Glycyrrhizina (Licorice Flavonoids — BGG)

Glycyrrhiza glabra
Evidence Level
Moderate
1 Clinical Trial
5 Documented Benefits
3/5 Evidence Score

Glycyrrhizina is BGG's LICORICE FLAVONOID extract from Glycyrrhiza glabra — distinguished from generic licorice by FLAVONOID-RICH STANDARDIZATION rather than glycyrrhizin-dominant profile. Reduces glycyrrhizin content to minimize blood pressure and aldosterone concerns while preserving bioactive flavonoids (glabridin, licochalcones). Used for: skin health, oral care, antioxidant defense, anti-inflammatory applications.

Studied Dose Per BGG product specification
Active Compound Licorice flavonoids (glabridin, licochalcones) reduced glycyrrhizin

Benefits

Skin Brightening (Glabridin)

Glabridin (licorice flavonoid) inhibits tyrosinase — relevant to skin brightening and hyperpigmentation; used in skincare formulations.

Anti-Inflammatory Skin Effects

Licorice flavonoids reduce inflammatory markers in skin; relevant to inflammatory skin conditions.

Reduced Glycyrrhizin (Safety Distinction)

Standard licorice extracts contain glycyrrhizin — causes blood pressure increase and aldosterone effects at high/chronic doses; Glycyrrhizina's flavonoid-focused approach minimizes these concerns while preserving bioactive flavonoids.

Oral Care Applications

Licochalcones have antimicrobial activity relevant to oral care; reduces bad breath and gingival inflammation.

Antioxidant Activity

Multiple flavonoid antioxidants provide cellular protection.

Mechanism of action

1

Glabridin Tyrosinase Inhibition

Glabridin is one of most potent natural tyrosinase inhibitors — reduces melanin production; mechanism for skin brightening applications.

2

Anti-Inflammatory Activity

Multiple licorice flavonoids reduce inflammatory pathway activation; relevant to skin and other applications.

3

Antimicrobial Activity

Licochalcones have documented antimicrobial activity against oral and skin pathogens.

4

Glycyrrhizin Reduction

Standard licorice's glycyrrhizin causes pseudoaldosteronism (blood pressure increase, potassium loss, edema) at high/chronic doses; Glycyrrhizina's processed approach minimizes these effects.

Clinical trials

1
Glabridin for Skin Brightening — Multiple Studies
PubMed

Multiple studies of glabridin and licorice flavonoids on skin pigmentation.

Adults with hyperpigmentation concerns.

Skin brightening effects; reduction in melanin markers.

About this ingredient

About the active ingredient

GLYCYRRHIZINA is BGG's LICORICE FLAVONOID extract (GLYCYRRHIZA GLABRA). LICORICE BACKGROUND: roots of Glycyrrhiza glabra; long traditional use in Chinese, Ayurvedic, Western herbal medicine; contains GLYCYRRHIZIN (intensely sweet glycoside) plus FLAVONOIDS (glabridin, licochalcones).

KEY DISTINCTION: REDUCED GLYCYRRHIZIN profile while preserving bioactive flavonoids — addresses primary safety concern (glycyrrhizin's blood pressure and aldosterone effects).

EVIDENCE-BASED USES: (1) SKIN BRIGHTENING (glabridin tyrosinase inhibition); (2) Anti-inflammatory skin effects; (3) Oral care (antimicrobial); (4) Antioxidant activity; (5) Reduced safety concerns vs full-spectrum licorice.

CRITICAL CAUTIONS: (1) GLYCYRRHIZIN CONCERNS — even reduced products may have residual; high/chronic doses cause hypertension, hypokalemia, edema; (2) PREGNANCY — AVOID concentrated licorice in pregnancy regardless of glycyrrhizin level; (3) HYPERTENSION — caution; verify glycyrrhizin reduction; (4) GLYCYRRHIZINA vs DGL (deglycyrrhizinated licorice) — different products; DGL for GI applications; Glycyrrhizina BGG's flavonoid-rich version; (5) DOSE — per BGG specification; (6) FOR SKIN HEALTH — glabridin among most evidence-based natural skin brightening compounds; (7) BRAND VERIFICATION — Glycyrrhizina is BGG product.

Side effects and drug interactions

Common Potential side effects

Generally well-tolerated when glycyrrhizin reduced.
Mild GI distress (rare).
Allergic reactions rare.
STANDARD LICORICE WARNING (less applicable to reduced-glycyrrhizin Glycyrrhizina): hypertension, hypokalemia, edema with glycyrrhizin-rich products.

Important Drug interactions

Antihypertensives — concern minimized with reduced glycyrrhizin but residual considerations.
Diuretics — potassium considerations.
Corticosteroids — interactions with hormonal pathways.
Pregnancy — AVOID concentrated licorice extracts in pregnancy (preterm labor risk with glycyrrhizin); reduced-glycyrrhizin safer but consult.
Lactation — limited data.

Frequently asked questions about Glycyrrhizina (Licorice Flavonoids — BGG)

What is the recommended dosage of Glycyrrhizina (Licorice Flavonoids — BGG)?

The clinically studied dose for Glycyrrhizina (Licorice Flavonoids — BGG) is Per BGG product specification. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Glycyrrhizina (Licorice Flavonoids — BGG) used for?

Glycyrrhizina (Licorice Flavonoids — BGG) is studied for skin brightening (glabridin), anti-inflammatory skin effects, reduced glycyrrhizin (safety distinction). Glabridin (licorice flavonoid) inhibits tyrosinase — relevant to skin brightening and hyperpigmentation; used in skincare formulations.

Are there side effects from taking Glycyrrhizina (Licorice Flavonoids — BGG)?

Reported potential side effects may include: Generally well-tolerated when glycyrrhizin reduced. Mild GI distress (rare). Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Glycyrrhizina (Licorice Flavonoids — BGG) interact with medications?

Known drug interactions may include: Antihypertensives — concern minimized with reduced glycyrrhizin but residual considerations. Diuretics — potassium considerations. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Glycyrrhizina (Licorice Flavonoids — BGG) good for hair, skin & nails?

Yes, Glycyrrhizina (Licorice Flavonoids — BGG) is researched for Hair, Skin & Nails support. Glabridin (licorice flavonoid) inhibits tyrosinase — relevant to skin brightening and hyperpigmentation; used in skincare formulations.