Top 5 — Ranked by Evidence
Very Strong
Omega-3 Fatty Acids
Heart Health
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduct
Very Strong
Pycnogenol® (French Maritime Pine Bark)
Cardiovascular health and blood pressure
50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic p
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
Strong
Boswellia Serrata (WokVel®)
Osteoarthritis and joint pain relief
100–250 mg/day high-AKBA extract (Aflapin® or 5-Loxin®); standard boswellia: 400
Strong
Capsaicin / Capsicum Extract (Capsimax®)
Thermogenesis and metabolic rate increase
100–200 mg/day Capsimax® (2% capsaicinoids = 2–4 mg active capsaicinoids); timin
All Anti-Inflammatory Ingredients (31)
Very Strong
Omega-3 Fatty Acids
Heart Health
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduct
Very Strong
Pycnogenol® (French Maritime Pine Bark)
Cardiovascular health and blood pressure
50–200 mg/day; cardiovascular: 100–200 mg/day; cognitive: 100 mg/day; athletic p
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
Strong
Boswellia Serrata (WokVel®)
Osteoarthritis and joint pain relief
100–250 mg/day high-AKBA extract (Aflapin® or 5-Loxin®); standard boswellia: 400
Strong
Capsaicin / Capsicum Extract (Capsimax®)
Thermogenesis and metabolic rate increase
100–200 mg/day Capsimax® (2% capsaicinoids = 2–4 mg active capsaicinoids); timin
Strong
Curcumin C3 Complex® (Most Studied Curcumin Extract)
Anti-inflammatory activity across 80+ studies
500–1,000 mg/day curcumin C3 Complex® (standardized to 95% curcuminoids); combin
Strong
Ginger (Zingiber officinale)
Nausea and vomiting relief
250–2,000 mg/day dried ginger powder or standardized extract; nausea: 1–1.5 g/da
Strong
Green Tea
Antioxidant Properties
250–500 mg/day EGCG standardized extract; whole green tea: 3–5 cups/day (≈240–32
Strong
Hytolive® (Olive Fruit Polyphenols / Hydroxytyrosol)
LDL oxidation protection (EU-authorized health claim)
5–20 mg/day hydroxytyrosol (as Hytolive®); EU health claim: ≥5 mg/day hydroxytyr
Strong
Olive Leaf Extract (Witholytin®)
Blood pressure reduction
500–1,000 mg/day standardized extract; EFSA cardiovascular claim dose: 5 mg/day
Strong
PEA — Palmitoylethanolamide (Levagen+®)
Chronic pain relief across multiple conditions
300–600 mg/day Levagen+® (LipiSperse® form); standard PEA: 300–1,200 mg/day in d
Strong
Tart Cherry Extract (Restoridyn®)
Muscle recovery and DOMS reduction
480 mg/day concentrated powder (equivalent to ~240 mL tart cherry juice twice da
Strong
Urolithin A (Mitopure® — Mitophagy Activator)
Muscle strength improvement — 12% gain in ATLAS RCT
500–1,000 mg/day Urolithin A (as Mitopure®); ATLAS trial: 500 mg (significant) a
Strong
goCOCOA® (Cocoa Flavanol Extract)
Cardiovascular health and blood pressure reduction
200–400 mg/day cocoa flavanols (epicatechin equivalent); cardiovascular/cognitiv
Moderate
Astaxanthin
Eye Health Benefits
4–12 mg/day from Haematococcus pluvialis extract; skin: 4–6 mg/day; exercise rec
Moderate
Bromelain
Anti-inflammatory and pain relief
200–400 mg/day (500–2,000 GDU) for anti-inflammatory; 400–800 mg/day with meals
Moderate
Calanus® Oil (Arctic Zooplankton Omega-3 Wax Esters)
Cardiovascular and heart function improvement
2g/day Calanus® Oil capsules; clinical study: 2–4g/day; wax ester form may have
Moderate
Celadrin® (Cetylated Fatty Acids)
Joint pain and stiffness reduction
Oral: 1,000–1,500 mg/day cetylated fatty acid complex; Topical: apply to affecte
Moderate
Colostrum
Immune Support
10-20g per day
Moderate
Curcumin/Turmeric
Anti-Inflammatory Effects
General studies suggest a dose of 500–2,000 mg of turmeric powder daily, which t
Moderate
Evening Primrose Oil (Oenothera biennis)
Eczema and atopic dermatitis improvement
3–6 g/day EPO (providing 240–480 mg GLA); eczema: 4–8 g/day; PMS: 3–4 g/day; dia
Moderate
MSM (Methylsulfonylmethane)
Joint Health and Arthritis Relief
1,000–3,000 mg/day elemental sulfur form; joint/anti-inflammatory: 1,500–3,000 m
Moderate
Metabolaid® (Hibiscus + Lemon Verbena)
AMPK activation and fat oxidation
500 mg/day Metabolaid® (325 mg lemon verbena + 175 mg hibiscus); taken before ex
Moderate
Pomegranate Extract (Pomella®)
Cardiovascular protection and blood pressure
200–1,000 mg/day standardized extract; pomegranate juice studies use 240–500 mL/
Moderate
Puremidine™ (Spermidine)
Autophagy induction and cellular rejuvenation
1–10 mg/day spermidine; observational longevity data at dietary intake of ~10–15
Moderate
Quercetin
Antioxidant Protection
500–1,000 mg/day; absorption enhanced significantly with vitamin C or bromelain;
Moderate
Resveratrol
Cardiovascular protection
150–500 mg/day trans-resveratrol; bioavailability enhanced with piperine or lipo
Moderate
Serezin™
Restorative sleep improvement
300 mg/day; benefits observed within 1 week, peak effects at 4 weeks
Moderate
Turkey Tail Mushroom
Immune system activation
1–3 g/day PSK extract; 2–9 g/day whole mushroom powder
Limited
Cat's Claw (Uncaria tomentosa)
Immune system modulation
250–500 mg/day standardized POA extract; rheumatoid arthritis trials: 60 mg free
Limited
Feverfew (Tanacetum parthenium)
Migraine prevention (variable evidence)
50–300 mg/day dried leaf (standardized to ≥0.2% parthenolide); MIG-99: 6.25 mg t