Home Ingredients Hi-Omega-7® (Palmitoleic Acid Omega-7)
Hair, Skin & Nails

Hi-Omega-7® (Palmitoleic Acid Omega-7)

Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Hi-Omega-7® supplies omega-7 fatty acids, chiefly palmitoleic acid, a monounsaturated fat found in sea buckthorn and macadamia. Omega-7 is studied mainly for supporting skin barrier health, with a clinical trial showing improved skin barrier function, though evidence for metabolic and inflammatory benefits is mixed.

Studied Dose Around 200 to 400 mg of palmitoleic acid per day.
Active Compound Omega-7 fatty acids, primarily palmitoleic acid (a monounsaturated fatty acid).

Benefits

Skin barrier support

In a 12-week randomized controlled trial, oral palmitoleic acid supported improvements in skin barrier function, the basis for omega-7's skin-health positioning.

Supported by Trial 1

Skin hydration and comfort

By reinforcing the skin's lipid barrier, omega-7 supports moisture retention and a smooth, comfortable feel.

Supported by Trial 1

Honest evidence note

Evidence is mixed for other uses: one trial found omega-7 did not significantly reduce inflammatory blood markers, so benefits beyond skin should be viewed cautiously.

Supported by Trial 1

Mechanism of action

1

Skin lipid replenishment

Palmitoleic acid is a natural component of skin lipids; supplementing it helps reinforce the barrier that locks in moisture.

2

Membrane fatty-acid support

As a monounsaturated fatty acid, palmitoleic acid is incorporated into cell membranes and lipid signaling.

Clinical trials

1
Palmitoleic Acid and Skin Barrier — RCT
PubMed

12-week randomized, double-blind, placebo-controlled study of oral palmitoleic acid on skin barrier function. (Koh et al. 2023, Heliyon)

Adults.

Oral palmitoleic acid supported improvements in skin barrier measures versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — fatty acids may have a mild additive effect; monitor.
Generally compatible with a healthy diet.
Tell your doctor if pregnant or breastfeeding.

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Frequently asked questions about Hi-Omega-7® (Palmitoleic Acid Omega-7)

What is Hi-Omega-7® (Palmitoleic Acid Omega-7)?

Hi-Omega-7® supplies omega-7 fatty acids, chiefly palmitoleic acid, a monounsaturated fat found in sea buckthorn and macadamia. Omega-7 is studied mainly for supporting skin barrier health, with a clinical trial showing improved skin barrier function, though evidence for metabolic and inflammatory benefits is mixed.

What is the recommended dosage of Hi-Omega-7® (Palmitoleic Acid Omega-7)?

The clinically studied dose for Hi-Omega-7® (Palmitoleic Acid Omega-7) is Around 200 to 400 mg of palmitoleic acid per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Hi-Omega-7® (Palmitoleic Acid Omega-7) used for?

Hi-Omega-7® (Palmitoleic Acid Omega-7) is studied for skin barrier support, skin hydration and comfort, honest evidence note. In a 12-week randomized controlled trial, oral palmitoleic acid supported improvements in skin barrier function, the basis for omega-7's skin-health positioning.

Are there side effects from taking Hi-Omega-7® (Palmitoleic Acid Omega-7)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Hi-Omega-7® (Palmitoleic Acid Omega-7) safe to take?

Whether Hi-Omega-7® (Palmitoleic Acid Omega-7) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. Hi-Omega-7® (Palmitoleic Acid Omega-7) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Koh YG, Seok J, Park JW, et al. Efficacy and safety of oral palmitoleic acid supplementation for skin barrier improvement: A 12-week, randomized, double-blinded, placebo-controlled study. Heliyon. 2023;9(6):e16711..PubMedUsed to support: RCT supporting skin-barrier benefit of palmitoleic acid (omega-7).