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Zynamite® PX (Mango Leaf Extract for Sports Performance)

Mangifera indica
Evidence Level
Strong
2 Clinical Trials
4 Documented Benefits
4/5 Evidence Score

Zynamite® PX (PLT Health Solutions / Nektium Pharma) is a patented combination of Zynamite® mango leaf extract (standardized to ≥60% mangiferin) and quercetin — specifically formulated for sports performance applications requiring acute power output, sprint performance, and exercise recovery. Single-dose studies confirm 2.8–3.8% peak power output improvement during repeated sprint exercise, with 10+ published clinical studies across strength, endurance, basketball performance, and exercise-induced muscle damage recovery.

Studied Dose 140 mg Zynamite® + 140 mg quercetin (single dose, 1 hour pre-exercise); 140 mg/day + 140 mg quercetin for 48 hours to 15 days (loading for enhanced performance); 10+ clinical studies across dose and timing protocols
Active Compound Mangifera indica leaf extract (≥60% mangiferin) + quercetin — Zynamite® PX by PLT Health Solutions / Nektium Pharma; quercetin enhances mangiferin bioavailability and provides synergistic polyphenol performance effects; 140 mg Zynamite® + 140 mg quercetin clinical dose

Benefits

Peak power output improvement in single dose

A published double-blind crossover RCT in 50 physically active men and women confirmed Zynamite® PX (140 mg + quercetin, single dose) improved peak power output by 2.8–3.8% during repeated Wingate sprint tests vs. placebo. This acute single-dose effect is unusual for polyphenol ingredients and reflects mangiferin's rapid oxygen utilization enhancement mechanism.

Supported by Trial 1

Basketball and team sport performance

An independent clinical study in national-level Greek basketball players confirmed Zynamite® PX significantly improved sprint speed, agility, and reduced perceived exertion during a basketball simulation test vs. placebo. This sport-specific evidence in elite athletes provides unusually strong ecological validity for real-world performance claims.

Supported by Trial 2, Trial 1

Exercise-induced muscle damage recovery

A recovery study (57 subjects, 10 km run + 100 drop jumps) confirmed Zynamite® PX (taken 1 hour pre-exercise and every 8 hours for 24 hours) significantly accelerated recovery from exercise-induced muscle damage vs. placebo — reducing CK elevation, muscle soreness, and functional impairment. This recovery application positions Zynamite® PX for post-workout and intra-workout formulas.

Supported by Trial 1, Trial 2

Oxygen utilization and exercise efficiency

The core mechanism (mangiferin's oxygen utilization enhancement) improves the efficiency of aerobic energy production — meaning athletes produce more ATP per unit oxygen consumed during exercise. This metabolic efficiency advantage contributes to both the acute power output benefits and the endurance/recovery benefits observed across 10+ clinical studies.

Supported by Trial 1, Trial 2

Mechanism of action

1

Mangiferin mitochondrial oxygen extraction and vascular NO enhancement

Mangiferin from Zynamite® enhances mitochondrial oxygen extraction efficiency by modulating complex I and II of the electron transport chain — improving ATP generation per O2 consumed. Quercetin enhances mangiferin bioavailability through P-glycoprotein inhibition and provides complementary eNOS/NO-mediated vasodilation improving oxygen and nutrient delivery to exercising muscle. The combined mitochondrial efficiency (mangiferin) + vascular delivery (quercetin-NO) mechanism explains the consistent performance improvements across power, sprint, endurance, and recovery endpoints.

Clinical trials

1
Zynamite® PX Single Dose and Peak Power Output — Crossover Clinical Trial

Randomized, double-blind, placebo-controlled crossover study in 50 active subjects (26M, 24F) examining single-dose Zynamite® PX (140 mg + quercetin) effects on repeated sprint performance. Published in Nutrients.

50 physically active subjects (26 men, 24 women). Acute crossover design.

Zynamite® PX improved peak power output by 2.8–3.8% during repeated Wingate sprints vs. placebo. Improved muscle oxygenation markers. Reduced perceived exertion at equivalent workloads. Both lipid-enhanced (with lecithin) and standard formulations effective.

2
Zynamite® PX (Mangiferin + Quercetin) Basketball Performance

Independent clinical study in national-level Greek basketball players examining pre-game Zynamite® PX supplementation effects on basketball-specific performance metrics.

38 male basketball players from Greece's top three national leagues. Randomized, double-blind, crossover study; single dose of Zynamite® PX (mango leaf extract with mangiferin + quercetin) vs placebo, 1 hour before intermittent high-intensity exercise. 24 circuits of 30-second activities measuring sprint and recovery metrics. Independent academic trial.

Mangiferin-quercetin supplementation significantly improved athletic performance metrics including sprint speed and reduced perceived exertion vs placebo. Confirms ergogenic effect previously seen in repeated sprint exercise (Gelabert-, n=40 men+women) and exercise-mimetic skeletal muscle effects (2023 Nutrients).

Side effects and drug interactions

Common Potential side effects

Excellent safety and tolerance profile across 10+ clinical studies
Non-stimulant — no caffeine-related effects
Quercetin component — rare sensitivity; well-tolerated at 140 mg

Important Drug interactions

P-glycoprotein drug substrates — quercetin inhibits P-gp; potential interaction with P-gp sensitive medications
Anticoagulants — quercetin has mild antiplatelet activity; monitor if on blood thinners
No significant interactions at clinical doses for most individuals

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Frequently asked questions about Zynamite® PX (Mango Leaf Extract for Sports Performance)

What is Zynamite PX?

Zynamite® PX (PLT Health Solutions / Nektium Pharma) is a patented combination of Zynamite® mango leaf extract (standardized to ≥60% mangiferin) and quercetin — specifically formulated for sports performance applications requiring acute power output, sprint performance, and exercise recovery.

What is Zynamite PX used for?

Zynamite PX is researched primarily for Athletic Performance and Muscle & Recovery. A published double-blind crossover RCT in 50 physically active men and women confirmed Zynamite® PX (140 mg + quercetin, single dose) improved peak power output by 2.8–3.8% during repeated Wingate sprint tests vs. placebo.

What is the recommended dosage of Zynamite PX?

The clinically studied dose is 140 mg Zynamite® + 140 mg quercetin (single dose, 1 hour pre-exercise); 140 mg/day + 140 mg quercetin for 48 hours to 15 days (loading for enhanced performance); 10+ clinical studies across dose and timing protocols Always follow the product label and check with a healthcare provider for personal advice.

Is Zynamite PX safe, and does it have side effects?

For most healthy adults, Zynamite PX is well tolerated at studied doses. Reported effects can include: Excellent safety and tolerance profile across 10+ clinical studies Non-stimulant — no caffeine-related effects It may also interact with some medications. Zynamite PX is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does Zynamite PX interact with any medications?

Possible interactions include: P-glycoprotein drug substrates — quercetin inhibits P-gp; potential interaction with P-gp sensitive medications Anticoagulants — quercetin has mild antiplatelet activity; monitor if on blood thinners If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for Zynamite PX?

NutraSmarts rates the evidence for Zynamite PX as Strong (4 out of 5). It is backed by 2 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Gelabert-Rebato M, Wiebe JC, Martin-Rincon M, Gericke N, Perez-Valera M, Curtelin D, et al. Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans. Frontiers in Physiology. 2018;9:740. doi: 10.3389/fphys.2018.00740.PubMedUsed to support: Human exercise trial showing Zynamite (mango leaf extract, standardized to mangiferin) with luteolin or quercetin enhanced VO2peak and peak power and preserved muscle function during ischemia-reperfusion. Supports the performance claim, but Zynamite is tested in combination (not alone), the sample is small, and the work is manufacturer (Nektium)-supported.
  2. Gelabert-Rebato M, Martin-Rincon M, Galvan-Alvarez V, Gallego-Selles A, Martinez-Canton M, Vega-Morales T, et al. A Single Dose of The Mango Leaf Extract Zynamite in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women. Nutrients. 2019;11(11):2592. doi: 10.3390/nu11112592.PubMedUsed to support: Acute RCT showing a single dose of Zynamite plus quercetin increased peak power output during repeated sprints. Backs the acute-performance claim; again a Zynamite+quercetin combination, modest sample, and Nektium-supported.
  3. Martin-Rincon M, Gelabert-Rebato M, Galvan-Alvarez V, Gallego-Selles A, Martinez-Canton M, Lopez-Rios L, et al. Supplementation with a Mango Leaf Extract (Zynamite) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise. Nutrients. 2020;12(3):614. doi: 10.3390/nu12030614.PubMedUsed to support: RCT reporting Zynamite plus quercetin reduced muscle pain/damage and sped recovery after a 10-km race plus drop jumps. Supports the recovery claim; combination product, modest sample, Nektium-supported.
  4. Wightman EL, Jackson PA, Forster J, Khan J, Wiebe JC, Gericke N, et al. Acute Effects of a Polyphenol-Rich Leaf Extract of Mangifera indica L. (Zynamite) on Cognitive Function in Healthy Adults: A Double-Blind, Placebo-Controlled Crossover Study. Nutrients. 2020;12(8):2194. doi: 10.3390/nu12082194.PubMedUsed to support: Double-blind crossover trial showing a single dose of Zynamite alone improved aspects of cognitive performance and mental energy in healthy adults. Notable as a Zynamite-only (not combination) cognition trial conducted by an independent academic group, though still manufacturer-funded and acute/single-dose.