Home Ingredients FORTIBONE® Bioactive Collagen Peptides
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FORTIBONE® Bioactive Collagen Peptides

Evidence Level
Moderate
2 Clinical Trials
5 Documented Benefits
3/5 Evidence Score

FORTIBONE® is a branded bioactive collagen peptide ingredient by GELITA AG, manufactured through a proprietary enzymatic hydrolysis of type I collagen to produce a specific peptide profile designed to stimulate osteoblast collagen synthesis and support bone mineral density. Distinct from generic collagen hydrolysate and from sister GELITA brands VERISOL® (skin) and FORTIGEL® (joints), FORTIBONE® is targeted at postmenopausal women and other adults seeking bone health support. A 12-month randomized controlled trial in postmenopausal women with reduced bone mineral density showed that 5 g/day of FORTIBONE® significantly increased lumbar spine and femoral neck BMD compared with placebo, with favorable changes in bone formation markers.

Studied Dose 5 g per day of FORTIBONE® dissolved in water or beverage, taken once daily, with significant changes in bone mineral density reported after 12 months of consistent use.
Active Compound Bioactive collagen peptides (~3-5 kDa) from porcine or bovine type I collagen, with a specific peptide profile optimized for osteoblast stimulation.

Benefits

Supports lumbar spine bone density

In a 12-month randomized trial in postmenopausal women, FORTIBONE® at 5 g/day was shown to support increases in lumbar spine bone mineral density compared with placebo, suggesting a role in maintaining skeletal strength during midlife and beyond.

Supported by Trial 1

Supports femoral neck bone density

FORTIBONE® supplementation has been shown to support increases in femoral neck bone mineral density in postmenopausal women with reduced BMD, a clinically meaningful site given fall- and hip-related concerns in aging adults.

Supported by Trial 1

Promotes a favorable bone remodeling balance

Markers of bone formation increased and markers of bone breakdown showed favorable trends in adults using FORTIBONE®, consistent with a shift in bone remodeling balance that helps maintain bone matrix over time.

Supported by Trial 1

Easy daily addition for women's bone routine

FORTIBONE® dissolves easily in water, coffee, or smoothies and is essentially tasteless, making it a convenient companion to calcium and vitamin D regimens for women focused on midlife and postmenopausal bone health.

Supported by Trial 2, Trial 1

Well-tolerated in long-term clinical use

FORTIBONE® showed a favorable tolerability profile across 12 months of daily 5 g use in postmenopausal women, supporting its suitability for long-term bone health programs.

Supported by Trial 1, Trial 2

Mechanism of action

1

Osteoblast stimulation by collagen peptides

Specific bioactive peptides in FORTIBONE® are absorbed and may reach bone tissue, where they can signal osteoblasts to increase synthesis of type I collagen, the main organic component of the bone matrix on which mineralization occurs.

2

Substrate supply for bone matrix

Collagen peptides provide glycine, proline, and hydroxyproline in the high concentrations needed for de novo synthesis of bone collagen, complementing minerals such as calcium and phosphate that build the mineral phase.

3

Optimized peptide profile

GELITA's proprietary enzymatic hydrolysis yields a defined peptide spectrum (~3-5 kDa) intended to maximize delivery of bioactive fragments relevant to bone cells, differentiating FORTIBONE® from non-specific collagen hydrolysates.

4

Modulation of bone turnover markers

Clinical data show that FORTIBONE® can favorably influence serum markers of bone formation and resorption, consistent with a net shift toward bone matrix accrual in postmenopausal women with low BMD.

Clinical trials

1
12-month RCT in postmenopausal women

Randomized, double-blind, placebo-controlled trial; 12 months; 5 g/day FORTIBONE®.

102 postmenopausal women with reduced (primary) BMD at lumbar spine or femoral neck.

Daily FORTIBONE® significantly increased lumbar spine and femoral neck BMD compared with placebo over 12 months, with favorable changes in bone formation markers, supporting its use as a bone health adjunct in postmenopausal women.

2
Collagen peptides with vitamin D and calcium in osteopenia

Controlled trial of calcium and vitamin D with or without collagen peptides; bone turnover markers assessed.

Postmenopausal women with osteopenia.

Addition of specific collagen peptides to calcium and vitamin D was associated with favorable changes in bone turnover markers compared with calcium and vitamin D alone, supporting a potential adjunctive role of collagen peptides in osteopenic women.

Side effects and drug interactions

Common Potential side effects

Mild gastrointestinal symptoms such as fullness or bloating can occur in some users.
Occasional reports of mild aftertaste or belching after mixing in beverages.
Rare allergic reactions in individuals sensitive to porcine or bovine proteins.
Loose stools may occur with higher than recommended servings.
No serious adverse events reported in long-term clinical trials at 5 g/day.

Important Drug interactions

No clinically significant interactions established with bisphosphonates or denosumab, but coordination with prescribing clinician advised.
Discuss with a clinician if combined with calcium or vitamin D supplements to avoid overlapping high intakes.
Use cautiously in chronic kidney disease where protein intake is medically managed.
May contribute to total daily protein relevant to medications adjusted by dietary protein load.

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Frequently asked questions about FORTIBONE® Bioactive Collagen Peptides

What is the recommended dosage of FORTIBONE® Bioactive Collagen Peptides?

The clinically studied dose for FORTIBONE® Bioactive Collagen Peptides is 5 g per day of FORTIBONE® dissolved in water or beverage, taken once daily, with significant changes in bone mineral density reported after 12 months of consistent use.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is FORTIBONE® Bioactive Collagen Peptides used for?

FORTIBONE® Bioactive Collagen Peptides is studied for supports lumbar spine bone density, supports femoral neck bone density, promotes a favorable bone remodeling balance. In a 12-month randomized trial in postmenopausal women, FORTIBONE® at 5 g/day was shown to support increases in lumbar spine bone mineral density compared with placebo, suggesting a role in maintaining skeletal strength during midlife and beyond.

Are there side effects from taking FORTIBONE® Bioactive Collagen Peptides?

Reported potential side effects may include: Mild gastrointestinal symptoms such as fullness or bloating can occur in some users. Occasional reports of mild aftertaste or belching after mixing in beverages. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does FORTIBONE® Bioactive Collagen Peptides interact with medications?

Known drug interactions may include: No clinically significant interactions established with bisphosphonates or denosumab, but coordination with prescribing clinician advised. Discuss with a clinician if combined with calcium or vitamin D supplements to avoid overlapping high intakes. Consult a pharmacist or healthcare provider if you take prescription medications.

Is FORTIBONE® Bioactive Collagen Peptides good for bone health?

Yes, FORTIBONE® Bioactive Collagen Peptides is researched for Bone Health support. In a 12-month randomized trial in postmenopausal women, FORTIBONE® at 5 g/day was shown to support increases in lumbar spine bone mineral density compared with placebo, suggesting a role in maintaining skeletal strength during midlife and beyond.

References(2 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific collagen peptides improve bone mineral density and bone markers in postmenopausal women — a randomized controlled study. Nutrients. 2018;10(1):97.PubMedUsed to support: 12-month RCT in 102 postmenopausal women with reduced BMD: 5 g/day FORTIBONE® significantly increased lumbar spine and femoral neck BMD vs placebo, with favorable bone formation markers.
  2. Argyrou C, Karlafti E, Lampropoulou-Adamidou K, Tournis S, Makris K, Trovas G, Dontas I, Triantafyllopoulos IK. Effect of calcium and vitamin D supplementation with and without collagen peptides on bone turnover in postmenopausal women with osteopenia. Journal of Musculoskeletal and Neuronal Interactions. 2020;20(1):12-17.PubMedUsed to support: Controlled trial in postmenopausal women with osteopenia: addition of specific collagen peptides to calcium and vitamin D modulated bone turnover markers favorably vs calcium/vitamin D alone.