Home Ingredients Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)
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Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)

Ginkgo biloba
Evidence Level
Strong
2 Clinical Trials
6 Documented Benefits
4/5 Evidence Score

Ginkgoselect® Phytosome is a GINKGO BILOBA EXTRACT PHYTOSOME® developed by Indena (Italy) — using Phytosome® technology applied to standardized ginkgo biloba leaf extract. Distinguished by enhanced bioavailability of ginkgo flavonoids and terpenoids, plus pharmaceutical-grade quality. Used for: cognitive function, microcirculation (especially cerebral), peripheral circulation, age-related cognitive support.

Studied Dose 120-240 mg/day Ginkgoselect Phytosome
Active Compound Ginkgo flavonoids (24%) and terpene lactones (6%) Phytosome®

Benefits

Cognitive Function and Working Memory

Ginkgo biloba has long history of use for cognitive function; Phytosome bioavailability advantage delivers more active to brain.

Supported by Trial 1, Trial 2

Cerebral Microcirculation

Improves cerebral blood flow and microcirculation — foundation for cognitive applications.

Supported by Trial 1

Peripheral Circulation

Supports peripheral circulation; useful for: cold extremities, claudication adjunct.

Age-Related Cognitive Support

Useful component of healthy aging cognitive support; some evidence for mild cognitive impairment.

Supported by Trial 1

Antioxidant Activity

Flavonoids provide antioxidant protection.

Enhanced Bioavailability vs Standard Ginkgo

Phytosome technology improves ginkgo bioactive absorption.

Supported by Trial 2

Mechanism of action

1

Ginkgo Flavonoids and Terpene Lactones

Active compounds: FLAVONOIDS (quercetin glycosides, kaempferol) — antioxidants; TERPENE LACTONES (ginkgolides A, B, C, J, bilobalide) — unique to ginkgo, modulate platelet activating factor (PAF) and provide neuroprotection.

2

Cerebral Blood Flow Enhancement

Increases cerebral microcirculation — supports cognitive function via improved brain perfusion.

3

Platelet-Activating Factor (PAF) Antagonism

Ginkgolides antagonize PAF — modest antiplatelet effect; relevant to vascular benefits but also bleeding risk.

4

Antioxidant Protection

Ginkgo flavonoids reduce oxidative stress in brain tissue.

5

Phytosome® Bioavailability

Enhanced absorption of ginkgo bioactives via Phytosome complex.

Clinical trials

1
Ginkgo Biloba for Cognitive Function — General Evidence
PubMed

Multiple ginkgo RCTs for cognitive function across populations.

Various populations including older adults and mild cognitive impairment.

Modest cognitive benefits; effect size variable; bioavailable forms more reliable.

2
Ginkgoselect Phytosome Specific Studies — Indena
PubMed

Indena studies of Ginkgoselect Phytosome bioavailability and clinical effects.

Adults across applications.

Enhanced bioavailability and clinical effects.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Headache rare.
BLEEDING RISK — ginkgo's antiplatelet effect from PAF antagonism is significant; theoretical risk.
Allergic reactions rare.
Soy allergy considerations (Phytosome).

Important Drug interactions

ANTICOAGULANTS — significant antiplatelet effect; theoretical bleeding risk; consult prescriber; relevance for warfarin, aspirin, clopidogrel.
MAOIs — theoretical interactions.
SSRIs — theoretical interactions.
Diabetes medications — modest hypoglycemic effects.
Pregnancy — ginkgo CONTRAINDICATED in pregnancy due to bleeding concerns; AVOID supplementation.
Lactation — limited safety data; AVOID.
PRE-SURGERY — DISCONTINUE 2-3 WEEKS BEFORE due to bleeding risk (longer than other supplements).
Anti-seizure medications — theoretical interactions; ginkgo may affect seizure threshold; AVOID with seizure disorders.

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Frequently asked questions about Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)

What is Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)?

Ginkgoselect® Phytosome is a GINKGO BILOBA EXTRACT PHYTOSOME® developed by Indena (Italy) — using Phytosome® technology applied to standardized ginkgo biloba leaf extract. Distinguished by enhanced bioavailability of ginkgo flavonoids and terpenoids, plus pharmaceutical-grade quality.

What is the recommended dosage of Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)?

The clinically studied dose for Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) is 120-240 mg/day Ginkgoselect Phytosome. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) used for?

Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) is studied for cognitive function and working memory, cerebral microcirculation, peripheral circulation. Ginkgo biloba has long history of use for cognitive function; Phytosome bioavailability advantage delivers more active to brain.

Are there side effects from taking Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena)?

Reported potential side effects may include: Generally well-tolerated. Mild GI distress. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Is Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) safe to take?

Whether Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) is safe depends on the dose, your overall health, and any medications you take. At studied doses, reported side effects can include: Generally well-tolerated. It may also interact with certain medications. Ginkgoselect® Phytosome (Ginkgo Phytosome — Indena) is not suitable for everyone — consult a healthcare provider before use if you are pregnant or breastfeeding, have a medical condition, or take prescription medications.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Mauri P, Simonetti P, Gardana C, Minoggio M, Morazzoni P, Bombardelli E, Pietta P Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts Rapid Commun Mass Spectrom. 2001;15(12):929-934. doi: 10.1002/rcm.316.PubMedUsed to support: Backs the bioavailability advantage of Ginkgoselect Phytosome: in human volunteers the phospholipid-complex (Ginkgoselect Phytosome) produced higher plasma terpene lactone levels than the free Ginkgoselect extract. Small Indena (Morazzoni/Bombardelli/Pietta) PK study; the bioavailability claim is the best-supported one for this ingredient.
  2. Bonassi S, Prinzi G, Lamonaca P, Russo P, Paximadas I, Rasoni G, Rossi R, Ruggi M, Malandrino S, Sanchez-Flores M, Valdiglesias V, Benassi B, Pacchierotti F, Villani P, et al. Clinical and genomic safety of treatment with Ginkgo biloba L. leaf extract (IDN 5933/Ginkgoselect Plus) in elderly: a randomised placebo-controlled clinical trial [GiBiEx] BMC Complement Altern Med. 2018;18(1):22. doi: 10.1186/s12906-018-2080-5.PubMedUsed to support: Backs the safety (clinical and genomic) of the branded Ginkgoselect Plus (IDN 5933) extract in elderly subjects. Randomized placebo-controlled trial focused on safety/genotoxicity endpoints rather than proving a cognition benefit; phytosome-specific human data overall remain limited.
  3. Naik SR, Pilgaonkar VW, Panda VS Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents Phytother Res. 2006;20(10):901-905. doi: 10.1002/ptr.1973.PubMedUsed to support: Backs a cognition/CNS rationale for Ginkgo biloba phytosome. HONESTY: preclinical (rodent) study only; ginkgo's human cognition evidence is weak overall and phytosome-specific human cognitive data are limited.
  4. Naik SR, Pilgaonkar VW, Panda VS Evaluation of antioxidant activity of Ginkgo biloba phytosomes in rat brain Phytother Res. 2006;20(11):1013-1016. doi: 10.1002/ptr.1976.PubMedUsed to support: Backs an antioxidant/neuroprotective rationale for Ginkgo biloba phytosome. Preclinical rat-brain study only; mechanistic support, not clinical proof of cognition/circulation benefit.