Vitaflavan® (Grape Seed Extract)

Vitis vinifera
Evidence Level
Moderate
1 Clinical Trial
3 Documented Benefits
3/5 Evidence Score

Vitaflavan® is a French grape seed (Vitis vinifera) extract standardized for oligomeric proanthocyanidins (OPCs), among the most powerful plant antioxidants. Grape seed OPCs are studied for supporting blood-vessel health, antioxidant defense, and, in women, menopause-related comfort and body composition.

Studied Dose Commonly 100 to 300 mg per day.
Active Compound Grape seed extract standardized for oligomeric proanthocyanidins (OPCs / procyanidins).

Benefits

Antioxidant defense

Grape seed OPCs are highly potent antioxidants that help protect cells and blood vessels from oxidative stress.

Vascular and cardiovascular support

OPCs support healthy blood-vessel function and circulation, contributing to cardiovascular health.

Menopausal support

In a randomized controlled trial, grape seed proanthocyanidin extract supported improvements in menopausal symptoms and body composition in middle-aged women.

Mechanism of action

1

Proanthocyanidin antioxidant action

OPCs neutralize free radicals and support the body's antioxidant enzymes, protecting blood vessels and tissues.

2

Endothelial support

Grape seed polyphenols support nitric-oxide-mediated blood-vessel relaxation and healthy circulation.

Clinical trials

1
Grape Seed OPCs and Menopause — RCT
PubMed

Randomized, double-blind, placebo-controlled pilot trial of grape seed proanthocyanidin extract on menopausal symptoms and body composition. (Terauchi et al. 2014, Menopause)

Middle-aged women.

Grape seed extract supported improvements in menopausal symptoms, body composition, and cardiovascular measures.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses.
Mild digestive upset is occasionally reported.
Discontinue if any unusual reaction occurs.

Important Drug interactions

Anticoagulants — grape seed may have a mild blood-thinning effect; monitor.
Blood pressure medication — possible additive effect; monitor.
Tell your doctor before surgery.

Frequently asked questions about Vitaflavan® (Grape Seed Extract)

What is Vitaflavan® (Grape Seed Extract)?

Vitaflavan® is a French grape seed (Vitis vinifera) extract standardized for oligomeric proanthocyanidins (OPCs), among the most powerful plant antioxidants. Grape seed OPCs are studied for supporting blood-vessel health, antioxidant defense, and, in women, menopause-related comfort and body composition.

What is the recommended dosage of Vitaflavan® (Grape Seed Extract)?

The clinically studied dose for Vitaflavan® (Grape Seed Extract) is Commonly 100 to 300 mg per day.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Vitaflavan® (Grape Seed Extract) used for?

Vitaflavan® (Grape Seed Extract) is studied for antioxidant defense, vascular and cardiovascular support, menopausal support. Grape seed OPCs are highly potent antioxidants that help protect cells and blood vessels from oxidative stress.

Are there side effects from taking Vitaflavan® (Grape Seed Extract)?

Reported potential side effects may include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. Mild digestive upset is occasionally reported. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Vitaflavan® (Grape Seed Extract) safe to take?

Whether Vitaflavan® (Grape Seed Extract) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: GENERALLY WELL-TOLERATED — adverse effects are uncommon at normal doses. It may also interact with certain medications. Vitaflavan® (Grape Seed Extract) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Terauchi M, Horiguchi N, Kajiyama A, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause. 2014;21(9):990-6..PubMedUsed to support: RCT supporting menopausal and body-composition benefit of grape seed OPCs.