Home Ingredients Naticol® (Marine Fish Collagen Peptides — Weishardt)
Hair, Skin & NailsJoint HealthMuscle & RecoveryGut Health

Naticol® (Marine Fish Collagen Peptides — Weishardt)

Hydrolyzed type I marine collagen peptides
Evidence Level
Moderate
3 Clinical Trials
7 Documented Benefits
3/5 Evidence Score

Branded marine fish collagen peptides from Weishardt International (France — 170+ years collagen and gelatin expertise). Type I marine collagen peptides via proprietary enzymatic hydrolysis of fish skins — sustainably upcycled from fish filleting industry by-products. >99% protein content on dry matter (among purest collagen peptides on market). Naticol-Cyskin combination with BCF Life Sciences for skin beauty. Sarcopenia 24-week RCT in elderly at 15 g/day showed increased lean muscle mass, handgrip strength, Short Physical Performance Battery, and Chair Stand Test improvements. Skin aging 12-week RCT (n=57 mature women) at LOW DOSE 2.5 g/day reduced wrinkles, fine lines, and dry skin — efficacy at lower doses than typical 5-10 g collagen products. NCT03872297 — Institut Pasteur de Lille 3-month weight management trial.

Studied Dose SARCOPENIA: 15 g/day Naticol® × 24 weeks in elderly. SKIN AGING: 2.5 g/day × 12 weeks (low-dose effective). NCT03872297 weight management: 3 months. Standard range: 2.5-15 g/day. Marine source — fish-allergic individuals: avoid.
Active Compound Type I marine collagen peptides — small molecular weight peptides via Weishardt's gentle enzymatic hydrolysis. Specific amino acid profile + unique molecular weight distribution for high bioavailability + rapid absorption

Benefits

Sarcopenia 24-week RCT in elderly (PIVOTAL)

Susan/Gillian/Bonnet/Donovan 2021 (JOJ Case Stud 12(5):555850) — sarcopenia 24-week RCT at 15 g/day Naticol® in elderly. Significantly improved sarcopenia symptoms with increased lean muscle mass, handgrip strength, Short Physical Performance Battery, and Chair Stand Test. Multi-functional outcomes important for healthy aging — addresses the major clinical concerns in age-related muscle loss.

Supported by Trial 1

Skin aging 12-week LOW-DOSE RCT (Naticol-Cyskin)

Skin aging 12-week RCT in 57 mature women at 2.5 g/day Naticol or Naticol-Cyskin. Reduced visible signs of aging including wrinkles, fine lines, and dry skin. Demonstrating clinical efficacy at lower dose than typical 5-10 g collagen products — practical advantage for product formulation in functional foods and beverages.

Supported by Trial 2

Weight management 3-month RCT (NCT03872297)

NCT03872297 NATICOL Trial — Institut Pasteur de Lille. 3-month quadruple-masked weight management RCT in overweight volunteers. Status: completed. Emerging weight management indication — adds to the multi-domain evidence base beyond classic skin and joint applications.

Supported by Trial 3

Joint health and osteoarthritis (clinical evidence)

Joint comfort general support evidence per Weishardt research base — consistent with the broader collagen peptide joint health framework. Smaller-scale evidence for joint-specific indications relative to the strong sarcopenia and skin RCTs.

Supported by Trial 2, Trial 1

Sustainable circular economy upcycling

Weishardt upcycles fish skins discarded by the fish fillet industry into a premium value-added product. Sustainable species sourced. Distinguishing positioning increasingly relevant to environmentally-conscious consumers and regulatory sustainability frameworks.

Premium organoleptic profile

Neutral odor, neutral taste, colorless, water-soluble, heat-resistant. Distinguishing formulation features for functional beverages, hot drinks, sachets, capsules, and soft gels. Major advantage over typical fish collagens which often carry residual fishy taste or odor that limits formulation options.

Supported by Trial 2

High protein purity (>99% on dry matter)

>99% protein content on dry matter — among the purest collagen peptides on market. Reflects the proprietary enzymatic hydrolysis process and quality control.

Supported by Trial 2

Mechanism of action

1

Type I collagen peptide bioavailability

Specific molecular weight peptide profile via gentle enzymatic hydrolysis enables high bioavailability and rapid absorption. Type I collagen is the primary structural collagen in skin, bone, tendon, and most connective tissues — relevance to skin and joint applications.

2

Amino acid pool for collagen synthesis

Provides glycine, proline, and hydroxyproline — the characteristic collagen amino acids — as substrate for endogenous collagen synthesis.

3

Specific peptide bioactivity

Beyond pure amino acid provision, specific di- and tripeptides (Pro-Hyp, Hyp-Gly) directly stimulate fibroblasts and chondrocytes. The bioactivity goes beyond simple protein nutrition.

4

MMP inhibition (matrix metalloproteinase)

Matrix metalloproteinase suppression contributes to skin and joint matrix preservation. Reduces degradation of existing collagen alongside supporting new synthesis.

5

Muscle protein synthesis stimulation

Mechanism for the sarcopenia trial outcomes — the amino acid pool plus specific peptide bioactivity stimulate muscle protein synthesis in the elderly population.

6

Marine collagen distinction from bovine/porcine

Marine type I collagen differs from bovine or porcine collagen in molecular weight distribution and amino acid profile. Avoids mammalian-source concerns (BSE, religious dietary restrictions) and offers different absorption kinetics.

Clinical trials

1
Naticol Sarcopenia 24-Week Elderly RCT (PIVOTAL)

Susan/Gillian/Bonnet/Donovan 2021 (JOJ Case Stud 12(5):555850). 24-week RCT at 15 g/day Naticol® in elderly. Significantly improved sarcopenia symptoms with increased lean muscle mass, handgrip strength, Short Physical Performance Battery, and Chair Stand Test. Multi-functional healthy aging outcomes.

2
Naticol Skin Aging 12-Week Low-Dose RCT (n=57)

12-week RCT in 57 mature women at 2.5 g/day Naticol or Naticol-Cyskin. Reduced visible signs of aging (wrinkles, fine lines, dry skin) at lower dose than typical 5-10 g collagen products.

3
NATICOL Trial NCT03872297 — Weight Management Pilot

NCT03872297 NATICOL Trial — Institut Pasteur de Lille. 3-month quadruple-masked weight management RCT in overweight volunteers. Status: completed. Emerging weight management indication.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated — derived from food protein.
GI upset (rare).
Allergic reactions in fish/seafood-allergic individuals — IMPORTANT contraindication.
Marine origin: NOT vegetarian, NOT vegan.
Pregnancy/lactation: food-grade origin supports general safety.
Long-term safety: 24-week sarcopenia trial supports favorable profile + extensive marine collagen use record.
Sustainable upcycled fish skin source (no whole-fish harvesting).

Important Drug interactions

Most medications: NO significant interactions documented.
Iron supplements: separate by 2 hours (theoretical mineral chelation).
Vitamin C: SYNERGISTIC effects on collagen synthesis (vitamin C is collagen synthesis cofactor) — rational stack.
Other amino acid supplements: compatible.
Anticoagulants: minimal interactions.
Most prescription medications: well-tolerated combination profile.

More Hair, Skin & Nails Ingredients

Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a…
Eye Health
FloraGLO® Lutein (Kemin)
FloraGLO® is a branded free-form lutein extract manufactured by Kemin Industries from mari…
Immune Support
Vitamin C
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin commonly used in supple…
Antioxidant
AstaZine® (Natural Astaxanthin from Haematococcus pluvialis — BGG)
AstaZine® is BGG's PREMIUM NATURAL ASTAXANTHIN from Haematococcus pluvialis microalgae — d…

Explore Other Ingredients

Metabolic Health
Ginger (Zingiber officinale)
Ginger is one of the most widely consumed spices and medicinal plants globally, with over…
Athletic Performance
Beef Protein Isolate
Hydrolyzed beef protein supplement — typically derived from collagen-rich connective tissu…
Muscle & Recovery
Tart Cherry Extract (Restoridyn®)
Tart cherry (Montmorency variety) is one of the most clinically validated natural recovery…

Frequently asked questions about Naticol® (Marine Fish Collagen Peptides — Weishardt)

What is the recommended dosage of Naticol® (Marine Fish Collagen Peptides — Weishardt)?

The clinically studied dose for Naticol® (Marine Fish Collagen Peptides — Weishardt) is SARCOPENIA: 15 g/day Naticol® × 24 weeks in elderly. SKIN AGING: 2.5 g/day × 12 weeks (low-dose effective). NCT03872297 weight management: 3 months. Standard range: 2.5-15 g/day. Marine source — fish-allergic individuals: avoid.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Naticol® (Marine Fish Collagen Peptides — Weishardt) used for?

Naticol® (Marine Fish Collagen Peptides — Weishardt) is studied for sarcopenia 24-week rct in elderly (pivotal), skin aging 12-week low-dose rct (naticol-cyskin), weight management 3-month rct (nct03872297). Susan/Gillian/Bonnet/Donovan 2021 (JOJ Case Stud 12(5):555850) — sarcopenia 24-week RCT at 15 g/day Naticol® in elderly.

Are there side effects from taking Naticol® (Marine Fish Collagen Peptides — Weishardt)?

Reported potential side effects may include: Generally extremely well-tolerated — derived from food protein. GI upset (rare). Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Naticol® (Marine Fish Collagen Peptides — Weishardt) interact with medications?

Known drug interactions may include: Most medications: NO significant interactions documented. Iron supplements: separate by 2 hours (theoretical mineral chelation). Consult a pharmacist or healthcare provider if you take prescription medications.

Is Naticol® (Marine Fish Collagen Peptides — Weishardt) good for hair, skin & nails?

Yes, Naticol® (Marine Fish Collagen Peptides — Weishardt) is researched for Hair, Skin & Nails support. Susan/Gillian/Bonnet/Donovan 2021 (JOJ Case Stud 12(5):555850) — sarcopenia 24-week RCT at 15 g/day Naticol® in elderly. Significantly improved sarcopenia symptoms with increased lean muscle mass, handgrip strength, Short Physical Performance Battery, and Chair Stand Test.