Home Ingredients MitoGreens® (Ergothioneine-Amplified Superfood Greens — NNB Nutrition)
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MitoGreens® (Ergothioneine-Amplified Superfood Greens — NNB Nutrition)

Evidence Level
Limited
3 Clinical Trials
7 Documented Benefits
2/5 Evidence Score

MitoGreens® is NNB Nutrition's antioxidant-packed superfood greens formula amplified with MitoPrime® (L-ergothioneine) — the body's 'longevity vitamin' that has been shown to outperform glutathione, vitamin C, and CoQ10. Combines 29 potent botanical superfood ingredients with the super-antioxidant power of MitoPrime in a 100 mg per serving concentrated dose. High ORAC, non-GMO, gluten-free. Particularly versatile for greens powders, RTDs, gummies, and capsules. Supports healthy aging, cognitive function, immune function, sports nutrition, antioxidant, wellness, and energy applications. Includes quercetin alongside fruit/berry extracts (blueberry, acerola, bilberry, apple, camu-camu).

Studied Dose 100 mg/day MitoGreens — concentrated dose enabling broad formulation. Actual MitoPrime ergothioneine doses 5-25 mg/day from MitoPrime research. Supports greens powders, RTDs, gummies, or capsules.
Active Compound 29 potent superfood botanicals + MitoPrime® (L-ergothioneine) antioxidant. Key fruit/berry extracts: blueberry, acerola, bilberry, apple, camu-camu, raspberry. Quercetin for mito support. 100 mg per serving concentrated dose. High ORAC value (Oxygen Radical Absorbance Capacity). Non-GMO, gluten-free. Patent-protected MitoPrime ergothioneine.

Benefits

L-Ergothioneine — the longevity vitamin

MitoPrime (L-ergothioneine) included in MitoGreens has been shown to outperform glutathione, vitamin C, and coenzyme Q10 in antioxidant activity. Many researchers believe L-ergothioneine should be classified as a vitamin — given its potency and body's natural transporters specifically for this compound. Provides antioxidant power class generic greens products can't match.

Supported by Trial 1

29 potent superfood botanicals

Concentrated blend of 29 clean and potent superfood ingredients including blueberry, acerola, bilberry, apple, camu-camu, raspberry, and other fruit/berry extracts. Multi-botanical approach provides broad phytonutrient coverage. Distinguishes from generic greens products that may contain impurities and inactive filler ingredients.

Supported by Trial 2

High ORAC antioxidant power

MitoGreens delivers high ORAC (Oxygen Radical Absorbance Capacity) — a standardized measure of antioxidant capacity. Daily consumption of fruits, vegetables, and herbs significantly reduced production of free radicals from both cells and their mitochondria. Concentrated antioxidant delivery in a smaller serving size.

Supported by Trial 2

Quercetin inflammation + mitochondria support

Quercetin — a major component in MitoGreens — promotes healthy inflammatory response, reduces erythrocyte lipid peroxidation levels and susceptibility to hemolysis, and supports mitochondrial function. The mitochondrial support aligns with the broader MitoGreens positioning vs general greens products.

Supported by Trial 3

Healthy aging support

Supports healthy aging through combined antioxidant, anti-inflammatory, and mitochondrial mechanisms. L-ergothioneine accumulation correlates with longevity in mammals — addressing the cellular damage accumulation that drives aging. Multi-mechanism approach addresses aging at the cellular level vs single nutrient interventions.

Supported by Trial 1, Trial 3

Cognitive and immune function

Supports cognitive function and immune function — both areas where the antioxidant + ergothioneine combination has documented effects. Ergothioneine specifically accumulates in immune cells via the OCTN1 transporter — supporting their function. Cognitive applications relate to oxidative stress protection of neuronal tissue.

Supported by Trial 1, Trial 2

Concentrated 100 mg per serving

Concentrated 100 mg per serving dose enables broad formulation applications without large pill or scoop burden. Versatile across greens powders, ready-to-drink beverages, gummies, and capsule applications. Particularly valuable for combining with other actives (vitamins, creatine, electrolytes) in multi-ingredient formulas.

Supported by Trial 2

Mechanism of action

1

L-Ergothioneine — mitochondrial protection

L-ergothioneine accumulates in mitochondria via the OCTN1 transporter — providing localized antioxidant protection where free radical generation is highest. The body has dedicated transporters for ergothioneine (unique among antioxidants) suggesting essential physiological role. Mitochondrial targeting addresses the source of cellular aging.

2

Quercetin AMPK and mitochondrial biogenesis

Quercetin activates AMPK and PGC-1α — driving mitochondrial biogenesis (creation of new mitochondria). Mechanism supports cellular energy production and metabolic flexibility. Complementary to ergothioneine's mitochondrial protection — addresses both quality (protection) and quantity (biogenesis) of mitochondria.

3

Polyphenol multi-pathway antioxidant

29 superfood botanicals provide multiple polyphenol classes — flavonoids, anthocyanins, proanthocyanidins, phenolic acids. Each polyphenol class targets different reactive oxygen species and tissue compartments. Multi-pathway approach provides broader antioxidant coverage than single-compound interventions.

4

Free radical reduction (cellular + mitochondrial)

Daily consumption of fruits, vegetables, and herbs significantly reduces production of free radicals from both cells and their mitochondria. MitoGreens concentrates this dietary effect into a supplemental format. Addresses oxidative damage at multiple cellular locations.

5

Immune cell ergothioneine accumulation

Ergothioneine accumulates in immune cells (neutrophils, monocytes, lymphocytes) via the OCTN1 transporter. The high concentrations in immune cells suggest specific protective role. Mechanism explains ergothioneine's immune support applications — protecting immune cells from oxidative damage during their function.

Clinical trials

1
L-Ergothioneine (MitoPrime) Class Evidence

Extensive class evidence for L-ergothioneine including comparison studies showing superiority to glutathione, vitamin C, and CoQ10 in antioxidant capacity. Research on OCTN1 transporter-mediated accumulation in mitochondria and immune cells. Foundation for MitoGreens' ergothioneine-amplified positioning.

Various — extensive preclinical and clinical research on L-ergothioneine biological activity.

L-ergothioneine outperforms glutathione, vitamin C, and CoQ10 in antioxidant capacity per published research. Body has dedicated OCTN1 transporter for ergothioneine — unique among antioxidants. Accumulates in mitochondria and immune cells for localized protection. Researchers believe should be classified as a vitamin given essential physiological role.

2
Plant Food Antioxidant Class Evidence

Class evidence on fruit, vegetable, and herb antioxidant effects. Daily consumption documented to reduce free radical production from cells and mitochondria. MitoGreens concentrates these dietary effects in supplemental format.

Various — research on dietary antioxidant intake and free radical reduction.

Daily consumption of fruits, vegetables and herbs significantly reduces production of free radicals from both cells and their mitochondria. Short-term increases in high fruit and vegetable diet positively affect antioxidant defenses and decrease oxidative damage. Concentrated superfood blends extend these benefits in supplemental form.

3
MitoGreens Quercetin Mechanism Research

Mechanism research on quercetin — a key MitoGreens component. Quercetin documented effects on inflammatory response, erythrocyte lipid peroxidation, and mitochondrial function. Foundation for the mitochondrial-targeted positioning of MitoGreens.

Various — preclinical and clinical research base for quercetin biological activity.

Quercetin promotes healthy inflammatory response, reduces erythrocyte lipid peroxidation levels and susceptibility to hemolysis, and supports mitochondrial function. AMPK activation and PGC-1α induction drive mitochondrial biogenesis. Mechanism complements ergothioneine for comprehensive mitochondrial support.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated; concentrated dietary botanical blend with strong food history.
Mild GI effects rare; some individuals may experience mild bloating.
Non-GMO and gluten-free supports broad consumer applications.
L-ergothioneine has GRAS status and excellent safety profile.
Concentrated 100 mg serving — well below dietary equivalent intake levels.
Pregnancy and lactation: dietary botanicals generally safe; consult clinician for supplemental concentrations.
Allergy considerations: verify individual botanical allergens for sensitive individuals.

Important Drug interactions

Anticoagulants (warfarin) — polyphenol-rich botanicals may have mild antiplatelet effects; consult prescriber.
Diabetes medications — quercetin may have mild glucose-lowering effects; monitor blood glucose.
Iron supplements — polyphenols may inhibit iron absorption; separate timing.
Immunosuppressants — ergothioneine accumulates in immune cells; consult prescriber.
Antioxidant supplements — generally complementary; verify total intake.
Pregnancy and lactation: consult clinician.
Quercetin-containing supplements — verify total quercetin intake to avoid duplication.

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Frequently asked questions about MitoGreens® (Ergothioneine-Amplified Superfood Greens — NNB Nutrition)

What is MitoGreens?

MitoGreens® is NNB Nutrition's antioxidant-packed superfood greens formula amplified with MitoPrime® (L-ergothioneine) — the body's 'longevity vitamin' that has been shown to outperform glutathione, vitamin C, and CoQ10.

What is MitoGreens used for?

MitoGreens is researched primarily for Energy, Antioxidant, and Immune Support. MitoPrime (L-ergothioneine) included in MitoGreens has been shown to outperform glutathione, vitamin C, and coenzyme Q10 in antioxidant activity.

What is the recommended dosage of MitoGreens?

The clinically studied dose is 100 mg/day MitoGreens — concentrated dose enabling broad formulation. Actual MitoPrime ergothioneine doses 5-25 mg/day from MitoPrime research. Supports greens powders, RTDs, gummies, or capsules. Always follow the product label and check with a healthcare provider for personal advice.

Is MitoGreens safe, and does it have side effects?

For most healthy adults, MitoGreens is well tolerated at studied doses. Reported effects can include: Generally well-tolerated; concentrated dietary botanical blend with strong food history. Mild GI effects rare; some individuals may experience mild bloating. It may also interact with some medications. MitoGreens is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does MitoGreens interact with any medications?

Possible interactions include: Anticoagulants (warfarin) — polyphenol-rich botanicals may have mild antiplatelet effects; consult prescriber. Diabetes medications — quercetin may have mild glucose-lowering effects; monitor blood glucose. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for MitoGreens?

NutraSmarts rates the evidence for MitoGreens as Limited (2 out of 5). It is backed by 3 clinical trials and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Halliwell B, Cheah IK, Tang RMY Ergothioneine - a diet-derived antioxidant with therapeutic potential. FEBS Letters. 2018;592(20):3357-3366. doi: 10.1002/1873-3468.13123.PubMedUsed to support: Key review by leading ergothioneine researchers establishing L-ergothioneine (the active in MitoPrime®/MitoGreens®) as a potent diet-derived antioxidant with cytoprotective and therapeutic potential. Supports 'L-ergothioneine — longevity vitamin', 'high ORAC antioxidant power', and 'healthy aging support' benefits; this is component evidence, not a MitoGreens® brand trial.
  2. Tian X, Thorne JL, Moore JB Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing? British Journal of Nutrition. 2023;129(1):104-114. doi: 10.1017/S0007114522003592.PubMedUsed to support: Review showing plasma ergothioneine declines after age 60 and lower levels associate with faster cognitive decline and increased cardiovascular/overall mortality, proposing it may be a conditionally essential micronutrient for healthy ageing. Supports 'healthy aging support' and 'L-ergothioneine' benefit; component-level evidence.
  3. Ou Q, Zheng Z, Zhao Y, Lin W Impact of quercetin on systemic levels of inflammation: a meta-analysis of randomised controlled human trials. International Journal of Food Sciences and Nutrition. 2020;71(2):152-163. doi: 10.1080/09637486.2019.1627515.PubMedUsed to support: Meta-analysis of human RCTs showing quercetin supplementation reduces CRP in disease populations and IL-6 in females and higher-dose groups, supporting 'quercetin inflammation + mitochondria support' benefit listed for MitoGreens®; quercetin is a named component, not a MitoGreens® brand trial.
  4. Yau YF, Cheah IK, Mahendran R, Tang RM, Chua RY, Goh RE, Feng L, Li J, Kua EH, Chen C, Halliwell B Investigating the efficacy of ergothioneine to delay cognitive decline in mild cognitively impaired subjects: A pilot study. Journal of Alzheimer's Disease. 2024;102(3):841-854. doi: 10.1177/13872877241291253.PubMedUsed to support: Randomised double-blind placebo-controlled pilot (n=19, 60+ years, MCI) showing 25 mg ergothioneine three times weekly for 1 year improved learning scores and stabilised neurofilament light chain vs. placebo. Supports 'healthy aging support' and the ergothioneine longevity vitamin claim; component-level human trial, not a MitoGreens® brand study.