Home Ingredients FitGrape® (Grape Polyphenol Extract)
AntioxidantCardiovascular

FitGrape® (Grape Polyphenol Extract)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

FitGrape® is a grape (Vitis vinifera) extract concentrated for polyphenols, including the oligomeric proanthocyanidins (OPCs) that make grape one of the richest plant antioxidant sources. Grape polyphenols are studied for supporting blood-vessel health and antioxidant defense.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape extract concentrated for polyphenols and oligomeric proanthocyanidins (OPCs).

Benefits

Antioxidant defense

Grape polyphenols are potent antioxidants; in a clinical study, a grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation.

Supported by Trial 1

Vascular support

By lowering oxidative stress, grape polyphenols support healthy blood-vessel function and circulation.

Supported by Trial 1

Cellular protection

The OPCs help protect cells and tissues from free-radical damage.

Mechanism of action

1

Proanthocyanidin antioxidants

Grape OPCs neutralize free radicals and support the body's antioxidant enzymes, protecting blood vessels and tissues.

2

Vascular signaling

Grape polyphenols support nitric-oxide-mediated blood-vessel relaxation and healthy circulation.

Clinical trials

1
Grape Proanthocyanidins and Oxidative Stress — Study
PubMed

Study of a grape seed proanthocyanidin extract on oxidative stress and vascular adhesion molecules. (Kalin et al. 2002, Free Radical Research)

Adults.

The grape proanthocyanidin extract reduced markers of oxidative stress and vascular adhesion molecules.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape polyphenols may have a mild additive effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

More Antioxidant Ingredients

Immune Support
Vitamin C
Vitamin C (L-ascorbic acid) is a water-soluble essential nutrient that humans cannot synth…
Immune Support
Zinc
Zinc, an essential trace mineral, is commonly supplemented in forms like zinc gluconate, a…
Immune Support
Vitamin A
Vitamin A is a fat-soluble nutrient essential for vision, immune defense, reproduction, an…
Bone Health
Copper
Copper is an essential trace mineral and cofactor for over 30 enzymatic reactions, includi…

Explore Other Ingredients

Cognitive
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and As…
Cardiovascular
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), an…
Sleep Health
Serezin™
Serezin™ is PLT Health Solutions' patented blend of Boswellia serrata and ginger (Zingiber…

Frequently asked questions about FitGrape® (Grape Polyphenol Extract)

What is FitGrape® (Grape Polyphenol Extract)?

FitGrape® is a grape (Vitis vinifera) extract concentrated for polyphenols, including the oligomeric proanthocyanidins (OPCs) that make grape one of the richest plant antioxidant sources. Grape polyphenols are studied for supporting blood-vessel health and antioxidant defense.

What is the recommended dosage of FitGrape® (Grape Polyphenol Extract)?

The clinically studied dose for FitGrape® (Grape Polyphenol Extract) is Commonly 100 to 300 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is FitGrape® (Grape Polyphenol Extract) used for?

FitGrape® (Grape Polyphenol Extract) is studied for antioxidant defense, vascular support, cellular protection. Grape polyphenols are potent antioxidants; in a clinical study, a grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation.

Are there side effects from taking FitGrape® (Grape Polyphenol Extract)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is FitGrape® (Grape Polyphenol Extract) safe to take?

Whether FitGrape® (Grape Polyphenol Extract) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED. It may also interact with certain medications. FitGrape® (Grape Polyphenol Extract) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kalin R, Righi A, Del Rosso A, et al. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res. 2002;36(8):819-25..PubMedUsed to support: Study supporting antioxidant and vascular benefit of grape proanthocyanidins.