Home Ingredients i-Sabi® (Wasabi Extract — 6-MSITC)
Cognitive

i-Sabi® (Wasabi Extract — 6-MSITC)

Eutrema japonicum
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

i-Sabi® is a standardized wasabi (Eutrema japonicum) extract delivering 6-MSITC, the bioactive isothiocyanate behind wasabi's pungency. Beyond its culinary kick, 6-MSITC is studied for brain health, and a randomized controlled trial found wasabi extract improved memory in healthy older adults.

Studied Dose About 0.8 mg of 6-MSITC (around 100 mg of wasabi extract) per day.
Active Compound Standardized wasabi extract delivering 6-MSITC (6-methylsulfinyl hexyl isothiocyanate).

Benefits

Memory in older adults

In a double-blind randomized controlled trial, wasabi extract with 6-MSITC improved memory functioning in healthy adults aged 60 and older.

Supported by Trial 1

Cognitive support

6-MSITC is studied for supporting cognitive performance, with the strongest signal in age-related memory.

Supported by Trial 1

Antioxidant brain protection

6-MSITC is a potent antioxidant and anti-inflammatory compound that helps protect brain cells from oxidative stress.

Supported by Trial 1

Mechanism of action

1

6-MSITC antioxidant action

6-MSITC activates the body's Nrf2 antioxidant defense system and calms inflammation, protecting neurons involved in memory.

2

Hippocampal support

By reducing oxidative and inflammatory stress, 6-MSITC supports the hippocampus, the brain region central to forming new memories.

Clinical trials

1
Wasabi 6-MSITC and Memory — RCT
PubMed

Double-blinded randomized controlled trial of wasabi supplements with 6-MSITC on memory in healthy adults aged 60 and older. (Nouchi et al. 2023, Nutrients)

Healthy adults aged 60 and older.

Wasabi extract with 6-MSITC improved memory functioning versus placebo.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

No major drug interactions are established for this ingredient.
Tell your doctor about all supplements if you take prescription medication.
Use caution if pregnant, breastfeeding, or managing a health condition.

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Frequently asked questions about i-Sabi® (Wasabi Extract — 6-MSITC)

What is i-Sabi® (Wasabi Extract — 6-MSITC)?

i-Sabi® is a standardized wasabi (Eutrema japonicum) extract delivering 6-MSITC, the bioactive isothiocyanate behind wasabi's pungency. Beyond its culinary kick, 6-MSITC is studied for brain health, and a randomized controlled trial found wasabi extract improved memory in healthy older adults.

What is the recommended dosage of i-Sabi® (Wasabi Extract — 6-MSITC)?

The clinically studied dose for i-Sabi® (Wasabi Extract — 6-MSITC) is About 0.8 mg of 6-MSITC (around 100 mg of wasabi extract) per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is i-Sabi® (Wasabi Extract — 6-MSITC) used for?

i-Sabi® (Wasabi Extract — 6-MSITC) is studied for memory in older adults, cognitive support, antioxidant brain protection. In a double-blind randomized controlled trial, wasabi extract with 6-MSITC improved memory functioning in healthy adults aged 60 and older.

Are there side effects from taking i-Sabi® (Wasabi Extract — 6-MSITC)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is i-Sabi® (Wasabi Extract — 6-MSITC) safe to take?

Whether i-Sabi® (Wasabi Extract — 6-MSITC) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. i-Sabi® (Wasabi Extract — 6-MSITC) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Nouchi R, Kawata NYS, Saito T, et al. Benefits of Wasabi Supplements with 6-MSITC (6-Methylsulfinyl Hexyl Isothiocyanate) on Memory Functioning in Healthy Adults Aged 60 Years and Older: Evidence from a Double-Blinded Randomized Controlled Trial. Nutrients. 2023;15(21). doi: 10.3390/nu15214608..PubMedUsed to support: RCT supporting memory benefit of wasabi 6-MSITC in older adults.