Home Ingredients Natavid® (Whole Grapevine Extract — Natac)
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Natavid® (Whole Grapevine Extract — Natac)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

Natavid® is a whole-grapevine (Vitis vinifera) extract from Natac that captures the full plant profile, combining vine leaves, grape seeds, and grape skin in one standardized extract rich in proanthocyanidins. It is positioned to support vein health, healthy circulation, and antioxidant defense.

Studied Dose Per the product specification.
Active Compound Whole-grapevine extract standardized to about 50% proanthocyanidins, with flavonoids and resveratrol or anthocyanins.

Benefits

Vein and circulation support

Grapevine proanthocyanidins are traditionally used to support vein tone and healthy circulation, of interest for tired, heavy legs.

Antioxidant defense

The grapevine polyphenols are potent antioxidants that protect blood vessels and cells from oxidative stress.

Supported by Trial 1

Cardiovascular support

By supporting blood-vessel health and reducing oxidative stress, grapevine polyphenols support cardiovascular wellness.

Supported by Trial 1

Mechanism of action

1

Vascular protection

Grape proanthocyanidins support the integrity and tone of blood-vessel and capillary walls, aiding healthy venous return.

2

Free-radical scavenging

The polyphenols neutralize free radicals and protect LDL cholesterol and vessel linings from oxidation.

Clinical trials

1
Grape Extract and LDL Oxidation — Trial
PubMed

Trial of a standardized grape extract on LDL cholesterol's susceptibility to oxidation. (Vigna et al. 2003, Metabolism)

Adults.

The standardized grape extract reduced LDL cholesterol's susceptibility to oxidation, reflecting the antioxidant value of grape polyphenols; Natavid is a whole-grapevine extract.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED.
Mild digestive upset or headache is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape polyphenols may have a mild additive effect; monitor.
Blood pressure medication — possible mild additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about Natavid® (Whole Grapevine Extract — Natac)

What is Natavid® (Whole Grapevine Extract — Natac)?

Natavid® is a whole-grapevine (Vitis vinifera) extract from Natac that captures the full plant profile, combining vine leaves, grape seeds, and grape skin in one standardized extract rich in proanthocyanidins. It is positioned to support vein health, healthy circulation, and antioxidant defense.

What is the recommended dosage of Natavid® (Whole Grapevine Extract — Natac)?

The clinically studied dose for Natavid® (Whole Grapevine Extract — Natac) is Per the product specification.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Natavid® (Whole Grapevine Extract — Natac) used for?

Natavid® (Whole Grapevine Extract — Natac) is studied for vein and circulation support, antioxidant defense, cardiovascular support. Grapevine proanthocyanidins are traditionally used to support vein tone and healthy circulation, of interest for tired, heavy legs.

Are there side effects from taking Natavid® (Whole Grapevine Extract — Natac)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED. Mild digestive upset or headache is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Natavid® (Whole Grapevine Extract — Natac) safe to take?

Whether Natavid® (Whole Grapevine Extract — Natac) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED. It may also interact with certain medications. Natavid® (Whole Grapevine Extract — Natac) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Vigna GB, Costantini F, Aldini G, et al. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism. 2003;52(10):1250-7..PubMedUsed to support: Trial supporting the antioxidant action of grape polyphenols (Natavid is a whole-grapevine extract rich in proanthocyanidins).