Home Ingredients Mitopure® (Urolithin A — Amazentis)
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Mitopure® (Urolithin A — Amazentis)

Evidence Level
Strong
3 Clinical Trials
7 Documented Benefits
4/5 Evidence Score

Mitopure® is the branded urolithin A from Amazentis (Switzerland) — essentially the only commercial source of direct urolithin A with reliable manufacturing capability and FDA New Dietary Ingredient (NDI) acceptance. The proprietary synthesis produces pharmaceutical-grade urolithin A standardized for purity and bioavailability. All published clinical evidence for direct urolithin A supplementation uses Mitopure®. Documented clinical effects include mitochondrial gene expression improvements, mitochondrial function biomarker enhancement, muscle strength preservation, and exercise capacity support in older adults. The Amazentis research program includes multiple ongoing clinical trials across aging, athletic performance, and skin health applications. The honest framing: Mitopure® has the strongest justification for brand premium of any supplement in our database — it's essentially the only validated commercial urolithin A source with clinical research backing and manufacturing reliability. Generic urolithin A alternatives are essentially non-existent at quality supplement scale.

Studied Dose Standard clinical dose: 500-1,000 mg/day Mitopure®. Most clinical trials use 500-1,000 mg/day for 12+ weeks. Long-term safety established through clinical trial use up to 4+ months.
Active Compound Mitopure® synthetic urolithin A (Amazentis). FDA NDI accepted. Pharmaceutical-grade purity with documented bioavailability and clinical trial validation.

Benefits

Essentially the only validated commercial urolithin A

Mitopure® has effectively a monopoly on quality urolithin A supplementation. The manufacturing complexity means generic alternatives at quality scale don't really exist. The brand premium reflects this manufacturing reality rather than typical brand markup.

Supported by Trial 2

Foundational mitochondrial function trials

Clinical trials specifically using Mitopure® document mitochondrial gene expression improvements and mitochondrial function biomarker enhancement in middle-aged and older adults. Foundational evidence specific to this branded form.

Supported by Trial 1

Muscle strength preservation

The foundational ATLAS trial (Cell Reports Medicine, 2022) showed Mitopure® at 500-1,000 mg/day improved muscle strength by approximately 12% over 4 months in middle-aged adults. Important transparency note: the trial actually failed its primary endpoint (peak power output) but succeeded on multiple secondary endpoints including muscle strength, aerobic endurance (VO2 peak), and 6-minute walk test. The mixed primary/secondary results mean the evidence is real but more nuanced than 'urolithin A boosts muscle strength' marketing suggests.

Supported by Trial 1

FDA NDI acceptance

Mitopure® has FDA New Dietary Ingredient (NDI) notification acceptance — important regulatory credential supporting clinical-grade use. The NDI review process specifically validates safety and ingredient identity claims.

Supported by Trial 2

Mitophagy mechanism with documented effects

Mitopure® induces mitophagy in clinical trial subjects with documented gene expression changes. The mechanism distinguishes from typical mitochondrial supplements and provides a more fundamental cellular renewal mechanism.

Supported by Trial 1, Trial 2

Independent of gut microbiome conversion

Mitopure® provides direct urolithin A regardless of individual gut microbiome conversion capacity. Important advantage over dietary ellagitannin sources (pomegranate, walnuts) where 60-70% of people don't efficiently convert to bioactive urolithins.

Supported by Trial 2

Active research program

Amazentis runs an active clinical research program with multiple ongoing trials across aging, athletic performance, and skin health applications. The dedicated research investment supports continued evidence generation specific to Mitopure®.

Supported by Trial 3

Mechanism of action

1

Mitophagy induction

Mitopure® urolithin A induces mitophagy — the cellular cleanup process that removes damaged mitochondria and supports renewal. Mechanism foundation for the cellular aging and muscle preservation applications.

2

Mitochondrial biogenesis support

Beyond cleanup of damaged mitochondria, urolithin A supports new mitochondrial biogenesis. The combination of cleanup and renewal supports overall mitochondrial health and capacity.

3

Direct supplementation bypasses gut conversion

Mitopure® direct urolithin A delivery bypasses individual variation in gut microbial conversion of dietary ellagitannins. Provides reproducible urolithin A levels across users regardless of microbiome status.

Clinical trials

1
Foundational mitochondrial trial

The ATLAS trial (Cell Reports Medicine, 2022) in 88 middle-aged adults at 500-1,000 mg/day for 4 months documented mitochondrial gene expression improvements, mitochondrial biomarker enhancement, and ~12% muscle strength improvement. The trial failed its primary endpoint (peak power output) but succeeded on multiple secondary endpoints — honest characterization matters when communicating the evidence base.

2
Muscle preservation studies

Trials in older adults show Mitopure® preserves muscle strength and endurance over 4+ months of supplementation. Clinical relevance for sarcopenia prevention and aging applications.

3
Ongoing research program

Amazentis runs ongoing clinical trials across aging, athletic performance, and skin health. Continued research investment supports evidence base expansion.

Side effects and drug interactions

Common Potential side effects

GENERALLY WELL-TOLERATED in clinical trial use.
Mild GI discomfort possible at higher doses in sensitive individuals.
Long-term safety established through clinical trial use up to 4+ months.
No significant adverse events documented in published trials.
Pregnant women should consult healthcare providers — limited specific safety data.

Important Drug interactions

Generally minimal drug interactions documented.
No significant interactions with common cardiovascular, metabolic, or psychiatric medications.
Theoretical caution with medications affecting mitochondrial function (some chemotherapy).
Consult healthcare providers when combining with prescription medications, particularly cancer therapies or experimental aging interventions.

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Frequently asked questions about Mitopure® (Urolithin A — Amazentis)

What is Mitopure® (Urolithin A — Amazentis)?

Mitopure® is the branded urolithin A from Amazentis (Switzerland) — essentially the only commercial source of direct urolithin A with reliable manufacturing capability and FDA New Dietary Ingredient (NDI) acceptance.

What does Mitopure® (Urolithin A — Amazentis) do?

Mitopure® urolithin A induces mitophagy — the cellular cleanup process that removes damaged mitochondria and supports renewal. Mechanism foundation for the cellular aging and muscle preservation applications. In clinical research, Mitopure® (Urolithin A — Amazentis) has been studied for essentially the only validated commercial urolithin a, foundational mitochondrial function trials, muscle strength preservation.

Who should take Mitopure® (Urolithin A — Amazentis)?

Mitopure® (Urolithin A — Amazentis) may be most relevant for people interested in antioxidant, athletic performance, muscle & recovery. It has been clinically studied for essentially the only validated commercial urolithin a, foundational mitochondrial function trials, muscle strength preservation. As with any supplement, consult your healthcare provider before starting, especially if you have medical conditions or take prescription medications.

How long does Mitopure® (Urolithin A — Amazentis) take to work?

In clinical trials, effects typically appear over 4+ months of consistent use. Acute or same-day effects (where applicable) typically appear within hours, but most cumulative benefits — particularly those affecting biomarkers, mood, sleep quality, or chronic symptoms — require 4-12 weeks of regular use to fully assess. If you don't notice benefit after 12 weeks at the appropriate dose, it may not be your responder.

When is the best time to take Mitopure® (Urolithin A — Amazentis)?

For anti-inflammatory and joint goals, Mitopure® (Urolithin A — Amazentis) is typically taken with meals — fat-containing food often improves absorption for fat-soluble compounds. Daily consistency matters more than precise timing for cumulative anti-inflammatory effects. Always check product labeling and follow personalized guidance from your healthcare provider.

Is Mitopure® (Urolithin A — Amazentis) worth taking?

Mitopure® (Urolithin A — Amazentis) has strong clinical evidence (Evidence Level 4/5 on NutraSmarts) for its primary uses, with multiple randomized controlled trials and meta-analyses supporting its benefits. Whether it's worth taking depends on your specific goals, what you've already tried, your budget, and your overall supplement strategy. The honest framing: no supplement is essential for most people, and lifestyle factors (sleep, exercise, diet, stress management) typically produce larger effects than any single supplement. Mitopure® (Urolithin A — Amazentis) is most worth trying if its evidence-supported uses align with your specific goals.

What is the recommended dosage of Mitopure® (Urolithin A — Amazentis)?

The clinically studied dose for Mitopure® (Urolithin A — Amazentis) is Standard clinical dose: 500-1,000 mg/day Mitopure®. Most clinical trials use 500-1,000 mg/day for 12+ weeks. Long-term safety established through clinical trial use up to 4+ months.. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Mitopure® (Urolithin A — Amazentis) used for?

Mitopure® (Urolithin A — Amazentis) is studied for essentially the only validated commercial urolithin a, foundational mitochondrial function trials, muscle strength preservation. Mitopure® has effectively a monopoly on quality urolithin A supplementation. The manufacturing complexity means generic alternatives at quality scale don't really exist.