SteviUp® M2 (Next-Gen Stevia Reb M — Layn USA)

Superior Water Solubility

SteviUp M2 has superior water solubility compared with conventional stevia Reb M — addresses formulation challenges of stevia products.

Supported by Trial 1

More Sugar-Like Taste

Optimized to deliver more sugar-like taste with shorter lingering sweetness — major taste advance for natural sweeteners.

FDA GRAS Approved

Reviewed by FDA and recognized as GRAS for use as general-purpose sweetener in food and beverage products.

Supported by Trial 1

Enzymatic Bioconversion (Non-GMO)

Derived through enzymatic conversion of purified steviol glycosides — clean-label, non-GMO, plant-based.

Customizable

Can be customized to complement specific food and beverage products.

Sustainability and Scalability

Layn invested in R&D for breeding new stevia leaf varieties and optimizing manufacturing processes; sustainable scalable production.

Rebaudioside M2 Activity

Reb M2 is steviol glycoside variant produced via enzymatic conversion; differs from natural Reb A and Reb M in glycoside chain pattern; provides superior taste/solubility profile.

Enzymatic Conversion Process

Enzymes convert one steviol glycoside to another; allows production of less abundant but more functional glycosides; more efficient than agricultural cultivation alone.

No Insulin Response

Like other steviol glycosides, does not stimulate insulin release.

Improved Taste Profile Mechanism

Reb M2's specific structure activates sweet taste receptors with reduced activation of bitter receptors — cleaner overall taste.

SteviUp M2 GRAS Determination — FDA Review

Study info

FDA GRAS notification for SteviUp M2 as general-purpose sweetener.

Population & duration

Toxicological and safety evaluation.

Findings

Recognized as GRAS for general-purpose sweetener use.

Common Potential side effects

Generally extremely well-tolerated.

Mild GI distress at very high doses (rare).

Allergic reactions extremely rare.

FDA GRAS approved.

Important Drug interactions

Generally minimal drug interactions.

Antihypertensives — modest theoretical effects from steviol glycosides.

Pregnancy — generally considered safe at typical sweetening doses.

Lactation — generally safe.

Children — appropriate.

Diabetes — appropriate for diabetic dietary management.

Frequently asked questions about SteviUp® M2 (Next-Gen Stevia Reb M — Layn USA)

What is SteviUp M2?

SteviUp® M2 is a next-generation plant-based sweetener developed by Layn USA via enzymatic conversion of purified steviol glycosides — distinguished by superior water solubility, more sugar-like taste, shorter lingering sweetness compared with conventional stevia Reb M. FDA GRAS for general-purpose sweetening. Non-GMO.

What is SteviUp M2 used for?

SteviUp M2 is researched primarily for Metabolic Health. SteviUp M2 has superior water solubility compared with conventional stevia Reb M — addresses formulation challenges of stevia products.

What is the recommended dosage of SteviUp M2?

The clinically studied dose is Sweetener use per product specification Always follow the product label and check with a healthcare provider for personal advice.

Is SteviUp M2 safe, and does it have side effects?

For most healthy adults, SteviUp M2 is well tolerated at studied doses. Reported effects can include: Generally extremely well-tolerated. Mild GI distress at very high doses (rare). It may also interact with some medications. SteviUp M2 is not right for everyone, so check with a healthcare provider first if you are pregnant or breastfeeding, have a medical condition, or take prescription medication.

Does SteviUp M2 interact with any medications?

Possible interactions include: Generally minimal drug interactions. Antihypertensives — modest theoretical effects from steviol glycosides. If you take prescription medication, check with a pharmacist or doctor before using it.

How strong is the scientific evidence for SteviUp M2?

NutraSmarts rates the evidence for SteviUp M2 as Moderate (3 out of 5). It is backed by 1 clinical trial and 4 cited references summarized on this page. A higher rating reflects more, larger, and better-designed human studies.

References(4 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

Zare M, Zeinalabedini M, Ebrahimpour-Koujan S, Bellissimo N, Azadbakht L Effect of stevia on blood glucose and HbA1C: A meta-analysis Diabetes & Metabolic Syndrome. 2024;18(7):103092. doi: 10.1016/j.dsx.2024.103092.PubMedUsed to support: Meta-analysis of stevia's effects on blood glucose and HbA1C; provides highest-level evidence for the no-glycemic-impact claim of steviol glycoside sweeteners including Reb M at the compound class level.
Zhang R, Noronha JC, Khan TA, McGlynn N, Back S, Grant SM, Kendall CWC, Sievenpiper JL The Effect of Non-Nutritive Sweetened Beverages on Postprandial Glycemic and Endocrine Responses: A Systematic Review and Network Meta-Analysis Nutrients. 2023;15(4):1050. doi: 10.3390/nu15041050.PubMedUsed to support: Systematic review and network meta-analysis of non-nutritive sweetened beverages on postprandial glycemic and endocrine responses; supports the FDA GRAS approved and more sugar-like taste with no glycemic impact claims for steviol glycoside sweeteners including Reb M at the compound class level.
Suez J, Cohen Y, Valdés-Mas R, Mor U, Dori-Bachash M, Federici S, Zmora N, Leshem A, Heinemann M, Linevsky R, Zur M, Ben-Zeev Brik R, Bukimer A, Eliyahu-Miller S, Metz A, Fischbein R, Sharov O, Malitsky S, Itkin M, Stettner N, Harmelin A, Shapiro H, Stein-Thoeringer CK, Segal E, Elinav E Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance Cell. 2022;185(18):3307-3328.e19. doi: 10.1016/j.cell.2022.07.016.PubMedUsed to support: Well-powered RCT (n=120) showing stevia-class sweeteners did not significantly impair glucose tolerance (unlike saccharin and sucralose); supports the more sugar-like taste and no glycemic impact claims for SteviUp M2 (Reb M) at the compound level.
Tey SL, Salleh NB, Henry CJ, Forde CG Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles European Journal of Clinical Nutrition. 2017;71(9):1129-1132. doi: 10.1038/ejcn.2017.37.PubMedUsed to support: RCT showing no significant differences in 24-h glucose profiles between stevia-sweetened and sucrose-sweetened beverages; supports FDA GRAS approved and no glycemic impact positioning for SteviUp M2 steviol glycoside sweeteners at the compound level.