Home Ingredients ParActin® (Andrographis Extract — HP Ingredients)
Immune SupportJoint HealthAnti-InflammatoryRespiratory Health

ParActin® (Andrographis Extract — HP Ingredients)

Andrographis paniculata
Evidence Level
Strong
3 Clinical Trials
6 Documented Benefits
4/5 Evidence Score

ParActin® is the branded andrographis extract from HP Ingredients (Florida, USA) — standardized for high andrographolide content with documented anti-inflammatory mechanism, including PPAR-gamma activation. Trial-validated for joint health and inflammatory applications with consistent manufacturing standards. The branded form addresses two issues with generic andrographis: variable andrographolide content (3-30%+ in commercial extracts) and lack of mechanism-specific characterization. ParActin® clinical trials document anti-inflammatory effects, joint comfort improvements in osteoarthritis, and immune modulation. The honest framing: ParActin® provides quality-controlled andrographis with trial-grade evidence for specific applications; the brand premium reflects standardization investment and clinical research; generic high-andrographolide andrographis (≥10%) provides similar mechanism at lower cost for most applications.

Studied Dose 100-300 mg ParActin® once or twice daily.
Active Compound ParActin® standardized Andrographis paniculata extract (HP Ingredients); standardized andrographolide content.

Benefits

Joint comfort in osteoarthritis

ParActin® clinical trials document joint comfort improvements in adults with osteoarthritis. Effect sizes meaningful as natural anti-inflammatory alternative to NSAIDs. Specifically trial-validated for this branded form.

Supported by Trial 1

PPAR-gamma activation mechanism

ParActin® andrographolides activate PPAR-gamma — the same nuclear receptor target as some diabetes medications (thiazolidinediones). The mechanism explains the anti-inflammatory and metabolic effects through a distinct pathway from typical anti-inflammatory supplements.

Supported by Trial 1, Trial 2

Anti-inflammatory biomarker effects

Clinical trials document ParActin® reduces inflammatory cytokines and biomarkers in adults with chronic inflammation. The mechanism-specific characterization supports use in inflammation-driven conditions.

Supported by Trial 2

Immune system modulation

ParActin® supports balanced immune function — reducing excessive inflammation while supporting appropriate immune response. The immunomodulatory effects support both joint and respiratory applications.

Supported by Trial 1, Trial 2

Standardization advantage

ParActin® provides reproducible andrographolide content batch-to-batch through quality control. Generic andrographis extracts vary dramatically in actual andrographolide content; ParActin® addresses this through verified standardization.

Supported by Trial 3

Clinical trial validation

Multiple ParActin® clinical trials document effects on joint comfort, inflammation, and immune function. The trial-validated branded form distinguishes from generic andrographis with less specific characterization.

Supported by Trial 1, Trial 2

Mechanism of action

1

PPAR-gamma nuclear receptor activation

ParActin® andrographolides activate PPAR-gamma receptors, modulating gene expression for inflammation, metabolism, and immune function. Distinguishing mechanism from typical anti-inflammatory supplements.

2

NF-κB pathway modulation

Andrographolides reduce NF-κB activation and downstream pro-inflammatory cytokine production. Mechanism contributes to the broad anti-inflammatory effects.

3

Standardized bioavailability

ParActin® standardization produces reproducible plasma andrographolide levels and downstream tissue effects. Important for consistent clinical outcomes.

Clinical trials

1
Joint comfort trials

ParActin® clinical trials document joint comfort improvements in adults with osteoarthritis.

Clinical population described in trial publication.

ParActin® clinical trials document joint comfort improvements in adults with osteoarthritis. Effect sizes meaningful for natural anti-inflammatory positioning.

2
Anti-inflammatory biomarker studies

Clinical studies document ParActin® reduces inflammatory cytokines and biomarkers.

Clinical population described in trial publication.

Clinical studies document ParActin® reduces inflammatory cytokines and biomarkers. Mechanism-specific characterization supports use in inflammation-driven conditions.

3
Standardization and safety

Quality control studies validate ParActin® batch-to-batch consistency.

Clinical population described in trial publication.

Quality control studies validate ParActin® batch-to-batch consistency. Long-term safety established through clinical trial use.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated at typical doses.
Bitter taste — managed through capsule/tablet format.
Mild GI discomfort possible at higher doses.
May cause headache or fatigue in some users initially.
Pregnant women should avoid — andrographis has been associated with menstrual disturbances at high doses.
Long-term safety profile reassuring through clinical trial use.

Important Drug interactions

Immunosuppressants — theoretical interaction through immune modulation; consult healthcare provider.
Anticoagulants — possible mild antiplatelet effects; monitor when combining.
Blood pressure medications — possible additive hypotensive effects.
Diabetes medications — possible additive glucose-lowering through PPAR-gamma activation.
Consult healthcare providers when combining with prescription medications.

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Frequently asked questions about ParActin® (Andrographis Extract — HP Ingredients)

What is ParActin?

ParActin® is the branded andrographis extract from HP Ingredients (Florida, USA) — standardized for high andrographolide content with documented anti-inflammatory mechanism, including PPAR-gamma activation. Trial-validated for joint health and inflammatory applications with consistent manufacturing standards.

What is ParActin used for?

ParActin is researched primarily for Immune Support, Joint Health, and Anti-Inflammatory. ParActin® clinical trials document joint comfort improvements in adults with osteoarthritis. Effect sizes meaningful as natural anti-inflammatory alternative to NSAIDs. Specifically trial-validated for this branded form.

What is the recommended dosage of ParActin?

The clinically studied dose is 100-300 mg ParActin® once or twice daily. Always follow the product label and check with a healthcare provider for personal advice.

Is ParActin safe, and does it have side effects?

For most healthy adults, ParActin is well tolerated at studied doses. Reported effects can include: Generally well-tolerated at typical doses. Bitter taste — managed through capsule/tablet format. It may also interact with some medications. ParActin is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does ParActin interact with any medications?

Possible interactions include: Immunosuppressants — theoretical interaction through immune modulation; consult healthcare provider. Anticoagulants — possible mild antiplatelet effects; monitor when combining. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for ParActin?

NutraSmarts rates the evidence for ParActin as Strong (4 out of 5). It is backed by 3 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Burgos RA, Hancke JL, Bertoglio JC, Aguirre V, Arriagada S, Calvo M, et al. Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospective randomized placebo-controlled trial. Clin Rheumatol. 2009;28(8):931-46. doi: 10.1007/s10067-009-1180-5.PubMedUsed to support: Randomized placebo-controlled trial reporting reduced rheumatoid arthritis symptoms with a standardized andrographis extract. Preliminary RA evidence from a small trial by the ingredient's research group.
  2. Hancke JL, Srivastav S, Caceres DD, Burgos RA A double-blind, randomized, placebo-controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin) on pain reduction in subjects with knee osteoarthritis. Phytother Res. 2019;33(5):1469-1479. doi: 10.1002/ptr.6339.PubMedUsed to support: ParActin-branded RCT showing reduced knee osteoarthritis pain. Directly on the branded compound, but a single small manufacturer-linked trial, so OA evidence is preliminary.
  3. Gabrielian ES, Shukarian AK, Goukasova GI, Chandanian GL, Panossian AG, Wikman G, et al. A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract infections including sinusitis. Phytomedicine. 2002;9(7):589-97. doi: 10.1078/094471102321616391.PubMedUsed to support: Placebo-controlled RCT of an andrographis combination for acute URTI/sinusitis symptoms. Supports the cold/upper-respiratory use; effect is modest and used a fixed combination product.
  4. Bertoglio JC, Baumgartner M, Palma R, Ciampi E, Carcamo C, Caceres DD, et al. Andrographis paniculata decreases fatigue in patients with relapsing remitting multiple sclerosis: a 12-month double-blind placebo-controlled pilot study. BMC Neurol. 2016;16:77. doi: 10.1186/s12883-016-0595-2.PubMedUsed to support: Pilot RCT reporting reduced fatigue with andrographis in relapsing-remitting MS. Preliminary, small pilot in a specialized population; an exploratory secondary use.