Home Ingredients Xorialyc® (Olive Leaf Extract for Skin Inflammation)
Hair, Skin & NailsAnti-Inflammatory

Xorialyc® (Olive Leaf Extract for Skin Inflammation)

Olea europaea
Evidence Level
Moderate
2 Clinical Trials
6 Documented Benefits
3/5 Evidence Score

Xorialyc® is a NEXT-GENERATION OLIVE LEAF EXTRACT developed by Pharmactive Biotech Products (Spain) — designed for skin inflammation and skin quality applications. Distinguished by activity from luteolin, quercetin, and ortho-diphenols — inhibits NF-κB, COX-2, and PGE₂ inflammatory pathways while providing antioxidant protection. 60-day consumer study (n=50, ages 40-60) at 300 mg/day showed: 74% reduction in redness, 76% reduction in itching, 72% reduction in tightness, ~72% improvement in skin hydration and quality. 80% noticed visible effects. Used for: skin redness, itching, inflammatory skin conditions, beauty-from-within.

Studied Dose 300 mg/day (research-validated dose)
Active Compound Olive leaf polyphenols (luteolin, quercetin, ortho-diphenols, oleuropein)

Benefits

Skin Redness Reduction

Pharmactive 60-day consumer study (50 adults aged 40-60) at 300 mg/day showed 74% reduction in skin redness. Useful for inflammatory skin conditions, sensitivity, rosacea-adjacent concerns.

Supported by Trial 1

Itching Reduction

Same study: 76% reduction in itching. Relevant for: eczema-adjacent conditions, dry skin itching, sensitive skin.

Supported by Trial 1, Trial 2

Skin Tightness Reduction

72% reduction in skin tightness sensation. Improves overall skin comfort.

Supported by Trial 1, Trial 2

Hydration and Skin Quality (~72% improvement)

Improvements in skin hydration and overall quality. Beauty-from-within mechanism complementing topical interventions.

Supported by Trial 1, Trial 2

Strong User Satisfaction (80% Visible Effects)

80% noticed visible effects; 78% said it worked fast and would recommend it. Clinically meaningful real-world satisfaction.

Supported by Trial 1

Multiple Inflammatory Pathway Inhibition

Activity via inhibition of NF-κB, COX-2, and PGE₂ — foundational anti-inflammatory pathways. Strong antioxidant protection from polyphenol fraction.

Supported by Trial 2

Mechanism of action

1

NF-κB Pathway Inhibition

NF-κB is master inflammatory transcription factor; Xorialyc compounds inhibit NF-κB activation — reduces downstream inflammatory gene expression in skin cells.

2

COX-2 Inhibition

COX-2 produces inflammatory prostaglandins; Xorialyc compounds inhibit COX-2 — reduces inflammatory prostaglandin synthesis. Same target as NSAIDs.

3

PGE₂ Reduction

Prostaglandin E2 (PGE₂) drives inflammatory skin reactions; Xorialyc reduces PGE₂ formation.

4

Luteolin and Quercetin Bioactivity

Luteolin is potent anti-inflammatory flavonoid; quercetin has documented anti-inflammatory/antioxidant effects; Xorialyc concentrates these compounds for skin applications.

5

Ortho-Diphenol Antioxidant Activity

Ortho-diphenols (catechol-type structures including hydroxytyrosol-related compounds) provide potent antioxidant activity protecting skin from oxidative damage.

Clinical trials

1
Xorialyc 60-Day Consumer Study — Pharmactive
PubMed

60-day consumer study of Xorialyc 300 mg/day in 50 adults aged 40-60.

50 adults aged 40-60.

74% redness reduction, 76% itching reduction, 72% tightness reduction, ~72% hydration/skin quality improvement; 80% noticed visible effects; 78% would recommend.

2
Olive Polyphenol Anti-Inflammatory Mechanism
PubMed

Multiple studies of olive polyphenols on inflammatory pathways including NF-κB, COX-2, PGE₂.

Cell, animal, and human studies.

Confirmed inhibition of NF-κB, COX-2, PGE₂; established anti-inflammatory mechanism for skin and other inflammatory applications.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Allergic reactions to olive rare.
Bitter taste characteristic of olive polyphenols (minimal in capsule).

Important Drug interactions

Antihypertensives — modest additive BP effects.
Anticoagulants — modest effects.
Diabetes medications — modest hypoglycemic effects.
Pregnancy/lactation — culinary olive use safe; concentrated extract supplementation limited safety data; consult.
Photosensitizing medications — generally non-interactive.
Featured In

Symptom-specific supplement guides

✨Best Supplements for Acne🌿Best Supplements for Eczema

More Hair, Skin & Nails Ingredients

Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a…
Cardiovascular
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), an…
Immune Support
Vitamin C
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin commonly used in supple…
Immune Support
Zinc
Zinc, an essential trace mineral, is commonly supplemented in forms like zinc gluconate, a…

Explore Other Ingredients

Antioxidant
Lutein
Lutein is a yellow carotenoid antioxidant that plays a key role in eye health, particularl…
Hair, Skin & Nails
Hyaluronic Acid
Hyaluronic acid is a naturally occurring substance in the body, primarily found in connect…
Antioxidant
Setria® Glutathione
Setria® is Kyowa Hakko's patented reduced L-glutathione (GSH) produced via fermentation —…

Frequently asked questions about Xorialyc® (Olive Leaf Extract for Skin Inflammation)

What is Xorialyc® (Olive Leaf Extract for Skin Inflammation)?

Xorialyc® is a NEXT-GENERATION OLIVE LEAF EXTRACT developed by Pharmactive Biotech Products (Spain) — designed for skin inflammation and skin quality applications.

What does Xorialyc® (Olive Leaf Extract for Skin Inflammation) do?

NF-κB is master inflammatory transcription factor; Xorialyc compounds inhibit NF-κB activation — reduces downstream inflammatory gene expression in skin cells. In clinical research, Xorialyc® (Olive Leaf Extract for Skin Inflammation) has been studied for skin redness reduction, itching reduction, skin tightness reduction.

Who should take Xorialyc® (Olive Leaf Extract for Skin Inflammation)?

Xorialyc® (Olive Leaf Extract for Skin Inflammation) may be most relevant for people interested in hair, skin & nails, anti-inflammatory. It has been clinically studied for skin redness reduction, itching reduction, skin tightness reduction. As with any supplement, consult your healthcare provider before starting, especially if you have medical conditions or take prescription medications.

How long does Xorialyc® (Olive Leaf Extract for Skin Inflammation) take to work?

Most clinical trial effects appear over weeks of consistent use; individual response varies. Acute or same-day effects (where applicable) typically appear within hours, but most cumulative benefits — particularly those affecting biomarkers, mood, sleep quality, or chronic symptoms — require 4-12 weeks of regular use to fully assess. If you don't notice benefit after 12 weeks at the appropriate dose, it may not be your responder.

When is the best time to take Xorialyc® (Olive Leaf Extract for Skin Inflammation)?

Xorialyc® (Olive Leaf Extract for Skin Inflammation) can typically be taken with breakfast or dinner — taking with food reduces GI sensitivity for most supplements. Specific timing matters less than daily consistency for cumulative effects. Always check product labeling and follow personalized guidance from your healthcare provider.

Is Xorialyc® (Olive Leaf Extract for Skin Inflammation) worth taking?

Xorialyc® (Olive Leaf Extract for Skin Inflammation) has moderate clinical evidence (Evidence Level 3/5 on NutraSmarts) — meaningful trial support exists, though results are less consistent than top-tier ingredients. Whether it's worth taking depends on your specific goals, what you've already tried, your budget, and your overall supplement strategy. The honest framing: no supplement is essential for most people, and lifestyle factors (sleep, exercise, diet, stress management) typically produce larger effects than any single supplement. Xorialyc® (Olive Leaf Extract for Skin Inflammation) is most worth trying if its evidence-supported uses align with your specific goals.

What is the recommended dosage of Xorialyc® (Olive Leaf Extract for Skin Inflammation)?

The clinically studied dose for Xorialyc® (Olive Leaf Extract for Skin Inflammation) is 300 mg/day (research-validated dose). Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Xorialyc® (Olive Leaf Extract for Skin Inflammation) used for?

Xorialyc® (Olive Leaf Extract for Skin Inflammation) is studied for skin redness reduction, itching reduction, skin tightness reduction. Pharmactive 60-day consumer study (50 adults aged 40-60) at 300 mg/day showed 74% reduction in skin redness. Useful for inflammatory skin conditions, sensitivity, rosacea-adjacent concerns.