Benefits
Nitric oxide, pump, and blood flow
Citrulline raises arginine and nitric oxide more efficiently than arginine itself, supporting vasodilation, exercise blood flow, and the muscle 'pump'.
Exercise performance and recovery
Systematic reviews report citrulline can support exercise performance and reduce post-exercise soreness, making it a popular pre-workout active.
Blood pressure support
By boosting nitric oxide, citrulline supplementation has been shown to modestly lower blood pressure in systematic reviews.
Mechanism of action
Citrulline-to-arginine-to-nitric-oxide pathway
Citrulline bypasses the gut and liver breakdown that limits oral arginine, recycling efficiently into arginine and then nitric oxide to widen blood vessels.
Peptide-bound delivery
Whey-peptide binding gives a soluble, palatable form well suited to pre-workout drinks and powders.
Clinical trials
Systematic review (Nutrients, 2025).
Active adults
Citrulline or watermelon supplementation supported aspects of performance and body composition, with effects depending on dose and training.
Systematic review (Clinical Nutrition ESPEN, 2025).
Adults
L-citrulline supplementation modestly lowered blood pressure versus control, consistent with nitric-oxide signaling.