Home Ingredients Opextan® (Olive Fruit Extract — Indena)
CardiovascularAntioxidant

Opextan® (Olive Fruit Extract — Indena)

Olea europaea
Evidence Level
Moderate
2 Clinical Trials
5 Documented Benefits
3/5 Evidence Score

Opextan® is a STANDARDIZED OLIVE FRUIT EXTRACT developed by Indena (Italy) — distinguished from olive leaf extracts (Isenolic, Olivactive, Xorialyc) by FRUIT source providing different polyphenol profile. Standardized to high hydroxytyrosol content. Used for: cardiovascular health, antioxidant defense, oxidative stress reduction. Provides Mediterranean diet polyphenol benefits in concentrated standardized form.

Studied Dose Per Indena product specification
Active Compound Olive fruit polyphenols (high hydroxytyrosol content)

Benefits

Cardiovascular Health Support

Olive polyphenols have established cardiovascular benefits — endothelial function, lipid markers, oxidative stress reduction. Mediterranean diet's cardiovascular benefits are partly attributed to olive polyphenol intake.

Supported by Trial 1, Trial 2

EFSA-Approved Health Claim — LDL Oxidation Protection

EU EFSA approved health claim: olive oil polyphenols (5 mg hydroxytyrosol + derivatives daily) protect LDL particles from oxidative damage. Foundation regulatory positioning.

Supported by Trial 1

Antioxidant Activity (Hydroxytyrosol)

HYDROXYTYROSOL is among most potent natural antioxidants — even more potent than vitamin C in some assays. Direct radical scavenging plus regeneration of other antioxidants.

Supported by Trial 2

Endothelial Function Support

Olive polyphenols support endothelial nitric oxide production and vascular function.

Supported by Trial 1

Olive Fruit vs Leaf Distinction

Distinct from olive leaf extracts (different polyphenol profile); fruit polyphenols closer to extra virgin olive oil composition.

Supported by Trial 1

Mechanism of action

1

Hydroxytyrosol Antioxidant Activity

HYDROXYTYROSOL is the most potent olive polyphenol antioxidant; directly scavenges free radicals; protects LDL from oxidation; supports endogenous antioxidant systems.

2

LDL Oxidation Protection

Oxidized LDL is critical in atherosclerosis pathogenesis; hydroxytyrosol protects LDL from oxidation — mechanism for cardiovascular benefits.

3

Endothelial NO Support

Olive polyphenols support endothelial nitric oxide production — vasodilation and vascular function.

4

Anti-Inflammatory NF-κB Pathway

Olive compounds inhibit NF-κB inflammatory signaling.

Clinical trials

1
Olive Polyphenols and LDL Oxidation — EUROLIVE Trial
PubMed

Major RCT of olive oil polyphenols on LDL oxidation and cardiovascular markers. Foundation for EFSA health claim.

Adults across multiple European centers.

Significant LDL oxidation protection; cardiovascular marker improvements. Foundation for EFSA-approved health claim.

2
Opextan Specific Studies — Indena
PubMed

Indena studies of Opextan for cardiovascular and antioxidant applications.

Adults with cardiovascular concerns.

Improvements in oxidative stress and cardiovascular markers.

Side effects and drug interactions

Common Potential side effects

Generally extremely well-tolerated.
Mild GI distress (rare).
Allergic reactions to olive rare.
Bitter taste characteristic of olive polyphenols (minimal in capsule).

Important Drug interactions

Antihypertensives — modest additive BP effects.
Anticoagulants — modest effects.
Diabetes medications — modest hypoglycemic effects.
Pregnancy — culinary olive use safe; concentrated extract supplementation generally safe at moderate doses.
Lactation — generally safe.

More Cardiovascular Ingredients

Cardiovascular
Niacin
Niacin, or vitamin B3, is a vital nutrient that supports energy production by serving as a…
Cardiovascular
Omega-3 Fatty Acids
Omega-3 fatty acids, primarily eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), an…
Cardiovascular
Potassium
Potassium is the most abundant intracellular cation in the human body, critical for mainta…
Cardiovascular
Pycnogenol® (French Maritime Pine Bark)
Pycnogenol® (Horphag Research) is a standardized extract from the bark of French maritime…

Explore Other Ingredients

Cardiovascular
L-Arginine
L-arginine is an amino acid that serves as a building block for proteins and plays a key r…
Cognitive
Rhodiola Rosea
Rhodiola rosea is an adaptogenic herb from arctic and mountainous regions of Europe and As…
Cognitive
L-Theanine
L-Theanine, an amino acid primarily found in green tea (Camellia sinensis), is commonly su…

Frequently asked questions about Opextan® (Olive Fruit Extract — Indena)

What is the recommended dosage of Opextan® (Olive Fruit Extract — Indena)?

The clinically studied dose for Opextan® (Olive Fruit Extract — Indena) is Per Indena product specification. Always follow product labeling and consult a healthcare provider for personalized dosing recommendations.

What is Opextan® (Olive Fruit Extract — Indena) used for?

Opextan® (Olive Fruit Extract — Indena) is studied for cardiovascular health support, efsa-approved health claim — ldl oxidation protection, antioxidant activity (hydroxytyrosol). Olive polyphenols have established cardiovascular benefits — endothelial function, lipid markers, oxidative stress reduction. Mediterranean diet's cardiovascular benefits are partly attributed to olive polyphenol intake.

Are there side effects from taking Opextan® (Olive Fruit Extract — Indena)?

Reported potential side effects may include: Generally extremely well-tolerated. Mild GI distress (rare). Always consult a healthcare provider before starting any new supplement, especially if you have underlying conditions or take medications.

Does Opextan® (Olive Fruit Extract — Indena) interact with medications?

Known drug interactions may include: Antihypertensives — modest additive BP effects. Anticoagulants — modest effects. Consult a pharmacist or healthcare provider if you take prescription medications.

Is Opextan® (Olive Fruit Extract — Indena) good for cardiovascular?

Yes, Opextan® (Olive Fruit Extract — Indena) is researched for Cardiovascular support. Olive polyphenols have established cardiovascular benefits — endothelial function, lipid markers, oxidative stress reduction. Mediterranean diet's cardiovascular benefits are partly attributed to olive polyphenol intake.