Top 5 — Ranked by Evidence
Very Strong
Omega-3 Fatty Acids
Heart Health
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduct
Very Strong
Psyllium Husk (Plantago ovata)
Cholesterol reduction (FDA-approved claim)
5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/da
Strong
Alpha Lipoic Acid
Universal antioxidant
300–600 mg/day racemic ALA; 100–300 mg/day R-ALA (more bioavailable)
Strong
Alpha-GPC
Enhances Cognitive Function
300–600 mg/day; cognitive: 300–400 mg/day in divided doses; athletic performance
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
All Liver Health Ingredients (33)
Very Strong
Omega-3 Fatty Acids
Heart Health
1–3 g/day combined EPA+DHA for general health; 2–4 g/day for triglyceride reduct
Very Strong
Psyllium Husk (Plantago ovata)
Cholesterol reduction (FDA-approved claim)
5–15 g/day psyllium husk (1–3 teaspoons); FDA cholesterol claim requires ≥7 g/da
Strong
Alpha Lipoic Acid
Universal antioxidant
300–600 mg/day racemic ALA; 100–300 mg/day R-ALA (more bioavailable)
Strong
Alpha-GPC
Enhances Cognitive Function
300–600 mg/day; cognitive: 300–400 mg/day in divided doses; athletic performance
Strong
Andrographis (ParActin®)
Cold and upper respiratory infection treatment
200–400 mg/day standardized extract (at 30% andrographolide); cold/flu treatment
Strong
Beta-Glucans (Oat & Yeast-Derived)
Cholesterol and LDL reduction (FDA-approved claim)
3 g/day oat beta-glucan for FDA cholesterol health claim; immune modulation: 250
Strong
Choline
Fetal brain development and pregnancy
425 mg/day (women AI); 550 mg/day (men AI); 930 mg/day (pregnant); up to 3,500 m
Strong
Flaxseed / Flaxseed Oil (Linum usitatissimum)
Cardiovascular protection and blood pressure
1–2 tablespoons (10–20g) ground flaxseed/day; flaxseed oil: 1–2 tablespoons/day
Strong
Glucomannan (Konjac Root Fiber)
Weight loss and appetite suppression
3–4 g/day before meals (1 g three times daily, 30 minutes before meals with 250
Strong
NAC (N-Acetylcysteine)
Antioxidant Support
600–1,800 mg/day in divided doses; respiratory: 600 mg twice daily; liver suppor
Moderate
Amla / Indian Gooseberry (Capros®)
Exceptional antioxidant capacity and vitamin C delivery
250–500 mg/day Capros® standardized extract; traditional amla powder: 3–6 g/day;
Moderate
Betaine / TMG (Trimethylglycine)
Athletic performance — power and strength
2–6 g/day; athletic performance: 2.5 g/day (most studied dose); homocysteine red
Moderate
Curcumin/Turmeric
Anti-Inflammatory Effects
General studies suggest a dose of 500–2,000 mg of turmeric powder daily, which t
Moderate
Earthlight® (Whole Food Mushroom Vitamin D2)
Plant-based whole food Vitamin D for clean labels
250–1000 IU Vitamin D2 equivalent per serving as Earthlight®; dosing equivalent
Moderate
Glycine
Improved Sleep Quality
3–5 g/day for sleep quality; metabolic/detox: 5–10 g/day; collagen support: 3–5
Moderate
L-Methionine
SAMe synthesis and methylation support
500–3,000 mg/day; general supplementation: 500–1,000 mg/day; therapeutic: up to
Moderate
L-Ornithine
Exercise fatigue reduction via ammonia clearance
2–6 g/day; fatigue reduction: 2 g before exercise; sleep: 400 mg before bedtime;
Moderate
Licorice Root (Glycyrrhiza glabra)
Digestive and GI mucosal protection (DGL form)
DGL for GI: 380–760 mg chewable before meals; whole licorice: 200–600 mg/day (li
Moderate
MCT Oil (Medium-Chain Triglycerides)
Rapid energy production and ketone generation
15–30 mL/day (1–2 tablespoons); start with 5–10 mL and increase gradually to avo
Moderate
Milk Thistle
Liver Health Support
The efficacy of these mechanisms depends on silymarin content (standardized extr
Moderate
Molybdenum
Sulfite detoxification via sulfite oxidase
45 mcg/day (RDA for adults); tolerable upper intake level: 2,000 mcg (2 mg)/day;
Moderate
PhosphatidylCholine
Gut Health
1–3 g/day (providing ~450–1,350 mg choline); take with meals
Moderate
Robuvit® (French Oak Wood Extract)
Chronic fatigue reduction
300 mg/day Robuvit®; fatigue studies use 300 mg/day; athletic performance: 300 m
Moderate
SAMe (S-Adenosyl-L-Methionine)
Mood and Depression Support
400–800 mg/day for depression; 600–1,200 mg/day for osteoarthritis; taken on emp
Moderate
iXOS® (Xylooligosaccharides Prebiotic)
Highly selective bifidogenic prebiotic at low dose
1–2g/day iXOS® for prebiotic bifidogenic effects (much lower than other prebioti
Limited
Aloe Vera (Aloe barbadensis miller)
Blood sugar regulation
Inner leaf gel: 50–300 mL/day juice; 100–300 mg/day freeze-dried gel powder; blo
Limited
Chitosan
Modest fat absorption reduction
3–6 g/day with meals; fat blocking requires taking with fat-containing meals; mo
Limited
Chlorella
Heavy metal and toxin binding
3–10 g/day dried powder (tablets or powder); cracked cell wall preparation essen
Limited
Dandelion Root
Liver support and detoxification
2–8 g/day dried root; 250–500 mg standardized extract three times daily
Limited
Fucoxanthin
White adipose tissue thermogenesis (UCP1 induction)
2.4–8 mg/day fucoxanthin; human trials use 2.4–8 mg/day combined with pomegranat
Limited
Guayusa (AMATEA® Organic Guayusa)
Clean energy and sustained focus
300–600 mg/day AMATEA® extract (providing 50–100 mg natural caffeine equivalent)
Limited
Vanadium (Vanadyl Sulfate)
Insulin sensitivity and blood sugar reduction
10–100 mg/day vanadyl sulfate in human studies; organic vanadium (BMOV): 10–30 m
Limited
goFAT® (Structured Lipid Blend)
Rapid ketogenic fuel and energy
Per product label; typical fat blend 5–15g/day; MCT component provides rapid ket