Home Ingredients Leucoselect® Phytosome (Grape Seed Phytosome — Indena)
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Leucoselect® Phytosome (Grape Seed Phytosome — Indena)

Vitis vinifera
Evidence Level
Strong
2 Clinical Trials
5 Documented Benefits
4/5 Evidence Score

Leucoselect® Phytosome is a GRAPE SEED EXTRACT PHYTOSOME® developed by Indena (Italy) — using Phytosome® technology applied to grape seed proanthocyanidins (OPCs). Distinguished by enhanced OPC bioavailability vs standard grape seed extracts. Used for: cardiovascular health, vascular function, antioxidant defense, microcirculation. OPCs are among most-studied flavonoid antioxidants for vascular applications.

Studied Dose 100-300 mg/day Leucoselect Phytosome (research-validated)
Active Compound Grape seed oligomeric proanthocyanidins (OPCs) Phytosome® formulation

Benefits

Cardiovascular and Vascular Function

Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.

Supported by Trial 1, Trial 2

Antioxidant Activity

OPCs are among most potent natural antioxidants — protect cells from oxidative damage.

Supported by Trial 1, Trial 2

Microcirculation Support

Improves microcirculation and capillary integrity — relevant to vascular health and recovery.

Supported by Trial 1, Trial 2

Lipid Profile (Modest)

Modest improvements in lipid markers in some trials.

Supported by Trial 2, Trial 1

Enhanced Bioavailability vs Standard Grape Seed

Phytosome® technology improves OPC absorption — addresses standard grape seed extract bioavailability limitations.

Supported by Trial 2

Mechanism of action

1

OPC Antioxidant Activity

Oligomeric proanthocyanidins (OPCs) are among most potent natural antioxidants — direct radical scavenging plus regeneration of vitamins C and E.

2

Phytosome® Bioavailability Enhancement

Standard OPCs have variable bioavailability; Phytosome improves absorption.

3

Endothelial Nitric Oxide Support

OPCs support endothelial NO production — vasodilation and improved vascular function.

4

Capillary Integrity

OPCs reduce capillary permeability — improves microcirculation; foundation for venous insufficiency adjunct applications.

Clinical trials

1
Leucoselect for Cardiovascular Health
PubMed

Clinical studies of Leucoselect Phytosome on cardiovascular markers and vascular function.

Adults with cardiovascular concerns.

Improvements in vascular function, antioxidant status, lipid markers.

2
Grape Seed OPCs Meta-Analysis
PubMed

Meta-analyses of grape seed extracts on cardiovascular markers.

Pooled across multiple trials.

Modest improvements in BP, lipid markers, vascular function. Foundation for Phytosome applications.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated.
Mild GI distress.
Allergic reactions to grape rare.
Theoretical bleeding at high doses.
Soy allergy considerations (Phytosome).

Important Drug interactions

ANTICOAGULANTS — modest antiplatelet effects.
Antihypertensives — modest BP effects.
Pregnancy — generally safe at moderate doses; concentrated supplementation limited specific data.
Pre-surgery — discontinue 1-2 weeks.
SOY ALLERGY — Phytosome consideration.

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Frequently asked questions about Leucoselect® Phytosome (Grape Seed Phytosome — Indena)

What is the recommended dosage of Leucoselect® Phytosome (Grape Seed Phytosome — Indena)?

The clinically studied dose for Leucoselect® Phytosome (Grape Seed Phytosome — Indena) is 100-300 mg/day Leucoselect Phytosome (research-validated). Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Leucoselect® Phytosome (Grape Seed Phytosome — Indena) used for?

Leucoselect® Phytosome (Grape Seed Phytosome — Indena) is studied for cardiovascular and vascular function, antioxidant activity, microcirculation support. Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.

Are there side effects from taking Leucoselect® Phytosome (Grape Seed Phytosome — Indena)?

Reported potential side effects may include: Generally well-tolerated. Mild GI distress. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Leucoselect® Phytosome (Grape Seed Phytosome — Indena) interact with medications?

Known drug interactions may include: ANTICOAGULANTS — modest antiplatelet effects. Antihypertensives — modest BP effects. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Leucoselect® Phytosome (Grape Seed Phytosome — Indena) good for cardiovascular?

Yes, Leucoselect® Phytosome (Grape Seed Phytosome — Indena) is researched for Cardiovascular support. Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.