Benefits
Strongest anthocyanin antioxidant by ORAC
The oxygen radical absorbance capacity (ORAC) method validated BGG's Cyanidin-3-O-Glucoside (C3G) as the strongest antioxidant of the 14 main anthocyanins. Published test results have proven BGG's proprietary formula is three-times stronger than the Trolox reference standard. Sets benchmark for antioxidant potency in the anthocyanin category.
Eye health and visual function support
In a clinical trial, subjects were randomized to 300 mg/day BSHE/C3G or placebo based on eyesight level. C3G is a key bioactive linked to vision support — particularly relevant for age-related vision concerns and the broad eye-health supplement category alongside lutein and bilberry extracts.
Metabolic syndrome improvement
BSHE/C3G has been clinically demonstrated for metabolic syndrome applications — a key BGG patent area. C3G mechanism involves NLRP3 inflammasome inactivation and SirT1/NF-κB signaling pathway modulation. Particularly relevant for alcoholic steatohepatitis (preclinical evidence) and broader metabolic dysfunction associated with chronic low-grade inflammation.
Hepatoprotective oxidative stress reduction
C3G prevents hydrogen peroxide (H2O2)-induced oxidative damage in HepG2 hepatocyte cells in preclinical research. The hepatoprotective effect is relevant for alcoholic and non-alcoholic fatty liver disease applications — addressing both oxidative stress and inflammasome activation that drive liver tissue damage.
Anti-inflammatory NLRP3 inflammasome inhibition
Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome — a key regulator of inflammatory responses across multiple disease contexts. The NLRP3 mechanism alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway modulation. NLRP3 inhibition is a major drug development target — C3G provides natural NLRP3 modulation.
Memory and motor skills support
C3G has been linked to reduction in memory loss and enhanced motor skills based on existing research. Combined with the antioxidant activity, this supports broader cognitive aging applications. The antioxidant mechanism crosses the blood-brain barrier providing direct CNS neuroprotection.
Cardiovascular and weight management
C3G research has documented improved blood circulation, cardiovascular protection, and weight management support — addressing multiple components of metabolic health simultaneously. The broad-spectrum metabolic effects make CyaniMax suitable for foundational metabolic health formulations.
Cancer prevention and chemotherapy adjuvant (research)
C3G may prevent certain cancers and aid chemotherapy, according to research published in the Journal of Biological Chemistry. Mechanism involves antioxidant protection, anti-inflammatory NLRP3 inhibition, and apoptotic signaling in cancer cells. Cancer adjuvant applications remain in research phase but represent significant potential.
Mechanism of action
Anthocyanin antioxidant pigment activity
C3G is the strongest of 14 main anthocyanin pigments per ORAC testing — 3× Trolox reference. Anthocyanins scavenge reactive oxygen species (ROS) directly and indirectly via cellular antioxidant enzyme upregulation. The high antioxidant potency underlies most of CyaniMax's downstream biological effects.
NLRP3 inflammasome inactivation
C3G inactivates NLRP3 inflammasome — a major regulator of inflammatory responses involving IL-1β and IL-18 cytokine production. NLRP3 hyperactivation drives multiple disease processes including metabolic syndrome, neurodegenerative disease, and chronic inflammation. C3G's NLRP3 inhibition is rare among natural products.
SirT1/NF-κB signaling pathway modulation
C3G modulates SirT1 (sirtuin 1) and NF-κB (master inflammatory regulator) signaling pathways. SirT1 activation supports cellular longevity, mitochondrial function, and metabolic health. NF-κB inhibition reduces inflammation. Combined effects address both cellular aging and inflammation simultaneously.
Eye tissue antioxidant protection
Eye tissue is particularly vulnerable to oxidative damage due to high oxygen consumption, UV exposure, and metabolic activity. C3G's strong antioxidant activity supports retinal and lens health — explaining the eye-health applications. Combined with the broader anti-inflammatory effects, comprehensive ocular tissue support.
Blood-brain barrier crossing
C3G can cross the blood-brain barrier providing direct CNS antioxidant and anti-inflammatory effects. The BBB crossing is essential for cognitive and neuroprotective applications — many antioxidants are excluded by the BBB and have limited brain effects despite peripheral antioxidant activity.
Clinical trials
Clinical trial evaluating black soybean hull extract/C3G (CyaniMax) at 300 mg/day for eyesight support. Randomized subjects divided by eyesight level. Test group (n=30) received 300 mg/day BSHE/C3G; control group (n=30) received placebo. Foundation for BGG's patent-protected eyesight claims.
60 subjects randomly divided based on eyesight level. Test group received 300 mg/day BSHE/C3G; control received placebo.
Demonstrated effects on visual function with 300 mg/day BSHE/C3G. The trial supports the BGG patent that limits eyesight and metabolic syndrome claims to CyaniMax-branded material. Combined with class evidence for anthocyanin eye health benefits, establishes CyaniMax as the clinically-validated C3G ingredient for vision support formulations.
Preclinical studies on cyanidin-3-glucoside's hepatoprotective and anti-inflammatory mechanisms. HepG2 hepatocyte cell line studies of H2O2-induced oxidative damage prevention. Mechanistic studies of NLRP3 inflammasome inactivation in alcoholic steatohepatitis models. Published in Biotechnology Letters.
Not applicable — HepG2 cell line and alcoholic steatohepatitis preclinical models.
C3G prevented H2O2-induced oxidative damage in HepG2 cells. Inactivated NLRP3 inflammasome and alleviated alcoholic steatohepatitis via SirT1/NF-κB signaling pathway modulation. Mechanistic foundation supports liver health and metabolic syndrome applications. C3G's NLRP3 inhibition is among the rare natural products with this mechanism.
Class evidence from broader anthocyanin clinical research. Multiple controlled trials of anthocyanin-rich extracts (bilberry, blackcurrant, blueberry) for eye health, cardiovascular, and metabolic outcomes. C3G is the strongest of 14 main anthocyanins by ORAC — supports class-leading positioning.
Various — adults across multiple anthocyanin clinical trials in eye health, cardiovascular, and metabolic contexts.
Anthocyanins consistently improve eye health markers, cardiovascular parameters, and metabolic markers across the research base. C3G specifically is the most potent antioxidant among anthocyanins by ORAC testing. The CyaniMax patent protects the specific BSHE/C3G material for metabolic syndrome and eyesight claims — branding-protected commercial position.