotic trials 2-10 g/day; laxative 10-20 g/day, up to 40 g; hepatic encephalopathy
Moderate
Resistant Dextrin (Resistant Maltodextrin)
More regular bowel movements and stool volume
Post-meal glucose and fat tests: 5 to 10 g with a meal. Bowel trials: about 4 to 15
Strong
Bifidobacterium bifidum
Digestive comfort — MIMBb75 studied in IBS with high-quality evidence
IBS (live MIMBb75): 1×10⁹ CFU/day for 4+ weeks; IBS (heat-inactivated MIMBb75 / SYN-H
Moderate
Bifidobacterium animalis subsp. lactis (BB-12 / HN019)
Constipation relief and bowel regularity
1–10 billion CFU/day (BB-12); 17.2 billion CFU/day (HN019 in constipation studies)
Moderate
Fibruline® (Chicory Inulin — Cosucra)
Prebiotic gut support
Commonly 5 to 15 grams per day.
Moderate
Peppermint (Mentha × piperita)
Overall gut comfort and bowel symptoms
180–200 mg enteric-coated peppermint oil 3 times daily (540–600 mg/day) for IBS; pepp
Strong
Escherichia coli Nissle 1917 (Mutaflor®)
Anti-inflammatory gut effects
Ulcerative colitis maintenance: 100 mg twice daily (5×10⁹ CFU/capsule × 2/day) per Mu
Strong
FOS (Fructo-Oligosaccharides)
Selective Bifidobacterium Stimulation (Bifidogenic Effect)
5-15 g/day; gradual introduction (start 2-3 g/day, titrate to tolerance) due to GI fe
Strong
Lactase (β-Galactosidase)
Better digestion of the lactose in a dairy meal
About 3,000 or 6,000 units taken with milk containing 20 g lactose; the EU claim requires at least 4,500 FCC units with each lactose-containing meal.
Strong
Magnesium Citrate
Osmotic laxative and bowel cleansing effect
200–400 mg elemental magnesium/day for general supplementation; 150–300 mL of 1.745 g
Strong
Oliggo-Fiber® Inulin (Chicory Root Fiber — Cargill)
Established Prebiotic Effect
5-10 g/day inulin (typical prebiotic dose; up to 20 g/day with adjustment)
Strong
BarleyTrim® (Barley Beta-Glucan)
Digestive and gut health
About 3 grams of barley beta-glucan per day for cholesterol benefit.
Strong
Glucomannan (Konjac Root Fiber)
Bowel regularity and gut bacteria
About 3 g/day (1 g three times daily before meals) in the cholesterol meta-analysis; always take with a large glass of water.
Moderate
Bacillus coagulans (Weizmannia coagulans)
Abdominal discomfort, bloating and stool form
1 to 2 billion CFU once daily for 4 weeks to 90 days: 2 billion for Unique IS2 and
Moderate
Partially Hydrolyzed Guar Gum (PHGG)
Bowel regularity
5 to 6 g/day in most adult trials (5 g/day in the stool-form, care-home and
Moderate
Kiwifruit (Actinidia deliciosa)
Bowel regularity with two green kiwifruit a day
Whole fruit: 2 green kiwifruit a day (about 200 g flesh) for 4 weeks in bowel trials;
Moderate
Sunfiber® (Partially Hydrolyzed Guar Gum)
Less bloating and gas
5-7 g/day for digestive applications; up to 21 g/day in some clinical trials; pediatr
Moderate
Bacillus clausii (Enterogermina® / Erceflora)
Gut recovery support: shorter loose-stool spells in young children
Standard dose: 2 billion spores (2×10⁹ CFU) 2-3 times daily as oral suspension. AAD p
Moderate
Alpha-Galactosidase
Less gas and bloating after a meal high in raffinose-family sugars (beans, legumes,…
300 or 1,200 GalU with a 420 g cooked-bean meal in healthy volunteers; retail products list 150 to 1,200 GalU per serving.
Moderate
Fibalance® (Partially Hydrolyzed Guar Gum)
Less bloating and gas
5-10 g/day; clinical trials commonly 5-6 g/day
Moderate
GutGard® (Deglycyrrhizinated Licorice — Natural Remedies)
Heartburn and regurgitation
Around 150 mg per day.
Moderate
Menthol
Digestive comfort: abdominal pain and bowel symptoms (peppermint oil)
IBS (enteric-coated peppermint oil): 180-225 mg three times daily; menthol is only one component of peppermint oil, and no cited trial tested isolated menthol.
Moderate
Artichoke Leaf (Cynara scolymus / Cynara cardunculus)
Digestive Comfort and Indigestion
320-1,920 mg/day standardized leaf extract; clinical trials commonly use 600-1,800 mg
Moderate
Asafin® (Asafoetida Gum for Gut Health — Akay Bioactives)
Indigestion symptom scores in a 30-day trial
Per Akay Asafin product specification
Moderate
Digestive Enzyme Blends (DigeZyme® and similar)
Indigestion and stomach comfort after meals
50–150 mg/day DigeZyme® (providing standardized enzyme activity); taken with meals fo
Moderate
EcoGuar® (Partially Hydrolyzed Guar Gum)
Digestive regularity and microbiome
Commonly 5 to 7 grams per day.
Moderate
Gingever® (High-Potency Ginger Extract — OmniActive)
Occasional constipation
280 mg/day Gingever (Eraiah 2024 constipation trial, taken nightly after dinner for 8
Moderate
GOS (Galacto-Oligosaccharides)
Strong Bifidogenic Effect (Infant and Adult)
Cited studies used 5 g a day (calcium absorption) and 15 g a day (prediabetes); products commonly supply 2.5 to 15 g a day.
Moderate
Lactobacillus reuteri
Infant digestive comfort: less crying in breastfed babies (DSM 17938)
10^8 CFU/day (DSM 17938 for infant colic); 2.9×10^9 CFU/day (NCIMB 30242 for choleste
Moderate
LactoSpore® (Heat-Stable Bacillus coagulans MTCC 5856 — Sabinsa)
Bowel comfort, gas and bloating in placebo-controlled trials
1–4 billion CFU/day LactoSpore® Bacillus coagulans; IBS and gut health: 2 billion CFU
Moderate
Pectin (Apple and Citrus Pectin)
Bowel regularity and colonic transit
6 g/day (EU cholesterol claim) up to 15 g/day in cholesterol trials; 10 g with a meal
Limited
Lactobacillus casei
Constipation-related symptoms in women after childbirth
The one cited study used a daily fermented milk drink with L. casei Shirota, not a capsule; labels commonly provide about 1 to 10 billion CFU a day. Higher C. difficile doses involve different strains.
Moderate
Amla (Indian Gooseberry)
Less frequent and milder heartburn and regurgitation in one trial
Reflux symptoms: two 500 mg amla tablets twice daily after meals (2 g a day) for 4
Moderate
Bioferrin® (Lactoferrin — Glanbia)
Gut health in children's lactoferrin trials
100-1000 mg/day lactoferrin (varies by application; immune support typical 100-300 mg
Moderate
Black Seed Oil
Indigestion and fullness after meals
5 mL of oil a day in a honey formulation for 8 weeks, as studied in functional
Moderate
Fibersol® (Digestion-Resistant Maltodextrin — ADM/Matsutani)
Gut bacteria and butyrate fermentation
Commonly 5 to 10 grams per day.
Moderate
Magnesium Oxide
Constipation/Laxative
400–800 mg magnesium oxide/day for supplementation (delivers ~100–250 mg actually abs
Moderate
Resistant Starch
Butyrate production in the colon
GUT/MICROBIOME: 15-30 g/day (1-2 tbsp Hi-Maize® or raw potato starch). T2D METABOLIC:
Moderate
Brox-25® (Bromelain)
Digestive enzyme support
Commonly 200 to 500 mg (or defined enzyme-activity units) per day.
Moderate
GingerWarmer® (Ginger Extract)
Digestive support
Commonly around 1 gram of ginger per day.
Moderate
Ginginoll® (Ginger Extract — Akay)
Digestive support
Commonly around 1 gram of ginger per day.
Moderate
NūGensia™
Gut-barrier support
~10 billion CFU/day
Moderate
Phytase
Digestive comfort is not established
Labels commonly list 500 to 1,500 FTU per serving. In absorption studies, 20 to 320 phytase units per 100 g of flour improved iron absorption, with the enzyme mixed into food rather than a capsule.
Moderate
Prodiet® Lactoferrin (Native Bovine Lactoferrin — Ingredia)
Gut health
Commonly 100 to 200 mg per day.
Limited
Aloe Vera (Aloe barbadensis miller)
Supports digestive comfort
INNER LEAF GEL: 50-300 mL/day juice OR 100-300 mg/day freeze-dried powder (blood suga
Limited
Consolax® (Soluble and Insoluble Fiber Blend — Zeus Hygia)
Bowel regularity
Zeus Hygia suggests 1.8 g twice a day, about 3.6 g of fiber daily. No dose of Consolax itself has been tested; the cited studies used more, 5 g twice daily.
Limited
Dairylytic® (Lactase Enzyme)
Lactose digestion
Taken with dairy meals; dose measured in enzyme activity units (FCC).
Limited
Butyrate (Sodium and Calcium Butyrate)
Bowel habits and abdominal discomfort in adults
300 mg/day sodium butyrate (150 mg twice daily) in common coated products; 600 mg/day
Limited
Limosilactobacillus fermentum (Lactobacillus fermentum)
Digestive comfort during antibiotic therapy (strain MN-LF23)
Strain-specific: 1 x 10^9 to 1.26 x 10^10 CFU/day of VRI-003 (PCC) in athletes; 1 x
Limited
Lactobacillus helveticus (Probiotic Species)
Bowel habits in trials of specific strains and fermented milk
3 to 10 billion CFU/day of R0052 with B. longum R0175; 8 billion CFU/day of R0052 with
Limited
Polydextrose (Soluble Glucose-Polymer Fiber)
Gut bacteria shifts as a prebiotic fiber
Appetite tests used 6.3 to 25 g in a single snack, drink or meal; a body fat trial
Strong
Ginger (Zingiber officinale)
Digestive comfort and stomach emptying
250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/day; an
Limited
Clostridium butyricum MIYAIRI 588 (CBM588 / MIYA-BM® / Butirrisan®)
Butyrate production in the gut
20-80 mg/day MIYA-BM powder (1-4×10⁸ CFU) is the range cited for the Japanese prescription product. No adult dose is established here: the diarrhea study was in children and the cancer trials were supervised.
Limited
PreforPro® (Bacteriophage Blend — Deerland)
Modestly lowers E. coli within the gut microbiota
15 mg/day capsule (about 1 million PFU) for 4 weeks, alone or with 1 billion CFU B.
Limited
Acacia Fiber (inavea™ Pure Acacia)
Gentle prebiotic fiber
Nearly all the human evidence used 30 g/day of gum arabic powder for 6 weeks to 3 months. Mild gas, bloating and rumbling are reported around 40 g/day.
Limited
Akkermansia muciniphila
Gut barrier integrity
Depommier 2019: 10¹⁰ CFU/day pasteurized × 3 months. Most products: 10⁸-10⁹ CFU/day.
Limited
Bifidobacterium infantis 35624 (Align® / Bifantis® / Meta Align®)
Digestive comfort in women: dose-ranging trial
PIVOTAL: 100 million CFU/day (1×10⁸) — narrow window, both 1 million and 10 billion C
Limited
Bifidobacterium longum
Abdominal comfort and bloating (35624 strain)
1–10 billion CFU/day; 1714 strain studies use 1 billion CFU/day for psychobiotic effe
Limited
Bovine Colostrum
Exercise-induced gut permeability
10-20 g/day for 8-12 weeks in most human trials; a smaller set of trials used 0.5-1.0
Limited
ButiShield™ (Encapsulated Butyric Acid for Gut)
Digestive comfort in adults with mild GI symptoms
Per Kemin product specification
Limited
DE111® (Bacillus subtilis Probiotic — ADM Deerland)
Gut bacteria balance in preschool children
Commonly 1 billion CFU per day.
Limited
Enterococcus faecium SF68® (Bioflorin / Cernivet)
Studied in 1,143 people with acute infectious diarrhea
Three times daily for 7 days in acute diarrhea, twice daily for 7 days with antibiotics; the live bacteria count is not stated and no dose is tested for general use.
Limited
L-Glutamine
IBS-D and post-infectious IBS — strongest gut evidence
Gut barrier: 15 g/day (3x5g); permeability studies used more than 30 g/day for under 2 weeks.
Limited
Lactobacillus acidophilus
IBS: no change in abdominal pain, small change in flatus
1–10 billion CFU/day for general use; up to 50 billion CFU/day in IBS or vaginal heal
Limited
Lactobacillus plantarum
Abdominal pain and bloating (strain 299v)
10–50 billion CFU/day; 299v strain typically 20 billion CFU/day; weight management st
Limited
Limonene (D-Limonene)
Occasional heartburn: patent-reported studies
About 10 mg/kg/day (roughly 700 mg for a 70 kg adult) in the inflammation trial; 2 g/day in the breast tissue study; the 1,000 mg heartburn doses come from unpublished patent studies.
Limited
Optibiome® BS50 (Bacillus subtilis MB40 — BIO-CAT Microbials)
Decreased gastrointestinal symptoms in healthy adults
Per BIO-CAT Optibiome BS50 product specification
Limited
Streptococcus thermophilus (Specific Strains)
Lactose digestion improvement
ST81: 3 billion CFU/day. ST36: similar consumer dose. AAD prevention combination with
Limited
Yacon Syrup
Prebiotic fiber for gut bacteria
0.14 g FOS/kg/day (roughly 10 g FOS, or 20 to 25 g of syrup for a 70-kg adult) in the single 120-day trial; the higher 0.29 g FOS/kg/day dose caused digestive side effects.
Strong
Melatonin
Heartburn as an add-on to acid-reducing medicine
Heartburn: 3 mg/day (sublingual, added to omeprazole 20 mg, 4 weeks). Sleep: pooled
Limited
Actazin® (Kiwifruit Extract — Anagenix)
Digestive regularity
About 600 mg to 2.4 g per day, depending on the goal.
Limited
Aminogen® (Protease Enzyme Blend — Deerland)
Improved protein digestion
Labels typically provide 250 to 500 mg with a protein meal; trials used 2.5 g or 5 g of the enzyme blend, and no published trial has tested whether 250 to 500 mg works.
Limited
Asdamarin™
Digestive comfort and transit
250 mg twice daily
Limited
Bacillus subtilis
Bowel regularity and stool consistency
1–10 billion CFU/day; DE111 commonly dosed at 1 billion CFU/day
Limited
Beef Pancreas (Desiccated)
Natural digestive enzyme content
Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef pa
Limited
Cellulase
Reduced bloating and gas from raw vegetables and high-fiber foods
300–1,500 CU per meal; typical multi-enzyme blends contain 500–2,000 CU per dose
Limited
Faecalibacterium prausnitzii (Next-Generation Probiotic)
Gut barrier strengthening
Clinical trial doses: typically 1-10 billion CFU/day in oxygen-protected formulations
Limited
Fibregum™ (Prebiotic Acacia Gum)
Generally Good Digestive Tolerance
Trials used 5, 10, 20, 30 and 40 g/day; about 10 g/day was optimal in the one dose-response study. 30-40 g/day has caused GI symptoms.
Limited
inavea™ BAOBAB ACACIA
Prebiotic Activity in a Laboratory Gut Model
5 g/day (synergistic dose; lower than individual ingredients alone)
Limited
inavea™ CAROB ACACIA
Microbiota Diversity Enhancement
5 g/day (research-validated for microbiome diversity effects)
Limited
MicrobiomeX® (Citrus Flavonoid Extract — BioActor)
Shifts gut fatty acids toward butyrate
500 mg/day (studied 250-500 mg)
Limited
MucoSave® FG (Prickly Pear and Olive Extract — Bionap)
Digestive comfort scores in healthy adults (one trial, 400 mg alone)
6 grams per day of a blend in the one trial; the roughly 200 mg per day figure often quoted is far below the amount actually studied.
Limited
PepZinGI® (Zinc-Carnosine for Gut Lining)
Gut permeability under an NSAID or exercise challenge
75–150 mg/day PepZinGI® (polaprezinc); 75 mg twice daily for gut lining repair; estab
Limited
Prickly Pear Cactus (Opuntia ficus-indica)
Bowel symptom relief with nopal fiber powder
Depends on the plant part: about 300 g cooked nopal pads with a meal; pad fiber 3 g a
Limited
Tolerase® G (AN-PEP Gluten-Digesting Enzyme — DSM)
Breaks down gluten in the stomach
With gluten-containing meals
Limited
Tributyrin (CoreBiome® Butyrate Prodrug)
Colonic butyrate delivery vs free butyrate (laboratory gut simulator, not people)
300 to 1,000 mg/day with meals is the CoreBiome label range; no dose of CoreBiome has been tested for benefit in people.
Limited
Zeolite (Clinoptilolite)
Gut barrier marker shifted in endurance athletes
1-9 g/day in human studies; most often 2 g once to three times daily (up to 6 g/day);
Limited
Activated Charcoal
Intestinal gas reduction (modest evidence)
ACUTE POISONING (medical, supervised): 50-100 g (1-2 g/kg) within 1 hr. MDAC: 25-50 g
Limited
AstraGin® (Astragalus and Notoginseng Saponin Extract)
Intestinal absorption of amino acids from whey protein
50 mg twice daily (100 mg/day) in both supplementation trials; the two acute absorption tests gave 50 mg the night before and 50 mg with the test drink.
Limited
BeneGut® (Perilla Extract — Vital Solutions)
Digestive comfort
Around 150 to 300 mg of extract per day.
Limited
Biotis® GOS (Galacto-Oligosaccharides — FrieslandCampina)
Regularity and stool comfort
Commonly a few grams per day.
Limited
Dietary Nucleotides (Nucleotide Supplements)
Gut comfort ratings in adults with sensitive bowels
Adult trials: 480 mg/day of a free-nucleotide blend for 30 days; 50 mg/day under the
Limited
effera® (Human-Identical Lactoferrin)
Gut bacteria and fecal short-chain fatty acids
No established effera® dose; the cited human trials used bovine lactoferrin at 200 to 600 mg a day, not effera® itself.
Limited
FiberSMART® (Soluble Tapioca Fiber — Anderson)
Fiber and digestive support
The one supporting human study used 6 g a day of maize soluble fiber; finished products list servings as several grams of fiber, which may be more or less than the amount studied.
Limited
GlucoVantage® (Dihydroberberine)
Gut microbiome support
100–200 mg/day before meals; the only human study gave single 100 mg or 200 mg doses, so no trial has established an effective daily dose.
Limited
iXOS® (Xylooligosaccharides Prebiotic)
Microbiome composition shifts, with limited measured health outcomes
1.4 and 2.8 g/day in the bifidobacteria trial, 2 g/day for prediabetes, 4 g/day for type 2 diabetes, 5 g/day and 8 g/day in immune trials; no trial tested the iXOS brand.
Limited
Juniper Berry (Juniperus communis)
Eases bloating, fullness and upper abdominal discomfort
Dried berry tea 2-2.5 g per cup, 2.5-10 g/day (EMA traditional use); juniper berry oil
Limited
KiOtransine® (Chitin-Glucan Prebiotic Fiber — KitoZyme)
Gut microbiome support
Commonly a few grams per day.
Limited
Lactobacillus salivarius (Multi-Strain)
Ls-33 obesity / gut barrier
Oral health (WB21): 2.0×10⁹ CFU/day; periodontal (CP3365): three tablets a day, 4.4 billion cells each, heat-killed. Match strain to indication.
Limited
LBiome™ (Lactobacillus LB Postbiotic — Stratum Nutrition)
Microbiome Modulation
No adult dose is established by the studies cited here; the published trials used the heat-killed preparation in children during an acute illness.
Limited
Lipase
Fat digestion and steatorrhea in diagnosed pancreatic insufficiency
Healthy-adult trials used 280 mg acid-resistant lipase before a fatty meal, or three pancrelipase capsules with a meal. Prescription replacement is 10,000 to 80,000 USP lipase units per meal.
Limited
Odilia™
Gut microbiome composition
300 mg once a day; the single randomized trial used 300 mg a day for 8 weeks, and nothing is known about other doses or longer use.
Limited
GluteAX® (Gluten-Targeting Enzyme — BIO-CAT)
Alpha-gliadin 33-mer peptide digestion
Per BIO-CAT GluteAX product specification
Limited
Optiziome® P3 Hydrolyzer® (Protease Blend — BIO-CAT)
Protein digestion: 14% higher blood EAA, 15% BCAA after whey (one acute trial)
Per BIO-CAT P3 Hydrolyzer product specification
Limited
ResistAid® (Larch Arabinogalactan — Lonza)
Gut Microbiome Modulation
1.5-4.5 g/day ResistAid (research-validated)
Limited
Trpti™ (Bioavailable OEA for Metabolic/Gut Health)
Intestinal barrier marker (occludin) higher at 12 weeks
300 mg/day (delivering 250 mg OEA) as two 150 mg capsules; a 150 mg/day dose is also described, but only in an unpublished, unverified manufacturer study.
Limited
Turkey Tail Mushroom
Gut microbiome support
1–3 g/day PSK extract; 2–9 g/day whole mushroom powder
Limited
VitaFiber® (Isomalto-Oligosaccharide — BioNeutra)
Prebiotic fiber
Used as a fiber and sweetener; a few grams per serving.
Limited
Xanthohumol (Hop Chalcone, Humulus lupulus)
Gut microbiota and bile acid metabolism in healthy adults
24 mg/day for 8 weeks in the two safety trials; single doses of 20 to 180 mg in
Limited
Zinc-L-Carnosine (Polaprezinc)
Gut permeability under an NSAID or exercise challenge
75 mg/day (37.5 mg twice daily) in the NSAID study; 150 mg/day for 4 weeks in the aspirin pilot; 150 or 300 mg/day in the H. pylori trial. Japanese prescription dose 75 mg twice daily.
Strong
Oat Bran (Beta-Glucan)
Bowel regularity in older adults
FDA HEALTH CLAIM: ≥3 g beta-glucan/day (~75 g raw oat bran, ~140 g cooked oatmeal). W
Limited
Arabinoxylan (Arrabina®)
Prebiotic feeding of bifidobacteria
15 g/day for 6 weeks in the impaired-glucose-tolerance trial; 6 to 12 g with a meal in the acute glucose study; 10 g/day AXOS for 3 weeks in the prebiotic study.
Limited
Diamine Oxidase (DAO Enzyme)
Breaks down histamine from food in the gut
Taken right before histamine-rich meals; trials used porcine DAO (about 4.2 mg per
Limited
DPP-IV (Dipeptidyl Peptidase-IV)
Improved digestive comfort in mixed-food sensitivity
500–1,000 DPP-IV units (ALU equivalent) per meal containing potential gluten or casei
Limited
EpiCor® (Postbiotic Yeast Fermentate — Cargill)
Constipation and GI discomfort reduction
500 mg/day EpiCor (research-validated)
Limited
FenuFibers® (Fenugreek Fiber)
Digestive support
Commonly a few grams of fenugreek fiber per day with meals.
Limited
Gastrap® (Chitin-Glucan for Gas and Bloating — KitoZyme)
Gas and bloating relief
Per the product specification.
Limited
Myrrh (Commiphora molmol)
Traditional digestive use; human data only for a myrrh-chamomile-charcoal combination
Supplement 250-500 mg extract 2-3x/day with food; no antiparasitic dose is listed, and a suspected parasitic infection needs diagnosis and prescription treatment from a doctor.
Limited
Prodiet® Colostrum (Bovine Colostrum — Ingredia)
Gut health
Trials used 20 g/day, 25 g/day, or 3.2 g/day of colostrum powder. Ingredia's suggested minimum, about 0.4 to 0.5 g of powder a day, is far below the amounts used in those trials.
Limited
Progestive® (Bacillus coagulans Probiotic — Nutraceuticals International Group)
Bowel comfort in trials of other B. coagulans strains
Commonly billions of CFU per day.
Limited
Protease (Proteolytic Enzymes)
Improved protein digestion in high-protein meals
Digestive: 30,000–60,000 HUT with meals; Systemic anti-inflammatory: Wobenzym® 3 tabl
Limited
SynBalance® (Probiotic Strains — ROELMI)
Gut health
Commonly billions of CFU per day, depending on the strain.
Preliminary
Ox Bile Extract (Bovine Bile)
Supports fat digestion when bile acids run short
One case report: 2 g conjugated bile acids from ox bile per meal; retail capsules
Limited
Bifidobacterium breve
Gut colonization in preterm babies (hospital use only)
INFANT AD (M-16V Morinaga): 1×10⁹ CFU/day × 1 mo. PRETERM (M-16V): 1×10⁹ CFU/day NICU
Moderate
Berberine
Fewer loose stools and less bowel urgency
500 to 1,500 mg per day, split into 2 or 3 doses with meals. Long-term safety at these
Moderate
Lactobacillus plantarum 299v (Lp299v / LP299V®)
Abdominal pain and bloating comfort
PIVOTAL 10¹⁰ CFU/day (10 billion) Axling 2020 athlete 12 wk + Hoekstra 2021 pregnancy
Preliminary
Bacillus licheniformis (Standalone Probiotic)
CDI gut microbiota preservation
Roughly 2-5 x 10^8 CFU per day (hundreds of millions, not billions) of the CMCC63516 strain; the single cited study was in children, so this is not an established adult dose.
Preliminary
Hemicellulase (Plant Fiber Digestive Enzyme)
Digests plant cell-wall fibers humans cannot (laboratory work, not people)
No studied dose; labels list about 200 to 2,000 HCU per serving. Health Canada caps it at 45,000 FCC HCU per day.
Preliminary
Kwd+® (Kiwi Extract for Healthy Digestion)
Protein digestion via actinidin
Supplier-suggested 300 mg a day, or 600 mg before a large meal; no published trial has tested either dose, and the cited studies used whole kiwifruit, not this extract.
Limited
Bifidobacterium adolescentis
GABA production in the gut (laboratory and animal finding)
PRL2019: 20 billion CFU once daily for 12 weeks in a pediatric IBS trial; other strains studied at 1 billion to over 100 billion cells daily.
Limited
Humic Extract
Colonic microbiome modulation (clinical evidence)
Traditional/clinical doses: 100-500 mg/day humic acid extract. No FDA-recognized stan
Limited
Oregano Oil (Origanum vulgare)
Possible Gut Health Support
600 mg/day emulsified oregano oil for enteric parasites; consumer softgels 100-300 mg/day; no dose has been established, and no study has tested dosing beyond six weeks.
Limited
Slippery Elm
IBS Symptoms: Combination Formula Evidence Only, No Placebo Control
No trial has tested slippery elm alone; traditional oral use is 2 to 4 g powdered inner bark in water 3 to 4 times daily, or 400 to 500 mg capsules 3 times daily.
Preliminary
BioEcolians® (Alpha-Glucan Oligosaccharide — Solabia)
Prebiotic fiber that feeds gut bifidobacteria in lab fermentation
8 g/day for eight weeks in the only human study, taken alongside a probiotic; no dose has been shown to work when taken on its own.
Preliminary
ColostrumOne™ (Bovine Colostrum — PanTheryx)
Intestinal barrier support, from colostrum as a class
500 mg to 1 g per serving
Preliminary
Fructan Hydrolase (FODMAP-Targeted)
Breaks down fructans in laboratory digestion models
FODZYME®-style products: 1 sprinkle per serving with FODMAP-containing meals (label-directed use); no dose has been established in a human trial.
Preliminary
NatureKnit® (whole-food fruit & vegetable prebiotic fiber — FutureCeuticals)
Supports a gentle, sustained prebiotic effect
In vitro M-SHIME at ~3.3 g/L product (1.67 g fiber/L); ~2 g typical serving
Limited
Colostrum
Gut Health
10-20 g/day for 8-12 weeks in most human trials; a smaller set of trials used 0.5-1.0
Limited
FenuLife® (Fenugreek Galactomannan Fiber — IFF)
Occasional heartburn comfort
Products typically supply a few grams of fenugreek galactomannan fiber per day with meals. No FenuLife-specific dose-finding trial; the pooled doses were whole-seed preparations.
Limited
Fucoidan (Brown Seaweed Polysaccharide)
Bowel regularity and gut bacteria balance
300 mg/day (vaccine trial); 500 mg to 1 g/day (blood sugar, urinary symptom and
Limited
Gastro-AD® (Fermented Soy Postbiotic — Lallemand)
Occasional heartburn severity and frequency
Per the product specification.
Limited
N-Acetylglucosamine (NAG)
Glycosaminoglycan substrate for the gut barrier
500-1,500 mg/day in joint studies; 3-6 g/day in the bowel disease pilot
Limited
Pancrelipase / Pancreatin
Post-meal bloating and fullness after a high-fat meal in healthy volunteers
OTC pancreatin capsules are labelled at roughly 5,000 to 10,000 USP lipase units each; trials used prescription dosing of 25,000 to 80,000 lipase units per meal under medical supervision.
Limited
Sterculia (Karaya Gum)
Regularity and Colonic Transit Time
ADULT STANDARD: 7-14 g/day (1-2 sachets granules) once or BID with ≥250 mL water. Sri
Preliminary
Amylase
Starch digestion
No cited trial establishes a dose of supplemental amylase for healthy people. Blend labels commonly list 5,000 to 25,000 DU per meal, a typical label amount rather than a tested dose.
Preliminary
DigeSEB® (Digestive Enzyme Blend — Deerland)
Complete-meal digestion
Taken with meals as directed, typically one serving per meal.
Preliminary
Glucoamylase (Amyloglucosidase / γ-Amylase)
CSID starch digestion
No human trial has established a dose; digestive blends usually declare glucoamylase in activity units (AGU) and take it with meals.
Preliminary
Morinaga BB536 (Bifidobacterium longum BB536)
Gut bacteria measures: no change found
46 billion CFU per day for 4 weeks in the single cited trial, which did not show a significant benefit over placebo. Typical labels list 1 to 5 billion CFU per day, far below the amount tested.
Preliminary
Optiziome® Fructanase® (Fructan-Digesting Enzyme — BIO-CAT)
FODMAP digestive support (fructan-specific)
Per BIO-CAT Fructanase product specification
Moderate
Cinaran® (Artichoke Leaf Extract)
Digestive comfort
Commonly 600 mg to 1.8 g of extract per day.
Moderate
Fennel (Foeniculum vulgare)
Bloating and indigestion — traditional carminative
RAHIMIKIAN 2017 menopause: 100 mg fennel oil soft caps BID = 200 mg/day × 8 wk. SEED
Limited
ActivAloe® (Standardized Aloe Vera — Aloecorp)
Digestive comfort
Per the product specification.
Limited
Betaine HCl / Pepsin
Short-term stomach acid support for digestion
Highly variable, typically 1–3 capsules with high-protein meals; clinical 'titration'
Limited
Fenumannan® (Fenugreek Galactomannan Fiber)
Occasional heartburn (studied with FenuLife, not Fenumannan)
An acute satiety trial used 4 g and 8 g of isolated fenugreek fiber, with 8 g working
Limited
Wheatgrass (Young Wheat Leaf)
Gut lining support: one small trial in ulcerative colitis
Fresh juice 60-100 mL/day; tablets of dried powder, 12/day of unstated strength, in
Limited
Wormwood (Artemisia absinthium)
Digestive/Appetite Stimulation (Traditional Use)
OMER 2007 Crohn's herbal blend: 3 × 500 mg/day × 10 wk. Krebs 2010: SedaCrohn® × 6 wk
Preliminary
BiAloe® (Aloe Vera Polysaccharides)
Digestive support
Commonly a few hundred milligrams per day, near the 500 mg per day of a different aloe inner-leaf extract used in the irritable bowel studies.
Preliminary
Bio-Zyme® (Digestive Enzyme Complex)
Digestive support
Taken with meals; dose varies by product. No dose of this blend has been tested in a published clinical trial. Enzyme units differ between brands, so milligram amounts are not comparable.
Preliminary
Biootic® (Probiotic Cultures)
Digestive support
Commonly billions of CFU per day, depending on the strain.
Preliminary
Brewster Probiotics™ (Probiotic Cultures)
Digestive support
Varies by strain and product; commonly billions of CFU per day.
Preliminary
Champex® (Champignon Mushroom Extract — Agaricus bisporus)
Gut environment support
Commonly around 200 to 400 mg per day.
Preliminary
DAOgest® (Porcine Kidney Diamine Oxidase - Bioiberica)
Breaks down histamine from food in the gut
Taken just before histamine-containing meals; consumer products supply roughly
Preliminary
Digesten® (Digestive Enzyme Blend)
Digestive support
Taken with meals; dose varies by product and no dose of this blend has been studied. The cited trials used prescription-strength pancrelipase far beyond what a consumer enzyme capsule provides.
Preliminary
Gevalin® (Bael Fruit for Digestive Health — Zeus Hygia)
Occasional acidity and stomach comfort
Around 250 mg per day.
Preliminary
Lysozyme (Salivary Antimicrobial Enzyme)
Gut barrier and diarrhea studied with lactoferrin in young children
Toothpaste twice daily or lozenge one tablet three times daily, both mouth-only routes
Preliminary
Rējen™ (Fulvic and Humic Acid Trace Minerals — Compound Solutions)
Gut health, energy and metabolism (maker's stated uses)
Not established: Compound Solutions publishes no serving size, and no human study of
Preliminary
Diamine Oxidase (Vegan, Pea-Sprout Derived)
Plant-based way to break down food histamine in the gut
About 1,000,000 HDU (typically one tablet) taken 15-30 minutes before histamine-rich