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Top Picks — Antioxidant

🛡️ Best Antioxidant Supplements

Polyphenols, vitamins, and free radical scavengers studied for cellular protection, oxidative stress reduction, and aging defense.

232 ingredients reviewed Ranked by clinical evidence
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Top 5 — Ranked by Evidence

Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyrosol
Very Strong
Copper
Antioxidant defense (SOD)
0.9 mg/day (RDA); 1–2 mg/day supplement; upper limit 10 mg/day; use 1 mg copper per 1
Very Strong
Vitamin C
Antioxidant Defense and Glutathione Regeneration
75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip
Very Strong
Zinc
Antioxidant Properties
8–11 mg/day (RDA); therapeutic: 25–40 mg/day elemental zinc; upper limit 40 mg/day; a
Strong
CoEnzyme Q10
Mitochondrial antioxidant — relevant but indirect
Heart failure (Q-SYMBIO): 100 mg 3×/day. Migraine: 100-300 mg/day. Statin myopathy: 1

📈 Fastest Growing Antioxidant Ingredients

Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.

Trending
Very Strong
Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)
Three Macular Carotenoids in Dietary Ratio
Adults: 10mg lutein+2mg zeaxanthin (low) or 20mg+4mg (high) daily. Children: 10mg+2mg gummy.…
Trending
Very Strong
MegaNatural®-BP (Patented Grape Seed Extract — Polyphenolics)
Blood Pressure Within Normal Range — UC Davis Trials
150-300 mg/day MegaNatural-BP (research-validated)
Trending
Strong
Quercefit® (Quercetin Phytosome — Indena)
Antioxidant and Anti-Inflammatory Action
250-500 mg/day Quercefit® (delivering ~100-200 mg quercetin), one or two tablets daily, across…

🔬 Future Antioxidant Ingredients to Watch

Lower current evidence but active research underway — these may become top picks within 2–3 years.

Watch
Strong
R-Lipoic Acid (Natural / Stabilized R-ALA)
Antioxidant Activity (Both Water and Lipid Soluble)
100-300 mg/day R-ALA (equivalent to ~200-600 mg racemic ALA); diabetic neuropathy 600 mg/day…
Watch
Moderate
CyaniMax® (Cyanidin-3-O-Glucoside Anthocyanin — BGG World)
Strongest anthocyanin antioxidant by ORAC
300 mg/day BSHE/C3G (black soybean hull extract) — the dose used in the pivotal eyesight…
Watch
Moderate
GlyNAC (Glycine + N-Acetylcysteine)
Reduced oxidative stress (TBARS -80%)
PIVOTAL: glycine 1.33 mmol/kg/day (~7 g/70 kg) + NAC 0.83 mmol/kg/day (~9.5 g/70 kg) × 16 wk.…

All Antioxidant Ingredients (232)

Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyrosol
Very Strong
Copper
Antioxidant defense (SOD)
0.9 mg/day (RDA); 1–2 mg/day supplement; upper limit 10 mg/day; use 1 mg copper per 1
Very Strong
Vitamin C
Antioxidant Defense and Glutathione Regeneration
75–90 mg/day (RDA); immune/antioxidant: 200–500 mg/day; upper limit 2,000 mg/day; lip
Very Strong
Zinc
Antioxidant Properties
8–11 mg/day (RDA); therapeutic: 25–40 mg/day elemental zinc; upper limit 40 mg/day; a
Strong
CoEnzyme Q10
Mitochondrial antioxidant — relevant but indirect
Heart failure (Q-SYMBIO): 100 mg 3×/day. Migraine: 100-300 mg/day. Statin myopathy: 1
Moderate
Clovinol® (Clove Bud Extract for Metabolic — Akay Bioactives)
6-fold plasma glutathione increase vs synthetic GSH
Per Akay Clovinol product specification
Moderate
Glycyrrhizina (Licorice Flavonoids — BGG)
GABAergic and antioxidant neuroprotection
Per BGG product specification
Strong
Pomella® (Pomegranate Extract — Verdure Sciences)
Antioxidant biomarker enhancement
Standard cardiovascular protocol: 500-1,500 mg/day Pomella® standardized extract. Mos
Strong
Quercefit® (Quercetin Phytosome — Indena)
Antioxidant and Anti-Inflammatory Action
250-500 mg/day Quercefit (research-validated)
Moderate
Saberry® (Amla / Indian Gooseberry — Sabinsa)
Antioxidant and rejuvenative properties
Per Sabinsa product specification (typical 250-500 mg/day)
Strong
Alpha Lipoic Acid
Universal antioxidant
DIABETIC NEUROPATHY: 600 mg/day racemic ALA (SYDNEY 2 + NATHAN 1). T2DM IR: 300 mg/da
Strong
Broccoli Extract (Glucoraphanin)
Antioxidant pathway activation — what's actually happening
Glucoraphanin: 30-100 mg/day with myrosinase. Sulforaphane: 10-50 mg/day. ASD trials:
Strong
Grape Seed Extract (OPC)
Antioxidant protection and LDL oxidation prevention
100–400 mg/day standardized extract (≥95% OPCs); blood pressure: 150–300 mg/day MegaN
Strong
Green Tea
Antioxidant Properties
250–500 mg/day EGCG standardized extract; whole green tea: 3–5 cups/day (≈240–320 mg
Strong
Leucoselect® Phytosome (Grape Seed Phytosome — Indena)
Antioxidant Activity
100-300 mg/day Leucoselect Phytosome (research-validated)
Strong
Mirtoselect® (Standardized Bilberry Extract — Indena)
Antioxidant and oxidative stress reduction
160-320 mg/day Mirtoselect (manufacturer-recommended range). Standard ophthalmology d
Strong
NAC (N-Acetylcysteine)
Antioxidant Support
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver support: 60
Strong
Pine Bark Extract
Antioxidant activity
Standard dose: 100-300 mg/day standardized pine bark extract (≥85% proanthocyanidins)
Strong
C-Fence® (Sustained-Release Vitamin C — Nutriventia)
Antioxidant protection
Commonly providing a standard daily vitamin C dose in one sustained-release serving.
Strong
Curcumin C3 Complex® (Most Studied Curcumin Extract)
Antioxidant and neuroprotective activity
500–1,000 mg/day curcumin C3 Complex® (standardized to 95% curcuminoids); combine wit
Strong
L-OptiZinc® (Zinc Mono-L-Methionine — Lonza)
Antioxidant Defense (Cofactor for SOD)
10-30 mg elemental zinc/day (per L-OptiZinc product specification)
Strong
Manganese
Mitochondrial antioxidant defense via MnSOD
1.8–2.3 mg/day (AI for adults); upper limit 11 mg/day; most multivitamins contain 2–5
Strong
NatAxtin™ (Chilean Astaxanthin — Stratum Nutrition)
Powerful Antioxidant Activity
4-12 mg/day astaxanthin (typical supplemental range)
Strong
Olive Leaf Extract
Antioxidant and anti-inflammatory effects
Standard dose: 500-1,000 mg/day standardized olive leaf extract (containing 20-40% ol
Strong
Pomegranate Extract
Antioxidant capacity
Standard cardiovascular dose: 500-1,500 mg/day pomegranate extract standardized to ≥3
Strong
R-Lipoic Acid (Natural / Stabilized R-ALA)
Antioxidant Activity (Both Water and Lipid Soluble)
100-300 mg/day R-ALA (equivalent to ~200-600 mg racemic ALA); diabetic neuropathy 600
Strong
Selenium
Antioxidant defense
55 mcg/day (RDA); therapeutic studies: 100–200 mcg/day; upper limit 400 mcg/day
Strong
SelenoForce® (Selenium-Enriched Yeast — Sabinsa)
Glutathione peroxidase antioxidant activity
100-200 mcg/day elemental selenium from SelenoForce. RDA: 55 mcg/day; tolerable upper
Strong
Sulforaphane / Glucoraphanin
NRF2 activation (master antioxidant response)
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Strong
Tart Cherry Extract
Antioxidant capacity
Exercise recovery: 480 mg standardized extract or 8-12 oz tart cherry juice 1-2 times
Strong
Ubiqsome® (Coenzyme Q10 Phytosome — Indena)
Antioxidant Activity
100-300 mg/day Ubiqsome (CoQ10 equivalent)
Strong
Vitamin E
Antioxidant protection
15 mg/day (RDA); therapeutic studies use 400–1,000 IU/day
Moderate
Lycopene
Antioxidant activity — strongest mechanistic story
8-21 mg/day food or supplement. CV/prostate: 15-45 mg/day. Bone (LycoRed): 8 mg/day.
Moderate
Terminalia Chebula (Rejuna®)
Exceptional antioxidant capacity and cellular protection
500–1,000 mg/day standardized extract; Rejuna® clinical dose: 500 mg/day; traditional
Moderate
GlyNAC (Glycine + N-Acetylcysteine)
Reduced oxidative stress (TBARS -80%)
PIVOTAL: glycine 1.33 mmol/kg/day (~7 g/70 kg) + NAC 0.83 mmol/kg/day (~9.5 g/70 kg)
Limited
Camu Camu
Superior antioxidant effect vs isolated vitamin C
RCT: 70 mL 100% camu juice daily (~1050 mg vit C) × 7 d. POWDER SUPPLEMENTS: 100-500
Moderate
Aged Black Garlic ABG10+® (Pharmactive)
Antioxidant capacity enhancement
Standard dose: 250-500 mg/day ABG10+® standardized aged black garlic extract. Cardiov
Moderate
Betalains (Beetroot Pigments)
Antioxidant capacity
BEETROOT JUICE: 250-500 mL/day (~5-10 mmol nitrate + 30-100 mg betalains). FREEZE-DRI
Moderate
CyaniMax® (Cyanidin 3-Glucoside — BGG)
Strongest anthocyanin antioxidant by ORAC
Per BGG CyaniMax product specification
Moderate
MitoQ (Mitoquinone)
Reduced mitochondrial oxidative stress (mechanism)
ROSSMAN 2018 VASCULAR: 20 mg/day × 6 wk endothelial function. PD PHASE II: 40-80 mg/d
Moderate
Setria® Glutathione
Increased blood and tissue glutathione levels
250–500 mg/day; 250 mg shown effective for increasing blood glutathione levels
Moderate
Silbinol® (Indian Kino Pterostilbene Extract — Sabinsa)
Antioxidant — exceeds resveratrol
50 mg/day Silbinol® Pterocarpus marsupium extract
Moderate
Taurine
Antioxidant and Anti-inflammatory Effects
500–3,000 mg/day; energy drinks typically contain 1,000 mg; athletic performance: 1–3
Moderate
BioTurmin® (Bioavailable Turmeric)
Antioxidant defense
Commonly 500 to 1000 mg of curcuminoids per day.
Moderate
CitrOlive® (Olive + Citrus for Cardiovascular — Frutarom)
Strong antioxidant + anti-inflammatory activity
Per Frutarom CitrOlive product specification
Moderate
CurcuZen® (Curcumin Extract)
Antioxidant defense
Commonly 500 to 1000 mg of curcuminoids per day.
Moderate
Ferulic Acid
Antioxidant activity in vivo
Hyperlipidemia: 1,000 mg/day × 6 weeks (the best-studied protocol). Asian clinical do
Moderate
Hydrovas® 10
Protects blood lipids from oxidation (EFSA-authorized claim)
50–100 mg/day
Moderate
LingonMax® (Lingonberry Extract — BGG)
ORAC 16,000 — 2× bilberry antioxidant capacity
Per BGG LingonMax product specification
Moderate
Mixed Tocopherols (Naturally Sourced Vitamin E — Cargill)
Antioxidant Activity
Varies by application; antioxidant supplementation typical 100-400 IU vitamin E
Moderate
Moringa
Antioxidant and anti-inflammatory
2–7 g/day leaf powder; clinical studies typically use 6–8 g/day
Moderate
Opextan® (Olive Fruit Extract — Indena)
Wrinkle prevention (oxidative damage)
Per Indena product specification
Moderate
Quercetin
Antioxidant Protection
500–1,000 mg/day; absorption enhanced significantly with vitamin C or bromelain; quer
Moderate
Sesamin
Antioxidant capacity enhancement (vitamin E sparing)
BP: 60 mg/day × 4 wk hypertensive. LIPID: 200-247 mg/day (Wu 2006: 50 g/d seed). 20-H
Moderate
VinCare® (Whole Grape Extract — Ethical Naturals)
Antioxidant defense
About 350 mg per day.
Moderate
Amla / Indian Gooseberry (Capros®)
Exceptional antioxidant capacity and vitamin C delivery
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day; vita
Moderate
Amlaac® (Amla / Indian Gooseberry Extract)
Antioxidant defense
Commonly around 500 mg to 1 g per day.
Moderate
AroniaPURE® (Chokeberry Powder)
Antioxidant defense
Commonly around 300 mg to 2 g of aronia per day.
Moderate
Asta-Marine® (Marine Astaxanthin)
Antioxidant power
Commonly 4 to 12 mg of astaxanthin per day.
Moderate
AstaBead® (Astaxanthin Beadlet)
Antioxidant power
Commonly 4 to 12 mg of astaxanthin per day.
Moderate
AstaReal® Astaxanthin
Antioxidant power
Commonly 4 to 12 mg of astaxanthin per day.
Moderate
AstaSana™ (Natural Astaxanthin)
Antioxidant power
Commonly 4 to 12 mg of astaxanthin per day.
Moderate
Bakuchi (Bakuchiol)
Antioxidant and anti-inflammatory mechanisms
TOPICAL: 0.5-1.0% bakuchiol cream 1-2×/day (Dhaliwal 2019: 0.5% × 12 wk = retinol-equ
Moderate
Baobab Fruit Powder (Adansonia digitata)
Antioxidant Activity
5-15 g/day baobab fruit powder; provides ~2-7 g soluble fiber per 10 g serving
Moderate
Berkemyol® (Olive Leaf Extract — Berkem)
Antioxidant defense
Commonly 250 to 1000 mg of olive extract per day.
Moderate
Bilberon® (Standardized Bilberry Extract)
Antioxidant eye protection
Commonly 160 mg of standardized extract per day.
Moderate
Bilberry (Vaccinium myrtillus)
Antioxidant protection and anti-inflammatory activity
80–480 mg/day standardized extract (25% anthocyanosides = 20–120 mg anthocyanins); ey
Moderate
Chlorogenic Acid
Antioxidant activity in the body
BP: 140 mg/day green coffee bean × 4 wk. WEIGHT: 500 mg/day GBCE ≥30% CGA → -1.30 kg
Moderate
CocoaGanic® (Organic Cocoa Flavanols)
Antioxidant defense
Commonly providing a few hundred milligrams of cocoa flavanols per day.
Moderate
CocoaNol® (Cocoa Flavanol Extract)
Antioxidant defense
Commonly providing a few hundred milligrams of cocoa flavanols per day.
Moderate
Coffee Fruit Extract (CoffeeFruit Pure™)
Antioxidant and neuroprotection
100–200 mg/day whole coffee fruit concentrate; NeuroFactor™ clinical dose: 100 mg/day
Moderate
Cordiart® (Tomato Nutrient Complex)
Antioxidant defense
Providing about 15 to 30 mg of lycopene per day.
Moderate
Cranberry
Antioxidant Properties
400–500 mg/day standardized extract (PAC 36 mg); for UTI prevention: daily long-term;
Moderate
Curcumin/Turmeric
Antioxidant Protection
RAW POWDER: 500-2000 mg/day = 60-100 mg curcumin. STANDARDIZED 95% curcuminoids: 400-
Moderate
Ecklonia Cava (Brown Seaweed Polyphenol)
Superior antioxidant activity — unique marine polyphenols
400–800 mg/day Ecklonia cava extract standardized for phlorotannins; clinical studies
Moderate
Elderberry
Antioxidant protection
600–900 mg extract/day during illness; 150–300 mg/day for prevention
Moderate
EnduBerry™ Nu
Anthocyanin antioxidant support during exercise
Anthocyanin-rich serving before exercise
Moderate
Ergothioneine (ErgoActive®)
Exceptional cellular antioxidant protection
5–30 mg/day; most human studies use 5–20 mg/day; dietary intake from mushrooms typica
Moderate
Eriocitrin / Eriomin® (Lemon Flavonoid)
Antioxidant and anti-inflammatory activity
200–400 mg/day Eriomin® standardized extract; blood sugar: 200 mg/day; uric acid: 200
Moderate
EVNol® (Palm Tocotrienol Complex — ExcelVite)
Antioxidant protection
Commonly 200 to 400 mg of mixed tocotrienols per day.
Moderate
Eye-Pro MD® (Lutein, Zeaxanthin and Meso-Zeaxanthin)
Antioxidant protection
Commonly 10 mg lutein with zeaxanthin and meso-zeaxanthin per day.
Moderate
EyeMuse® (Lutein and Zeaxanthin for Vision)
Antioxidant protection
Commonly 10 to 20 mg lutein with 2 to 4 mg zeaxanthin per day.
Moderate
Idebenone
Topical antioxidant in cosmetic skincare
LHON (Raxone® EMA-approved): 900 mg/day in 3 divided doses (150 mg × 2 caps × 3/day).
Moderate
Lutemax® Free Lutein (Marigold Lutein)
Antioxidant protection
Commonly 10 to 20 mg lutein with 2 to 4 mg zeaxanthin per day.
Moderate
Lutemax® Lutein Esters (Marigold Lutein Esters)
Antioxidant protection
Commonly 10 to 20 mg lutein with 2 to 4 mg zeaxanthin per day.
Moderate
Melostacio® (Mango Leaf Extract)
Anti-inflammatory and antioxidant protection
100–300 mg/day mangiferin (as Melostacio® standardized extract); metabolic effects wi
Moderate
Milk Thistle
Antioxidant Properties
The efficacy of these mechanisms depends on silymarin content (standardized extracts
Moderate
Morosil® (Moro Red Orange Extract)
Anthocyanin antioxidant content
PIVOTAL DOSE: 400 mg/day Morosil® dry extract. CARDILE 2015: × 12 wk. BRISKEY 2022: ×
Moderate
MSM (Methylsulfonylmethane)
Antioxidant glutathione synthesis
Standard dose: 1.5-3 g/day, often split as 1 g twice daily. Joint applications: 3-6 g
Moderate
MyrtiPRO® (Premium Bilberry Extract — BGG)
Antioxidant Defense
160-320 mg/day MyrtiPRO (research-validated dose)
Moderate
Oceanix™ (Marine Phytoplankton — Lonza)
Indirect antioxidant via SOD enhancement
Per Lonza product specification (typically 25 mg/day Oceanix)
Moderate
Oli-Ola® (Olive Fruit Extract)
Antioxidant defense
Commonly 250 to 1000 mg of olive extract per day.
Moderate
Olivactive® (Olive Leaf Extract for Immune Support)
Antioxidant phenolic content
Per Pharmactive product specification
Moderate
OptiLut® (Lutein and Zeaxanthin)
Antioxidant protection
Commonly 10 to 20 mg lutein with 2 to 4 mg zeaxanthin per day.
Moderate
P40p™ (Pomegranate Extract — PLT Health)
Antioxidant defense
Per the product specification.
Moderate
Polypodium Leucotomos
Antioxidant Support
Typically dosed at 240–480 mg/day
Moderate
PurTea® (Organic Green Tea Caffeine — Applied Food Sciences)
Antioxidant support
Commonly 100 to 200 mg of caffeine per serving.
Moderate
Reishi Mushroom
Antioxidant protection
1.5–9 g/day whole mushroom powder; 1–1.5 g/day standardized extract
Moderate
Schisandra Chinensis (Five-Flavor Berry)
Antioxidant and Anti-Inflammatory
500-2,000 mg/day extract (standardized to schisandrin content); berry powder 1-6 g/da
Moderate
Sea Buckthorn (Hippophae rhamnoides)
Vitamin C and Antioxidant Source
1-3 g/day sea buckthorn oil (berry pulp or seed oil); berry powder 5-10 g/day; vitami
Moderate
SelectSIEVE® Apple PCQ (Apple Polyphenols)
Antioxidant defense
Around 300 mg of apple polyphenols per day in studies.
Moderate
SelectSIEVE® Olive (Olive Polyphenols — Bionap)
Antioxidant defense
Commonly 250 to 1000 mg of olive extract per day.
Moderate
SOD B Dimpless® (Melon Superoxide Dismutase)
Antioxidant defense
Around 10 mg (about 140 IU of SOD) per day.
Moderate
Spirulina
Antioxidant and anti-inflammatory
1–8 g/day; most clinical trials use 2–4 g/day
Moderate
Squalene
Antioxidant/singlet oxygen quenching (mechanistic)
CV: 860 mg/day × 20 wk hypercholesterolemia. STRANDBERG 1990: 900 mg/day. PK: 500 mg
Moderate
Terminalia Arjuna (Oxyjun®)
Exercise-induced oxidative stress reduction
500 mg/day Oxyjun®; traditional cardiac use: 1–3 g/day bark powder; effects on cardio
Moderate
Tocotrienols (Vitamin E Family)
Antioxidant Activity (Distinct from Tocopherols)
100-400 mg/day total tocotrienols; for cholesterol/CV: 200-300 mg gamma+delta tocotri
Moderate
Tremella fuciformis (Snow Mushroom / Silver Ear Fungus)
Polysaccharide antioxidant + immunomodulation
TOPICAL: snow mushroom extract 1-2× daily. ORAL: 1-3 g dried fruiting body or 500-1,0
Moderate
Turkey Tail Mushroom
Antioxidant protection
1–3 g/day PSK extract; 2–9 g/day whole mushroom powder
Moderate
Vitaflavan® (Grape Seed Extract)
Antioxidant defense
Commonly 100 to 300 mg per day.
Moderate
Yerba Mate (Ilex paraguariensis)
Antioxidant and Lipid Effects
1-3 g dried leaves per day (typical traditional consumption); 500-2,000 mg/day standa
Moderate
Zanthin® (Natural Astaxanthin)
Antioxidant power
Commonly 4 to 12 mg of astaxanthin per day.
Moderate
Zeaxanthin
Antioxidant Properties
2–10 mg/day; AREDS2 formula uses 2 mg zeaxanthin + 10 mg lutein; combined lutein/zeax
Limited
L-Cysteine
Glutathione Precursor
500–1,500 mg/day for hair/skin support; for glutathione support, NAC (600–1,200 mg/da
Limited
Acai Berry
Exceptional antioxidant capacity
100–200 g fresh pulp/day (the dose used in the Udani 2011 metabolic pilot was 200 g/d
Limited
MitoGreens® (Mitochondrial Greens Complex)
High ORAC antioxidant power
Per product label serving size; typical greens blend 3–8g/day; specific MitoGreens® d
Limited
MitoReds™ (Mitochondrial Reds Complex)
Best-in-class reds antioxidant power
Per product label; typical reds blend 3–6g/day; specific MitoReds™ dosing per NNB pro
Strong
Beta-Carotene
Antioxidant and free radical scavenging
DIETARY: 1.8-2.4 mg/day average. WHOLE-FOOD MIXED CAROTENOIDS: safe. SYNTHETIC TRIAL
Limited
Burdock Root (Arctium lappa)
Antioxidant Status Improvement
MAGHSOUMI-NOROUZABAD 2016 OA: 3 cups burdock tea daily (each 2 g root in 150 mL boile
Limited
CompleteGreens™ (Comprehensive Greens Base)
MitoPrime ergothioneine antioxidant power
3–8g/day comprehensive greens blend; specific CompleteGreens™ dosing per NNB product
Limited
CyanthOx™ (Sea Buckthorn Proanthocyanidin Extract)
Antioxidant capacity (ORAC and cellular)
Drapeau 2019 acute trial: 500 mg CyanthOx™30 (~150 mg sea buckthorn proanthocyanidins
Limited
ActiVin® (Grape Seed Proanthocyanidin Extract)
Antioxidant defense
Commonly 50 to 300 mg per day.
Limited
Curcumin C3 Reduct® (Tetrahydrocurcuminoids — Sabinsa)
Antioxidant defense
Commonly around 150 to 600 mg per day.
Limited
FitGrape® (Grape Polyphenol Extract)
Antioxidant defense
Commonly 100 to 300 mg per day.
Limited
Glabridin (Licorice Isoflavone)
LDL oxidation reduction (6-month trial)
LDL oxidation: 250 mg/day for 6 months. Type 2 diabetes and metabolic syndrome: 300 m
Limited
Kaempferol
Antioxidant Activity
NO STANDARDIZED CLINICAL DOSE. DIETARY: 5-10 mg/day Western, up to 50+ mg/day high-ve
Limited
Natavid® (Whole Grapevine Extract — Natac)
Antioxidant defense
Per the product specification.
Limited
NeuGrape® (Grape Seed Extract for Cognition)
Antioxidant defense
Commonly 100 to 300 mg per day.
Limited
AcaiVida® (Açaí Berry Extract)
Antioxidant defense
Commonly around 1 to 2 g of açaí preparation per day.
Limited
ActriSave™
Antioxidant support for skin and scalp
250 mg/day, 4.5–5.5% anthocyanins
Limited
Alliàge™
Antioxidant support
200 mg/day
Limited
AllOlive® (Full-Spectrum Olive Extract — Natac)
Antioxidant defense
Commonly around 250 to 500 mg of the extract per day.
Limited
Apfenol® (Apple Polyphenol Extract — ECA Healthcare)
Antioxidant defense
Commonly a few hundred milligrams of apple polyphenols per day.
Limited
ApPhenols® (Apple Polyphenols)
Antioxidant defense
Commonly a few hundred milligrams of apple polyphenols per day.
Limited
AppleActiv® (Dried Apple Peel Polyphenols — Leahy Orchards)
Antioxidant support
Commonly a few hundred milligrams of apple peel polyphenols per day.
Limited
Astrion® (NuLiv Science Beauty-From-Within)
Skin antioxidant protection
Per Astrion® product specifications; NuLiv Science beauty-from-within dosing data
Limited
Brainberry® (Aronia melanocarpa Extract)
Antioxidant + anti-inflammatory CNS effects
: 90 mg or 150 mg AME daily × 24 wk middle-aged adults. CROSSOVER: 160 mg/day older a
Limited
BroccoRaphanin® (Broccoli Seed Glucoraphanin)
Antioxidant defense
Commonly providing tens of milligrams of glucoraphanin per day.
Limited
CaroCare® (Natural Beta-Carotene — DSM)
Antioxidant defense
Commonly providing a few milligrams of beta-carotene per day.
Limited
Carotex® (Natural Beta-Carotene and Carotenoids — Zeus Hygia)
Vitamin A and antioxidant support
Commonly providing a few milligrams of carotenoids per day.
Limited
Cosmythic® (Maritime Pine Bark for Skin — Purextract)
Antioxidant defense
Commonly around 50 to 100 mg per day.
Limited
Dandelion Root
Antioxidant protection
2–8 g/day dried root; 250–500 mg standardized extract three times daily
Limited
elaVida® (Olive Hydroxytyrosol — DSM)
Antioxidant defense
About 5 mg of hydroxytyrosol per day (the level in 20 g of extra virgin olive oil).
Limited
EllagiRush® (Pomegranate Extract — Arjuna)
Antioxidant defense
Commonly a few hundred milligrams of pomegranate polyphenols per day.
Limited
EVSpectra® (Red Palm Oil Concentrate — ExcelVite)
Vitamin A and antioxidant support
Commonly providing several milligrams of carotenoids per day.
Limited
FenuKale™ Nu
Nrf2-pathway antioxidant / pollution-detox support
350 mg/day for 56 days
Limited
Fisetin
Antioxidant Activity
100-1,500 mg/day (continuous) for general antioxidant; HIT PROTOCOL: 20 mg/kg body we
Limited
HTEssence® (Hydroxytyrosol — Wacker)
Antioxidant defense
Commonly 5 to 25 mg of hydroxytyrosol per day.
Limited
Luravida® (Cranberry Omega-3 Oil — AHD International)
Antioxidant Activity
Per AHD Luravida product specification (typical 1-3 g/day)
Limited
Masquelier's® French Pine Bark (OPCs)
Antioxidant defense
Commonly 100 to 200 mg per day.
Limited
Masquelier's® Original OPCs
Antioxidant defense
Commonly 100 to 200 mg per day.
Limited
Melagenol® (Oral Skin-Tone Botanical)
Antioxidant skin support
Per the product specification.
Limited
MintyBright™ Nu
Antioxidant defense support
150 mg/day for 12 weeks
Limited
Naringenin
Antioxidant Activity
150-500 mg/day; emerging supplement category; standardized doses not yet well-establi
Limited
Phytofare® (Bioavailable Green Tea Catechin Complex — Plandaí)
Antioxidant defense
A standardized daily dose of bioavailable catechins.
Limited
PhytoPin® (French Maritime Pine Bark Extract)
Antioxidant defense
Commonly 100 to 200 mg per day.
Limited
Pterostilbene
Anti-Inflammatory / Antioxidant
50-250 mg/day; trial used 125 mg twice daily (250 mg/day total)
Limited
Resvinol® (Trans-Resveratrol)
Antioxidant defense
Commonly 150 to 500 mg of trans-resveratrol per day.
Limited
TruFulvic® (Fulvic Acid from Shilajit — Natreon)
Antioxidant support
Commonly around 250 to 500 mg per day.
Limited
Xanthigen® (Fucoxanthin + Pomegranate Seed Oil)
Pomegranate seed oil punicic acid antioxidants
PIVOTAL: 600 mg Xanthigen®/day × 16 weeks (300 mg PSO + 300 mg brown seaweed extract
Limited
ZinjaBurn® (Dehydrozingerone)
Antioxidant activity
100–300 mg/day dehydrozingerone; NNB ZinjaBurn® formulation dose per product label; e
Limited
α-Lacys Reset® (Alpha-Lipoic Acid and Cysteine Complex — Nutraceutics)
Antioxidant and redox support
Used at a low daily dose within finished formulas (for example, about 25 mg).
Limited
Pelargonidin
Antioxidant via metabolite effects
DIETARY: ~30-50 mg glycosides per 150 g strawberries. STRAWBERRY RCTs: 250-500 g fres
Moderate
Aronia / Chokeberry (Aronia melanocarpa)
Antioxidant Capacity
STANDARDIZED EXTRACT: 100-300 mg/day (25-50 mg anthocyanins) OR juice 200-300 mL/day
Limited
Acerola Cherry
Antioxidant and free-radical scavenging
UCHIDA 2011 BIOAVAILABILITY: 50 mg vit C from acerola juice. COMMERCIAL: 100-500 mg p
Limited
Chaga Mushroom (Inonotus obliquus)
Antioxidant Activity
500-2,000 mg/day extract; standardized to beta-glucan content (typically 30%+); tradi
Limited
Myricetin
Antioxidant and anti-inflammatory
DIETARY: 1-4 mg/day (walnuts, cranberries, blueberries, red wine, tea). SUPPLEMENT: 1
Preliminary
Noni (Morinda citrifolia)
Antioxidant activity
30–750 mL/day noni juice; most studies use 29–118 mL (1–4 oz) daily; freeze-dried pow
Moderate
EGCG (Epigallocatechin Gallate)
Antioxidant Activity
200-400 mg/day general use; 400-800 mg/day weight management trials; CRITICAL — EFSA
Limited
Apigenin
Anti-Inflammatory / Antioxidant
50-100 mg/day common in longevity stacks (Bryan Johnson protocol uses 50 mg/day); cha
Limited
Humic Extract
Antioxidant activity (preclinical)
Traditional/clinical doses: 100-500 mg/day humic acid extract. No FDA-recognized stan
Limited
Theaflavins
Antioxidant Activity
MARON 2003: 375 mg/day theaflavin-enriched green tea (75 mg theaflavins + 150 mg cate
Preliminary
Alluvia® (Purple Tea Extract — Maypro)
Antioxidant defense
Commonly around 100 to 400 mg per day.
Preliminary
AuroraBlue® (Wild Alaskan Blueberry Complex)
Antioxidant support
Commonly a few hundred milligrams of the berry complex per day.
Preliminary
AuroraGreen® (Wild Alaska Dandelion — Denali BioTechnologies)
Antioxidant support
Per the product specification.
Preliminary
BerryPlus™ (Mixed Berry Antioxidant Blend — AuNutra)
Antioxidant support
Per the product specification.
Preliminary
ChloroBlast® (Alfalfa Chloroplast Concentrate — Ingredients by Nature)
Antioxidant content
Per the product specification.
Preliminary
Chrysin (5,7-Dihydroxyflavone)
Anti-inflammatory and antioxidant (mechanistic)
CRITICAL: poor oral bioavailability (<1%) — most marketed doses mechanistically irrel
Preliminary
OxiCyan® (Bilberry and Spirulina Antioxidant Complex — Biosfered)
Antioxidant defense
Commonly a few hundred milligrams per day.
Very Limited
PhytoCellTec™ Md Nu
Apple polyphenol antioxidant background
Low daily serving
Very Strong
AstaZine® (Natural Astaxanthin from Haematococcus pluvialis — BGG)
Visual Function for Digital Screen Users (VDT)
4-12 mg/day AstaZine (research-validated; some applications 12-24 mg)
Very Strong
DeltaGold® (Annatto Tocotrienols — American River Nutrition)
Type 2 Diabetes Glycemic Control (24-Week RCT)
125-300 mg/day DeltaGold (250 mg in T2DM trial)
Very Strong
Lutemax® 2020 (Lutein + Both Zeaxanthins — OmniActive)
Three Macular Carotenoids in Dietary Ratio
20 mg lutein + 4 mg total zeaxanthins daily (Lutemax 2020 standard dose)
Very Strong
MegaNatural®-BP (Patented Grape Seed Extract — Polyphenolics)
Blood Pressure Within Normal Range — UC Davis Trials
150-300 mg/day MegaNatural-BP (research-validated)
Very Strong
Pycnogenol® (French Maritime Pine Bark)
Blood pressure — modest effect, mostly in hypertensives
50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic perfor
Very Strong
Vitamin A
Childhood Mortality Reduction in Deficient Populations
700–900 mcg RAE/day (adults); upper limit 3,000 mcg RAE/day
Strong
ApplePhenon® (Apple Polyphenol Extract — BGG)
Visceral fat reduction (94-subject RCT)
600 mg/day ApplePhenon over 8-12 weeks (the dose used in both BGG-funded RCTs). Lower
Strong
BioPerine® (Black Pepper Extract — Sabinsa)
Documented curcumin bioavailability enhancement
Standard formulation use: 5-10 mg BioPerine® per dose alongside compounds requiring a
Strong
Black Seed Oil
Blood pressure reduction
Standard cardiometabolic dose: 500-2,000 mg/day cold-pressed black seed oil. Higher-d
Strong
Greenselect® Phytosome (Decaffeinated Green Tea Catechin Phytosome — Indena)
Weight loss with hypocaloric diet (Di Pierro 2009)
300 mg/day Greenselect Phytosome, split as 150 mg twice daily (one dose before lunch,
Strong
Kyolic® (Aged Garlic Extract — Wakunaga)
Blood pressure reduction (extensive trial evidence)
Standard cardiovascular protocol: 1,200-2,400 mg/day Kyolic® in divided doses. Differ
Strong
Lutein
AMD progression — strong evidence in intermediate AMD
6–20 mg/day; AREDS2: 10 mg/day lutein + 2 mg zeaxanthin; eye health: 10–20 mg/day wit
Strong
Mitopure® (Urolithin A — Amazentis)
Essentially the only validated commercial urolithin A
Standard clinical dose: 500-1,000 mg/day Mitopure®. Most clinical trials use 500-1,00
Strong
Neumentix® (Spearmint Extract — Kemin)
Working memory in older adults
Standard cognitive protocol: 900 mg/day Neumentix® (typically 600 mg morning + 300 mg
Strong
Niagen® (Nicotinamide Riboside — ChromaDex)
Foundational blood NAD+ elevation evidence
Clinical trial doses: 250-1,000 mg/day Niagen®. Most studies use 300-600 mg/day. Take
Strong
Restoridyn® (Tart Cherry Extract — Anthocyte)
Documented exercise recovery effects
Standard exercise recovery protocol: 480 mg Restoridyn® 1-2 times daily for 4-7 days
Strong
Selenium Yeast (High-Selenium Yeast)
Used in Major Cancer Trials
100-200 µg elemental selenium/day; SELECT used 200 µg/day; NPC trial used 200 µg/day
Strong
Selenomethionine
Hashimoto's Thyroiditis Adjunct
100-200 µg elemental selenium/day; Hashimoto's trials typically 200 µg/day
Strong
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
Cardiovascular biomarker improvements
Standard formulation use: 30-150 mg Truebroc® daily (providing 4-20 mg glucoraphanin)
Strong
TurmiPure Gold® (Bioavailable Turmeric — Naturex)
24× Bioavailability vs Standard Turmeric
Per Naturex/Givaudan TurmiPure Gold product specification
Strong
Ubiquinol (Reduced CoQ10)
Heart Failure Adjunct (Q-SYMBIO Trial)
100-300 mg/day for general use; 200-400 mg/day for heart failure adjunct; 100-200 mg/
Strong
VeriSperse® (Stabilized Astaxanthin)
Skin Health (UV Protection, Skin Quality)
4-12 mg/day astaxanthin; VeriSperse format provides improved bioavailability
Moderate
Agaricus blazei Murill (AbM / Himematsutake / Royal Sun Mushroom)
Multiple myeloma chemotherapy immunomodulation
ANDOSAN™ ORAL: 60 mL/day liquid extract × 7 weeks (multiple myeloma protocol). NSCLC
Moderate
Antrodia cinnamomea (Niu-Chang-Chih / Stout Camphor Fungus)
NASH 6-month RCT
NASH RCT: 3 capsules/day = 420 mg ACM × 6 months (n=28). SUBHEALTH ALT RCT: 250 mg AC
Moderate
Astaxanthin
Eye health and visual function
4–12 mg/day from Haematococcus pluvialis extract; skin: 4–6 mg/day; exercise recovery
Moderate
Chlorophyll / Chlorophyllin
Reduction of aflatoxin-DNA adducts (high-risk populations)
AFLATOXIN PROTECTION: 100 mg sodium copper chlorophyllin 3×/day (300 mg/day total). D
Moderate
CocoaVia® (Mars Edge Cocoa Flavanol Extract)
Cardiovascular death reduction
Standard dose: 500-750 mg cocoa flavanols daily (1-2 CocoaVia® servings). COSMOS tria
Moderate
Ellagic Acid
Metabolic syndrome — multiple markers improve together
METABOLIC SYNDROME (Hidalgo-Lozada 2022): 500 mg BID = 1000 mg/day pomegranate 90% EA
Moderate
GOPO® Rosehip (Hyben Vital — Rosa canina)
Hip and knee osteoarthritis pain relief
5 g/day rosehip powder (typically split as 2.5 g twice daily). Onset of pain relief:
Moderate
Limonene (D-Limonene)
GERD/heartburn symptom relief (open trials)
GERD (Wilkins 2002 + Sun 2007): 1000 mg orally daily or QOD. CANCER PHASE I/II: 0.5-1
Moderate
Maplifa® (Red Maple Leaf Skin Extract — Verdure Sciences)
Photoaging clinical trial — NCT04586816
50-100 mg/day Maplifa® standardized red maple leaf skin extract
Moderate
Molecular Hydrogen (H2)
Metabolic syndrome improvement (pivotal)
HRW: 1.5-7 ppm H2 in water, 0.5-2 L/day. LeBaron 2020 high-conc: ~7 ppm × 24 wk metab
Moderate
Nutroxsun® (Rosemary + Grapefruit Skin Protection)
Internal UV photoprotection
250 mg/day Nutroxsun®; take 1–2 hours before anticipated UV exposure for best photopr
Moderate
Oligonol® (Lychee + Green Tea Polyphenol — Amino Up)
Visceral fat reduction (10-week trial)
Visceral fat protocol: 200 mg/day Oligonol® (50 mg twice daily) for 10 weeks. Periphe
Moderate
OmniXan® (Zeaxanthin Standalone — OmniActive)
Standalone Zeaxanthin from Paprika
2-4 mg/day zeaxanthin (typical eye health dose)
Moderate
Phellinus linteus (Meshimakobu / Sanghuang)
Immune improvement RCT (, LDH cytotoxicity)
: PL mycelium extract 1,000 mg/day × 8 weeks (n=98, KCTC0399BP strain). IMMUNITY RCT:
Moderate
Punicalagins (Pomegranate Polyphenols)
Modest blood pressure reduction
POMEGRANATE JUICE: 240 mL/day = ~318 mg punicalagins. POMx: 1000 mg/day. STANDARDIZED
Moderate
Rosehip (Rosa canina)
Reduced osteoarthritis pain (meta-analysis evidence)
STANDARD: 5 g/day rosehip powder (Hyben Vital® / LitoZin®) split 2-3 doses with meals
Moderate
Rosmarinic Acid
Reduced seasonal allergic rhinitis symptoms
ALLERGIC RHINITIS: 50-200 mg/day Perilla × 21 d. AD COGNITION (Noguchi-Shinohara): 50
Strong
Witholytin® (Olive Leaf Extract — Verdure Sciences)
Reduced fatigue and low energy
Clinical trial protocol: 500 mg twice daily (1,000 mg/day total) for 8 weeks. Mainten
Moderate
Yüth® (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine (Yüth® formulation specifications); typical supplement use: 1.
Limited
Anserine (β-alanyl-3-methyl-L-histidine)
Verbal memory preservation in older adults
HISATSUNE 2016 COGNITIVE: 1.0 g anserine/carnosine 3:1 daily × 3 mo. MASUOKA 2019 MCI
Limited
Chlorella
NAFLD/MASLD support — strongest evidence
General use: 3-6 g/day. NAFLD studies: 1.2-1.5 g/day × 3 months. Metabolic syndrome:
Limited
Cognigrape® (Vitis vinifera Grape Extract)
Cognitive function in older adults
PIVOTAL: 250 mg/day Cognigrape® × 12 wk single daily dose. 2024 FOLLOW-UP: 250 mg/day
Limited
E-TPGS (Water-Soluble Vitamin E)
Vitamin E source
Per the product or formulation.
Limited
Enzogenol® (Pinus radiata Bark Extract)
Working memory in healthy older adults
Cognitive: 480 mg/day × 5 weeks. Mild TBI: 1,000 mg/day × 6-12 weeks. Take with food.
Limited
IP6 (Inositol Hexaphosphate / Phytic Acid)
Improved quality of life during breast cancer chemotherapy
ORAL CANCER: 1-8 g/day IP6 + 1-8 g/day myo-inositol on empty stomach (Druzijanic: 6-8
Limited
Japanese Knotweed (Polygonum cuspidatum)
Anti-inflammatory effects (small basketball player trial)
STANDARDIZED EXTRACTS (8% trans-resveratrol): 250-500 mg 1-2×/day → 20-40 mg resverat
Limited
Memophenol™ (Grape + Blueberry Polyphenol Extract)
Episodic memory in healthy elderly
Healthy elderly: 600 mg/day Memophenol™ (containing 258 mg flavonoids) × 6 months. MC
Limited
Mexidol (Ethylmethylhydroxypyridine Succinate)
Hemispheric ischemic stroke (EPICA RCT)
MIR 2024 STROKE PROTOCOL: 500 mg IV 2×/day × 10 days, then Mexidol FORTE 250 mg PO 3×
Limited
Phaeodactylum tricornutum (PT Microalga)
Plant-Based EPA Source (Bioavailable)
STIEFVATTER 2021 BIOAVAILABILITY: 5.3 g/day whole PT biomass × 2 wk (~150-200 mg EPA
Limited
Sparassis crispa (Cauliflower Mushroom / Hanabiratake)
Highest β-glucan content (>40% dry weight)
β-GLUCAN content: >40% of dry weight (highest among medicinal mushrooms). MOUSE Sarco