Home Ingredients NeuGrape® (Grape Seed Extract for Cognition)
CognitiveAntioxidant

NeuGrape® (Grape Seed Extract for Cognition)

Vitis vinifera
Evidence Level
Limited
1 Clinical Trial
3 Documented Benefits
2/5 Evidence Score

NeuGrape® is a grape (Vitis vinifera) seed extract concentrated for oligomeric proanthocyanidins (OPCs), studied for supporting brain health. Grape polyphenols are potent antioxidants that protect neurons and support blood flow to the brain, the basis for NeuGrape's cognitive positioning.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape seed extract concentrated for oligomeric proanthocyanidins (OPCs).

Benefits

Cognitive support

Grape seed proanthocyanidins are studied for supporting cognitive function and protecting the brain from oxidative stress.

Supported by Trial 1

Antioxidant defense

Grape OPCs are potent antioxidants that protect neurons and blood vessels from free-radical damage.

Supported by Trial 1

Brain blood flow

By supporting healthy blood-vessel function, grape polyphenols support circulation to the brain.

Supported by Trial 1

Mechanism of action

1

Proanthocyanidin neuroprotection

Grape OPCs scavenge free radicals and support antioxidant defenses in brain tissue, protecting neurons from oxidative stress.

2

Vascular support

Grape polyphenols support nitric-oxide-mediated blood-vessel relaxation, aiding blood flow to the brain.

Clinical trials

1
Grape Proanthocyanidins and Oxidative Stress — Study
PubMed

Study of a grape seed proanthocyanidin extract on oxidative stress and vascular markers. (Kalin et al. 2002, Free Radical Research)

Adults.

The grape proanthocyanidin extract reduced markers of oxidative stress and vascular inflammation, relevant to neuroprotection.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape OPCs may have a mild additive effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

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Frequently asked questions about NeuGrape® (Grape Seed Extract for Cognition)

What is NeuGrape® (Grape Seed Extract for Cognition)?

NeuGrape® is a grape (Vitis vinifera) seed extract concentrated for oligomeric proanthocyanidins (OPCs), studied for supporting brain health. Grape polyphenols are potent antioxidants that protect neurons and support blood flow to the brain, the basis for NeuGrape's cognitive positioning.

What is the recommended dosage of NeuGrape® (Grape Seed Extract for Cognition)?

The clinically studied dose for NeuGrape® (Grape Seed Extract for Cognition) is Commonly 100 to 300 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is NeuGrape® (Grape Seed Extract for Cognition) used for?

NeuGrape® (Grape Seed Extract for Cognition) is studied for cognitive support, antioxidant defense, brain blood flow. Grape seed proanthocyanidins are studied for supporting cognitive function and protecting the brain from oxidative stress.

Are there side effects from taking NeuGrape® (Grape Seed Extract for Cognition)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is NeuGrape® (Grape Seed Extract for Cognition) safe to take?

Whether NeuGrape® (Grape Seed Extract for Cognition) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. NeuGrape® (Grape Seed Extract for Cognition) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Kalin R, Righi A, Del Rosso A, et al. Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis. Free Radic Res. 2002;36(8):819-25..PubMedUsed to support: Study supporting antioxidant and vascular benefit of grape proanthocyanidins.