Top 5 — Ranked by Evidence
Very Strong
Omega-3 Fatty Acids
Cardiovascular events in high-risk patients
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction (
Very Strong
Niacin
Supports Energy Metabolism
14–16 mg/day (RDA); lipid-lowering: 1,500–3,000 mg/day (extended-release niacin, unde
Very Strong
Pycnogenol® (French Maritime Pine Bark)
Blood pressure — modest effect, mostly in hypertensives
50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic perfor
Very Strong
Fish Oil (EPA + DHA)
Cardiovascular events — formulation matters
General: 1 g/day EPA+DHA. Hypertriglyceridemia: 3-4 g/day. REDUCE-IT regimen: 4 g/day
Very Strong
Phytosterols (Plant Sterols & Stanols)
LDL cholesterol reduction — strongest evidence
LDL reduction: 1.5-3 g/day of plant sterols/stanols, taken with meals. Higher doses (
📈 Fastest Growing Cardiovascular Ingredients
Branded ingredients seeing rapid growth in formulator adoption and clinical research in 2024–2026.
Trending
Very Strong
MegaNatural®-BP (Patented Grape Seed Extract — Polyphenolics)
Blood Pressure Within Normal Range — UC Davis Trials
150-300 mg/day MegaNatural-BP (research-validated)
Trending
Very Strong
DeltaGold® (Annatto Tocotrienols — American River Nutrition)
Type 2 Diabetes Glycemic Control (24-Week RCT)
125-300 mg/day DeltaGold (250 mg in T2DM trial)
Trending
Very Strong
Curcuwin Ultra+® (144× Bioavailable Curcumin — OmniActive)
144× Bioavailability vs Standard Curcumin
250 mg or 500 mg/day Curcuwin Ultra+ (each providing 50 mg or 100 mg curcuminoids)
🔬 Future Cardiovascular Ingredients to Watch
Lower current evidence but active research underway — these may become top picks within 2–3 years.
Watch
Strong
Sulforaphane / Glucoraphanin
NRF2 activation (master antioxidant response)
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10-40 mg…
Watch
Very Strong
CoroWise® (Plant Sterols for Cholesterol — Cargill)
FDA-Approved Cholesterol Health Claim
2 g/day plant sterols (FDA-recommended; 1.3 g/day plant sterol esters minimum)
All Cardiovascular Ingredients (164)
Very Strong
Omega-3 Fatty Acids
Cardiovascular events in high-risk patients
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduction (
Very Strong
Niacin
Supports Energy Metabolism
14–16 mg/day (RDA); lipid-lowering: 1,500–3,000 mg/day (extended-release niacin, unde
Very Strong
Pycnogenol® (French Maritime Pine Bark)
Blood pressure — modest effect, mostly in hypertensives
50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic perfor
Very Strong
Fish Oil (EPA + DHA)
Cardiovascular events — formulation matters
General: 1 g/day EPA+DHA. Hypertriglyceridemia: 3-4 g/day. REDUCE-IT regimen: 4 g/day
Very Strong
Phytosterols (Plant Sterols & Stanols)
LDL cholesterol reduction — strongest evidence
LDL reduction: 1.5-3 g/day of plant sterols/stanols, taken with meals. Higher doses (
Very Strong
DeltaGold® (Annatto Tocotrienols — American River Nutrition)
Cardiovascular Health
125-300 mg/day DeltaGold (250 mg in T2DM trial)
Very Strong
MegaNatural®-BP (Patented Grape Seed Extract — Polyphenolics)
Blood Pressure Within Normal Range — UC Davis Trials
150-300 mg/day MegaNatural-BP (research-validated)
Very Strong
Potassium
Blood pressure reduction (well-established)
AI 4,700 mg/day (NAM) or 3,500–4,700 mg/day (WHO/AHA). Supplements limited to 99 mg/s
Very Strong
CoroWise® (Plant Sterols for Cholesterol — Cargill)
FDA-Approved Cholesterol Health Claim
2 g/day plant sterols (FDA-recommended; 1.3 g/day plant sterol esters minimum)
Very Strong
Curcuwin Ultra+® (144× Bioavailable Curcumin — OmniActive)
Heart Health and Sports Nutrition
250 mg or 500 mg/day Curcuwin Ultra+ (each providing 50 mg or 100 mg curcuminoids)
Very Strong
Psyllium Husk (Plantago ovata)
Cholesterol reduction (FDA-approved claim)
5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/day; ta
Strong
Vitamin K
Heart Health
90–120 mcg/day K1 (RDA); MK-7 (K2): 90–200 mcg/day for bone/cardiovascular; MenaQ7® s
Strong
Berberine
Cardiovascular Health
500–1,500 mg per day, often divided into 2–3 doses taken with meals to improve absorp
Strong
Beta-Glucans (Oat & Yeast-Derived)
FDA-authorized cholesterol claim — strongest evidence
Cholesterol (FDA claim): 3 g/day oat β-glucan. Immune (Wellmune®): 250-500 mg/day yea
Strong
CoEnzyme Q10
Heart failure mortality reduction
Heart failure (Q-SYMBIO): 100 mg 3×/day. Migraine: 100-300 mg/day. Statin myopathy: 1
Strong
Ginger (Zingiber officinale)
Pregnancy nausea (NVP) — strongest evidence
250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/day; an
Strong
L-Citrulline
Cardiovascular Health
3–6 g/day L-citrulline or 6–8 g/day citrulline malate (2:1 ratio) 30–60 minutes pre-e
Strong
Pomegranate Extract
Blood pressure and arterial health
Standard cardiovascular dose: 500-1,500 mg/day pomegranate extract standardized to ≥3
Strong
Algal Oil DHA (Vegan Omega-3)
Vegan and vegetarian source of preformed EPA and DHA
General health: 200-500 mg DHA/day. Pregnancy: 200-300 mg DHA/day minimum (matches in
Strong
Beta-Sitosterol
Cholesterol reduction (LDL 6-15%)
BPH: 60-130 mg/day (typically 20 mg three times daily). Cholesterol reduction: 1.5-3
Strong
Diosmin
Chronic venous insufficiency symptom reduction
Standard dose: 900 mg diosmin + 100 mg hesperidin (1,000 mg MPFF total) once or twice
Strong
Pine Bark Extract
Cardiovascular support
Standard dose: 100-300 mg/day standardized pine bark extract (≥85% proanthocyanidins)
Strong
Soy Protein
LDL cholesterol reduction (FDA-recognized heart health claim)
MUSCLE/RT: 20-40 g/day. FDA HEART CLAIM: 25 g/day. Anderson 1995 NEJM meta 38 trials:
Strong
ABG10+® / ABG+® (Aged Black Garlic for Cardiovascular Health)
Blood Pressure Reduction in Hypertension
250 mg/day ABG10+ (1.25 mg SAC) per Pharmactive clinical trials
Strong
Carnipure® (L-Carnitine — Lonza)
Cardiovascular applications
Same as generic L-carnitine: 1-3 g/day general supplementation. Specific applications
Strong
Citrus Bergamot (Citrus bergamia)
LDL cholesterol reduction
500–1,500 mg/day standardized BPF; lipid-lowering studies typically use 500 mg twice
Strong
Garlic (Allium sativum)
Blood pressure reduction
600–1,200 mg/day aged garlic extract (AGE); raw garlic equivalent: 2–4 cloves/day; al
Strong
Gynostemma pentaphyllum (Jiaogulan / Southern Ginseng)
Blood pressure reduction
Standardized extract: 200-450 mg twice daily (containing standardized gypenosides). W
Strong
Kyolic® (Aged Garlic Extract — Wakunaga)
Blood pressure reduction (extensive trial evidence)
Standard cardiovascular protocol: 1,200-2,400 mg/day Kyolic® in divided doses. Differ
Strong
Mycoprotein (Quorn)
LDL cholesterol reduction
Typical dietary serving: 90-180 g cooked mycoprotein per meal (providing 11-22 g prot
Strong
Oat Bran (Beta-Glucan)
LDL cholesterol reduction — strong evidence
FDA HEALTH CLAIM: ≥3 g beta-glucan/day (~75 g raw oat bran, ~140 g cooked oatmeal). W
Strong
Pomella® (Pomegranate Extract — Verdure Sciences)
Cardiovascular trial evidence base
Standard cardiovascular protocol: 500-1,500 mg/day Pomella® standardized extract. Mos
Strong
Quatrefolic® (L-5-MTHF Methylfolate — Gnosis)
Patent-protected stable crystal form
General supplementation: 400-1,000 mcg DFE Quatrefolic® daily. Pregnancy: 400-800 mcg
Strong
Sulforaphane / Glucoraphanin
Cardiovascular and metabolic biomarkers
Standard supplementation: 60-150 mg glucoraphanin with active myrosinase (provides 10
Strong
ThymoQuin® (Black Seed Oil — TriNutra)
Standardized thymoquinone delivery
Standard formulation use: 500-1,000 mg ThymoQuin® daily. Cardiometabolic protocols ty
Strong
Truebroc® (Glucoraphanin Broccoli Seed Extract — Brassica Protection Products)
Cardiovascular biomarker improvements
Standard formulation use: 30-150 mg Truebroc® daily (providing 4-20 mg glucoraphanin)
Strong
Witholytin® (Olive Leaf Extract — Verdure Sciences)
Blood pressure reduction in clinical trials
Clinical trial protocol: 500 mg twice daily (1,000 mg/day total) for 8 weeks. Mainten
Strong
Aged Garlic Extract
Blood pressure reduction in hypertension
Standard cardiovascular dose: 600-2,400 mg/day AGE standardized to S-allyl cysteine c
Strong
Ahiflower® (Buglossoides Plant Omegas — Stratum Nutrition)
Stearidonic Acid (SDA) Content
1-3 g/day Ahiflower oil
Strong
ApplePhenon® (Apple Polyphenol Extract — BGG)
Cholesterol improvement (71-subject RCT)
600 mg/day ApplePhenon over 8-12 weeks (the dose used in both BGG-funded RCTs). Lower
Strong
Artichoke Leaf (Cynara scolymus / Cynara cardunculus)
Cholesterol Reduction
320-1,920 mg/day standardized leaf extract; clinical trials commonly use 600-1,800 mg
Strong
BarliV™ (Barley Beta-Glucan — Cargill)
FDA-Approved Cholesterol Health Claim
3 g/day barley beta-glucan (FDA health claim threshold)
Strong
Beetroot
Blood pressure reduction
300–500 mg nitrate/day (equivalent to 70–140 mL concentrated beet juice or 500 mg ext
Strong
BioBerb® (Bioavailable Berberine — Saanroo)
Blood glucose reduction (berberine class evidence)
Standard berberine clinical dose: 500 mg three times daily with meals (1,500 mg/day t
Strong
Cod Liver Oil
Same cardiovascular/inflammation effects as fish oil
1 teaspoon (5 mL) typical dose providing ~750-2,500 IU vitamin A, ~400-1,000 IU vitam
Strong
Flaxseed / Flaxseed Oil (Linum usitatissimum)
Cardiovascular protection and blood pressure
1–2 tablespoons (10–20g) ground flaxseed/day; flaxseed oil: 1–2 tablespoons/day (14–2
Strong
Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)
Cognitive Function and Working Memory
120-240 mg/day Ginkgoselect Phytosome
Strong
Glucomannan (Konjac Root Fiber)
Cholesterol and LDL reduction
3–4 g/day before meals (1 g three times daily, 30 minutes before meals with 250 mL wa
Strong
Grape Seed Extract (OPC)
Blood pressure reduction
100–400 mg/day standardized extract (≥95% OPCs); blood pressure: 150–300 mg/day MegaN
Strong
Hawthorn (Crataegus spp.)
Heart failure exercise tolerance improvement
160–1,800 mg/day standardized extract; mild-moderate heart failure: 900 mg/day (450 m
Strong
Hesperidin
Modest Cardiovascular Risk Marker Effects
500-1,000 mg/day general; 450-900 mg/day combined with diosmin for venous insufficien
Strong
Horse Chestnut (Aesculus hippocastanum)
Chronic venous insufficiency treatment
300 mg HCSE twice daily (providing 100 mg aescin/day, 50 mg per dose); effects on leg
Strong
L-Carnitine
Cardiovascular support in heart failure and angina
General supplementation: 1-3 g/day L-carnitine. Athletic recovery: 2 g/day L-carnitin
Strong
Leucoselect® Phytosome (Grape Seed Phytosome — Indena)
Cardiovascular and Vascular Function
100-300 mg/day Leucoselect Phytosome (research-validated)
Strong
Methylcobalamin (Active B12)
Bioactive Coenzyme Form
500-2,000 µg/day sublingual or oral for general supplementation; 1,000-2,500 µg/day f
Strong
Methylfolate
MTHFR variant bypass
General supplementation: 400-1,000 mcg DFE methylfolate. Pregnancy/preconception: 400
Strong
Mirtoselect® (Standardized Bilberry Extract — Indena)
Vascular health and microcirculation
160-320 mg/day Mirtoselect (manufacturer-recommended range). Standard ophthalmology d
Strong
Nitrosigine® (Arginine Silicate)
Superior nitric oxide and arginine elevation
1,500 mg/day; most studies use 1,500 mg taken 30–60 minutes pre-exercise
Strong
Olive Leaf Extract
Blood pressure reduction (strongest evidence)
Standard dose: 500-1,000 mg/day standardized olive leaf extract (containing 20-40% ol
Strong
Potassium Citrate
Blood Pressure Modest Reduction
Nutritional: 100-500 mg/day; Pharmaceutical for stones: 30-90 mEq/day (Urocit-K®, pre
Strong
Red Yeast Rice (Monascus purpureus)
Effective LDL Cholesterol Reduction
1,200-2,400 mg/day red yeast rice extract; clinically effective dose typically provid
Strong
Shiitake Mushroom (Lentinula edodes)
Cholesterol-Lowering (Eritadenine)
1,000-3,000 mg/day mushroom extract; lentinan is typically given INJECTABLY (1-2 mg/w
Strong
Soy Isoflavones (Glycine max)
Cardiovascular protection
40–80 mg/day total isoflavones; menopausal symptoms: 50–80 mg/day; bone health: 54–10
Strong
Svetol® (Decaffeinated Green Coffee Extract — Givaudan/Naturex)
Weight loss vs placebo (Dellalibera 2006)
400 mg/day Svetol, taken before meals (often 1-3 doses daily). Dellalibera 2006 used
Strong
Ubiqsome® (Coenzyme Q10 Phytosome — Indena)
Cardiovascular Health Support
100-300 mg/day Ubiqsome (CoQ10 equivalent)
Strong
Ubiquinol (Reduced CoQ10)
Heart Failure Adjunct (Q-SYMBIO Trial)
100-300 mg/day for general use; 200-400 mg/day for heart failure adjunct; 100-200 mg/
Strong
Vitamin E
Cardiovascular support
15 mg/day (RDA); therapeutic studies use 400–1,000 IU/day
Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyrosol
Strong
K2Quest® (Fermentation-Derived Vitamin K2 MK-7)
Cardiovascular protection — preventing arterial calcification
90–180 mcg/day MK-7 for bone and cardiovascular health; PMS: 90 mcg/day; 3-year RCT d
Strong
goCOCOA® (Cocoa Flavanol Extract)
Cardiovascular health and blood pressure reduction
200–400 mg/day cocoa flavanols (epicatechin equivalent); cardiovascular/cognitive: 40
Moderate
Quercetin
Heart Health
500–1,000 mg/day; absorption enhanced significantly with vitamin C or bromelain; quer
Moderate
L-Arginine
Heart Health
3–6 g/day for cardiovascular effects; 6–10 g/day pre-exercise for blood flow; often o
Moderate
Taurine
Heart Health
500–3,000 mg/day; energy drinks typically contain 1,000 mg; athletic performance: 1–3
Moderate
Curcumin/Turmeric
Cardiovascular Health Support
RAW POWDER: 500-2000 mg/day = 60-100 mg curcumin. STANDARDIZED 95% curcuminoids: 400-
Moderate
Astaxanthin
Cardiovascular Health Benefits
4–12 mg/day from Haematococcus pluvialis extract; skin: 4–6 mg/day; exercise recovery
Moderate
Ginkgo Biloba
Circulation and Cardiovascular Health
120–240 mg/day standardized extract (EGb 761® or similar, 24% flavonol glycosides, 6%
Moderate
Lycopene
Cardiovascular markers — modest effect
8-21 mg/day food or supplement. CV/prostate: 15-45 mg/day. Bone (LycoRed): 8 mg/day.
Moderate
PhosphatidylCholine
Cardiovascular markers — uncertain net effect
NAFLD/MASLD: 1.5-2.1 g/day standardized PC × 6 months. General choline/cognitive: 500
Moderate
Red Clover (Trifolium pratense)
Cardiovascular protective effects
Standard dose: 40-80 mg isoflavones per day, often formulated as Promensil® or simila
Moderate
Aged Black Garlic ABG10+® (Pharmactive)
Blood pressure reduction in hypertensive adults
Standard dose: 250-500 mg/day ABG10+® standardized aged black garlic extract. Cardiov
Moderate
Aronia / Chokeberry (Aronia melanocarpa)
Modest Blood Pressure Reduction
STANDARDIZED EXTRACT: 100-300 mg/day (25-50 mg anthocyanins) OR juice 200-300 mL/day
Moderate
Benfotiamine
Endothelial function improvement (postprandial)
DIABETIC NEUROPATHY (BENDIP): 600 mg/day × 6 wk then 300 mg/day. BOND: 300 mg BID × 1
Moderate
Betalains (Beetroot Pigments)
Modest blood pressure reduction (beetroot)
BEETROOT JUICE: 250-500 mL/day (~5-10 mmol nitrate + 30-100 mg betalains). FREEZE-DRI
Moderate
Butcher's Broom (Ruscus aculeatus)
Chronic venous insufficiency — leg edema reduction (Pivotal RCT)
VANSCHEIDT 2002 PROTOCOL: 36-37.5 mg extract = 7-11 mg ruscogenins/day. ESCP guidelin
Moderate
Chlorogenic Acid
Modest blood pressure reduction
BP: 140 mg/day green coffee bean × 4 wk. WEIGHT: 500 mg/day GBCE ≥30% CGA → -1.30 kg
Moderate
CocoaVia® (Mars Edge Cocoa Flavanol Extract)
Cardiovascular death reduction
Standard dose: 500-750 mg cocoa flavanols daily (1-2 CocoaVia® servings). COSMOS tria
Moderate
Ellagic Acid
Metabolic syndrome — multiple markers improve together
METABOLIC SYNDROME (Hidalgo-Lozada 2022): 500 mg BID = 1000 mg/day pomegranate 90% EA
Moderate
Eucommia Bark (Du Zhong)
Modest blood pressure reduction
BP: 500 mg standardized extract 3×/day = 1.5 g/day, 8% pinoresinol diglucoside × 2 wk
Moderate
Ferulic Acid
Improved lipid profile in hyperlipidemia
Hyperlipidemia: 1,000 mg/day × 6 weeks (the best-studied protocol). Asian clinical do
Moderate
Glavonoid® / Kaneka Glavonoid™ (Licorice Flavonoid Oil)
LDL-cholesterol reduction 11 mg/dL
TOMINAGA 2009 DOSE-FINDING: 300, 600, or 900 mg LFO/day × 8 weeks in overweight adult
Moderate
Kudzu (Pueraria lobata)
Cardiovascular support — mostly preliminary
LUKAS/PENETAR PROTOCOL (NPI-031): 500 mg 3×/day (1500 mg/day) standardized 19% puerar
Moderate
Lactobacillus plantarum
Cholesterol reduction
10–50 billion CFU/day; 299v strain typically 20 billion CFU/day; weight management st
Moderate
Lactobacillus reuteri
Cholesterol reduction (NCIMB 30242)
10^8 CFU/day (DSM 17938 for infant colic); 2.9×10^9 CFU/day (NCIMB 30242 for choleste
Moderate
MitoQ (Mitoquinone)
Improved endothelial function in older adults (pivotal)
ROSSMAN 2018 VASCULAR: 20 mg/day × 6 wk endothelial function. PD PHASE II: 40-80 mg/d
Moderate
Oligonol® (Lychee + Green Tea Polyphenol — Amino Up)
Visceral fat reduction (10-week trial)
Visceral fat protocol: 200 mg/day Oligonol® (50 mg twice daily) for 10 weeks. Periphe
Moderate
Pantesin® (Pantethine — Daiichi Fine Chemical)
Trial-validated lipid management
Standard clinical protocol: 600-900 mg/day Pantesin® in divided doses (300 mg three t
Moderate
Pleurotus ostreatus (Oyster Mushroom)
Cardiometabolic systematic review of 8 trials
OYSTER MUSHROOM SOUP: 30 g dried daily × 21 days (lipid trial). β-GLUCAN SUPPLEMENT:
Moderate
Pueraria Mirifica (Kwao Kruea Khao)
Lipid profile improvement in postmenopausal women
MENOPAUSE: 50-100 mg/day root powder × 6 mo. LIPID/BONE: 20-50 mg/day × 24 wk. Onset
Moderate
Punicalagins (Pomegranate Polyphenols)
Modest blood pressure reduction
POMEGRANATE JUICE: 240 mL/day = ~318 mg punicalagins. POMx: 1000 mg/day. STANDARDIZED
Moderate
Resveratrol
Cardiovascular protection
150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or liposomal
Moderate
Sesamin
Modest blood pressure reduction in hypertension (meta-analysis)
BP: 60 mg/day × 4 wk hypertensive. LIPID: 200-247 mg/day (Wu 2006: 50 g/d seed). 20-H
Moderate
Squalene
Cholesterol reduction in elderly hypercholesterolemia
CV: 860 mg/day × 20 wk hypercholesterolemia. STRANDBERG 1990: 900 mg/day. PK: 500 mg
Moderate
Veri-te™ Resveratrol (Evolva)
Modest blood pressure reduction
RESHAW PIVOTAL: 75 mg trans-resveratrol BID = 150 mg/day × 12-24 months in postmenopa
Moderate
Yüth® (Spermidine)
Cardiovascular health and longevity support
1–10 mg/day spermidine (Yüth® formulation specifications); typical supplement use: 1.
Moderate
Amla / Indian Gooseberry (Capros®)
Cardiovascular protection and lipid improvement
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day; vita
Moderate
Betaine / TMG (Trimethylglycine)
Homocysteine reduction and cardiovascular protection
2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine reductio
Moderate
Bilberry (Vaccinium myrtillus)
Microvascular health and chronic venous insufficiency
80–480 mg/day standardized extract (25% anthocyanosides = 20–120 mg anthocyanins); ey
Moderate
D-Ribose (Bioenergy Ribose®)
Cardiac energy and heart failure support
5–15 g/day in divided doses; athletic performance: 5 g pre/post exercise; cardiac/fib
Moderate
Gencinia® (Healthy Cinnamon)
Cardiovascular Markers
Per Saanroo product specification
Moderate
Gotu Kola (Centella asiatica)
Wound Healing and Scar Improvement
60-120 mg/day standardized extract (containing total triterpenes ~30%); whole herb 1-
Moderate
Krill Oil
Better Bioavailability vs Fish Oil (Phospholipid Form)
1-3 g/day krill oil (providing approximately 200-600 mg EPA+DHA — typically lower tha
Moderate
LuraLean® (Glucomannan Fiber Blend — AHD International)
Healthy Cholesterol Maintenance
Per LuraLean product specification (typical 2-4 g/day)
Moderate
Metabolaid® (Hibiscus + Lemon Verbena)
Blood pressure and cardiovascular health
500 mg/day Metabolaid® (325 mg lemon verbena + 175 mg hibiscus); taken before exercis
Moderate
MyrtiPRO® (Premium Bilberry Extract — BGG)
Vascular Health and Microcirculation
160-320 mg/day MyrtiPRO (research-validated dose)
Moderate
Nattokinase
Blood Pressure Modest Reduction
100-400 mg/day standardized to 2,000-8,000 FU (fibrinolytic units); typically taken o
Moderate
Opextan® (Olive Fruit Extract — Indena)
Cardiovascular Health Support
Per Indena product specification
Moderate
P-5-P (Pyridoxal-5-Phosphate / Active B6)
Bioactive Coenzyme Form
25-100 mg/day general supplementation; 50-100 mg/day for PMS, morning sickness; up to
Moderate
Pantethine
Lipid profile improvement (primary application)
Standard lipid management dose: 600-900 mg/day pantethine in divided doses (typically
Moderate
Puremidine™ (Spermidine)
Cardiovascular health and longevity
1–10 mg/day spermidine; observational longevity data at dietary intake of ~10–15 mg/d
Moderate
Rutin
Capillary Fragility / Bleeding Gum Support
250-1,000 mg/day; often combined with vitamin C and other bioflavonoids
Moderate
Saberry® (Amla / Indian Gooseberry — Sabinsa)
Cardiovascular Markers
Per Sabinsa product specification (typical 250-500 mg/day)
Moderate
Sea Buckthorn (Hippophae rhamnoides)
Cardiovascular Support
1-3 g/day sea buckthorn oil (berry pulp or seed oil); berry powder 5-10 g/day; vitami
Moderate
Terminalia Arjuna (Oxyjun®)
Cardiovascular protection and heart failure
500 mg/day Oxyjun®; traditional cardiac use: 1–3 g/day bark powder; effects on cardio
Moderate
Tocotrienols (Vitamin E Family)
Cholesterol-Lowering Effects
100-400 mg/day total tocotrienols; for cholesterol/CV: 200-300 mg gamma+delta tocotri
Moderate
inavea™ CINNAMON ACACIA
Glycemia and Insulinemia Improvement
5 g/day (research-validated dose)
Moderate
Calanus® Oil (Arctic Zooplankton Omega-3 Wax Esters)
Cardiovascular and heart function improvement
2g/day Calanus® Oil capsules; clinical study: 2–4g/day; wax ester form may have diffe
Moderate
CitrOlive® (Olive + Citrus for Cardiovascular — Frutarom)
Cardiovascular Health Support
Per Frutarom CitrOlive product specification
Moderate
Epicatechin (Myostatin Inhibitor / Muscle Flavonol)
Cardiovascular health and nitric oxide
50–200 mg/day (-)-epicatechin; muscle/anabolic applications: 150–200 mg/day; cardiova
Moderate
GG-Gold® (Geranylgeraniol — American River Nutrition)
Endogenous Nutrient Declining with Age
Per ARN GG-Gold product specification
Moderate
Nitratene® (Stabilized Beet Root Nitrate)
Blood pressure reduction
200–400 mg inorganic nitrate equivalent; 1–3 hours pre-exercise for peak NO elevation
Moderate
OptiSol® (Functional Dairy Ingredients — Glanbia)
Tailored Functional Properties
Per Glanbia OptiSol product specification
Moderate
Oxystorm® (Red Spinach Nitrate)
Blood pressure support
1–2g Oxystorm® providing ~200–400 mg dietary nitrate; consume 2–3 hours before exerci
Moderate
Salba® / Premium Chia (Salvia hispanica — AHD International)
Cardiovascular Health Profile
1-2 tablespoons (10-25 g) chia seeds daily
Moderate
cellflo6® (Gallate-Enhanced Green Tea Oligomers)
Cardiovascular and circulation support
Per cellflo6® clinical dosing specifications from PLT Health Solutions; clinical stud
Limited
Enzogenol® (Pinus radiata Bark Extract)
Cardiovascular markers — pilot evidence
Cognitive: 480 mg/day × 5 weeks. Mild TBI: 1,000 mg/day × 6-12 weeks. Take with food.
Limited
Guggul (Commiphora mukul)
Cholesterol Effects — Mixed Results
INDIAN RCTs: 50 mg guggulipid (~3.5 mg guggulsterones) BID × 12-24 wk. WESTERN: 1000-
Limited
Lecithin (Phosphatidylcholine Complex)
Cholesterol Reduction — Variable Evidence
CV: 500 mg to 22.5 g/day soy lecithin (Knuiman 1980: 7.5 g × 3/day). Spilburg 2003 st
Limited
Auricularia auricula-judae (Wood Ear / Black Jelly Mushroom)
Cholesterol-lowering polyphenolic + polysaccharide
EDIBLE WOOD EAR: dietary consumption common in Asian cuisine — supports general food-
Limited
Beef Heart (Desiccated)
CoQ10 supplements vs beef heart
Typical supplementation: 1.5-3 g/day (2-4 capsules at 750 mg each) desiccated beef he
Limited
Brainberry® (Aronia melanocarpa Extract)
Brain vascular function + cognition crossover trial (160 mg/day)
: 90 mg or 150 mg AME daily × 24 wk middle-aged adults. CROSSOVER: 160 mg/day older a
Limited
CyanthOx™ (Sea Buckthorn Proanthocyanidin Extract)
Cardiovascular and skin claims — mechanism-level
Drapeau 2019 acute trial: 500 mg CyanthOx™30 (~150 mg sea buckthorn proanthocyanidins
Limited
Danshen (Salvia miltiorrhiza)
Cardiovascular use in TCM and Chinese hospital practice
ORAL ROOT: 9-15 g dried decoction OR 1-3 g powdered. STANDARDIZED: 500-1500 mg 2-3×/d
Limited
Glabridin (Licorice Isoflavone)
LDL oxidation reduction (6-month trial)
LDL oxidation: 250 mg/day for 6 months. Type 2 diabetes and metabolic syndrome: 300 m
Limited
IP6 (Inositol Hexaphosphate / Phytic Acid)
Anti-vascular calcification (intravenous SNF472)
ORAL CANCER: 1-8 g/day IP6 + 1-8 g/day myo-inositol on empty stomach (Druzijanic: 6-8
Limited
Japanese Knotweed (Polygonum cuspidatum)
Cardiovascular and lipid effects (animal evidence)
STANDARDIZED EXTRACTS (8% trans-resveratrol): 250-500 mg 1-2×/day → 20-40 mg resverat
Limited
Kaempferol
Cardiovascular Risk Reduction (Epidemiological)
NO STANDARDIZED CLINICAL DOSE. DIETARY: 5-10 mg/day Western, up to 50+ mg/day high-ve
Limited
Lumbrokinase (Earthworm Fibrinolytic Enzyme)
Acute ischemic stroke (2024 meta-analysis)
JIN CEREBRAL INFARCT: 3 × 400 mg/day × 28 d. REY DFU: 3 × 500 mg/day × 7 d. STANDARD:
Limited
Mexidol (Ethylmethylhydroxypyridine Succinate)
Hemispheric ischemic stroke (EPICA RCT)
MIR 2024 STROKE PROTOCOL: 500 mg IV 2×/day × 10 days, then Mexidol FORTE 250 mg PO 3×
Limited
Mildronate (Meldonium)
Post-myocardial infarction heart failure
RUSSIAN/LATVIAN APPROVED: 500-1,000 mg/day oral. POST-MI: 1,000 mg/day IV × 10-14 day
Limited
Myricetin
Cardiovascular effects (preclinical, dietary)
DIETARY: 1-4 mg/day (walnuts, cranberries, blueberries, red wine, tea). SUPPLEMENT: 1
Limited
Pelargonidin
Cardiovascular benefits via strawberry consumption
DIETARY: ~30-50 mg glycosides per 150 g strawberries. STRAWBERRY RCTs: 250-500 g fres
Limited
Trehalose
Improved glucose tolerance in metabolic syndrome
GLUCOSE TOLERANCE: 3.3-10 g/day (Mizote 2017: 10 g; Yoshizane 2020: 3.3 g). PAD pilot
Limited
Chromium Polynicotinate (Niacin-Bound Chromium)
Cholesterol Modest Effects (Likely Niacin-Driven)
200-400 µg elemental chromium/day; some trials use up to 1,000 µg combined with other
Limited
Hemp Seed Oil
Balanced Omega Fatty Acid Profile
1-2 tablespoons (15-30 mL) daily; provides ~2-4 g ALA, ~7-10 g LA, ~0.4-0.8 g GLA
Limited
Luravida® (Cranberry Omega-3 Oil — AHD International)
Balanced Omega Fatty Acid Profile
Per AHD Luravida product specification (typical 1-3 g/day)
Limited
Magnesium Taurate
Cardiovascular Support
200–400 mg elemental magnesium/day combined with 500–2,000 mg taurine in the chelate
Limited
Naringenin
Cardiovascular / Lipid Effects
150-500 mg/day; emerging supplement category; standardized doses not yet well-establi
Limited
Phaeodactylum tricornutum (PT Microalga)
Plant-Based EPA Source (Bioavailable)
STIEFVATTER 2021 BIOAVAILABILITY: 5.3 g/day whole PT biomass × 2 wk (~150-200 mg EPA
Limited
Pterostilbene
Cardiovascular Effects
50-250 mg/day; trial used 125 mg twice daily (250 mg/day total)
Limited
Theaflavins
LDL Cholesterol Reduction (Mixed Evidence)
MARON 2003: 375 mg/day theaflavin-enriched green tea (75 mg theaflavins + 150 mg cate
Limited
Chitosan
Cholesterol reduction
3–6 g/day with meals; fat blocking requires taking with fat-containing meals; most st
Limited
MitoReds™ (Mitochondrial Reds Complex)
Nitric oxide and cardiovascular support
Per product label; typical reds blend 3–6g/day; specific MitoReds™ dosing per NNB pro
Preliminary
Dong Quai (Angelica sinensis)
Traditional 'female ginseng' use (limited modern RCT support)
TCM TRADITIONAL: 4.5-9 g dried root decoction OR 2-3 g powdered (typically multi-herb
Preliminary
Picamilon (N-Nicotinoyl-GABA)
Cerebrovascular disease and cerebral circulation
RUSSIAN APPROVED: 50 mg 3×/day (150 mg/day). CEREBROVASCULAR: 100-300 mg/day. ANXIETY