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Hair, Skin & NailsAntioxidant

Dermaval®

Evidence Level
Limited
1 Clinical Trial
4 Documented Benefits
2/5 Evidence Score

Dermaval® is a proprietary, polyphenol-rich fruit and vegetable concentrate developed by FutureCeuticals and marketed as a beauty-from-within ingredient. The patent-pending blend typically combines extracts of açaí berry, gotu kola, prickly pear cactus, white tea, hawthorn berry, and lycium berry, contributing a mix of anthocyanins, betalains, catechins, and other plant antioxidants. Branded research has focused on Dermaval's ability to inhibit human neutrophil elastase (HNE), an enzyme that degrades skin elastin during oxidative or glycemic stress. Marketed to support skin elasticity, antioxidant defense, and a youthful complexion when consumed orally at a low daily serving (typically 50 mg).

Studied Dose 50 mg per day of branded Dermaval® powder in published acute human work.
Active Compound Standardized polyphenol blend: anthocyanins (açaí), asiaticosides (gotu kola), betacyanins (prickly pear), catechins (white tea), proanthocyanidins (hawthorn), lycium polysaccharides.

Benefits

Helps Support Skin Elasticity

Dermaval® is positioned as a skin-from-within nutricosmetic that helps maintain elastin integrity by inhibiting elastase activity associated with oxidative and glycemic stress, which may support a firmer, more elastic skin appearance over time.

Supported by Trial 1

Provides Polyphenol Antioxidant Support

The blended fruit and herbal concentrates deliver a broad mix of anthocyanins, betacyanins, catechins, and flavonoids, which contribute to overall antioxidant defense and help neutralize reactive oxygen species generated by sun, pollution, and high-glycemic meals.

Supported by Trial 1

May Support a Youthful Complexion

By targeting enzymes that break down structural skin proteins like elastin and collagen, Dermaval® is formulated to support skin smoothness, suppleness, and a youthful look as part of an inside-out beauty regimen.

Supported by Trial 1

Convenient Low-Dose Beauty Blend

Standardized to deliver meaningful polyphenol activity at just 50 mg, Dermaval® fits easily into capsules, gummies, drink mixes, and skin-focused multivitamins without contributing significant calories or flavor.

Supported by Trial 1

Mechanism of action

1

Human Neutrophil Elastase Inhibition

In vitro and acute human work indicates that Dermaval® polyphenols inhibit HNE, a serine protease that cleaves elastin in the dermal extracellular matrix during inflammation and after glucose challenges.

2

Reactive Oxygen Species Quenching

Anthocyanins, betacyanins, and catechins in the blend donate electrons to free radicals generated by UV exposure and metabolic stress, supporting cellular redox balance in skin and circulating cells.

3

AGE-Related Skin Stress Modulation

By blunting the post-meal HNE spike that follows glucose intake, the blend is theorized to limit one downstream pathway by which dietary sugar can contribute to elastin breakdown and skin aging.

Clinical trials

1
Acute Elastase Inhibition in Healthy Adults

Randomized, double-blind, crossover trial; single 50 mg dose of Dermaval® or placebo before a glucose challenge

20 healthy adult volunteers

A single 50 mg dose of the polyphenol blend significantly blunted the glucose-induced rise in circulating human neutrophil elastase activity at 60 and 120 minutes post-ingestion compared with placebo, supporting the proposed elastin-sparing mechanism.

Side effects and drug interactions

Common Potential side effects

Generally well tolerated at the standard 50 mg serving in healthy adults.
Mild gastrointestinal upset is possible with any concentrated polyphenol extract.
Berry-allergic individuals should review the full ingredient panel before use.
Long-term safety data beyond short acute studies are limited.

Important Drug interactions

Theoretical additive effects with other polyphenol-rich antioxidant supplements are possible.
Açaí and related berries may modestly interact with anticoagulant therapy.
Consult a clinician before combining with prescription skin or systemic medications.

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Frequently asked questions about Dermaval®

What is the recommended dosage of Dermaval®?

The clinically studied dose for Dermaval® is 50 mg per day of branded Dermaval® powder in published acute human work.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Dermaval® used for?

Dermaval® is studied for helps support skin elasticity, provides polyphenol antioxidant support, may support a youthful complexion. Dermaval® is positioned as a skin-from-within nutricosmetic that helps maintain elastin integrity by inhibiting elastase activity associated with oxidative and glycemic stress, which may support a firmer, more elastic skin appearance over time.

Are there side effects from taking Dermaval®?

Reported potential side effects may include: Generally well tolerated at the standard 50 mg serving in healthy adults. Mild gastrointestinal upset is possible with any concentrated polyphenol extract. Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Dermaval® interact with medications?

Known drug interactions may include: Theoretical additive effects with other polyphenol-rich antioxidant supplements are possible. Açaí and related berries may modestly interact with anticoagulant therapy. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Dermaval® good for hair, skin & nails?

Yes, Dermaval® is researched for Hair, Skin & Nails support. Dermaval® is positioned as a skin-from-within nutricosmetic that helps maintain elastin integrity by inhibiting elastase activity associated with oxidative and glycemic stress, which may support a firmer, more elastic skin appearance over time.

References(1 citations)

Evidence ratings on NutraSmarts are based on the totality of human clinical research, with emphasis on randomized controlled trials, meta-analyses, and systematic reviews. The references below directly support claims made throughout this page.

  1. Nemzer B, Fink N, Fink B, Pietrzkowski Z. Dermaval inhibits glucose-induced neutrophil elastase activity in healthy subjects. Nutritional and Dietary Supplements. 2014;6:25-31. doi: 10.2147/NDS.S53838.SourceUsed to support: Acute crossover human study in 20 subjects showing 50 mg Dermaval significantly inhibited the glucose-induced rise in serum HNE activity vs placebo (peer-reviewed but not PubMed-indexed).