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Sukré® (Ultra-Pure Allulose)

Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Sukré® (Compound Solutions) is an ultra-pure allulose (D-psicose) sweetener — a rare monosaccharide found naturally in trace amounts in figs, raisins, and maple syrup that provides 70% of sucrose's sweetness at 0.4 kcal/g (vs. 4 kcal/g for sucrose). Unlike other sugar alcohols and alternative sweeteners, allulose has FDA GRAS status, is excluded from total and added sugar counts on Nutrition Facts labels (FDA ruling), produces no glycemic or insulinemic response, and has demonstrated metabolic health benefits at higher intakes. Sukré® differentiates through purity and clean taste profile.

Studied Dose As sweetener: 5–15g/serving; metabolic health benefits: 7–15g/day allulose with meals; FDA acceptable daily intake not formally established but well-tolerated up to 54g/day in studies
Active Compound D-psicose (allulose) — Sukré® by Compound Solutions; ultra-pure allulose; FDA GRAS; excluded from sugar labeling per FDA guidance

Benefits

Sugar-free, zero-glycemic sweetening with calorie label exclusion

Sukré® provides sweetness at ~70% of sucrose intensity with only 0.4 kcal/g caloric contribution — and per FDA guidance, allulose can be excluded from total and added sugar labeling. This dual advantage (functional sweetness + label-friendly status) makes Sukré® uniquely valuable for clean-label products targeting sugar reduction without resorting to artificial sweeteners or high-intensity sweetener blends.

Supported by Trial 1

Blood glucose and insulin reduction

Multiple clinical RCTs confirm allulose reduces postprandial blood glucose and insulin response when consumed with carbohydrate meals — inhibiting intestinal alpha-glucosidase enzymes (similar to acarbose, a diabetes medication) to slow glucose absorption. This glucose-lowering mechanism extends allulose beyond sweetening into active metabolic health ingredient territory.

Supported by Trial 1

Body fat reduction and anti-obesity effects

A meta-analysis of RCTs confirmed allulose supplementation (7–15g/day) significantly reduced body weight, BMI, waist circumference, and body fat percentage vs. control — effects attributed to alpha-glucosidase inhibition reducing carbohydrate absorption, improved fat oxidation signaling, and gut microbiome modulation including increased Akkermansia muciniphila abundance.

Supported by Trial 1

Mechanism of action

1

Alpha-glucosidase inhibition and Akkermansia stimulation

Allulose competitively inhibits intestinal brush border alpha-glucosidases (maltase, sucrase) — enzymes that break down complex carbohydrates into glucose for absorption. This mechanism reduces glucose absorption rate and postprandial glycemia, functioning similarly to the pharmaceutical alpha-glucosidase inhibitor acarbose but with substantially better GI tolerance. Unabsorbed allulose reaching the colon selectively promotes Akkermansia muciniphila growth — a keystone mucus-layer bacterium associated with improved metabolic health, insulin sensitivity, and reduced gut permeability.

Clinical trials

1
Allulose and Postprandial Glycemia — Meta-Analysis of RCTs
PubMed

Meta-analysis of 9 randomized controlled trials examining allulose effects on postprandial blood glucose, insulin, body composition, and metabolic markers.

Adults across 9 RCTs including subjects with and without metabolic syndrome.

Allulose significantly reduced postprandial blood glucose (−0.44 mmol/L), insulin area under the curve, body weight (−0.58 kg), and body fat vs. control. Alpha-glucosidase inhibitory mechanism confirmed. Well-tolerated up to 54g/day. Supports allulose as both a functional sweetener and metabolic health ingredient.

Side effects and drug interactions

Common Potential side effects

GI distress (bloating, diarrhea) at high single doses (>25g) — stay within 5–15g per serving
FDA GRAS status; excellent long-term safety data
May cause loose stools if consumed with other polyols (sorbitol, xylitol) — additive osmotic effect

Important Drug interactions

Diabetes medications — additive glucose-lowering effects at therapeutic doses; monitor blood glucose
No significant pharmacokinetic drug interactions at sweetener use levels

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Frequently asked questions about Sukré® (Ultra-Pure Allulose)

What is the recommended dosage of Sukré® (Ultra-Pure Allulose)?

The clinically studied dose for Sukré® (Ultra-Pure Allulose) is As sweetener: 5–15g/serving; metabolic health benefits: 7–15g/day allulose with meals; FDA acceptable daily intake not formally established but well-tolerated up to 54g/day in studies. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Sukré® (Ultra-Pure Allulose) used for?

Sukré® (Ultra-Pure Allulose) is studied for sugar-free, zero-glycemic sweetening with calorie label exclusion, blood glucose and insulin reduction, body fat reduction and anti-obesity effects. Sukré® provides sweetness at ~70% of sucrose intensity with only 0.4 kcal/g caloric contribution — and per FDA guidance, allulose can be excluded from total and added sugar labeling.

Are there side effects from taking Sukré® (Ultra-Pure Allulose)?

Reported potential side effects may include: GI distress (bloating, diarrhea) at high single doses (>25g) — stay within 5–15g per serving FDA GRAS status; excellent long-term safety data Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Sukré® (Ultra-Pure Allulose) interact with medications?

Known drug interactions may include: Diabetes medications — additive glucose-lowering effects at therapeutic doses; monitor blood glucose No significant pharmacokinetic drug interactions at sweetener use levels Consult a pharmacist or healthcare provider if you take prescription medications.

Is Sukré® (Ultra-Pure Allulose) good for metabolic health?

Yes, Sukré® (Ultra-Pure Allulose) is researched for Metabolic Health support. Multiple clinical RCTs confirm allulose reduces postprandial blood glucose and insulin response when consumed with carbohydrate meals — inhibiting intestinal alpha-glucosidase enzymes (similar to acarbose, a diabetes medication) to slow glucose absorption.