Benefits
Cardiovascular Markers
Multiple Pomella and pomegranate trials show improvements in lipid profile, blood pressure (modest), endothelial function, and cardiovascular markers.
Antioxidant Activity
Pomegranate ellagitannins among most potent natural antioxidants; comprehensive cellular protection.
Punicalagin Standardization (30%)
Punicalagins are pomegranate's signature ellagitannins — Pomella's 30% standardization ensures consistent active compound delivery.
Urolithin A Precursor
Pomegranate ellagitannins are converted by gut bacteria to urolithin A — bioactive metabolite associated with mitochondrial health and longevity. Some individuals don't produce urolithin A and may benefit from direct urolithin A supplements (different ingredient).
Exercise Recovery
Some evidence for pomegranate supporting exercise recovery and reduced muscle soreness.
Skin Health (Beauty-from-Within)
Pomegranate polyphenols support skin antioxidant defense and elasticity.
Mechanism of action
Punicalagin and Ellagitannin Activity
Punicalagins are unique pomegranate ellagitannins; convert to ellagic acid in body; ellagic acid is converted to UROLITHIN A by gut microbiome (in those with appropriate bacteria).
Urolithin A and Mitophagy
Urolithin A induces mitophagy — recycling of damaged mitochondria; relevant to muscle health and longevity.
Antioxidant / NF-kB Inhibition
Direct antioxidant activity plus NF-kB pathway modulation.
Endothelial Nitric Oxide Support
Supports endothelial function and vascular health.
Clinical trials
Multiple pomegranate extract trials on cardiovascular markers.
Adults with cardiovascular concerns.
Improvements in BP (modest), lipid markers, oxidative stress, endothelial function.
Verdure clinical evaluation of Pomella for cardiovascular and antioxidant applications.
Adults across applications.
Cardiovascular and antioxidant benefits; punicalagin bioavailability validation.
About this ingredient
POMELLA® is a STANDARDIZED POMEGRANATE EXTRACT (PUNICA GRANATUM) developed by VERDURE SCIENCES. POMEGRANATE BACKGROUND: ancient fruit cultivated for thousands of years; rich in unique ELLAGITANNINS especially PUNICALAGINS; long traditional and modern use for cardiovascular health and antioxidant applications.
KEY DISTINCTIONS: (1) STANDARDIZED to 30% punicalagins; (2) Comprehensive ellagitannin profile; (3) Verdure quality; (4) Multiple clinical trials.
EVIDENCE-BASED USES: (1) Cardiovascular markers; (2) Antioxidant activity; (3) Urolithin A precursor (gut-bacteria-converted); (4) Exercise recovery; (5) Skin health; (6) Healthy aging applications.
CRITICAL CAUTIONS: (1) DOSE — 250-500 mg/day Pomella research-validated; (2) UROLITHIN A PRODUCTION — only some individuals (~30-40%) produce significant urolithin A from pomegranate ellagitannins due to gut bacteria variations; non-producers may benefit from direct urolithin A supplements (different ingredient like Mitopure); (3) DRUG INTERACTIONS — pomegranate juice interactions don't all apply to extracts but verify CYP3A4 substrates; (4) POMELLA vs POMEGRANATE JUICE — concentrated extract vs juice; both have value; juice has sugar content; extract more concentrated and standardized; (5) POMELLA vs OTHER POMEGRANATE EXTRACTS — Pomella's 30% punicalagin standardization distinguishes; verify branding; (6) PREGNANCY — pomegranate food safe; supplementation generally safe; (7) FOR CARDIOVASCULAR HEALTH — pomegranate among most-studied natural cardiovascular ingredients; complementary to omega-3, CoQ10 (Ubiqsome), garlic (ABG10+); (8) FOR LONGEVITY — urolithin A pathway interest; direct urolithin A supplements alternative; (9) BRAND VERIFICATION — Pomella® is Verdure Sciences trademark.