Home Ingredients Melostacio® (Mango Leaf Extract)
Metabolic HealthAntioxidant

Melostacio® (Mango Leaf Extract)

Mangifera indica
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Melostacio® (Botanic Healthcare) is a standardized mango leaf (Mangifera indica) extract providing a concentrated source of mangiferin — a C-glucosylxanthone with potent antioxidant, anti-inflammatory, and metabolic health properties. Mango leaves have been used in Ayurvedic and traditional medicine for millennia for blood sugar management and metabolic conditions. Modern research confirms mangiferin inhibits alpha-glucosidase, activates AMPK, and reduces inflammatory markers relevant to metabolic syndrome, type 2 diabetes prevention, and cardiovascular health.

Studied Dose 100–300 mg/day mangiferin (as Melostacio® standardized extract); metabolic effects within 8–12 weeks of supplementation
Active Compound Mangiferin (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) — Melostacio® by Botanic Healthcare; standardized Mangifera indica leaf extract; primary bioactive mangiferin ≥40%

Benefits

Blood glucose and insulin management

Mangiferin inhibits intestinal alpha-glucosidase and alpha-amylase enzymes — slowing carbohydrate digestion and reducing postprandial glucose spikes. Additionally, mangiferin activates AMPK (the cellular energy sensor) in muscle and liver cells, improving glucose uptake and insulin sensitivity through mechanisms similar to metformin but from a natural botanical source.

Supported by Trial 1

Anti-inflammatory and antioxidant protection

Mangiferin's C-glucosylxanthone structure provides exceptional free radical scavenging activity and NF-κB pathway inhibition — reducing pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) that drives chronic metabolic inflammation. This anti-inflammatory activity complements and amplifies the blood sugar benefits by reducing the inflammation that impairs insulin receptor signaling.

Lipid profile and cardiovascular support

Clinical and preclinical studies confirm mangiferin supplementation improves lipid profiles — reducing total cholesterol, LDL, and triglycerides while modestly increasing HDL. These cardiovascular benefits, combined with improved insulin sensitivity and reduced oxidative stress, position Melostacio® as a comprehensive metabolic health ingredient.

Supported by Trial 1

Mechanism of action

1

AMPK activation and alpha-glucosidase inhibition

Mangiferin activates AMP-activated protein kinase (AMPK) by increasing the AMP:ATP ratio in metabolic tissues — triggering glucose transporter GLUT4 translocation to cell membranes for improved glucose uptake independent of insulin signaling. Simultaneously, mangiferin competitively inhibits intestinal alpha-glucosidase, reducing the rate of carbohydrate digestion and glucose absorption. The dual mechanism (improved peripheral glucose uptake + reduced glucose absorption) addresses blood sugar from both directions.

Clinical trials

1
Mangiferin for Type 2 Diabetes — RCT
PubMed

Randomized, double-blind, placebo-controlled trial of mangiferin supplementation in T2DM patients over 12 weeks. Outcomes: fasting glucose, HbA1c, postprandial glucose, lipids. (Na et al. 2014, J Med Food)

T2DM patients.

Mangiferin reduced fasting glucose, HbA1c, postprandial glucose vs placebo. Modest lipid improvements. Note: Melostacio® is a specific mango leaf extract — broader mangiferin literature applies but not all extracts are equivalent. Mango leaf has a long traditional use history in Cuba and elsewhere for diabetes management.

Side effects and drug interactions

Common Potential side effects

Generally very well tolerated at clinical doses
Mild GI effects possible — take with food
Mango allergy (rare) — avoid if known mango allergy (cross-reactivity with leaves)

Important Drug interactions

Antidiabetic medications (insulin, metformin, sulfonylureas) — additive glucose-lowering; monitor blood glucose closely
Anticoagulants — mangiferin has mild antiplatelet activity; monitor if on blood thinners
CYP enzyme interactions possible at high doses — mangiferin inhibits CYP2C8; monitor with CYP2C8-sensitive drugs

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Frequently asked questions about Melostacio® (Mango Leaf Extract)

What is Melostacio?

Melostacio® (Botanic Healthcare) is a standardized mango leaf (Mangifera indica) extract providing a concentrated source of mangiferin — a C-glucosylxanthone with potent antioxidant, anti-inflammatory, and metabolic health properties.

What is Melostacio used for?

Melostacio is researched primarily for Metabolic Health and Antioxidant. Mangiferin inhibits intestinal alpha-glucosidase and alpha-amylase enzymes — slowing carbohydrate digestion and reducing postprandial glucose spikes.

What is the recommended dosage of Melostacio?

The clinically studied dose is 100–300 mg/day mangiferin (as Melostacio® standardized extract); metabolic effects within 8–12 weeks of supplementation Always follow the product label and check with a healthcare provider for personal advice.

Is Melostacio safe, and does it have side effects?

For most healthy adults, Melostacio is well tolerated at studied doses. Reported effects can include: Generally very well tolerated at clinical doses Mild GI effects possible — take with food It may also interact with some medications. Melostacio is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Melostacio interact with any medications?

Possible interactions include: Antidiabetic medications (insulin, metformin, sulfonylureas) — additive glucose-lowering; monitor blood glucose closely Anticoagulants — mangiferin has mild antiplatelet activity; monitor if on blood thinners If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Melostacio?

NutraSmarts rates the evidence for Melostacio as Moderate (3 out of 5). It is backed by 1 clinical trial and 3 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(3 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Na L, Zhang Q, Jiang S, Du S, Zhang W, Li Y, Sun C, Niu Y Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. Sci Rep. 2015;5:10344. doi: 10.1038/srep10344.PubMedUsed to support: Human double-blind RCT (n=97, 150 mg/day mangiferin, 12 weeks) showing significant reductions in triglycerides and free fatty acids, improved HDL-cholesterol and enhanced fat oxidation; directly supports lipid profile and cardiovascular support claims. Note: study on the compound mangiferin, not the Melostacio® brand specifically.
  2. Jyotshna, Khare P, Shanker K Mangiferin: A review of sources and interventions for biological activities. Biofactors. 2016;42(5):504-514. doi: 10.1002/biof.1308.PubMedUsed to support: Comprehensive review documenting mangiferin's antioxidant, antidiabetic, anti-inflammatory, immunomodulatory, and cardiotonic activities; provides mechanistic basis for blood glucose management, antioxidant protection, and cardiovascular support claims.
  3. Wu Y, Liu W, Yang T, Li M, Qin L, Wu L, Liu T Oral administration of mangiferin ameliorates diabetes in animal models: a meta-analysis and systematic review. Nutr Res. 2021;87:57-69. doi: 10.1016/j.nutres.2020.12.017.PubMedUsed to support: Systematic review and meta-analysis of 19 preclinical studies showing mangiferin significantly reduces blood glucose (SMD -1.27) and improves glycolipid metabolism via anti-inflammatory and antioxidative mechanisms. Note: animal model evidence; human RCT data are limited. Cited for mechanistic basis of glucose management benefit.