Home Ingredients Siliphos® (Silybin Phytosome — Indena)
Liver Health

Siliphos® (Silybin Phytosome — Indena)

Silybum marianum
Evidence Level
Strong
2 Clinical Trials
5 Documented Benefits
4/5 Evidence Score

Siliphos® is a SILYBIN PHYTOSOME® formulation developed by Indena (Italy) — using Phytosome® technology applied to silybin (the most active component of milk thistle silymarin complex). Distinguished by ~10× higher silybin bioavailability vs standard silymarin, focusing on silybin (vs full silymarin complex) for clinical applications. Used for: liver health, hepatoprotection, fatty liver adjunct, hepatic detoxification support.

Studied Dose 120-360 mg/day Siliphos (silybin equivalent)
Active Compound Silybin Phytosome® (silybin-phosphatidylcholine complex from Silybum marianum)

Benefits

Liver Health and Hepatoprotection

Siliphos provides bioavailable silybin for liver protection — multiple clinical trials in liver applications including fatty liver, viral hepatitis adjunct, and hepatotoxic exposure protection.

Supported by Trial 1, Trial 2

Fatty Liver (NAFLD) Support

Multiple trials show Siliphos improves liver enzyme markers (ALT, AST) and steatosis markers in non-alcoholic fatty liver disease.

Supported by Trial 1

10× Bioavailability vs Standard Silymarin

Standard silymarin (containing silybin + other flavonolignans) has poor bioavailability; Siliphos addresses this. Critical for clinical efficacy.

Supported by Trial 2, Trial 1

Antioxidant Liver Cell Protection

Silybin protects hepatocytes from oxidative damage; supports glutathione regeneration; foundation of liver protective effects.

Supported by Trial 2

Hepatotoxic Exposure Adjunct

Used as adjunct for hepatotoxic medications, alcohol-related liver stress, environmental toxin exposure.

Supported by Trial 1, Trial 2

Mechanism of action

1

Silybin Most Active Component

Silymarin from milk thistle is mixture of flavonolignans — SILYBIN (silibinin) is the most active component; comprises ~50-60% of silymarin. Siliphos focuses on silybin specifically for higher activity.

2

Phytosome® Bioavailability Enhancement

Standard silymarin has poor bioavailability (~5-10%); Phytosome improves silybin absorption ~10×.

3

Hepatocyte Membrane Protection

Silybin stabilizes hepatocyte (liver cell) membranes; protects from toxin entry; foundation of antidote effect against amanita mushroom poisoning.

4

Antioxidant and Glutathione Support

Direct antioxidant + supports endogenous glutathione (master liver antioxidant) regeneration.

5

Anti-Inflammatory Liver Effects

Reduces inflammatory markers in liver tissue.

Clinical trials

1
Siliphos for Fatty Liver — Multiple Trials
PubMed

Multiple Siliphos trials in NAFLD patients on liver enzymes, steatosis, fibrosis markers.

NAFLD patients.

Significant improvements in ALT, AST, steatosis markers vs placebo. Established Siliphos NAFLD evidence.

2
Silymarin for Liver Health Meta-Analysis
PubMed

Meta-analyses of silymarin (including bioavailable forms like Siliphos) for various liver conditions.

Various liver disease populations.

Generally supportive evidence for liver enzyme improvements and protective effects; bioavailable forms more reliable.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated.
Mild GI distress (rare).
Allergic reactions to Asteraceae family rare.
Mild laxative effect at high doses.
Soy allergy considerations (Phytosome).

Important Drug interactions

Hepatically-metabolized medications — silymarin may modestly affect CYP enzymes; consult.
Diabetes medications — modest hypoglycemic effects.
Anticoagulants — modest interactions.
Pregnancy — milk thistle traditionally considered safe; supplemental use limited specific data; consult.
Lactation — milk thistle traditionally considered safe; widely used.
Active liver disease — consult hepatologist before use; not replacement for medical management.
SOY ALLERGY — Phytosome consideration.

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Frequently asked questions about Siliphos® (Silybin Phytosome — Indena)

What is the recommended dosage of Siliphos® (Silybin Phytosome — Indena)?

The clinically studied dose for Siliphos® (Silybin Phytosome — Indena) is 120-360 mg/day Siliphos (silybin equivalent). Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Siliphos® (Silybin Phytosome — Indena) used for?

Siliphos® (Silybin Phytosome — Indena) is studied for liver health and hepatoprotection, fatty liver (nafld) support, 10× bioavailability vs standard silymarin. Siliphos provides bioavailable silybin for liver protection — multiple clinical trials in liver applications including fatty liver, viral hepatitis adjunct, and hepatotoxic exposure protection.

Are there side effects from taking Siliphos® (Silybin Phytosome — Indena)?

Reported potential side effects may include: Generally extremely well-tolerated. Mild GI distress (rare). Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Siliphos® (Silybin Phytosome — Indena) interact with medications?

Known drug interactions may include: Hepatically-metabolized medications — silymarin may modestly affect CYP enzymes; consult. Diabetes medications — modest hypoglycemic effects. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Siliphos® (Silybin Phytosome — Indena) good for liver health?

Yes, Siliphos® (Silybin Phytosome — Indena) is researched for Liver Health support. Siliphos provides bioavailable silybin for liver protection — multiple clinical trials in liver applications including fatty liver, viral hepatitis adjunct, and hepatotoxic exposure protection.