Benefits
Cardiovascular and Vascular Function
Leucoselect Phytosome supports vascular function via OPC bioavailability; multiple trials show endothelial function improvements.
Antioxidant Activity
OPCs are among most potent natural antioxidants — protect cells from oxidative damage.
Microcirculation Support
Improves microcirculation and capillary integrity — relevant to vascular health and recovery.
Lipid Profile (Modest)
Modest improvements in lipid markers in some trials.
Enhanced Bioavailability vs Standard Grape Seed
Phytosome® technology improves OPC absorption — addresses standard grape seed extract bioavailability limitations.
Mechanism of action
OPC Antioxidant Activity
Oligomeric proanthocyanidins (OPCs) are among most potent natural antioxidants — direct radical scavenging plus regeneration of vitamins C and E.
Phytosome® Bioavailability Enhancement
Standard OPCs have variable bioavailability; Phytosome improves absorption.
Endothelial Nitric Oxide Support
OPCs support endothelial NO production — vasodilation and improved vascular function.
Capillary Integrity
OPCs reduce capillary permeability — improves microcirculation; foundation for venous insufficiency adjunct applications.
Clinical trials
Clinical studies of Leucoselect Phytosome on cardiovascular markers and vascular function.
Adults with cardiovascular concerns.
Improvements in vascular function, antioxidant status, lipid markers.
Meta-analyses of grape seed extracts on cardiovascular markers.
Pooled across multiple trials.
Modest improvements in BP, lipid markers, vascular function. Foundation for Phytosome applications.
About this ingredient
LEUCOSELECT® PHYTOSOME is a GRAPE SEED EXTRACT PHYTOSOME® developed by INDENA (Italy) — applying PHYTOSOME® technology to grape seed OPCs. GRAPE SEED OPCs (oligomeric proanthocyanidins) are flavonoid compounds — same family as cranberry PACs but different structure (B-type linkages vs cranberry's A-type); different source plants (grape vs cranberry).
KEY DISTINCTIONS: (1) PHYTOSOME® TECHNOLOGY for enhanced OPC bioavailability; (2) Standardized OPC content; (3) Pharmaceutical-grade Indena quality.
EVIDENCE-BASED USES: (1) Cardiovascular and vascular function; (2) Antioxidant activity; (3) Microcirculation; (4) Modest lipid and BP effects.
CRITICAL CAUTIONS: (1) PRE-SURGERY — discontinue 1-2 weeks for bleeding; (2) ANTICOAGULANTS — modest interactions; (3) DOSE — 100-300 mg/day; (4) SOY ALLERGY — Phytosome phosphatidylcholine consideration; (5) PREGNANCY — generally safe at moderate doses; (6) LEUCOSELECT vs PYCNOGENOL — both OPC-rich extracts; different sources (grape seed vs French maritime pine bark); both have evidence; (7) For COMPREHENSIVE CARDIOVASCULAR HEALTH — diet, exercise, weight, smoking cessation, blood pressure management foundational; supplements adjunct; (8) ANTIOXIDANT POSITIONING — OPCs among most potent natural antioxidants; (9) BRAND VERIFICATION — Leucoselect® Phytosome® is Indena trademark.